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All Journal Indonesian Journal of Chemistry
Yaung Kwee
Department of Chemistry, Airlangga University, Kampus C Mulyorejo, Surabaya 60115, Indonesia; Department of Chemistry, University of Mandalay, University Drive, 73rdMandalay, Myanmar
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells Yaung Kwee; Alfinda Novi Kristanti; Nanik Siti Aminah; Mochamad Zakki Fahmi
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.50327

Abstract

Carbon nanodots (CNDs) have widely received great attention as a result of favorable optical, electrical, optoelectrical, biocompatible, and non-toxic properties these nanoparticles possess. However, the exploration of nanoparticle from natural raw material was limited. In present work, the carbon dots were produced from catechin isolated from Uncaria gambir through a simple and facile process. Carbon nanodots were further produced by the pyrolysis process of catechin, which allowed it for carbonization. Owing to its unique properties such as photoluminescence with an emission peak at 500 nm (lex = 380 nm), average size diameter about 5 nm and non-toxic; Cat-CNDs were incredibly potential for staining targeted tumor cells. The staining ability by confocal microscopy observations showed their green fluorescence images which meant that the CNDs easily penetrated HeLa cells via endocytosis. The resulting CNDs which were analyzed using some significant techniques approved that the prepared Cat-CNDs were tremendously dispersible and water-soluble, good colloidal stability, excellent biocompatibility, favorable hydrophilicity, high photostability, and non-toxicity.
Co-Authors Alfinda Novi Kristanti Mochamad Zakki Fahmi Nanik Siti Aminah