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Pembuatan Matriks dari Kompleks Polielektrolit Kitosan Pektin untuk Sediaan Tablet Mengapung Sagita, Erny; Anwar, Effionora; Surini, Silvia
Majalah Ilmu Kefarmasian Vol. 7, No. 3
Publisher : UI Scholars Hub

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Chitosan is a natural cationic polymer. That cationic property makes chitosan can form polyelectrolite complex (PEC) with anionic polymer. In this research, pectin was used as anionic polymer that interact ionically with chitosan. The aim of this research is to produce and characterize chitosan-pectin PEC that would be used as matrix in floating tablet. The solutions of chitosan and pectin 0,3% w/v were mixed in ratio 1:9, 3:7, 1:1, 7:3 and 9:1 with pH of the solution 4,5 and 5,0. The best condition to produce PEC was in pH 5,0 with ratio of chitosan and pectin = 3:7. The differences between chitosan-pectin PEC characteristic and its origin polymer were shown by functional group analysis, thermal analysis, swelling capacity and gel strength. The PEC was then used as matrix in floating tablet.

Pembuatan Sediaan Tablet Mengapung Famotidin Menggunakan Kompleks Polielektrolit Kitosan-Pektin Sebagai Bahan Matriks Sagita, Erny; Anwar, Effionora; Surini, Silvia
Majalah Ilmu Kefarmasian Vol. 8, No. 1
Publisher : UI Scholars Hub

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Floating tablet is one of the drug delivery system retained in the stomach which aims to prolong the lag time of the drug in the stomach. This principle can be used to improve the efficacy of famotidine in treating diseases in the stomach The purpose of this research is to develop dosage form afloat by using Chitosan Pectin Electrolytes (PEC) as matrix then used as the matrix in tablet dosage form with famotidine as a drug model. PEC also combined with hydroxypropylmethylcellulose (HPMC) with different. PEC was also combined with hydroxypropilmethylcellulose (HPMC) in different concentrations. The results of the dissolution study showed that PEC could retard the release of famotidin for 10 hours. PEC in combination with HPMC could retard the release of famotidin for 20 hours. Tablet that only contains PEC as matrix could remain buoyant for 12 hours while tablet with combination of PEC and HPMC could remain buoyant for 24 hours.

Optimization of PVA-Arabic Gum–Honey-based Electrospun Nanofibers as Candidate Carrier for Peptide and Protein Delivery Rezeki, Ningsih; Khairurrijal,; Surini, Silvia
Pharmaceutical Sciences and Research Vol. 6, No. 2
Publisher : UI Scholars Hub

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Nanofibers dressing exhibit several advantageous characteristics for accelerating wound healing, such as its similar structure to the extracellular matrix (ECM), high surface area/volume ratio, high porosity and high loading capacity of drug. The nanofibers dressing which were prepared by the electrospinning technique using combination of synthetic and natural polymer excipients capable of fulfilling the ideal wound dressing criteria. This study aimed to develop nanofibers dressing prepared from polyvinyl alcohol (PVA), Arabic gum (GA) and honey by electrospinning method. This study focused on the effect of electrospinning parameters and the morphology of electrospun nanofibers of the blended solutions made from PVA (9% w/v) – GA (1% w/v) and honey (at varied concentrations of 0;1;3% w/v) with or without Triton X-100 (0.05% v/v). The effect of varied process parameters such as voltage and flow rate in electrospinning was also investigated. The blended solutions with the various concentration of honey at 0;1;3% w/v and Triton X-100 were named as FAt, FBt, and FCt, respectively, while the blended solutions without Triton X-100, were named as FA, FB, and FC. The optimum electrospining parameter were 18 KV and 5 µl/minute for FAt, FBt, and FCt; and 20 KV and 10 µl/minute for FA, FB, and FC. Electrospun nanofibers of FAt, FBt, FCt showed smoother and more uniform fibers in comparison to the nanofibers FA, FB, and FC. The average nanofibers diameter of FAt, FBt, FCt were 244±45; 266±45; 283±57 nm, respectively, while the average nanofibers diameter of FA, FB, FC was 406±140, 457±168, 594±204 nm, respectively. Higher concentration of honey increased the diameters of nanofibers. The average nanofibers diameter of FAt, FBt, and FCt were within nanoscale in range of the ECM (50-500 nm), which were suitable for accelerating wound healing. Therefore, this study indicated that PVA-GA-honey nanofibers dressing is suitable to be further developed as carrier for growth factors

Formulasi dan Karakterisasi Nanopartikel Sambungsilang Gom Xantan dan Gom Akasia Untuk Penghantaran Insulin Oral Rachmawati, Ade Laura; Surini, Silvia
Pharmaceutical Sciences and Research Vol. 5, No. 3
Publisher : UI Scholars Hub

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The insulin nanoparticles has been developed as an alternative to oral insulin delivery. Nanoparticle drug delivery system could be prepared by a cross-linked polymer, which was composed of xanthan gum and acacia gum, and cross-linked by sodium trimetaphosphate. The aim of the present study was to produce insulin nanoparticles using the cross-linked polymer of xanthan gum and acacia gum for oral delivery. In this study, insulin nanoparticles was prepared by mixing xanthan gum and acacia gum colloid with the ratio 1:1 and using sodium trimetaphosphate as a cross-linking agent in bases condition. Afterwards, insulin solution in HCl was added into the colloid, and then dried to produce the insulin nanoparticles. Insulin nanoparticle powders were characterized in terms of degree of substitution (DS), entrapment efficiency, Dv90, swelling ability, in vitro release study, and stability test. The results showed that the substitution degree of the insulin nanoparticles was 0.08 – 0.10 and the entrapment efficiency was 26.11% - 48.73%. Moreover, the insulin nanoparticles had Dv90 value 547 nm - 726 nm and swelling index of 1.1 - 2.9 in HCl pH 1.2 and 2.5 - 3.4 in phosphate buffer pH 6.8, respectively. According to the dissolution study, the insulin nanoparticles provided the insulin release of 78.42% - 85.67% within 3 hours. Furthermore, stability testing showed insulin content after 9 weeks incubation at 4oC was 74.46% - 85.09%. Therefore, this work demonstrated that a cross-linked polymer of xanthan gum and acasia gum nanoparticle could be potential for could be potential for oral insulin delivery system.

Kompleks Polielektrolit Kitosan-Xanthan sebagai Matriks Sediaan Mukoadhesif Setio Putri, Kurnia Sari; Sulistomo, Bambang; Surini, Silvia
Pharmaceutical Sciences and Research Vol. 4, No. 1
Publisher : UI Scholars Hub

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Mucoadhesive dosage form is a pharmaceutical dosage form with prolonged gastric residence time which can increase bioavailability of drugs. An excipient with suitable swelling and bioadhesive characteristics plays important role to obtain good mucoadhesive dosage form. Our pre-eliminary study showed that chitosan-xanthan gum polyelectrolyte complex (CXPC) in ratio 1:1 exhibit suitable swelling index to be developed as mucoadhesive dosage forms. This research was performed to study CXPC characteristics as matrix for mucoadhesive granules dosage form matrix. In this study CXPC 1:1 was utilized as the matrix in the mucoadhesive granules with drug-CXPC ratio of 1:1, 1:2, and 1:3, using diltiazem HCl as a drug model. The granules were prepared by wet granulation method, and the in vitro bioadhesive properties of the granules, as well as the drug release profile, were evaluated. The results showed that formula containing diltiazem HCl and CXPC in ratio of 1:2 possessed a good bioadhesive ability up to 8-12 hours and showed controlled drug release profile up to 8 hours. The results can be concluded that the CXPC is a suitable excipient as a mucoadhesive matrix.

Harnessing the Potential of Several Local Indonesian Tuber-derived Starches as Pharmaceutical Excipients Horison, Ronald; Surini, Silvia
Pharmaceutical Sciences and Research Vol. 11, No. 2
Publisher : UI Scholars Hub

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Starch is one of the widely required excipients in pharmaceutical dosage forms manufacturing. Indonesia’s rich biodiversity, encompassing tubers like arrowroot, taro beneng, porang, ganyong and yams, harbours the potential for novel starch excipient sources. These tubers provide starch variations with distinct functional properties influenced by the natural starch granules’ properties and amylose-amylopectin ratio. Previous research utilizing natural and modified starches from these tubers has demonstrated their potential in pharmaceutical formulation. These starch tubers have been studied and provided promising results in tablet formulation and film development. Additionally, they could be involved in developing more advanced dosage forms, such as starch nanoparticles and nanocrystals. The rich versatility of these tuber starches solidified a promising future for their development, offering significant advantages for both pharmaceutical technology and economic value perspectives. Optimization of the starch yield, mainly through extraction, is crucial to fully realizing the economic prospect of tuber-derived starches.

Utilization of PVP-PLA Combination in Fabricating Theophylline-loaded Filament for 3D Printing with Immediate Release Behavior Kurniawan, Arief; Surini, Silvia
Pharmaceutical Sciences and Research Vol. 10, No. 2
Publisher : UI Scholars Hub

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Fused deposition modeling (FDM), known as a highly effective 3D printing technique, holds promise as an alternative approach to tablet manufacturing. While commonly employing thermoplastic polymers as starting materials, the integration of established pharmaceutical excipients remains unexplored. Polyvinyl pyrrolidone (PVP) is a frequently used excipient known for its potential to confer immediate-release properties to drugs. However, its suitability for extrusion is hindered by its thermal and melt-rheological properties. In contrast, polylactic acid (PLA), which has robust mechanical strength and thermal plasticity, was expected to overcome PVP’s limitations. This study aims to obtain drug-loaded filaments using the combination of PVP and PLA through a hot-melt extrusion process, aiming for favorable mechanical properties and immediate-release behavior. Utilizing a twin-screw extruder, and theophylline was used as the model drug, three formulations were optimized –FP1, FP2, and FP3– containing 0%, 10%, and 20% theophylline, respectively. Subsequent evaluation including filament morphology, mechanical properties, drug content, and drug release profile, were performed to each filament. FP2 emerged as the most promising formulation, with 10.35% (w/w) drug load and over 95% drug released in an hour. All formulations exhibited slightly rough filament surfaces with diameters averaging 1.4-1.6 mm. Notably, an increase in the theophylline content correlates with the diminished filament strength, evident in reduced hardness and a rise in brittleness. This study emphasized the potential of PVP-PLA-based filaments for future pharmaceutical 3D printing formulations, providing immediate drug release characteristics.

A Preliminary Study of Formulations of Transfersomes for Improved Transdermal Peptide Delivery Surini, Silvia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.55269

Peptide-containing dosage forms are often administered through invasive injection. However, due to their great ultra-mobility, transfersomes offer a promising alternative for non-invasive and non-allergenic transdermal peptide delivery. Therefore, this study aimed to conduct preliminary investigations into the formulations of transfersomes for transdermal peptide delivery. Transfersomes were prepared using the thin-layer hydration method with Tweenâ 80 as an edge activator and Phospholiponâ 90G as vesicle formers. Four formulations: F1, F2, F3, and F4 were optimized with various ratios of the two components, including 90:10, 85:15, 80:20, and 75:25. Particle size, zeta potential, deformability index, polydispersity index (PDI), and vesicle morphology were used to assess transfersomes. As a result, the zeta potential was -37.2 ± 2.19, the deformability index was 1.78 ± 0.03 and the smallest vesicle size (147 ± 1.93), PDI value of 0.105 ± 0.01 and spherical were all found in the optimal formula, F3, with an 80:20 ratio. These results suggest significant potential for the further development of transfersomes using Tweenâ 80 and Phospholiponâ 90G as effective transdermal peptide delivery systems.

Natural deep eutectic solvents (NaDES) improves extraction and antioxidant activity of stem bark of Garcinia cowa Roxb. Fahleni, Fahleni; Mun'im, Abdul; Saputri, Fadlina Chany; Surini, Silvia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1722

Garcinia cowa Roxb. ex DC. is a plant belonging to the Clusiaceae family, and commonly dicovered in Southeast and South Asia. This study aimed to assess the efficiency of eight natural deep eutectic solvents (NaDES) in extracting total xanthones and phenolic compounds from the stem bark using ultrasound-assisted extraction as there is limited research on the use of NaDES in this plant extraction process. The study also examined their antioxidant properties. The NaDES were synthesized with choline chloride and betaine as hydrogen-bond acceptors, accompanied by various acids, alcohols, and glucose as hydrogen-bond donors. In comparison, ethanol was used as standard solvent. The NaDES exhibited higher densities than water, ranging from 1.059 to 1.244 g/cm³, with density increasing according to the number of hydroxyl groups present in the constituents. The total phenolic content (TPC) varied from 22.82 to 28.73 mg GAE/g extract, with NaDES1 (a combination of choline chloride, 1,2-propanediol, and water in a ratio of 1:3:1) showing the highest TPC at 28.73±0.18 mg GAE/g extract. It also exhibited significant antioxidant activities, as demonstrated by DPPH (28.98±0.03 µg/mL) and FRAP assays (43.66±1.51 mmol trolox/g dw). A significant negative correlation was observed between total xanthone, total phenolic content, and IC50 values. These findings suggest that NaDES, particularly NaDES1, have considerable advantages in extracting phenolic compounds and xanthones from G. cowa stem bark, resulting in enhanced antioxidant properties.This highlights the potential of NaDES as eco-friendly and effective solvents for the extraction of bioactive compounds from plant materials.

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