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All Journal Pharmaciana: Jurnal Kefarmasian Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Gizi dan Pangan Soedirman (JGPS)
Sri Sutji Susilowati
Pharmacy and Medicine, FKIK Universitas Jendral Sudirman. Jl. Dr. Soeparno, Karangwangkal, Purwokerto, 53122
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Journal : Acta Pharmaciae Indonesia : Acta Pharm Indo

 1 
Physical Stability and Sun Protection Factors Measurement of Sunscreen Preparations in Stress Storage Conditions Using Spectrophotometry WULANDARI, WIDI; WASITO, HENDRI; SUSILOWATI, SRI SUTJI
Acta Pharmaciae Indonesia Vol 6 No 1 (2018): Acta Pharmaciae indonesia Vol.6 No.1 Tahun 2018
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.937 KB)

Abstract

Background : Sunscreen preparations can be used effectively to absorb sunlight especially in the UV wave emission region. The stress condition during storage of a preparation may affect physical and chemical properties. This study aims to determine the effect of stress storage conditions on physical stability and nilai  Sun  Protection  Factor (SPF) values as the effectiveness of sunscreen preparations that stored in three different temperatures. Method : This experimental study was conducted with the selection of sunscreen samples and performing physical stability tests in termed of color observation, physical observation, pH value, spreading test, adhesive test, and SPF value measurement of sunscreen using spectrophotometry in lotion and gel dosage forms stored at room temperature (25◦C), low temperature (4◦C), and high temperature (40◦C). Result : The results showed that the stress storage condition influenced the physical properties of the preparation in the form of adhesive property, spreading capacity, and significantly affect the SPF value of the sunscreen (p <0.05) after 14 days of storage.
Physical Stability and Sun Protection Factors Measurement of Sunscreen Preparations in Stress Storage Conditions Using Spectrophotometry Wulandari, Widi; Wasito, Hendri; Susilowati, Sri Sutji
Acta Pharmaciae Indonesia Vol 6 No 1 (2018): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2018.6.1.1442

Abstract

Latar belakang : Sediaan tabir surya dapat digunakan untuk menyerap sinar matahari secara efektif terutama pada daerah emisi gelombang UV. Kondisi stress saat penyimpanan suatu sediaan dapat mempengaruhi sifat fisik dan kimiawi. Penelitian ini bertujuan untuk menentukan pengaruh kondisi stress penyimpanan terhadap stabilitas fisik dan nilai Sun Protection Factor (SPF) sebagai efektivitas dari sediaan tabir surya yang disimpan dalam tiga suhu berbeda. Metode : Penelitian eksperimental ini dilakukan dengan pemilihan sampel tabir surya dan pengujian stabilitas fisik meliputi pengamatan warna, pengamatan fisik, uji pH, uji daya sebar, uji daya lekat, serta pengukuran nilai SPF sediaan tabir surya lotion dan gel dengan spektrofotometri yang disimpan pada suhu ruang (25◦C), suhu rendah (4◦C), dan suhu tinggi (40◦C). Hasil : kondisi stress penyimpanan mempengaruhi sifat fisik sediaan berupa daya lekat, daya sebar, dan mempengaruhi secara signifikan nilai SPF sediaan (p<0,05) mulai hari ke-14 penyimpanan.
Phytochemical screening and purification of n-hexane fraction of Calophyllum soulattri leaves Sunarto, Sunarto; Yuliasari, Agnes; Susilowati, Sri Sutji; Wasito, Hendri; Wijaya, Triyadi Hendra; Fareza, Muhamad Salman
Acta Pharmaciae Indonesia Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5858

Abstract

Background: Calophyllum soulattri Burm F. is widely utilized in traditional medicine. It is necessary to identify secondary metabolites from C. soulattri leaves to determine the pharmacologically active chemicals. Objective: This study aimed to screen the phytochemical content and purify the n-hexane fraction of C. soulattri leaves from Banyumas, Indonesia. Methods: The n-hexane fraction was macerated with methanol, followed by liquid-liquid fractionation with n-hexane. The n-hexane fraction was tested for flavonoids, triterpenoids/steroids, saponins, and phenols using the test tube method. In addition, the compounds were purified using column chromatography. The purified compound was identified by the Liebermann-Burchard reagent, which was compared with commercially available steroid drugs as reference. Results: Phytochemical analysis revealed that the n-hexane fraction of C. soulattri leaves contained secondary metabolites such as flavonoid, steroid, and phenol compounds. Analyses with the Liebermann-Burchard reagent indicated that the purified compound was potentially a steroid. Conclusion: The compound extracted from the n-hexane fraction of C. soulattri leaves was expected as a steroid.
Co-Authors Adi Amurwanto Fareza, Muhamad Salman HENDRI WASITO HERY WINARSI Monica, Sausa Rahardian, Ganjar Wahyu Sunarto Sunarto Triyadi Hendra Wijaya Wulandari, Widi WULANDARI, WIDI Yuliasari, Agnes