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All Journal e-Journal Pustaka Kesehatan Jurnal Berkala Epidemiologi Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Jurnal Dimensi Pendidikan dan Pembelajaran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Stem Cell Research and Tissue Engineering Jurnal Visionary : Penelitian Dan Pengembangan Di Bidang Administrasi Pendidikan Journal of English Language and Education International Journal of Contemporary Sciences (IJCS)
Rini Riyanti
Department Of Clinical Pathology, Faculty Of Medicine, University Of Jember, Jember, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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Hubungan antara Kadar Feritin dengan Kadar BUN-Kreatinin pada Pasien Talasemia Beta Mayor di RSD dr. Soebandi Jember (The Correlation between Ferritin Levels and BUN-Creatinine Levels of Major Beta Thalassemia Patients at dr. Soebandi Hospital Jember) Kurnia Elka Vidyarni; Mohamad Ali Shodikin; Rini Riyanti
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Major beta thalassemia patients with iron overload will have increase on ferritin levels. Free iron can cause damage in several organs including kidney. One of parameter used to investigate the function of kidney is BUN and creatinine. This study was aimed to determine the correlation between ferritin levels and BUN-creatinine levels of major beta thalassemia patients at dr. Soebandi Hospital Jember. This is an analytical observational study with cross sectional study design, using 15 patients of thalassemia at the Paediatrics Department of dr. Soebandi Hospital Jember who met inclusion criteria. The data was obtained from medical records or patients report book. Data was analyzed with Shapiro Wilk normality test and Spearman correlation test. The mean of ferritin levels was 3.145±57,99 ng/mL, BUN levels was 8,87±1,18 mg/dL, and creatinine levels was 0,53±0,24 mg/dL. The Spearman correlation test for the correlation between ferritin levels and BUN levels showed r=0,073 and p=0,795 and the correlation between ferritin levels and creatinine levels resulted r=0,173 and p=0,537. In conclusion, there was no correlation between ferritin levels and BUN-creatinine levels of major beta thalassemia patients at the dr. Soebandi hospital Jember. Keywords: thalassemia, ferritin, BUN, creatinine
Pengaruh Ekstrak Albumin Ikan Gabus (Chana striata) terhadap Kadar IFN-γ Pasien Tuberkulosis Paru dengan Pengobatan Fase Intensif (The Effect of Albumin Snakehead Fish (Chana striata) Extract on IFN-Y of Pulmonary Tuberculosis Patients during Intens Henggar Allest Pratama; Erfan Efendi; Rini Riyanti
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Pulmonary tuberculosis is a respiratory infection disease caused by Mycobacterium tuberculosis infection in lung tissue. Mycobacterium tuberculosis could inhibit macrophage activation by inducing an increase of SOCS1 which can inhibit IFN-γ signaling process. Meanwhile, IFN-γ production continues as long as Mycobacterium tuberculosis still exist, so the IFN-γ levels stay high. This study aimed to investigate the effect of albumin snakehead fish (Chana striata) extract to decrease IFN-γ level. The study design was a quasy experimental design. The study subject was 24 tuberculosis patients during intensive phase medication, were divided into 2 groups. Experimental group was given 1500 mg/day albumin snakehead fish (Chana striata) extract while control group was placebo for 30 days. This study showed that albumin snakehead fish (Chana striata) extraxt can decrease significanly IFN-γ levels in the experimental group (p=0.006) but not statistically signicant if compared with the decrease of control group (p=0.061). It can be concluded that albumin snakehead fish (Chana striata) extract in dose of 1500 mg/day had not able to decrease IFN-γ levels of pulmonary tuberculosis patients during intensive phase medication yet.   Keywords: tuberculosis, albumin, snakehead fish, IFN-γ
Uji Aktivitas Antiplatelet Ekstrak Etanol Kubis Merah (Brassica oleracea var. capitata L.) Antiplatelets activity of red cabbage ethanolic extract (Brassica oleracea var. capitata L.) Rizki Rica Rachim Fadilah Putri; Evi Umayah Ulfa; Rini Riyanti
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Antiplatelet aggregation effect of red cabbage ethanolic extract (Brassica oleracea var. capitata L.) was measured by bleeding time on Balb-C mice. The test substances given orally during the period of 8 days. Bleeding time was measured on first day and 9th day. Red cabbage ethanolic extract were divided into 3 doses: wich are 9.69 mg/kg body weight; 19,38 mg/kg body weight, and 38,76 mg/kg body weight. After getting the percentage of bleeding time increase, data were analyzed by analysis of variance test (Anova), followed by individual comparison within the groups by LSD test. The test substances above respectively increased bleeding time 58 ± 16%; 70,7 ± 8,9 %, and 113 ± 12%. As the conclusion, red cabbage ethanolic extract doses 38,76 mg/kg body weight could increase bleeding time as well as positive controle 129 ± 8,2%. Keywords: antiplatelets, Brassica oleracea red cabbage, bleeding time.
Analisis Nilai Laju Endap Darah pada Pasien Sindrom Koroner Akut dan Stable Angina di RSD dr. Soebandi Jember (The Erythrocyte Sedimentation Rate Analysis in Acute Coronary Syndrome and Stable Angina Patients at dr. Soebandi General Hospital) Rizki Nur Fitria; Suryono Suryono; Rini Riyanti
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Erythrocyte sedimentation rate (ESR) is non-specific blood tests that can be used as a marker of chronic inflammation. Some proteins that affect the erythrocyte sedimentation rate are fibrinogen, lipoprotein, and immunoglobulins. These proteins elevate in patients with atherosclerosis and acute coronary syndrome. This study aimed to determine the relationship between erythrocyte sedimentation rate and the incidence of acute coronary syndrome and stable angina at dr. Soebandi General Hospital Jember. This analytic observasional study using cross-sectional design.This study used 40 samples, divided into four groups; stable angina, UA, NSTEMI, and STEMI. The average value of ESR were 12,1mm/h, 20,7mm/h, 28,9mm/h, and 25,3mm/h for stable angina, UA, NSTEMI, and STEMI, respectively. Kolmogorov-Smirnov statistical test showed significant difference between groups(p=0.001). It indicated that there was relationship between erythrocyte sedimentation rate and the incidence of acute coronary syndrome and stable angina in dr. Soebandi General Hospital Jember. Keywords: erythrocyte sedimentation rate, acute coronary syndrome, stable angina
Hubungan antara Kadar Feritin dengan Malondialdehyde pada Pasien Talasemia β Mayor di RSD dr. Soebandi Jember Trinita Diyah Permatasari; Rini Riyanti; Desie Dwi Wisudanti
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17592

Abstract

Repeated blood transfusions, increased iron absorption, and ineffective erythropoiesis in major β thalassemia patients lead to iron overload characterized by elevated ferritin levels. Free iron will catalyze reactive oxygen species (ROS) formation by Fenton reaction that cause oxidative stress. Malondialdehyde (MDA) is the lipid peroxidation end product used to measure the oxidative stress. This study aimed to determine the correlation between ferritin levels and MDA levels in major β thalassemia patients at dr. Soebandi Hospital Jember. An analitic observational study with cross sectional study design which the subjects were 15 patients with major β thalassemia in the Pediatric Department at dr. Soebandi Hospital Jember who met inclusion and exclusion criteria. Ferritin levels measured by Enzyme-Linked Fluorescent Immuno Assay (ELFA) method and MDA levels measured by Thiobarbituric Acid Reactive Substances (TBARS) method using spectrophotometer at 535 nm. Data was analyzed with Shapiro Wilk normality test and Pearson correlation test. The mean of ferritin levels was 3540,46±3925,37 ng/mL and MDA levels was 4,77±2,03 nmol/mL. The result showed that there is strong positive correlation between ferritin levels and MDA levels with p value=0,001 and r=0,786 in major β thalassemia patients at dr. Soebandi Hospital Jember.
Hubungan Kadar SGOT dengan Kadar Leukosit pada Pasien NSTEMI di ICCU RSD dr. Soebandi Jember (Correlation between SGOT Level and Leukocytes in NSTEMI Patients at ICCU dr. Soebandi Hospital, Jember) Finty Arfian; Suryono Suryono; Rini Riyanti
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6797

Abstract

Acute Coronary Syndrome (ACS) is a syndrome that occurs because of blockage of the coronary artery causing clinical symptoms due to unfulfilled oxygen supply. Atherosclerosis is suspected as the main cause of ACS. Inflammation is one pathophysiology of atherosclerosis characterized by leukocytosis. NSTEMI is one spectrum of ACS that diagnosed by anamnesis, ECG, and cardiac marker such as troponin. SGOT is also released into the circulation when there is myocardial damage. Studies has reported that SGOT increased from the normal range during a myocardial infarction. The purpose of this study was to determine the relationship between levels of SGOT and leukocytes in patients with NSTEMI. The sample included 10 patients with NSTEMI in July-December 2016 from ICCU RSD dr. Soebandi Jember. The data was collected from medical record. The result showed that the average of SGOT increased from the normal range, while the average levels of leukocytes were in normal range. Pearson correlation test showed that there was no significant relationship between the two variables with p=0.083>0.05. In conclusion, there was no relationship between the levels of SGOT and leukocytes in patients with NSTEMI at ICCU RSD dr. Soebandi Jember. Keywords: NSTEMI, SGOT, Leukocyte
Pengaruh Pemberian Ekstrak Tauge (Vigna radiata (L)) terhadap Kadar Serum Trigliserida pada Tikus Wistar Jantan yang Diinduksi Kuning Telur (The Effect of Mungbean (Vigna radiata (L)) Sprout on Triglyceride Serum Levels of Male Wistar Rats Induced by Eg Fairuztya Naila Maris; Rena Normasari; Rini Riyanti
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Dyslipidemia is a condition of abnormal blood lipid profiles, including hypertriglyceridemia. One of antidislipidemia agent is niasin, that can be found in mungbean (Vigna radiata (L)) sprout. This study aimed to determine the difference in triglyceride serum after treatment with mungbean sprout extract on male wistar rats induced by egg yolk. This was an experimental study with randomized Post-test Only Control Group Design. Twenty five male wistar rats aged 2-3 months, divided into 5 groups: K(-), K(+), P1, P2 and P3. K(-) was treated with standard diet. The other four groups were injected with 0,006 mg/ 200 gram weight IV adrenalin on the first day followed by egg yolk diet for six weeks. P1, P2, and P3 group were treated with 50, 100, and 200 mg/ 200 g/day of mungbean sprout extract simultaneously with the diet. At the end of the treatment, the serum was taken to examine the triglyceride serum. Average levels of triglycerides serum in group K(-) 69,2±15,9; K(+) 92±14,9; P1 63,2±14,1; P2 53±6,9; P3 84,8±23,9. There was significant different of triglyceride serum means between group K(+) and P2 (p=0,014). In conclusion, 100 mg of mungbean sprout extract showed a significant difference in triglyceride serum with control group of male wistar rats induced with egg yolk.   Keywords: Mungbean sprout, egg yolk, triglyceride
CORRELATION OF CD4 WITH TOTAL LYMPHOCYTE COUNTS IN HIV PATIENTS Rini Riyanti
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Worldwide estimates of people living with HumanImmunodeficiency Virus was approximately 32million in 2007 with thousands of people gettinginfected every day therapy (Obirikorang et.al,2012). Globally, 34 million people were living withhuman immunodeficiency virus (HIV) at the end of2011 (Chen et.al, 2013). Most people living withHIV are from developing countries with less than5% receiving antiretroviral therapy (Obirikoranget.al, 2012).A CD4 count is a laboratory test that measures thenumber of CD4 T lymphocytes (CD4 cells) in asample of blood. In HIV patients, it is the mostimportant laboratory indicator of how well theimmune system is working and the strongestpredictor of HIV progression. Once a person isinfected with HIV, the virus begins to attack anddestroy the CD4 cells of the person’s immunesystem. HIV uses the CD4 cells to multiply andspread throughout the body. This is the HIV lifecycle.The associated immune deficiency in humanimmunodeficiency virus (HIV) patients leading toinfection by opportunistic pathogen is ascribed todepletion of CD4. CD4 count can therefore beregarded as the accurate measurement of therobustness and functionality of the immunecapability to protect the body against generalinfection. CD4 T lymphocyte cell depletion is one ofthe hallmarks of progression of HIV infection and amajor indicator of the stage of the disease in HIVinfected individuals. World Health Organizationrecommended that most treatment initiationdecisions be guided by CD4 measurement andclinical staging.AIDS is the stage of HIV infection that occurs whenthe immune system is badly damaged and it isbecome vulnerable to opportunistic infections.When the number of your CD4 cells falls below 200cells/mm3, these are considered to haveprogressed to AIDS. (In a healthy immune system,CD4 counts are between 500 and 1,600cells/mm3.)The initiation of antiretroviral therapy is based onCD4 counts of less than 350 cells/mm3 according tothe World Health Organization (WHO) and Centrefor Disease Control (CDC). The determination ofCD4 count however in resource-limited localities isdifficult.In April 2002, the World Health Organization(WHO) suggested that total lymphocyte count(TLC) could serve as a surrogate for CD4+cell countbecause TLC is easily obtained from routinecomplete blood cell counts by multiplying thepercentage of lymphocytes by the white-blood-cellcount (Chen et.al, 2013).Total lymphocyte count(TLC) is a derived immunological marker calculatedfrom white blood cell count and relativelymphocyte count. For instance, if a patient has atotal white blood cell count of 10.0 × 10⁹/L andrelative lymphocyte count of 30% obtained fromdifferential leukocyte count, total lymphocytecount of such patient would be 3 × 10⁹/L.The aim of this study was therefore to ascertainexisting relationships between CD4 count and TLCand to further ascertain if TLC could be used as asurrogate markerfor CD4 counts.
Correlation of Platelet Count and Hematocrit Levels to the Severity of Dengue Hemmoraghic Fever Patients at RSD dr. Soebandi Jember Salma Naqiyyah Tirtadevi; Rini Riyanti; Desie Dwi Wisudanti
Journal of Agromedicine and Medical Sciences Vol 7 No 3 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i3.24362

Abstract

Dengue hemorraghic fever (DHF) is an infectious disease caused by the dengue virus and It is still be a major health problem in Southeast Asia, especially in Indonesia. Kabupaten Jember is still categorized as a dengue endemic area with its disease development expanding from year to year. This study aims to determine the correlation of platelet count and hematocrit levels to the severity of DHF patients at RSD dr. Soebandi Jember, as well as knowing whether the platelet count and hematocrit levels can be used as a predictive value for the severity of DHF patients at RSD dr. Soebandi Jember. This study used an observational analytic study with a cross-sectional study design. The data of this study used secondary data from the medical records of DHF patients at RSD dr. Soebandi Jember. The results of this study with a total of 68 samples showed that there was a significant negative correlation between the platelet count to the severity of DHF patients (p = 0,000, r = -0,487). The hematocrit levels showed an insignificant and negative correlation to the severity of DHF patients (p = 0,658, r = -0,055). The platelet count can be used as a predictive value for the severity of DHF patients. Keywords: DHF, platelet count, hematocrit levels, severity of DHF patients
The Activity of Cainito Leaves Ethanol Extract (Chrysophyllum cainito L.) on Wistar’s Total Erythrocites Induced Cyclophosphamide Heri Puguh Widodo; Ika Rahmawati Sutejo; Rini Riyanti
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.7588

Abstract

One of the commonly used chemotherapy drugs is cyclophosphamide. However, the use of cyclophosphamide can provide various toxic effects. The most common toxic effect of cyclophosphamide is bone marrow suppression with anemia as one of its markers. The antioxidant content of cainito leaf potentially increase the production of blood cells, especially erythrocytes. The aims of this study is determining the effectiveness of the cainito leaf ethanol extract against cyclophosphamide induced mouse erythrocyte count in vivo. A sample of 20 male wistar rats was divided into five groups; normal group, negative control group, and three groups of ethanol extract of cainito leaf with dose 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW were administered for one week followed by intraperitoneal cyclophosphamide with dose 50 mg/kgBW as much as one time. One Way Anova Test result showed a significance of 0.015 (p<0.05). However, the LSD test results showed no significant different results between the negative control group and the treatment group. The conclusion was that there was no difference in the amount of erythrocytes in mice given only cyclophosphamide with previous rats given cainito extract.
Co-Authors . Suryono Adelia Handoko Amalia Nur Zahra Ancah Caesarina Novi Marchianti Anthia Ayu Nandira Arif, Dina Rizky Amalia Cholis Abrori Desie Dwi Wisudanti Dina Faizatur Rahmah Elly Nurus Sakinah, Elly Nurus Erfan Efendi Evi Umayah Ulfa Fairuztya Naila Maris Faliqul Bahar Muhammad Fantya Cerebella Aslamy Finty Arfian Gianevan, Nicholas Jirezra Helmawati Helmawati Henggar Allest Pratama Heri Puguh Widodo Ika Rahmawati Sutejo Kristianningrum Dian Sofiana Kurnia Elka Vidyarni Kuswanda, Wawan Leni Eka Yuniar M. Ali Shodikin M.Y Probohoesodo Mei Syafriadi Munandar, Eri Arif Nenden Rosmaya Prihatini . Prihatini Prihatini Putri, Rona Andini Rena Normasari Rizki Nur Fitria Rizki Rica Rachim Fadilah Putri Rohkmah, Dewi Rondhianto Rondhianto Rosita Dewi Rosmaya, Nenden Salma Naqiyyah Tirtadevi Sauri, R Supyan Sheilla Rachmania, Sheilla Siti Rochmatoen Sugih Utami, Wiwien SUHARSONO Suwandari, Lilis Trinita Diyah Permatasari Wahyuni, Ika Sri Wawan Kuswanda Wulandari, Winda Cindy Wydi Ulfa Pradini Yunita Armiyanti