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All Journal The Journal of Pure and Applied Chemistry Research Industria: Jurnal Teknologi dan Manajemen Agroindustri Tropical Animal Science Journal Indonesian Journal of Chemistry

Warsito Warsito

Chemistry Department, Brawijaya University

Author-ID : 3936266

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Energy Engineering Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Other

Published : 7 Documents Claim Missing Document

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Articles

Mitigation of Polycyclic Aromatic Hydrocarbons Formation in Goat Satay by Shallots Juices Marination E. Saputro; L. E. Radiati; W. Warsito; D. Rosyidi
Tropical Animal Science Journal Vol. 45 No. 2 (2022): Tropical Animal Science Journal
Publisher : Faculty of Animal Science, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5398/tasj.2022.45.2.227

This study aimed to mitigate the carcinogen formation of polycyclic aromatic hydrocarbons (PAHs) in charcoal-grilled goat satay by marinating raw goat-satay with shallots (Allium cepa var. Ascalonicum) juices. The experiment used a 2 x 4 split-plot factorial randomized block design. The experiment consisted of 2 treatments of 2 goat satay types (without and with sliced fat) and 4 treatments of marination with shallots juice at concentrations of 0%, 10%, 20%, and 30% (gmL-1 of fresh shallots in distilled water) for 60 minutes at 4 °C. A total of 24 samples of raw and grilled goat-satay were used for 3 replication groups. The marination with 10% and 20% shallots juices significantly reduced the BaP and BaA until they were not detected even though they increased the non-carcinogenic Pyr levels in the grilled goat-satay with and without sliced fat. The marination with 10%, 20%, and 30% shallots juice significantly prevented the formation of Phe, Ace, and Nap so that they were not detected in the grilled goat-satay with and without sliced fat. The marination with 30% shallots juice of raw goat-satay without sliced fat resulted in the highest antioxidant activities and detectable BaP levels (3.88 mg kg-1).

ENRICHMENT OF α-( ALPHA) LINOLENIC ACID OF BASIL SEED OIL, Ocinum Basillium L. BY FRACTIONAL CRYSTALIZATION AND CRYSTALIZATION IN UREA INCLUSION COMPLEXES Warsito Warsito; Jumina Jumina; Chairil Anwar; Rurini Retnowati; Ahmad Ghanaim; Suleman Duengo
Indonesian Journal of Chemistry Vol 11, No 1 (2011)
Publisher : Universitas Gadjah Mada

Enrichment of α-(alpha) linolenic acid (ALA) of basil seed oil, Ocinum basilicum L. can be done by fractional crystalization and crystalization of fatty acid in urea inclusion complexes (UIC) methods. In this research, the ALA of fatty acid of basil seed oil was fractionated by fractional crystallization in methanol solution at -3, -13 and -25 °C and by crystallization in urea solution (ratio 1:2) at 4, 2, -6 and -8 °C. The ALA percentages were analyzed by GC and GC/MS. The results showed that percentage of ALA obtained from fractional crystallization at -25 °C increase from 65.16 to 91.40, and acquired from UIC is 98.8 at 2 °C

Optimization on Supercritical CO2 Extraction Process to Improve the Quality of Patchouli Oil by Response Surface Methodology Approach Edi Priyo Utomo; Marina Marina; Warsito Warsito; Egi Agustian
Indonesian Journal of Chemistry Vol 18, No 2 (2018)
Publisher : Universitas Gadjah Mada

Until now, the patchouli oil is the largest commodity export of essential oil for Indonesia. But the price of patchouli oil is often unstable due to the quality of oil which fluctuates depending on the components. To improve the performance and quality of patchouli oil had been carried out the purification process using supercritical CO2 fluid extraction method. Optimization conditions of the extraction process using the approach of Response Surface Methodology (RSM) and the influence of independent variables include temperature (35–45 °C), pressure (80–150 atm) and the time of extraction (60–300 min), and then evaluated using a Box-Behnken Design (BBD). Analysis of the components in the extract was carried out by using GC-MS and GC-FID to detect the changes of compositions of the components containing the oil before and after the extraction process. The optimum condition of supercritical extraction within experimental range of the studied variables was at 38 °C, 146.35 atm and 74 min for predicted oil yield of 6.41% and at 41.45 °C, 135.17 atm and 252.62 min and the predicted patchouli alcohol content was 25.34%. The extracted oil is enriched with the main components such as patchouli alcohol compared to the original patchouli oil. The results of RSM evaluation showed consistency between the variables contained in the experiment and the prediction.

Preparation of Poly-(GMA-EDA-β-CD-co-TMPTMA) Monolith as High Performance Liquid Chromatography Chiral Stationary Phase Column Stevin Carolius Angga; Dias Septiana; Suci Amalia; Warsito Warsito; Elvina Dhiaul Iftitah; Akhmad Sabarudin
Indonesian Journal of Chemistry Vol 19, No 4 (2019)
Publisher : Universitas Gadjah Mada

An enantiomer molecule consisted of the chiral atom has different structure conformations, which exhibit different activities as well. Yet, its separation considerably difficult since ordinary separation could not separate both molecules. One of the popular enantioseparations which are often used was using organic polymer monolithic column modified by ethylenediamine-β-cyclodextrin (EDA-β-CD) as the enantioseparations site. The aim of this research was to produce chiral stationary phase column for enantioseparations of (±)-citronellal. It was conducted by preparing monolithic column using monomer glycidyl methacrylate (GMA), trimethylolpropane trimethacrylate (TMPTMA) as crosslinker, 1-propanol, 1,4-butanediol, and water as pore-forming agents (porogens) in the presence of α,α'-azoisobutyronitrile (AIBN) as radical initiator inside polyetheretherketone (PEEK) tubing. It was then modified with EDA-β-CD synthesized from β-CD. Finally, it was installed as a high-performance liquid chromatography column. The result shows the produced chiral stationary phase column could separate (±)-citronellal at a retention time of 44.76 and 45.71 min.

Novel Antimalarial Drug Screening Based on Methyl Eugenol, Cinnamaldehyde, and Thiosemicarbazone with Cysteine Protease Inhibition: In Silico Molecular Docking, Molecular Dynamics, and ADMET Studies Lucy Arianie; Feri Eko Hermanto; Elvina Dhiaul Iftitah; Warsito Warsito; Widodo Widodo
The Journal of Pure and Applied Chemistry Research Vol 11, No 2 (2022): Edition May-August 2022
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2022.011.02.652

Plasmodium falciparum malaria contributes to significant global diseases. Computer-aided drug design, screening, and discovery were used to analyze a novel series of Methyl Eugenol Benzaldehyde Thiosemicarbazone (MEBThi) and Methyl Eugenol Cinnamaldehyde Thiosemicarbazone (MECThi) derivatives for malaria falciparum inhibition. This present study showed that 16 molecules from 28 of MEBThi and MECThi have affinities and interaction with active-site residues of cysteine protease, a key player in erythrocyte proliferation of P. falciparum. 13-MECThi demonstrates the best binding affinity at ˗8.0 kcal/mol while co-drug ˗5.6 kcal/mol. Physicochemical and pharmacokinetic assays of 13- MECThi have also revealed this potent compound. Toxicity analysis shows that 13-MECThi does not have mutagenicity and carcinogenicity characters, whereas co-drug has mutagenicity probability. The molecular dynamic evaluation illustrated that the 13-MECThi complex has higher Root Mean Square Deviation (RMSD) values, indicating its structure was more flexible than the chloroquine complex. Root Mean Square Fluctuation (RMSF) complex of receptor and 13-MECThi has no fundamental differences with chloroquine complex. This designed compound should be considered a falciparum antimalarial drug.

On the Hypolipidemic Activity of Elicited Soybeans: Evidences Based on Computational Analysis Feri Eko Hermanto; Warsito Warsito; Muhaimin Rifa'i; Nashi Widodo
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.75777

Dietary intervention plays a significant role in regulating hyperlipidemia. Besides, elicited soybean has greater bioactive contents with numerous health benefits potential. However, there is no evidence of the hypolipidemic activity of elicited soybean. This study will explore the potential mechanism of hypolipidemic activity of bioactive compounds from elicited soybean through computational modeling. The phytocompounds from elicited soybean were identified by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS), then screened for potential toxicity and drug-likeness properties. Compounds with low potential toxicity and excellent drug-likeness properties were screened for hypolipidemic activity against 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) and Peroxisome Proliferator Activator Receptor-gamma (PPAR-γ) through molecular docking coupled with molecular dynamics. The result showed that phytocompounds from the isoflavonoid group have an excellent affinity to bind with the HMGCR and PPAR-γ. Daidzein, Genistein, and Glycitein interacted with the catalytic residues of HMGCR to act as potential inhibitors with great affinity and stability. Genistein and Glycitein showed strong affinity and stability during their interaction with the agonistic sites of PPAR-γ. Further, the protein network described that targeting HMGCR inhibitor and PPAR-γ had the advantage in orchestrating cholesterol metabolism homeostasis. In summary, isoflavonoids from elicited soybean may have hypolipidemic activity through HMGCR inhibition and PPAR-γ activation.

Uji Aktivitas Antibakteri Minyak Atsiri Jeruk Purut (Citrus hystrix DC) terhadap Klebsiella pneumoniae ATCC Nasrullah Jamaludin; Maimunah Hindun Pulungan; Warsito Warsito
Industria: Jurnal Teknologi dan Manajemen Agroindustri Vol 6, No 2 (2017)
Publisher : Department of Agro-industrial Technology, University of Brawijaya

AbstrakTujuan penelitian adalah membandingkan aktivitas antibakteri minyak atsiri ranting, kulit buah dan daun jeruk purut (Citrus hystrix DC) terhadap bakteri Klebsiella pneumoniae DC, serta mengetahui pengaruh konsentrasi minyak atsiri jeruk purut (Citrus hystrix DC) dalam menghambat pertumbuhan bakteri Klebsiella pneumoniae DC. Rancangan percobaan yang digunakan adalah rancangan acak tersarang (nested design) dengan dua faktor. Faktor pertama adalah jenis minyak atsiri (ranting, kulit buah dan daun jeruk purut). Faktor kedua adalah konsentrasi (100 µl/ml, 300 µl/ml dan 500 µl/ml). Diulang sebanyak 3 kali. Ethanol 95% sebagai kontrol positif dan aquades steril sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa minyak atsiri yang berasal dari kulit buah jeruk purut memiliki kemampuan menghambat pertumbuhan Klebsiella pneumoniae ATCC lebih kuat dari pada yang berasal ranting dan daun. Jumlah minyak atsiri kulit buah jeruk purut, ranting maupun daun jeruk purut tidak berpengaruh terhadap pertumbuhan Klebsiella pneumoniae ATCC.Kata kunci: antibakteri, jeruk purut (Citrus hystrix DC), Klebsiella pneumoniae ATCC, minyak atsiriAbstractThe objective of the study was to compare the antibacterial activity of essential oil of twigs, kaffir lime peels and leafs (Citrus hystrix DC) to Klebsiella pneumoniae DC bacteria, and to know the effect of citrus hystrix DC in limiting the growth of Klebsiella pneumoniae DC bacteria. The experimental design used was a nested design with two factors. The first factor is the type of essential oil (twigs, kaffir lime peels and leaves). The second factor is concentration (100 μl / ml, 300 μl / ml and 500 μl / ml). Repeated 3 times. Ethanol 95% as positive control and sterile aquades as negative control. The results showed that the essential oil derived from the kaffir lime peels has the ability to inhibit the growth of Klebsiella pneumoniae ATCC stronger than that derived from twigs and leaves. The amount of essential oil of kaffir lime leaves, twigs and leaves of kaffir lime has no effect on the growth of Klebsiella pneumoniae ATCC.Keywords: antibactery, essential oil, kaffir lime (Citrus hystrix DC), Klebsiella pneumoniae ATCC

Co-Authors A. Ghanaim Fasya Akhmad Sabarudin Chairil Anwar D. Rosyidi Dias Septiana E. Saputro Edi Priyo Utomo Egi Agustian Elvina Dhiaul Iftitah Hermanto, Feri Eko Jumina Jumina L. E. Radiati Lucy Arianie Maimunah Hindun Pulungan Marina Marina Muhaimin Rifa'i Nashi Widodo Nasrullah Jamaludin Rurini Retnowati Stevin Carolius Angga Suci Amalia Suleman Duengo Widodo Widodo

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