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All Journal JURNAL SAINS DAN TEKNOLOGI INDONESIA Media Penelitian dan Pengembangan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Nursing and Health Sciences Journal (NHSJ) Jurnal Ekonomi Manajemen Bisnis dan Akuntansi
Idah Rosidah
Pusat Teknologi Farmasi dan Medika- Badan Pengkajian dan Penerapan Teknologi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pengaruh Kondisi Proses Ekstraksi Batang Brotowali (Tinospora crispa (L) Hook.f & Thomson) Terhadap Aktivitas Hambatan Enzim Alfa Glukosidase Rosidah, Idah; Bahua, Humiaty; Mufidah, Rima; Pongtuluran, Olivia Bunga
Media Penelitian dan Pengembangan Kesehatan Vol 25, No 4 Des (2015)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.539 KB)

Abstract

AbstrakBrotowali (Tinospora crispa (L.) Hook.f. &Thomson) merupakan salah satu tanaman obat yang telah banyak digunakan untuk pengobatan tradisional dan memiliki aktivitas sebagai antidiabetes. Penelitian ini bertujuan untuk mengetahui pengaruh kondisi proses ekstraksi batang brotowali terhadap aktivitas hambatan enzim alfa glukosidase, kadar total fenol dan Total Dissolved Solids (TDS). Simplisia batang brotowali yang digunakan memiliki kadar susut pengeringan sebesar 11,59%; kadar air 9,11%; kadar abu total 7,62%; kadar abu tidak larut asam 5,00%; kadar sari larut air 2,24%; kadar sari larut etanol 0,53% dan kadar total fenol 2,90 mg Ekivalen Asam Galat (EAG)/g simplisia. Penelitian ini menggunakan variabel tetap yaitu metode ekstraksi perkolasi, konsentrasi etanol kualitas pangan 70% dan laju alir pelarut 250 mL/menit. Sedangkan variabel peubahnya adalah delapan waktu ekstraksi (30, 60, 90, 120, 150, 180, 210 dan 240 menit) dan tiga perbandingan simplisia-pelarut (1:10, 1:15 dan 1:20). Hasil penelitian menunjukkan bahwa nilai aktivitas hambatan enzim alfa glukosidase dan TDS tertinggi diperoleh pada perbandingan simplisia-pelarut 1:10 dan berbeda signifikan (P<0,05) dengan perbandingan simplisia-pelarut 1:15 dan 1:20. Kadar total fenol berbeda signifikan (P< 0,05) antara ketiga perbandingan simplisia-pelarut 1:10, 1:15 dan 1:20. Proses waktu ekstraksi menunjukkan perbandingan nisbah simplisia-pelarut 1:10 memiliki aktivitas hambatan enzim alfa glukosidase tertinggi 81,31%, kadar total fenol 40,52 mg EAG/g ekstrak pada180 menit. Perbandingan simplisia-pelarut 1:15 diperoleh hambatan enzim alfa glukosidase tertinggi 74,79%, kadar total fenol 22,74 mg EAG/g ekstrak pada 30 menit. Sedangkan perbandingan simplisia-pelarut 1:20 diperoleh hambatan enzim alfa glukosidase tertinggi 65,00%, kadar total fenol 30,69 mg EAG/g ekstrak pada 210 menit.Kata kunci : Ekstraksi, Tinospora crispa, alfa glukosidase AbstractBrotowali (Tinospora crispa (L.) Hook.f. &Thomson) is one of medicinal plants, which is widely used as traditional medicine and has been using as an antidiabetic activity. The aims of study were to investigate the influence of extraction process of T.crispa on alpha-glucosidase inhibitoryactivity, total phenols content and Total Dissolved Solids (TDS) content. T.crispa used content of loss on drying, water content, total ash, acid insoluble ash, compound soluble in water, soluble in ethanol and total phenols were found to be 11.59%, 9.11%, 7.62%, 5.00%, 2.24%, 0.53% and 2.90 mg Gallic Acide Equivalent (GAE)/g respectively. This study used dependent variables those were method of extraction using percolation, 70% ethanol food grade as solvent and 250 mL/min flow rate of extraction. There were eight extraction times (30, 60, 90, 120, 150, 180, 210 and 240 minutes) and three ratios of T.crispa-solvent (1:10, 1:15 and 1:20) as nondependent variable. The results of extraction process showed that alpha-glucosidase inhibition activity and TDS content of the highest in ratio T.crispa solvent of 1:10 and significantly difference (P<0.05) than 1:15 and 1:20. The total phenols content of all ratios of T.crispa-solvents 1:10, 1:15 and 1:20 having a significantly difference (P<0.05). The process of extraction time in ratio T.crispa-solven 1:10 with the best alpha-glucosidase inhibitory activity 8.13%, phenol total content 40.52 mg GAE/g was on 180 minutes. Extraction time in ratio T.crispa-solven 1:15 with alpha glucosidase inhibitory activity 74.79% and phenol total content 22.74 mg GAE/g was on 30 minutes. Extraction time in ratio T.crispa-solven 1:20 with alpha-glucosidase inhibitory activity 65.00%, phenol total content 30.69mg GAE/g was on 210 minutes.Keywords : Extraction, Tinospora crispa, alpha-glucosidase
SINTESIS DAN KARAKTERISASI NANOPARTIKEL KITOSAN – EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana) rismana, eriawan; Kusumaningrum, susi; p, olivia bunga; rosidah, idah; marhamah, marhamah
Jurnal Sains dan Teknologi Indonesia Vol. 14 No. 3 (2012)
Publisher : Badan Pengkajian dan Penerapan Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (137.139 KB) | DOI: 10.29122/jsti.v14i3.925

Abstract

The chitosan – Garcinia Mangostana extract nanoparticles has been prepared by ionic gelation reaction by mixture 0.2 % chitosan solution in acetic acid with Garcinia Mangostana extract and it’s continued by reaction process with 0.1 % sodium tripolyphosphate. The particle size of material was determined by Particle Size Analyzer (PSA) that it showed in the range of 200 – 500 nm. The color, pH, water, α- mangostin, mercury, arsenic, cadmium, lead, totally microbe aerobic, totally mold and yeast, and solvent residue contents of nanoparticles were also examined by many methods that these resulted are yellow, 4.50 – 5.50, 89 – 90 %, 1.05 %, < 0.005 ppm, < 0.01 ppm, < 0.01 ppm, < 0.05 ppm, < 10 CFU/g, < 10 CFU/g and not detected, respectively. The other characterization was also observed that it’sincluded stability andTLC chromatogram. A mixture of nanoparticles with cosmetics bases was showed that it’s increased stability, homogeneity and easy to formed.
PROFIL HEMATOLOGI TIKUS (Rattus norvegicus) GALUR SPRAGUE-DAWLEY JANTAN UMUR 7 DAN 10 MINGGU Rosidah, Idah; Ningsih, Sri; Renggani, Tiya Novita; Efendi, Julham; Agustini, Kurnia
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 7 No. 1 (2020): June 2020
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29122/jbbi.v7i1.3568

Abstract

Hematology Profile of Sprague-Dawley Male Rats (Rattus norvegicus) Aged 7 and 10 WeeksCurrently, the normal hematology profile has not been yet available for outbred rats in Indonesia. Most of the researchers use the data of hematology profile from references outside Indonesia in which the breeding environment is different. This study aimed to obtain a hematology profile of Sprague-Dawley male rats aged 7 and 10 weeks. The animals were obtained from the Laboratory of Animal Experiment, NADFC. Blood was drawn from the retro-orbital sinus and then analyzed to obtain the hematology profile including erythrocytes, hemoglobin, hematocrit, MCV, MCH, MCHC, leukocytes. Statistically significant differences for erythrocytes, hemoglobin, MCV, MCHC, thrombocyte, and leukocytes parameters were observed between rats aged 7 and 10 weeks. However, there were no statistically significant differences observed on MCH, thrombocyte, and body weight parameters. Data presented here would be useful as a reference for hematology research as well as in evaluating alterations in blood parameters.Keywords: erythrocyte, hematology, leukocyte, Sprague-Dawley, thrombocyteABSTRAKSaat ini belum banyak tersedia informasi profil hematologi untuk hewan coba tikus yang dikembangbiakkan di Indonesia. Kebanyakan peneliti menggunakan data profil hematologi dari referensi luar Indonesia. Penelitian ini bertujuan untuk mendapatkan data hematologi tikus jantan usia 7 dan 10 minggu.  Hewan coba yang digunakan adalah tikus jantan galur Sprague-Dawley yang diperoleh dari Laboratorium Hewan Percobaan-BPOM. Sebanyak 60 ekor tikus jantan yang terdiri dari 30 ekor usia 7 minggu dan 30 ekor usia 10 minggu diambil darahnya melalui sinus orbitalis. Selanjutnya, dianalisa jumlah sel eritrosit, hemoglobin, hematokrit, MCV, MCH, MCHC, leukosit. Hasil analisis statistik menunjukkan terdapat perbedaan signifikan antara tikus jantan usia 7 dan 10 minggu untuk parameter jumlah eritrosit, hemoglobin, hematokrit, MCV, MCHC dan leukosit. Tetapi tidak terdapat perbedaan signifikan untuk jumlah MCH, trombosit dan berat badan tikus. Data yang diperoleh dapat digunakan sebagai referensi penelitian yang berhubungan erat dengan profil hematologi dan penyakit kelainan darah lainnya.
ANALISIS PENERAPAN PSAP NO. 07 PADA AKUNTANSI ASET TETAP DI KANTOR KECAMATAN CIWIDEY. Rosidah, Idah; Kesumah, Priatna; Kurniawan, Sandy; Gunardi
Jurnal Ekonomi Manajemen Bisnis Dan Akuntansi : EMBA Vol 3 No 1 (2024): JURNAL EKONOMI MANAJEMEN BISNIS dan AKUNTANSI : EMBA
Publisher : Pusat Penelitian dan Pengabdian pada Masyarakat (P3M) Politeknik Pajajaran ICB Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59820/emba.v3i1.266

Abstract

This research aims to analyze the application of Government Accounting Standards Statement (PSAP) No. 07 related to fixed asset management at the Ciwidey District Office. The problem studied is the implementation of PSAP No. 07 which has not been optimal in the aspects of recording, measuring, depreciation and disclosure of fixed assets, as well as the technical obstacles faced. This research uses a descriptive method with a qualitative approach, where data is obtained through documentation of financial reports, interviews with the head of the accounting department, and direct observation of the accounting information system used. The research results show that the Ciwidey District Office has implemented most of the provisions of PSAP No. 07, but there are still obstacles in integrating accounting information systems with standard fixed asset reporting. In conclusion, the implementation of PSAP No. 07 on fixed assets needs to be improved through information system optimization and external audits to ensure transparency and reporting accuracy. The advice given is to strengthen the integration of the accounting system and carry out routine audits to comply with applicable accounting standards.
The effect of prenatal yoga on pubic bone pain in pregnant women in the third trimester Rosidah, Idah; Triana Indrayani; Risza Choirunissa
Nursing and Health Sciences Journal (NHSJ) Vol. 5 No. 3 (2025): September 2025
Publisher : KHD-Production

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53713/nhsj.v5i3.576

Abstract

Pubic bone pain is one of the discomforts that occurs in pregnant women in the third trimester. This problem often occurs in pregnant women, especially in the third trimester. Pharmacological and non-pharmacological methods can be used to manage pubic bone pain. Non-pharmacological pain management can be done in several ways, including relaxation, acupressure, and prenatal yoga. Prenatal yoga is one of the modifications of hatha yoga adapted to pregnant women's conditions. This study aims to determine the effect of prenatal yoga on pregnant women in the third trimester in overcoming pubic bone pain in the control and intervention groups. The method for this study uses quasi-experimental research, which uses a pre- and post-test design with a control group design. The sample in this study amounted to 50 pregnant women in the third trimester, consisting of 25 pregnant women in the intervention group and 25 pregnant women in the control group. The sampling technique used was purposive sampling. This research instrument used pain measurement with the NRS. Due to abnormal distribution, the data were analyzed using descriptive statistics and non-parametric tests, namely the Wilcoxon test. The results of the study showed that prenatal yoga affected pubic bone pain in third-trimester pregnant women, with a value of P = 0.000. Prenatal yoga was able to reduce pubic bone pain in pregnant women in the third trimester. The researcher was then able to provide both pharmacological and non-pharmacological treatment to pregnant women in the third trimester who experienced pubic bone pain.
Co-Authors Efendi, Julham Eriawan Rismana Gunardi Humiaty Bahua, Humiaty kesumah, priatna kurnia agustini Kurniawan, Sandy Marhamah Marhamah OLIVIA BUNGA PONGTULURAN, OLIVIA BUNGA p, olivia bunga Renggani, Tiya Novita Rima Mufidah, Rima Risza Choirunissa Silvia Surini Sri Ningsih Susi Kusumaningrum Triana Indrayani Wahono Sumaryono