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All Journal Bioeksperimen: Jurnal Penelitian Biologi Walisongo Journal of Chemistry Jurnal Abdimas Mahakam Jurnal Medikes (Media Informasi Kesehatan) KAIBON ABHINAYA : JURNAL PENGABDIAN MASYARAKAT Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Menara Pengabmas
Syarah Anliza
Poltekkes Kemenkes Banten
Agriculture, Biological Sciences & Forestry Humanities Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Pengaruh Variasi HPMC dan Carbopol pada Formulasi Sedian Gel Ekstrak Daun Namnam (Cynometra cauliflora L.) terhadap Methicillin-resistant Staphylococcus aureus (MRSA) Syarah Anliza; Hamtini Hamtini; Nurmeily Rachmawati
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 1 (2024): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i1.17833

Abstract

Antiseptic gel is a hand sanitizer that is useful for cleaning or eliminating germs on hands. One of the most important thing in antiseptic is antibacteria substances that had potential to destroy germs. Namnam leaves are an alternative for making antiseptic gel because they contain alkaloids and flavonoids. Making gel requires gel-forming materials such as HPMC and Carbopol. The aim of this research is to test the effect of gelling agents HPMC and Carbopol on namnam leaves extract as a gel sanitizer preparation and its ability to fight Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria which is a to interfere human health because it causes various infections that are difficult to treat. This research uses the maceration method in the extraction process, disc diffusion in the bacterial inhibition test, pH test, spreadability test, and homogeneity test on the gel sanitizer preparation. The conclusion of this research is that the gelling agent HPMC has the greatest active ability compared to Carbopol which is characterized by an inhibitory power of 14 mm at a variation of 0.25 grams. Increasing variations in HPMC and Carbopol will increase viscosity and reduce spreadability and inhibitory power against bacteria.
SINTESIS DAN KARAKTERISASI EKSTRAK DAUN NAMNAM SEBAGAI ANTIMIKROBA Rachmawati, Nurmeily; Syarah Anliza; Dian Pratiwi; Digna Renny Panduwati
Jurnal Medikes (Media Informasi Kesehatan) Vol. 12 No. 1 (2025)
Publisher : Politeknik Kesehatan Kementerian Kesehatan Banten

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Abstract

The biodiversity owned by a country is a gift that must be appreciated. The potential of these natural resources can be used as research material to overcome existing problems. One of them is about how to answer the challenges of the effects caused by the use of chemicals that can harm the environment and surrounding living things. Therefore, it is necessary to modify the use of chemicals to be more optimal and of course safe both in use and effects. Modification of the particle size of a substance provides benefits because the size of a substance becomes smaller (nanoparticles) so that it will expand the surface of the contact substance. Several applications of the use of nanoparticles of a substance as a drug target carrier agent, sensor, increased bioavailability, and reduced effects of a substance have been carried out by several researchers. This study aims to evaluate the continuation of the potential of namnam leaves which have quite good bioactivity as antimicrobials. The method used is laboratory experimental. The research stages include the manufacture of namnam leaf extract, phytochemical test of the extract, and antimicrobial activity test. The extract was made by maceration using methanol for 3x24 hours and produced a yield of 11.2%. The results of the phytochemical test showed that the methanol extract of namnam leaves contains active compounds such as flavonoids, saponins, phenolics, steroids, and tannins. The content of these active substances has the potential as antimicrobials. The preliminary bioactivity test was carried out using the well method which produced inhibition zones of 15 mm, 18 mm, and 18 mm. The value of this inhibition zone is included in the sensitive category according to the CLSI data division.
Co-Authors Dian Pratiwi Digna Renny Panduwati Hamtini - Hamtini Indah Wardatul Firdaus Ira Nuraeni Nurmeily Rachmawati Nurmeily Rachmawati Nurmeily Rachmawati Rachmawati, Nurmeily Shufiyani Shufiyani