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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kesehatan Tambusai ASPIRATOR - Journal of Vector-Borne Diseases Studies
Yuniarti Suryatinah
Balai Litbang P2B2 Tanah Bumbu, Kementerian Kesehatan RI. Jln. Loka Litbang Kawasan Perkantoran Pemda Tanah Bumbu, Gunung Tinggi Batulicin Kabupaten Tanah Bumbu, Kalimantan Selatan
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Analisis Keberhasilan Program Pemberian Obat Pencegahan Massal (POPM) Filariasis Re-TAS 1 di Kabupaten Hulu Sungai Utara: Success Analysis of the Mass Drug Administration (MDA) for Lympatic Program Re-TAS 1 in Hulu Sungai Utara District Suryatinah, Yuniarti; Rahayu, Nita; Sulasmi, Sri; Yuana, Windy Tri; Setyaningtyas, Dian Eka
Aspirator Vol 13 No 1 (2021): Jurnal Aspirator Volume 13 Nomor 1 2021
Publisher : Perkumpulan Entomologi Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/asp.v13i1.4651

Abstract

District of Hulu Sungai Utara conducted an additional 2 (two) rounds of Mass Drug Administration (MDA) for filariasis prevention in 2014 and 2015 that resulted in the success of the re-Transmission Assessment Survey Phase 1 (re-TAS 1) in 2016. This study was conducted to identify factors affecting the technical aspects of the aforementioned two additional rounds of MDA. This is a descriptive qualitative study, with a cross-sectional study design. The research was performed from September to November 2017. Data was collected through in-depth interviews with some executive stakeholders (health workers, cadres, community leaders, local women group) involved in the implementation of MDA for the filariasis elimination program. The result from indepth interviews shows the presence of technical factors at the execution level which supports the smooth implementation of the two additional rounds of MDA. Those factors include communication, resources, operational standard, bureaucracy, and pharmaceutical innovation. The success of the additional MDA rounds was marked by the absence of the re-TAS sample that was tested positive of Brugia Rapid™. The pharmaceutical innovation which transforms the dosage form of the medication into powdered form with some additional sweetener that was done in 2014-2015 can improve coverage of the treatment as well as the medication adherence for the early childhood population group. Changing pharmaceutical dosage forms require additional support in the form of human resources, infrastructure as well as financing.
The Development and Validation of The Indonesian Insulin Adherence Influence Factor Questionnaire (IIAIFQ) Suryatinah, Yuniarti; Athiyah, Umi; Mohd Ali, Adliah Binti; Zairina, Elida
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.369-378

Abstract

Background: Type 2 diabetes mellitus (DMT2) is a metabolic disease due to abnormalities in insulin secretion. Insulin is one of DMT2 therapy. Objective: This study aimed to validate a modified the insulin adherence influence factor questionnaire based on the health belief model (HBM) among Indonesian patients with DMT2. Methods: The Indonesian insulin adherence influence factor questionnaire (IIAIFQ) was developed based on modified some literature reviews and internal expert discussions. The study included 30 participants aged ≥ 17 y.o years old who had been taking insulin in the previous two months. The questionnaire consists of seven dimensions to measure HBM : perceived susceptibility, perceived severity, perceived benefits, perceived barriers, self-efficacy, cues to action and insulin adherence. Results: The construct validity test showed that of the 34 question items in the questionnaire, 10 items were invalid, 24 others were demonstrated valid based on the Pearson Correlation (>r table 0.361; p<0.05; loading factor > 0.5). Furthermore, 24 valid items were tested for reliability at a significance level of 0.05, and the results showed that each size had a  Cronbach's Alpa > 0.6 with an overall score was 0.858, indicating that all domains in the questionnaire were reliable. Conclusion: IIAIFQ  based The HBM theory is a valid and reliable instrument for assessing insulin adherence in diabetes mellitus patients.
PENDEKATAN DOCKING MOLEKULAR EUGENOL SEBAGAI INHIBITOR SEL KANKER PAYUDARA MCF-7 DAN ANTIOKSIDAN ROS 1 Junjung Buih, Putri Helena; Suryatinah, Yuniarti; Serawaidi, Nadya Putri Auliya
Jurnal Kesehatan Tambusai Vol. 7 No. 1 (2026): MARET 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i1.56373

Abstract

Eugenol atau yang biasa disebut minyak cengkeh merupakan salah satu senyawa aromatik yang terkandung dalam tanaman cengkeh (Syzigium aromaticum). Efektivitas eugenol sebagai senyawa antioksidan telah ditunjukkan di beberapa studi in vitro. Aktivitas antioksidan sangat berpengaruh terhadap potensinya sebagai antikanker. Tujuan utama docking molekular adalah untuk memperkirakan struktur kompleks antara ligan dan reseptor melalui pendekatan komputasi, guna memperoleh pemahaman mengenai afinitas dan orientasi ikatan yang paling stabil di antara keduanya. Penelitian ini bertujuan untuk mengetahui efektivitas eugenol sebagai antioksidan terhadap radikal bebas Reactive Oxygen Species (ROS1) kinase dan mengetahui potensi aktivitas yang dapat ditimbulkan sebagai antikanker dengan mengamati daya hambat terhadap sel kanker payudara Michigan Cancer Foundation (MCF-7) secara in silico dengan metode docking molekular. Tahapan penelitian yang dilakukan meliputi penyiapan database struktur ligan eugenol dan protein radikal bebas ROS1 kinase dan sel kanker payudara MCF-7 menggunakan aplikasi Biovia Discovery Studio, dilanjutkan dengan docking senyawa eugenol pada protein antioksidan ROS dan sel MCF-7 menggunakan aplikasi Autodock Vina dan visualisasi hasil penambatan ligan-protein dengan menggunakan aplikasi Ligplot+ v2.2. Studi docking molekular ini menunjukkan bahwa senyawa eugenol memiliki afinitas (energy ikatan) dan membentuk ikatan hydrogen dengan radikal bebas ROS1 kinase dan sel MCF-7 masing-masing sebesar -5,7 Kkal/mol dan -6,6 Kkal/mol. Sehingga dapat disimpulkan bahwa senyawa eugenol yang memiliki aktivitas sebagai antioksidan dan berpotensi dalam menghambat sel kanker payudara MCF-7 karena menghasilkan energi ikatan (afinitas) yang baik.
Co-Authors Buih, Putri Helena Junjung Dian Eka Setyaningtyas Elida Zairina Mohd Ali, Adliah Binti Nadya Putri Auliya Serawaidi Nita Rahayu Sri Sulasmi Umi Athiyah, Umi Windy Tri Yuana