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. Suryono
Fakultas Kedokteran Universitas Jember
Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Dentistry Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : e-Journal Pustaka Kesehatan

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Efek Angiogenesis Lumbrokinase terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi Angiogenesis Effect of Lumbrokinase on the Cardiac Histopathology of Hypertensive Wistar Rat Sharfina Sharfina; Suryono Suryono; Arief Suseno
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Hypertension remains a serious health problem it is dubbed as “the silent killer”. Pathophysiology of hypertension involve alteration of vascular structure. The use of anti hypertension leads to many side effects, and many people tend to choose natural therapy. The study aimed to investigate the effect of lumbrokinase on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Lumbrokinase 0.5 gr/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with lumbrokinase from 187 mmHg to 159 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of lumbrokinase. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 10.55± 1.44 compared to 7.45± 1.21 in control group. It can be concluded that lumbrokinase had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, lumbrokinase, vascular structure, angiogenesis.
Pengaruh Hemodialisis terhadap Fungsi Diastolik Ventrikel Kiri pada Pasien Penyakit Ginjal Kronik Stadium V Rifqi Rahadian; Yuli Hermansyah; Yohanes Sudarmanto; Suryono Suryono
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17584

Abstract

Stage V chronic kidney disease (CKD) patients need renal replacement therapy. Hemodialysis is main choice for renal replacement therapy and correlates with changes of left ventricular function. Left ventricular diastolic function is one parameter of left ventricular function. The aim of this study was to analyze the effect of hemodialysis towards left ventricular diastolic function in stage V CKD patients at RSD dr. Soebandi Jember. This study included 30 patients (17 female, age 48,20±8,02 years) and underwent echocardiography 30 min before and after a hemodialysis session. Sample characteristics were divided into sex, age, duration of hemodialysis, blood pressure before and after hemodialysis. Diastolic function was measured with E/E’ ratio. Diastolic function criteria of 16 samples (53,5%) were normal (E/E’ ratio <10) after doing a hemodialysis session. Mean ratio E/E’ was significantly reduced (13,09±4,55 vs 11,6±5,04, p<0,05). In conclusion, hemodialysis could increase left ventricular diastolic function in stage V CKD patients at RSD dr. Soebandi Jember.
Efek Angiogenesis Beraprost terhadap Gambaran Histopatologi Jantung Tikus Galur Wistar Hipertensi (Angiogenesis Effect of Beraprost on the Cardiac Histopathology of Hypertensive Wistar Rat) Cynthia Damayanti; Suryono Suryono; Arief Suseno
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Hypertension is a state where there is an increase of blood pressure above normal threshold,120/80 mmHg. The phatophysiology of hypertension involves the changes of vascular structure. Therefore, the beraprost drug was created. It is a vasodilator and antitrombolytic which is able to induce angiogenesis. The study aimed to investigate the effect of Beraprost on angiogenesis as a hypertension therapy agent. In true experimental design, 22 males wistar rat were divided into control group and treatment group (Beraprost 100mcg/KgBW/day). The results showed that the systolic blood pressure decrease after therapy with Beraprost from 180 mmHg to 143 mmHg whereas diastolic blood pressure consistant at 80 mmHg after induction of hypertension as well as therapy of Beraprost. An examination of cardiac histopathology, there was an increasing number of blood vessels in the treatment group, 16.637.29 compared to 7.45 1.21 in control group. It can be concluded that Beraprost had an angiogenesis effect and decrease systolic blood pressure in hypertensive rat model. Keyword : Hypertension, Beraprost, vascular structure, angiogenesis.
Analisis Nilai Laju Endap Darah pada Pasien Sindrom Koroner Akut dan Stable Angina di RSD dr. Soebandi Jember (The Erythrocyte Sedimentation Rate Analysis in Acute Coronary Syndrome and Stable Angina Patients at dr. Soebandi General Hospital) Rizki Nur Fitria; Suryono Suryono; Rini Riyanti
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Erythrocyte sedimentation rate (ESR) is non-specific blood tests that can be used as a marker of chronic inflammation. Some proteins that affect the erythrocyte sedimentation rate are fibrinogen, lipoprotein, and immunoglobulins. These proteins elevate in patients with atherosclerosis and acute coronary syndrome. This study aimed to determine the relationship between erythrocyte sedimentation rate and the incidence of acute coronary syndrome and stable angina at dr. Soebandi General Hospital Jember. This analytic observasional study using cross-sectional design.This study used 40 samples, divided into four groups; stable angina, UA, NSTEMI, and STEMI. The average value of ESR were 12,1mm/h, 20,7mm/h, 28,9mm/h, and 25,3mm/h for stable angina, UA, NSTEMI, and STEMI, respectively. Kolmogorov-Smirnov statistical test showed significant difference between groups(p=0.001). It indicated that there was relationship between erythrocyte sedimentation rate and the incidence of acute coronary syndrome and stable angina in dr. Soebandi General Hospital Jember. Keywords: erythrocyte sedimentation rate, acute coronary syndrome, stable angina
Hubungan Kadar SGOT dengan Kadar Leukosit pada Pasien NSTEMI di ICCU RSD dr. Soebandi Jember (Correlation between SGOT Level and Leukocytes in NSTEMI Patients at ICCU dr. Soebandi Hospital, Jember) Finty Arfian; Suryono Suryono; Rini Riyanti
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6797

Abstract

Acute Coronary Syndrome (ACS) is a syndrome that occurs because of blockage of the coronary artery causing clinical symptoms due to unfulfilled oxygen supply. Atherosclerosis is suspected as the main cause of ACS. Inflammation is one pathophysiology of atherosclerosis characterized by leukocytosis. NSTEMI is one spectrum of ACS that diagnosed by anamnesis, ECG, and cardiac marker such as troponin. SGOT is also released into the circulation when there is myocardial damage. Studies has reported that SGOT increased from the normal range during a myocardial infarction. The purpose of this study was to determine the relationship between levels of SGOT and leukocytes in patients with NSTEMI. The sample included 10 patients with NSTEMI in July-December 2016 from ICCU RSD dr. Soebandi Jember. The data was collected from medical record. The result showed that the average of SGOT increased from the normal range, while the average levels of leukocytes were in normal range. Pearson correlation test showed that there was no significant relationship between the two variables with p=0.083>0.05. In conclusion, there was no relationship between the levels of SGOT and leukocytes in patients with NSTEMI at ICCU RSD dr. Soebandi Jember. Keywords: NSTEMI, SGOT, Leukocyte
Co-Authors Ali Santosa Arief Suseno Aris Prasetyo Athiyah Fi Ramadani Azham Purwandhono Cynthia Damayanti Dwi Ariyanti Edy Junaidi Farid Lutfi Madhoni Finty Arfian Giovani Gianosa Hanny Poli Hendriek H. Karongkong Ika Aulia Kurniasari Indah Kusuma Wardani Jarwoto Roestanajie Madha Qoyyulledy Tursina Mirah Susanti Kartika Sari Mohamat Fatekurohman Muhammad Nadzir A. Akbar Naesilla Naesilla Naesilla Naesilla Paundanan, Selpi Pipiet Wulandari Pralampita, Pulong Wijang Punuh, Gratia S. Purnama, Lia Sari Ricky Roosdiana Dewi Rifqi Rahadian Rini Riyanti Rizki Nur Fitria Salsabila, Zadia Maheswari Sharfina Sharfina Sri Hartati Sudarmanto, Yohanes Systriana Esi Kamasita Toyibatul Hidayati Wahyu Ikhsan Yudha Nurdian Yuli Hermansyah Yuli Hermansyah