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All Journal Jurnal Ilmiah Kesehatan Media Husada Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Kesehatan dan Kedokteran
Ismatul Fauziah Rambe
Universitas Muhammadiyah Sumatera Utara
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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CENTRAL OBESITY AS A RISK FACTOR FOR TYPE 2 DIABETES MELLITUS. Rambe, Ismatul Fauziah; Fellani, Brizelia Fellani; Octavia, Meta; Salsabila, Shafa
Jurnal Ilmiah Kesehatan Media Husada Vol 15 No 1 (2026): April
Publisher : LPPMK STIKES Widyagama Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33475/jikmh.v15i1.451

Abstract

Central Obesity, Characterized By The Accumulation Of Fat Around The Abdomen, Has Been Increasingly Recognized As A Significant Risk Factor For Type 2 Diabetes Mellitus (T2DM). This Systematic Review Aims To Evaluate Between Central Obesity And The Incidence Of T2DM. A Literature Search Was Conducted In July 2025 Using Databases Such As Pubmed, Google Scholar, And Ebsco. The Inclusion Criterias Are: Studies Published In The Last 10 Years, Available In Full Text, And Accessible For Free. Five Relevant Studies Were Reviewed And Synthesized. The Results Consistently Show That Indicators Of Central Obesity, Including Waist Circumference, Waist-To-Hip Ratio, Weight-Adjusted Waist Index (WWI), And Triglyceridemic Waist Phenotype, Are Strongly Associated With The Risk Of T2DM, Outperforming General Obesity Metrics Like BMI. The Visceral Fat Accumulation Plays A Critical Role In Insulin Resistance And Metabolic Dysfunction. These Results Draw Attention To The Value Of Central Obesity Measurements As Essential Components Of Early Detection And Prevention Strategies Aimed At Combating The Global Diabetes Burden.
Gambaran Polimorfisme Gen LCAT Rs2292318 Dan Kadar Kolesterol Total Pada Penderita Diabetes Melitus (DM) Tipe 2 di RSU Haji Medan Intan Rahmatul Aina; Ismatul Fauziah Rambe; Rahmi Rahmi; Hasroni Fathurrahman
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 5 (2026): Volume 13 Nomor 5
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i5.22704

Abstract

Dislipidemia pada DM tipe 2 berhubungan dengan resistensi insulin yang menyebabkan peningkatan kadar trigliserida dan LDL serta penurunan HDL. Salah satu gen yang diduga berperan terhadap faktor risiko DM tipe 2 adalah gen Lecithin-Cholesterol Acyltransferase (LCAT) rs2292318. Penelitian ini bertujuan untuk mengidentifikasi polimorfisme gen LCAT rs2292318 terhadap kadar kolesterol total pada penderita DM tipe 2 di RSU Haji Medan. Penelitian deskriptif dilakukan pada 35 pasien DM tipe 2 yang dipilih menggunakan purposive sampling sesuai kriteria inklusi. Besar sample dihitung menggunakan aplikasi Gpower. Sampel darah yang diambil untuk isolasi DNA, kemudian dilakukan genotyping gen LCAT rs2292318 menggunakan metode PCR dan elektroforesis. Data dianalisis secara deskriptif. Sebagian besar pasien berjenis kelamin perempuan dengan rentang usia 55–60 tahun, memiliki kadar gula darah sewaktu dan kolesterol total dalam batas normal, serta hipertensi stadium I. Identifikasi polimorfisme gen LCAT rs2292318 menunjukkan genotipe CT sebanyak 5 orang, CC 2 orang, dan TT 28 orang. Pada penderita DM tipe 2 di RSU Haji Medan, genotipe TT merupakan polimorfisme LCAT rs2292318 yang paling banyak ditemukan, dengan sebagian besar pasien memiliki kadar kolesterol total normal.
Intermittent Fasting and GERD Symptoms: A Cross-Sectional Study in a Medical Faculty Academic Community Cherry Permata Putri; Ismatul Fauziah Rambe
Jurnal Kesehatan dan Kedokteran Vol. 5 No. 1 (2026): Februari: Jurnal Kesehatan dan Kedokteran
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jukeke.v5i1.2581

Abstract

Gastroesophageal Reflux Disease (GERD) is a chronic gastrointestinal disorder caused by the backflow of gastric contents into the esophagus and may reduce quality of life. Intermittent fasting (IF) is increasingly practiced among productive-age groups, including academic communities, yet alterations in eating windows may influence gastric acid dynamics and gastrointestinal motility, making its relationship with GERD symptoms clinically relevant. Objective: This study aimed to examine the association between intermittent fasting habits and the occurrence of GERD symptoms among the academic community at the Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Sumatera Utara. Methodology: An analytic observational study with a cross-sectional design was conducted among 64 respondents selected using purposive sampling. Data were collected using a structured questionnaire and analyzed with SPSS. The association between IF habits and GERD symptoms was tested using the Chi-square test at a significance level of p < 0.05. Findings: The analysis showed no statistically significant association between intermittent fasting habits and GERD symptoms (p = 0.633). Research implications: These findings suggest that intermittent fasting, as practiced in this population, may not be a key determinant of GERD symptoms; therefore, prevention and counseling efforts should emphasize other modifiable factors (e.g., meal composition, late-night eating, stress, caffeine intake, or obesity-related risk) when managing reflux complaints in academic settings. Originality/value: This study provides context-specific evidence on the IF–GERD symptom relationship within an Indonesian medical faculty academic community using a standardized symptom assessment approach, contributing local data to an area where findings remain variable across populations.
Relationship Between Waist Circumference and Body Mass Index with HbA1c Levels in Patients with Type 2 Diabetes Mellitus Sukma Febriani; Ismatul Fauziah Rambe; Shahrul Rahman; Ren Astrid Allail Siregar
Jurnal Kesehatan dan Kedokteran Vol. 5 No. 2 (2026): Juni: Jurnal Kesehatan dan Kedokteran
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jukeke.v5i2.2657

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and complex pathophysiological mechanisms. Obesity, assessed through Body Mass Index (BMI) and waist circumference (WC), is commonly associated with poor glycemic control, yet previous studies have reported inconsistent findings. Objective: This study aimed to analyze the relationship between waist circumference and BMI with HbA1c levels in patients with T2DM at Haji General Hospital Medan. Methods: A quantitative analytical study with a cross-sectional design was conducted involving 48 patients with T2DM who met the inclusion criteria. Anthropometric data, including BMI and WC, were measured directly, while HbA1c values were obtained from medical records. Bivariate analysis was performed using the Spearman correlation test, and multivariate analysis was conducted using ordinal logistic regression. Results: The analysis showed no significant association between waist circumference and HbA1c levels (r = −0.141; p = 0.339) or between BMI and HbA1c levels (r = 0.075; p = 0.611). Multivariate analysis also indicated that BMI and WC simultaneously did not significantly affect HbA1c categories (p > 0.05). Implications: These findings suggest that glycemic control in T2DM patients is influenced by multifactorial mechanisms beyond anthropometric parameters, highlighting the importance of considering behavioral, clinical, and therapeutic factors in diabetes management. Originality: This study provides context-specific evidence by simultaneously evaluating BMI and WC in a clinical outpatient population, contributing to the ongoing debate regarding the relevance of simple anthropometric indicators in predicting glycemic control.
TINJAUAN PUSTAKA: PERAN MITOKONDRIA PADA PENYAKIT METABOLIK Ismatul Fauziah Rambe
Jurnal Kesehatan Tambusai Vol. 7 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i2.57829

Abstract

Mitokondria memiliki peran penting dalam menjaga keseimbangan energi dan metabolisme sel. Dalam beberapa tahun terakhir, disfungsi mitokondria semakin dikenal sebagai salah satu faktor utama yang berkontribusi terhadap perkembangan penyakit metabolik, termasuk Diabetes Melitus (DM) tipe 2, obesitas, dan sindrom metabolik. Kondisi ini erat kaitannya dengan peningkatan stres oksidatif, inflamasi kronis, dan gangguan sensitivitas insulin yang berdampak pada berbagai jaringan tubuh. Artikel ini disusun menggunakan pendekatan tinjauan pustaka dengan mengkaji berbagai penelitian ilmiah terkini dalam 10 tahun terakhir yang membahas peran mitokondria, produksi reactive oxygen species (ROS), serta dampaknya terhadap jaringan metabolik utama. Disfungsi mitokondria ditandai oleh penurunan kemampuan produksi energi, gangguan oksidasi asam lemak, penurunan biogenesis mitokondria, serta peningkatan produksi ROS. Perubahan ini memicu akumulasi lemak dalam sel, mengganggu jalur sinyal insulin, dan berkontribusi terhadap resistensi insulin serta kerusakan sel β pankreas. Peninfkatan ROS juga memperburuk stres oksidatif dan inflamasi, yang memiliki dampak luas pada berbagai organ seperti hati, otot rangka, jaringan adiposa, jantung, ginjal, dan sistem saraf. Gangguan fungsi mitokondria juga diketahui dapat berperan dalam penurunan kapasitas metabolik sel dan mempercepat progresivitas komplikasi metabolik. Secara keseluruhan, mitokondria berperan penting dalam perkembangan penyakit metabolik melalui interaksi kompleks antara gangguan energi, stres oksidatif, dan inflamasi. Pemahaman yang lebih baik mengenai mekanisme ini diharapkan dapat membuka peluang baru dalam pengembangan strategi pencegahan dan terapi yang lebih efektif serta berbasis target molekuler.
Co-Authors Cherry Permata Putri Fellani, Brizelia Fellani Hasroni Fathurrahman Intan Rahmatul Aina Octavia, Meta Rahmi Rahmi Ren Astrid Allail Siregar Salsabila, Shafa Shahrul Rahman, Shahrul Sukma Febriani