Garuda - Garba Rujukan Digital

The Effect of Alopurinol on Blood Urea Nitrogen and Creatinine Serum Levels in Patients with Chronic Kidney Disease Miftakhul Huda; Pulong Wijang Pralampita; Dini Agustina; Cholis Abrori; Septa Surya Wahyudi
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.10928

Chronic kidney disease (CKD) is a structural and function disorder of renal for > 3 months with implications for individual health. CKD has become a health problem throughout the world and its implementation provides a considerable economic burden on the health system. The decreasing value of GFR (glomerular filtration rate) in CKD can cause uric acid retention so that serum uric acid levels increase (hyperuricemia). Hyperuricemia can occur due to an increase in urinary metabolism (overproduction), a decrease in uric acid expenditure (underexcretion), or a combination of both. The group of antihyperuricemic drugs that have good effectiveness and long-term safety is xanthine oxidase inhibitors. The commonly used xanthine oxidase inhibitor drug is allopurinol. The purpose of this study was to determine whether there was an effect of allopurinol on kidney function in CKD patients. The results of this study are expected to provide input in the treatment of hyperuricemia in CKD patients and reduce the progression of CKD. This study used a retrospective observational analytic design with a cross-sectional approach. The study population was CKD patients from January 2018 to January 2019 at Bina Sehat Hospital Jember. The sampling technique uses purposive sampling. This study uses secondary data obtained from medical records of CKD patients at Bina Sehat Hospital Jember. Secondary data obtained in the form of identity data and the results of laboratory tests of patients. The medical record data that has been obtained is distributed and analyzed using a paired T-test to compare the mean or mean differences of the two groups in pairs. The bivariate test results for blood urea nitrogen and serum creatinine levels in CKD patients were obtained p <0.001. Based on these results there is a significant relationship between blood urea nitrogen and serum creatinine levels before and after consuming allopurinol. The conclusion was that allopurinol was shown to be able to provide an effect on the kidney function of CKD patients based on blood urea nitrogen and serum creatinine levels. Keywords: Chronic kidney disease, hyperuricemia, allopurinol

Peningkatan Kemampuan dan Kemandirian Pengentasan Stunting melalui Pemberdayaan Petani Desa Sukogidri Kecamatan Ledokombo Jember Erma Sulistyaningsih; Parawita Dewanti; Pulong Wijang Pralampita
Warta Pengabdian Vol 13 No 1 (2019): Warta Pengabdian
Publisher : LP2M Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/wrtp.v13i1.9365

Angka stunting di Kabupaten Jember cukup tinggi di Propinsi Jawa Timur. Desa Sukogidri merupakan salah satu desa penyumbang stunting di Kabupaten Jember. Secara umum, kegiatan pengabdian ini bertujuan untuk membantu menyukseskan program pemerintah dalam menurunkan angka stunting di Kabupaten Jember, dengan tujuan khusus antara lain untuk meningkatkan kesadaran masyarakat akan stunting dan bahayanya, meningkatkan pengetahuan tentang pencegahannya serta meningkatkan kemandirian untuk pengentasan stunting dengan melatih tentang penanaman sistem hidroponik. Solusi yang diberikan oleh tim pelaksana pengabdian berupa kegiatan pendidikan dan penyuluhan serta pelatihan penyiapan menu sehat. Selain itu juga transfer pengetahuan tentang penanaman sistem hidroponik dan pemberian sistem hidroponik yang dapat digunakan untuk menyediakan bahan pangan yang sehat. Di akhir kegiatan pengabdian dilakukan pembentukan model keluarga sadar gizi (KADARZI) yang dapat secara mandiri mengenali dan mengelola masalah-masalah gizi anggota keluarganya melalui upaya menimbang berat badan secara teratur, memberikan air susu ibu (ASI) eksklusif, mengkonsumsi makanan beraneka ragam, menggunakan garam beryodium serta mengkonsumsi suplemen gizi yang sesuai dengan anjuran. Kata Kunci: stunting, gizi, kadar gizi, Sukogidri The prevalence of stunting in Jember Regency is quite high. Sukogidri village is one of the stunting contributing villages in Jember. In general, this public service activity aimed to support the government program to reduce stunting rates in Jember Regency and the specific objectives including increasing public awareness about stunting and its danger to health condition, increasing knowledge about prevention of stunting and increasing independence to alleviate stunting by training on planting hydroponic system and healthy menu preparation. The solution is provided by the service team including education and counseling activities, and training of healthy menu preparation. In addition, there was also transfer of knowledge about the planting of hydroponic system and the provision of hydroponic system that can be used to provide healthy food. At the end of the service activity, the team has developed the nutritionally aware family (KADARZI) model that can independently recognize and manage nutritional problems of family members by weighing regularly, provide exclusive breast feeding (ASI), consume diverse foods, use iodized-salt and consume supplements as recommended. Keywords: stunting, nutritionally aware family model, Sukogidri

Peningkatan Kemampuan Mengatasi Masalah Stunting dan Kesehatan melalui Pemberdayaan Masyarakat Desa Sukogidri, Jember Erma Sulistyaningsih; Parawita Dewanti; Pulong Wijang Pralampita; Wiji Utami
Jurnal Pengabdian Pada Masyarakat Vol 5 No 1 (2020)
Publisher : Universitas Mathla'ul Anwar Banten

INCREASING THE ABILITY IN OVERCOMING STUNTING AND HEALTH PROBLEM BY COMMUNITY EMPOWERMENT IN SUKOGIDRI VILLAGE, JEMBER. Indonesia has a high prevalence of stunting, and Jember is one of the six districts in East Java province that contribute to stunting prevalence. To overcome the stunting problem, it needs a holistic strategy including health, education and economic aspects, therefore the community empowerment is an important approach. The purpose of this public service program was to increase the awareness and capability of the community to overcome stunting and health problem by community empowerment. Several activities were conducted in this community service program, i.e. by examining the health status of the children, pregnant woman, and high risk people, counseling and education about stunting and the effect on health status and also the effect for the next generation, education about the efforts to prevent stunting, provide training to prepare a healthy food and specific training for the cadres who responsible for the stunting-alleviation program. The impact of the activity was an increase the knowledge and awareness of the community about stunting. And there were several trained-cadres about stunting and its prevention.

Analisis Penggunaan Jumlah Bahan Aktif Pestisida dan Banyaknya Keluhan Masalah Kesehatan Pada Petani di Wilayah Agroindustri Jember Kristianningrum Dian Sofiana; Laksmi Indreswari; Jauhar Firdaus; Aris Prasetyo; Pulong wijang Pralampita; Supangat Supangat
Poltanesa Vol 23 No 1 (2022): Juni 2022
Publisher : P2M Politeknik Pertanian Negeri Samarinda

Pestisida dapat menyebabkan masalah kesehatan baik akut ataupun kronik. Latar belakang dari penelitian ini adalah Penggunaan pestisida di kawasan agroindustri Jember yang tidak dapat dihindari.. Paparan pestisida pada petani Jember, baik paparan langsung ataupun tidak langsung, diduga menjadi salah satu penyebab munculnya masalah kesehatan.. Keterkaitan antar penggunaan bahan aktif pestisida dan masalah kesehatan pada petani di wilayah agroindustri jember perlu diteliti. Penelitian ini bertujuan untuk menganalisis penggunaan jumlah bahan aktif pestisida dengan banyaknya masalah kesehatan pada petani di wilayah Agroindustri Jember. Penelitian ini menggunakan metode deskriptif observational dengan pendekatan cross-sectional. Populasi yang diambil adalah petani yang berada di kabupaten jember yang diwakili oleh 11 kecamatan. Besar sampel berjumlah 84 orang yang diambil dengan accidental sampling. Variabel yang diambil adalah jenis pestisida, jumlah bahan aktif yang dipakai, keluhan masalah kesehatan, Analisis menggunakan analisis unvaried dan bivariate menggunakan Chi square tes dengan p <0,05. Penggunaan bahan aktif yang digunakan selama penyemprotan mayoritas 1 bahan aktif 51,19% .Keluhan masalah kesehatan sebesar 52,38% dengan keluhan terbanyak adalah pusing sebesar 29,76%.Hasil Analisis jumlah bahan aktif saat penyemprotan dengan banyaknya keluhan kesehatan dengan menggunakan Chi Square tes, p= 0,009 dengan nilai p<0,05. Dari penelitian ini didapatkan ada hubungan penggunaan bahan aktif residu pestisida dengan keluhan masalah kesehatan pada petani di Jember. Petani yang terpapar kebanyakan tidak merasakan keluhan kesehatan.

Hygiene Related Risk Factors for Giardia Infection in Sukowono District, Jember, Indonesia Selly Silfana Liensa; Wiwien Sugih Utami; Pulong Wijang Pralampita; Bagus Hermansyah
Journal of Agromedicine and Medical Sciences Vol 8 No 3 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i3.32125

Giardia spp. is a common cause of diarrhoeal disease in humans and is also known as a zoonotic agent in humans and animals. There are three risk factors of zoonotic Giardia, the first is individual characteristics, the second is hygiene, and the last is environmental. This study aimed to analyze the hygiene related risk factors for Giardia infection in Sukowono District, Jember. The research design was a cross-sectional study with 52 subjects from Sukowono District, Jember. The study was carried out from December 2020 to April 2021. The sampling method used purposive sampling is a non-probability sample and chi-square test for data analysis. Data was analyzed using SPSS statistics programme. P value < 0,05 was considered statistically significant.The result of microscopic examination of 52 fecal samples found 1.9% of the subjects were infected with Giardia spp. There was no association between hygiene behavior factors with Giardia spp. in Sukowono District, Jember (p>0.05). Data suggest that risk factors may not contribute to Giardia spp. infection. Based on these findings, need to do further research about hygiene related risk factors for Giardia spp. infection in Jember especially Sukowono District. Keywords: Hygiene factor, Giardia infection, zoonosis

Effect of Immunization of The Pili Protein 65.5 kDa Klebsiella pneumoniae on IFN-Î³ Levels of Spleen BALB/c Mice Sa'adah, Ajeng Samrotu; Mufida, Diana Chusna; Dini Agustina; Pulong Wijang Pralampita
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.54026

Klebsiella pneumoniae is a Gram-negative bacterium that poses a threat to the global community. Currently, no vaccine for K. pneumoniae is licensed by the Food and Drug Administration (FDA). The delay in the manufacture of the K. pneumoniae vaccine was because many vaccine candidates failed at the clinical trial stage due to adverse cross-reactions. Pili can be used as a choice as a vaccine candidate. Pili K. pneumoniae is an immunogenic substance that triggers an immune response, one of which is the cytokine IFN-Î³. Splenic splenocytes are the main source of IFN-Î³-producing cells. The aim of this study is to determine the effect of immunization pili protein 65.5 kDa K. pneumoniae on IFN-Î³ levels from spleen BALB/c mice. There were 3 groups, K1 as control given PBS, K2 given pili protein 65.5 kDa + adjuvant, and K3 given adjuvant. IFN-Î³ was then measured by the ELISA method and analyzed by the ANOVA test. The results of measuring IFN-Î³ levels using One-way ANOVA showed that the total for all groups was 243.50 ± 43.7 with p < 0.05, the Post Hoc LSD test was continued. The Post Hoc test showed significant differences between K1 control and K2 groups, and between K1 and K3 groups, but not between K2 and K3 groups. It can be concluded that immunization with 65.5 kDa of pili protein does not affect the increase in IFN-Î³ levels in the spleen of BALB/c mice.

Protective effect of Moringa oleifera leaves extract on cardiac fibrosis of streptozotocin-induced diabetic rats Salsabila, Zadia Maheswari; Suryono, .; Pralampita, Pulong Wijang
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202303

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia that induces excessive reactive oxygen species (ROS) production and causes oxidative stress. Diabetic cardiomyopathy is a diabetic complication characterized by structural and functional changes of the myocardium. Fibrosis is one of the pathological features of diabetic cardiomyopathy. Moringa oleifera leaves have been reported to possess antidiabetic and antioxidant activities which could prevent diabetic complications such as cardiomyopathy. A previous study reported that M. oleifera leaves extract have protective effects to the kidneys and liver of rats exposed to oxidative stress. This study aimed to investigate the protective effect of the M. oleifera leaves extract on cardiac fibrosis of rats induced by streptozotocin (STZ). This was an experimental study using a posttest-only control group design. Thirty-three male Wistar rats were randomly divided into three groups i.e. normal control group (Group 1) were administered normal saline, diabetic control group (Group 2) were administered normal saline, and diabetic treatment group (Group 3) were administered M. oleifera leaves extract. Diabetes induction of rats was conducted by intraperitoneally injection of STZ at dose of 45 mg/kg BW. The M. oleifera leaves extract at a dose of 1000 mg/kg BW was administered orally one time a day for 28 days. Statistical analysis was performed using the Kruskal-Wallis test followed by Mann Whitney. A significant difference in cardiac fibrosis occurrence between three groups was observed (p < 0.05). No cardiac fibrosis was observed in normal control group, meanwhile cardiac fibrosis was observed in all rats (9 rats) of the diabetic control group (G2). Only 2 rats in the treatment group (G3) had cardiac fibrosis. In conclusion, M. oleifera leaves extract can inhibit cardiac fibrosis in STZ-induced diabetic rats.

INFUSA KULIT BAWANG MERAH (Allium cepa L.) MEMPERBAIKI KERUSAKAN HATI TIKUS WISTAR YANG DIINDUKSI DIAZINON Aini, Nada Qurrota; Dewi, Rosita; Pralampita, Pulong Wijang; Helianti, Dina
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 6 No 4 (2023): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Penggunaan diazinon dalam membasmi hama tanaman akan meninggalkan residu pada tanaman sehingga jika dikonsumsi memberikan dampak buruk. Metabolisme diazinon di hati meningkatkan jumlah radikal bebas dan menurunkan aktivitas enzim antioksidan yang akan mengakibatkan kerusakan sel hati. Kulit bawang merah (Allium cepa L.) mengandung kuersetin yang dapat memperbaiki kerusakan jaringan akibat stres oksidatif. Penelitian ini bertujuan mengetahui hubungan antara dosis infusa kulit bawang merah (IKBM) dan tingkat kerusakan hati tikus yang diinduksi diazinon dan menentukan dosis efektif maksimum IKBM. Tikus dibagi menjadi kelompok normal, diazinon, dan IKBM. Diazinon diberikan dengan dosis 40 mg/kgBB selama 7 hari dilanjutkan dengan IKBM dengan dosis 125, 250, 500, 1.000, dan 2.000 mg/kgBB selama 7 hari. Pengamatan mikroskopik dilakukan terhadap 100 sel hati dengan pewarnaan hematoxylin-eosin (HE) berdasarkan skor Manja Roenigk. Tingkat kerusakan hati antara dua kelompok dianalisis menggunakan uji Mann-Whitney, sedangkan korelasi antara dosis IKBM dan tingkat kerusakan hati, dan dosis efektif maksimum IKBM ditentukan dengan uji regresi. Rerata skor histopatologi hati tertinggi didapatkan pada kelompok diazinon dan terendah pada kelompok normal (p<0,05). Uji regresi menunjukkan terdapat hubungan eksponensial antara dosis IKBM dan tingkat kerusakan hati (p<0,05), yaitu semakin tinggi dosis IKBM, semakin rendah skor histopatologi hati dan dosis efektif maksimum IKBM adalah 1.347,28 mg/kgBB. Sebagai kesimpulan, semakin tinggi dosis IKBM, semakin rendah tingkat kerusakan hati tikus yang diinduksi diazinon. Pemberian IKBM melebihi dosis 1.347,28 mg/kgBB akan meningkatkan kerusakan hati. Kata kunci: bawang merah, diazinon, hati, histopatologi DOI : 10.35990/mk.v6n4.p329-339

Analisis Penggunaan Jumlah Bahan Aktif Pestisida dan Banyaknya Keluhan Masalah Kesehatan Pada Petani di Wilayah Agroindustri Jember Sofiana, Kristianningrum Dian; Indreswari, Laksmi; Firdaus, Jauhar; Prasetyo, Aris; Pralampita, Pulong wijang; Supangat, Supangat
Poltanesa Vol 23 No 1 (2022): Juni 2022
Publisher : P3KM Politeknik Pertanian Negeri Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51967/tanesa.v23i1.1209

Pestisida dapat menyebabkan masalah kesehatan baik akut ataupun kronik. Latar belakang dari penelitian ini adalah Penggunaan pestisida di kawasan agroindustri Jember yang tidak dapat dihindari.. Paparan pestisida pada petani Jember, baik paparan langsung ataupun tidak langsung, diduga menjadi salah satu penyebab munculnya masalah kesehatan.. Keterkaitan antar penggunaan bahan aktif pestisida dan masalah kesehatan pada petani di wilayah agroindustri jember perlu diteliti. Penelitian ini bertujuan untuk menganalisis penggunaan jumlah bahan aktif pestisida dengan banyaknya masalah kesehatan pada petani di wilayah Agroindustri Jember. Penelitian ini menggunakan metode deskriptif observational dengan pendekatan cross-sectional. Populasi yang diambil adalah petani yang berada di kabupaten jember yang diwakili oleh 11 kecamatan. Besar sampel berjumlah 84 orang yang diambil dengan accidental sampling. Variabel yang diambil adalah jenis pestisida, jumlah bahan aktif yang dipakai, keluhan masalah kesehatan, Analisis menggunakan analisis unvaried dan bivariate menggunakan Chi square tes dengan p <0,05. Penggunaan bahan aktif yang digunakan selama penyemprotan mayoritas 1 bahan aktif 51,19% .Keluhan masalah kesehatan sebesar 52,38% dengan keluhan terbanyak adalah pusing sebesar 29,76%.Hasil Analisis jumlah bahan aktif saat penyemprotan dengan banyaknya keluhan kesehatan dengan menggunakan Chi Square tes, p= 0,009 dengan nilai p<0,05. Dari penelitian ini didapatkan ada hubungan penggunaan bahan aktif residu pestisida dengan keluhan masalah kesehatan pada petani di Jember. Petani yang terpapar kebanyakan tidak merasakan keluhan kesehatan.

Title

Found 9 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 9 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 9 Documents
Search