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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Rheumatology Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Essential: Essence of Scientific Medical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Rudy Hidayat
Department Of Internal Medicine, Rheumatology Division, Faculty Of Medicine Universitas Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Validity And Reliability Of Lupus Quality Of Life Questionnaire In Patients With Systemic Lupus Erythematosus In Indonesia Anindito, Bagus; Hidayat, Rudy; Koesnoe, Sukamto; Dewiasty, Esthika
Indonesian Journal of Rheumatology Vol 8, No 2 (2016)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (405.117 KB)

Abstract

Background: The development of Systemic Lupus Erythematosus (SLE) treatment has led the increased of patients survival. Quality of life has became a value based medicine component that should be evaluated in treating SLE. One standardized questionnaire to asses the quality of life in SLE patients is Lupus Quality of Life (Lupus QoL). Currently, in Indonesia, there has not been any spesific questionnaire to asses the quality of life in SLE patients. This study aims to prove that Lupus QoL is valid and reliable to asses the quality of life in SLEpatients in Indonesia.Methods: This study used cross sectional study method. Firstly, we translated the Lupus QoL into Indonesian language, then we tested to 10 respondents. Then, we continued the study with larger sample size. We analyzed the reliability of the test and the re-test result using the interclass coefficient correlation and the internal consistency of the tests using cronbach alpha. Construct validity was evaluated using multi trait scaling analysis and the extrenal validity was evaluated using correlation between domains in short form 36 (SF 36)with Lupus QoL and with disease activity.Results: Data collection was done to 65 SLE patients between October – November 2015 in RSCM. The test has good external validity SF 36 (r=0.38-0.66, p<0.05) and good construct validity (r >0.4; range: 0.44-0.93). The ICC value in one week >0.7 and Cronbach α was>0.7 in each domain. The correlation between lupus QoL and the disease activity was weak and consistentwith other studies.Conclusion: Lupus QoL questionnaire is valid and reliable to asses the quality of life in SLE patients inIndonesia.Key words: Quality of Life, Systemic Lupus Erythematosus, Lupus QoL, Validity, Reliability
Tophi which develop years before the first attack of acute gouty arthritis Hidayat, Rudy; Kasjmir, Yoga I
Indonesian Journal of Rheumatology Vol 1, No 1 (2009)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.678 KB)

Abstract

Gout is a clinical disease associated with hyperuricemia and caused by the deposition ofmonosodium urate crystals in and around the tissue of joints. The course of classic gout passes through three distinct stages: asymptomatic hyperuricemia, acute intermittent gout, and advanced gout/chronic tophaceous gout.1,2 Tophi; described as accumulation of articular, osseus, soft tissue, and cartilaginous crystalline deposits; is one of clinical manifestation of chronic tophaceous gout stage, and usually developedafter 10 or more years of acute intermittent gout.1,2 Although patients have been reported with tophias their initial clinical manifestation
Risk of cardiovascular disease in rheumatoid arthritis patients Utari, A P; Hidayat, Rudy; Setiyohadi, Bambang
Indonesian Journal of Rheumatology Vol 3, No 1 (2011)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.742 KB)

Abstract

Despite rheumatoid arthritis (RA) therapy development has been in advance level today, its mortality remains increasing in general population. The mortality is mainly caused by early-manifested atherosclerosis and other cardiovascular complications. Available evidences showthis condition appears in early stage of the disease. Thus, early detection and management of cardiovascular risk, followed by control of these factors are necessaryto reduce morbidity and mortality of RA patients
Diagnostic values of DAS28 and DAS28-squeeze in evaluating Rheumatoid Arthritis disease Santosa, David; Hidayat, Rudy; Prasetyo, Marcel; Nugroho, Pringgodigdo
Indonesian Journal of Rheumatology Vol 8, No 2 (2016)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.827 KB)

Abstract

Background : In recent years, rheumatoid arthritis (RA) uses a “treat to target”  treatment strategy. This strategy requires a valid and accurate tool for assessing disease activity. The most widely used tool is DAS28, which was developed from DAS with the omission of ankle and foot joints. There has been many critization aboutthe accuracy of DAS28 in classifying the state of RA disease. Most importantly, when an active disease state was misclassified as an inactive state (false negative)which lead to under treat and subsequently to disability. The difference between DAS28 and DAS lies mainly in the exclusion of ankle and foot joints, thus DAS28-squeeze, a new and simple tool has been proposed. It comprises the same 28 joints in DAS28 added with a sqeeze test on both metatarsophalangeal joints. However, this new tool has never been validated with any imaging techniques.Objective : To assess the diagnostic values of DAS28 and DAS28-squeeze.Methods : This study comprised a cross-sectional diagnostic study, using Power Doppler sonography as a standard reference in evaluating the diagnostic value ofDAS28 and DAS28-squeeze. This study uses the most sringent sonography criteria of active disease which is an active Doppler signal with a moderate synovial hypertrophy on B-mode. Results : Over the study period, 56 subjects underwent diagnostic tests using DAS28, DAS28-squeeze and Power Doppler sonography. There were 4 false negativecases in DAS28 and 1 case in DAS28-squeeze. The sensitivities of DAS28 and DAS28-squeeze to identify active disease using Power Doppler sonography as reference standard were 73.3% (95%CI ± 11.59) and 93.3% (95%CI ± 6.55), respectively. While the specificities of DAS28 and DAS28-squeeze were 36.6% (95%CI ± 12.62) and 34.1% (95%CI ± 12.42), respectively. Furthermore the negative likelihood ratioof DAS28 and DAS28-squeeze were 0.73 and 0.19, respectively.Conclusion : This study is the first to validate DAS28- squeeze using imaging techniques. From this study the false negative rate of DAS28-squeeze is lower thanDAS28. DAS28-squeeze has a better sensitivity and negative likelihood ratio than DAS28 in identifying RA disease state.Keywords : Rheumatoid Arthritis, DAS28, DAS28-squeeze, treat to target, Power Doppler, squeeze test
PERAN FIBRINOGEN SEBAGAI FAKTOR PROGNOSTIK KARSINOMA HEPATOSELULAR Gadang R. Dewantoro; Rudy Hidayat
Essence of Scientific Medical Journal Vol 16 No 1 (2018): Volume 16 No. 1 (Januari-Juni) : Essence Of Scientific Medical Journal
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2018.v16.i01.p03

Abstract

Pendahuluan: Tulisan ini bertujuan untuk menentukan peran fibrinogen sebagai faktor prognostik pada pasien karsinoma hepatoselular. Metode: Pencarian literatur secara terstruktur dilakukan dengan menggunakan PubMed, GoogleScholar, dan ScienceDirect sesuai dengan pertanyaan klinis yang dipilih. Pemilihan artikel dilakukan berdasarkan kriteria inklusi dan eksklusi. Tiga artikel yang terpilih kemudian dinilai kualitasnya dengan menggunakan kriteria yang mencakup validitas, importance, dan applicability. Pembahasan: Ketiga penelitian yang digunakan pada artikel ini semua menyatakan bahwa kadar fibrinogen yang tinggi berhubungan dengan overall survival pada pasien karsinoma hepatoselular. Simpulan: Kadar fibrinogen dapat menjadi faktor prognostik overall survival pada pasien karsinoma hepatoselular.
Tophi which develop years before the first attack of acute gouty arthritis Rudy Hidayat; Yoga I Kasjmir
Indonesian Journal of Rheumatology Vol. 1 No. 1 (2009): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.678 KB) | DOI: 10.37275/ijr.v1i1.19

Abstract

Gout is a clinical disease associated with hyperuricemia and caused by the deposition ofmonosodium urate crystals in and around the tissue of joints. The course of classic gout passes through three distinct stages: asymptomatic hyperuricemia, acute intermittent gout, and advanced gout/chronic tophaceous gout.1,2 Tophi; described as accumulation of articular, osseus, soft tissue, and cartilaginous crystalline deposits; is one of clinical manifestation of chronic tophaceous gout stage, and usually developedafter 10 or more years of acute intermittent gout.1,2 Although patients have been reported with tophias their initial clinical manifestation
Risk of cardiovascular disease in rheumatoid arthritis patients A P Utari; Rudy Hidayat; Bambang Setiyohadi
Indonesian Journal of Rheumatology Vol. 3 No. 1 (2011): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.742 KB) | DOI: 10.37275/ijr.v3i1.38

Abstract

Despite rheumatoid arthritis (RA) therapy development has been in advance level today, its mortality remains increasing in general population. The mortality is mainly caused by early-manifested atherosclerosis and other cardiovascular complications. Available evidences showthis condition appears in early stage of the disease. Thus, early detection and management of cardiovascular risk, followed by control of these factors are necessaryto reduce morbidity and mortality of RA patients
Diagnostic values of DAS28 and DAS28-squeeze in evaluating Rheumatoid Arthritis disease David Santosa; Rudy Hidayat; Marcel Prasetyo; Pringgodigdo Nugroho
Indonesian Journal of Rheumatology Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.827 KB) | DOI: 10.37275/ijr.v8i2.54

Abstract

Background : In recent years, rheumatoid arthritis (RA) uses a “treat to target”  treatment strategy. This strategy requires a valid and accurate tool for assessing disease activity. The most widely used tool is DAS28, which was developed from DAS with the omission of ankle and foot joints. There has been many critization aboutthe accuracy of DAS28 in classifying the state of RA disease. Most importantly, when an active disease state was misclassified as an inactive state (false negative)which lead to under treat and subsequently to disability. The difference between DAS28 and DAS lies mainly in the exclusion of ankle and foot joints, thus DAS28-squeeze, a new and simple tool has been proposed. It comprises the same 28 joints in DAS28 added with a sqeeze test on both metatarsophalangeal joints. However, this new tool has never been validated with any imaging techniques.Objective : To assess the diagnostic values of DAS28 and DAS28-squeeze.Methods : This study comprised a cross-sectional diagnostic study, using Power Doppler sonography as a standard reference in evaluating the diagnostic value ofDAS28 and DAS28-squeeze. This study uses the most sringent sonography criteria of active disease which is an active Doppler signal with a moderate synovial hypertrophy on B-mode. Results : Over the study period, 56 subjects underwent diagnostic tests using DAS28, DAS28-squeeze and Power Doppler sonography. There were 4 false negativecases in DAS28 and 1 case in DAS28-squeeze. The sensitivities of DAS28 and DAS28-squeeze to identify active disease using Power Doppler sonography as reference standard were 73.3% (95%CI ± 11.59) and 93.3% (95%CI ± 6.55), respectively. While the specificities of DAS28 and DAS28-squeeze were 36.6% (95%CI ± 12.62) and 34.1% (95%CI ± 12.42), respectively. Furthermore the negative likelihood ratioof DAS28 and DAS28-squeeze were 0.73 and 0.19, respectively.Conclusion : This study is the first to validate DAS28- squeeze using imaging techniques. From this study the false negative rate of DAS28-squeeze is lower thanDAS28. DAS28-squeeze has a better sensitivity and negative likelihood ratio than DAS28 in identifying RA disease state.Keywords : Rheumatoid Arthritis, DAS28, DAS28-squeeze, treat to target, Power Doppler, squeeze test
Validity And Reliability Of Lupus Quality Of Life Questionnaire In Patients With Systemic Lupus Erythematosus In Indonesia Bagus Anindito; Rudy Hidayat; Sukamto Koesnoe; Esthika Dewiasty
Indonesian Journal of Rheumatology Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (405.117 KB) | DOI: 10.37275/ijr.v8i2.60

Abstract

Background: The development of Systemic Lupus Erythematosus (SLE) treatment has led the increased of patients survival. Quality of life has became a value based medicine component that should be evaluated in treating SLE. One standardized questionnaire to asses the quality of life in SLE patients is Lupus Quality of Life (Lupus QoL). Currently, in Indonesia, there has not been any spesific questionnaire to asses the quality of life in SLE patients. This study aims to prove that Lupus QoL is valid and reliable to asses the quality of life in SLEpatients in Indonesia.Methods: This study used cross sectional study method. Firstly, we translated the Lupus QoL into Indonesian language, then we tested to 10 respondents. Then, we continued the study with larger sample size. We analyzed the reliability of the test and the re-test result using the interclass coefficient correlation and the internal consistency of the tests using cronbach alpha. Construct validity was evaluated using multi trait scaling analysis and the extrenal validity was evaluated using correlation between domains in short form 36 (SF 36)with Lupus QoL and with disease activity.Results: Data collection was done to 65 SLE patients between October – November 2015 in RSCM. The test has good external validity SF 36 (r=0.38-0.66, p<0.05) and good construct validity (r >0.4; range: 0.44-0.93). The ICC value in one week >0.7 and Cronbach α was>0.7 in each domain. The correlation between lupus QoL and the disease activity was weak and consistentwith other studies.Conclusion: Lupus QoL questionnaire is valid and reliable to asses the quality of life in SLE patients inIndonesia.Key words: Quality of Life, Systemic Lupus Erythematosus, Lupus QoL, Validity, Reliability
Correlation between Interleukin-6 and E-Selectin as a Marker of Endothelial Dysfunction in Rheumatoid Arthritis Patient without Traditional Cardiovascular Risk Factor Jerry Eddya Putra Boer; Rudy Hidayat; Ika Prasetya Wijaya; Ikhwan Rinaldi
Indonesian Journal of Rheumatology Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.443 KB) | DOI: 10.37275/ijr.v10i2.98

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease which has recently been recognized to manifest as not only intraarticular but also extraarticular symptoms. Cardiovascular events, presented either subclinically or clinically, were discovered more in AR patients. Atherogenic inflammatory mediator in AR including interleukin-6 (IL-6) was thought to be one of nontraditional cardiovascular risk factor contributing to increase the endothelial dysfunction biomarker such as E-Selectin. This study was purposed to determine the correlation between inflammatory mediator and endothelial dysfunction event, especially between IL-6 and E-Selectin, in RA patient without traditional cardiovascular risk factor. A cross-sectional study was performed to 40 RA patients of Rheumatology Clinic of Cipto Mangunkusumo National General Hospital, Indonesia from September to November 2017. Measurement of the level of IL-6 and E-Selectin were performed using enzyme-linked immunosorbent assay (ELISA). Bivariate correlation analysis was performed to determine the correlation between those two biomarkers. The mean age of this study subjects was 44.9 (13.1) years and median of disease duration was 36 months. This study showed weak correlation between IL-6 and E-Selectin level, but not statistically significant.232, p=0.149). There is weak correlation between IL-6 and sE-Selectin in rheumatoid arthritis patient without traditional risk factor cardiovascular Keywords: traditional risk factor cardiovascular, E-Selectin, interleukin-6, pro inflammatory mediator, rheumatoid arthritis
Co-Authors A P Utari ACHMAD FAUZI Achmad Fauzi Adiningsih Srilestari Adnan Prihartono, Nurhayati Andri Reza Rahmadi Anindito, Bagus Anna Ariane Anna Ariane Anna Ariane Anna Ariane Anna Ariane Araminta, Abirianti P. Arief Nurudhin Asicha, Nur Awalia Awalia Ayu Paramaiswari Ayu Paramaiswari Bagus Anindito Bambang Setiyohadi Bambang Setiyohadi Bambang Setyohadi C Rinaldi A Lesmana C. Adisasmita, Asri Christina Simadibrata Dadang Makmun David Santosa Diana Sunardi Dicky L. Tahapary Dicky Levenus Tahapary Djuwita Hatma, Ratna Dwi Budi Darmawati Dwi R Helianthi, Dwi R Dyah Purnamasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edy R Wahyudi, Edy R Eka Kurniawan Endang Susalit Endy Adnan Esthika Dewiasty Esthika Dewiasty, Esthika Evy Yunihastuti Faisal Parlindungan Faisal Parlindungan Faisal Parlindungan Farida Isroani Fauzia, Fara Gadang R. Dewantoro Gede Kambayana Ginting, Andi Raga Hamzah Shatri Handono Halim Handono Kalim Harry Isbagio Harry Isbagio Harry Isbagjo Hasan Maulahela Herlina Yani I Nyoman Suarjana Ika Prasetya Wijaya Ika Vemilia Ika Vemilia Warlisti Ikhwan Rinaldi Jerry Eddya Putra Boer Juferdy Kurniawan Kasjmir, Yoga I Laniyati Hamijoyo, Laniyati Linda Kurniaty Wijaya Lisa Kurnia Sari Malikul Chair Marcel Prasetyo Marcellus Simadibrata Marcellus Simadibrata Maruhum B.H. Marbun Muhadi Muhadi Muhadi Muhadi, Muhadi Najirman Najirman Nunuk Mardiana, Nunuk Pande Ketut Kurniari Pande Ketut Kurniari Perdana Aditya Pratama, Mirza Zaka Prihartono, Nurhayati Adnan Pringgodigdo Nugroho Pringgodigdo Nugroho, Pringgodigdo Purwita Wijaya Laksmi R.M. Suryo Anggoro Kusumo Wibowo Radiyati Umi Partan Rakhma Yanti Hellmi Rakhma Yanti Hellmi Rakhma Yanti Helmi Ratih Manuaba Reza Yogaswara Ricky Ridho Adriansyah RM Suryo Anggoro RM. Suryo Anggoro RM. Suryo Anggoro KW Safri, Ahmad Yanuar Santosa, David Sepmeitutu, Iwandheny Siti Setiati Sosialita, Tiara Diah Sukamto Koesnoe Sukamto Koesnoe Sukamto Koesnoe Sumariyono Sumariyono Sumariyono Sumariyono Sumariyono Sumariyono Sarmidi Sumartini Dewi Sumartini Dewi Surya Darma Surya Darma Suryana, Bagus Putu Putra Triyanta Yuli Pramana Umi Partan, Radiyati Utari, A P Virnanda Amu, Ivan Wahono, Cesarius Singgih Wardoyo, Elizabeth Y Wibowo, Suryo Anggoro Kusumo Wulansari Manuaba, Ida Ayu Ratih Yoga I Kasjmir Yogaswara, Reza Yulyani Werdiningsih Yulyani Werdiningsih