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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal Medikes (Media Informasi Kesehatan) Contagion: Scientific Periodical Journal of Public Health and Coastal Health Jurnal Prima Medika Sains Jurnal Sains Kesehatan Jurnal Abdi Masyarakat Indonesia Jurnal Pengabdian Masyarakat Akademisi Borneo Community Health Sevice Journal Lamahu: Jurnal Pengabdian Masyarakat Terintegrasi Jurnal Kesehatan Kartika
Digna Renny Panduwati
Politeknik Kesehatan Kementerian Kesehatan Medan
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Study ff Interaction Between ADT-C2 Cyclic Peptide (Ac-CADTPPC-NH2) and E-Kadherin Protein Using Docking Molecular Method Panduwati, Digna Renny
ALKIMIA Vol 5 No 2 (2021): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (876.501 KB) | DOI: 10.19109/alkimia.v5i2.11306

Abstract

Research has been conducted on the study of the interaction between cyclic peptide ADTC2(Ac-CADTPPC-NH2) and E-cadherin protein using the molecular docking method. The aim of this study is to determine the position of the binding site and the energy of interaction between the ADTC2 peptide and the EC1-EC2 domain of E-kadherin. This research was divided into two parts, (1) Preliminary test using molecular dynamics (DM) method with Gromacs v4.5.4 software, (2) interaction of the peptide ADTC2 with EC1-EC2 using the molecular docking method (MD) with Autodock 4.2 software. Docking was performed with the blind dock method on EC1 and EC2 position. In the second step, the gridbox position was reduced based on the binding activity between E-cadherin and peptides. The strongest interaction and Van der Walls bonds were obtained in boxes B, C and D. The results showed that the ADTC2 peptide had a biological activity to inhibit the interaction of E-cadherin...E-cadherin by forming a complex with the EC1-EC2 domain. This inhibition occured by forming two binding sites in the EC1 domain (interaction energies are -23.309 kJ / mol and -26.234 kJ / mol, respectively) and one binding site in the EC2 domain (interaction energies are -22.677 kJ / mol). Based on preliminary tests, it can be proven that the native structure of ADTC2 is cyclic with optimization energy of -52504.78 kJ/mol and very stable from the beginning to the end of DM with an RMSD was <2 Å.
Gambaran profil lemak darah pasien medical check-up di Laboratorium Klinik Prodia Medan Ningsih, Sri Widia; Agustinawati, Agustinawati; Pratiwi, Dian; Panduwati, Digna Renny
Jurnal Prima Medika Sains Vol. 4 No. 2 (2022): Desember
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v4i2.3240

Abstract

Dislipidemia merupakan abnormalitas metabolisme lemak darah berupa peningkatan kadar kolesterol total, kolesterol LDL dan trigliserida serta penurunan kolesterol HDL. Dislipidemia dapat menyebabkan terjadinya penyakit serebrovaskular dan kardiovaskular. Kurangnya tingkat kesadaran dan rendahnya kemampuan hidup sehat dapat meningkatkan terjadinya dislipidemia. Penelitian ini bertujuan untuk mengetahui gambaran profil lemak darah pasien medical check-up di Laboratorium Klinik Prodia Medan S. Parman periode September 2022. Jenis penelitian ini adalah deskriptif. Pasien terbanyak berusia 55-64 tahun (204 pasien) dengan hasil pemeriksaan yaitu kadar kolesterol total normal (39 pria, 52 wanita), kadar tinggi (12 pria, 33 wanita). Kolesterol HDL kadar normal (36 pria, 78 wanita), kadar tinggi (6 pria, 34 wanita). Kolesterol LDL optimal (10 pria, 8 wanita), kadar tinggi (15 pria, 35 wanita). Trigliserida normal (46 pria, 93 wanita), kadar tinggi (12 pria, 18 wanita).
Permen Jelly Andaliman: Pembuatan dan Inovasi Lezat untuk Menangkal Hipertensi Panduwati, Digna Renny
Borneo Community Health Service Journal VOLUME 4 NOMOR 2 TAHUN 2024
Publisher : Fakultas Ilmu Kesehatan Universitas Borneo Tarakan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35334/neotyce.v4i2.5561

Abstract

Hypertension is a condition where there is a chronic increase in blood pressure (over a long period) which can cause pain to a person and can even cause death. Andaliman as a source of biodiversity contains flavonoids, especially the compound quercetin which has ACE-I activity 30% so it has the potential to be a natural antihypertensive. This method of implementing community service begins with giving a pre-test regarding hypertension to see the respondent's initial knowledge and continues with socialization regarding hypertension. The activity was continued with training how to make andaliman jelly candy. The activity was closed by providing a post-test and health examination in the form of measuring blood pressure, blood sugar levels, cholesterole and uric acid. The results is PKK mothers became more aware of the food they consumed and which could cause hypertension. PKK women have additional knowledge regarding the processing of andaliman apart from being a spice. The creativity of PKK mothers also increases by knowing how to package attractive andaliman jelly candy. Based on the results of health examinations, it is known that there are still many PKK mothers who have high blood pressure accompanied by high cholesterol
Inhalation of Orange Peel Aroma: Study on the Effects of Exotic Oils on Blood Pressure Changes Digna Renny Panduwati; Dian Pratiwi
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 6, No 2 (2024): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v6i2.21175

Abstract

Oranges are a fruit that is in great demand by the public. Oranges have a sweet taste and distinctive aroma. Orange peel debris is one of the problems that is of concern to the government. This is because there are still many people who do not use it and just throw it away. This is because many people still don't know that orange peel waste contains the active substance d-lemonene. The d-lemonene compound is a compound that has a fragrant and refreshing aroma, so it can provide a calming feeling to those who inhale it. Therefore, this study aims to see the effect of the fragrant aroma of raw orange peel extract on changes in blood pressure. The extraction method used is steam distillation in order to maximize the yield obtained. After obtaining the raw extract, it was characterized using Gas Chromatography Mass Spectrometry (GC-MS) to determine the skin content. The research results showed that the yield of orange peel extract calculated based on the volume of extraction results divided by the sample weight in grams was 20% (v/w). Based on the results of Gas Chromatography Mass Spectrometry (GC-MS) characterization, it shows that the sample contains the compound d-lemonene. The effectiveness test showed a decrease in blood pressure in respondents who had high blood pressure and an increase in pressure in respondents who had low blood pressure. The reason is that the d-lemonene compound contained in orange peel can provide a calming sensation. This can happen because the d-lemonene compound is able to inhibit neuroinflammation and nitrite levels in the hippocampus and relieve anxiety through DAergic and GABAergic nerve activity mediated by A2A receptors.Keywords: Blood Pressure, Essencial Oil, Orange Peel
Edukasi Hubungan Stunting terhadap Faktor Resiko Penyakit Tidak Menular pada Gen Z di SMAN 10 Medan Pratiwi, Dian; Panduwati, Digna Renny; Wahyuni, Sri
Jurnal Pengabdian Masyarakat Akademisi Vol. 4 No. 2 (2025)
Publisher : Jurnal Pengabdian Masyarakat Akademisi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54099/jpma.v4i2.1333

Abstract

Stunting is caused by various factors, primarily nutritional intake during the first 1,000 days of life. Stunting has significant impacts on children's health and can hinder Indonesia's demographic bonus in the future by affecting the competitiveness of its productive human resources. All parties are expected to care and take action in the effort to prevent stunting in children, including adolescents, who are part of Generation Z and the successors of the millennial generation. This topic was chosen to educate Gen Z about the relationship between stunting and the risk factors for non-communicable diseases. The method used involved administering questionnaires to assess participants’ understanding before and after the educational intervention. The results showed an increase in Gen Z's knowledge from 14% to 74%. In terms of health screening outcomes, 90% had normal blood pressure and 72% had normal blood glucose levels.
Pemberdayaan Masyarakat Gereja GBKP Runggun, Medan dalam Deteksi Dini Kanker Serviks melalui IVA dan Donor Darah Sukarela Surbakti, Karolina Br; Panduwati, Digna Renny; Situmeang, Suryani M Florence; Rahmah, Lestari; Humaira, Wardati; Romeli, Fauzi
Jurnal Abdi Masyarakat Indonesia Vol 5 No 3 (2025): JAMSI - Mei 2025
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jamsi.1888

Abstract

Kanker serviks dan rendahnya partisipasi donor darah merupakan dua isu kesehatan masyarakat yang memerlukan perhatian serius, khususnya di Indonesia. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kesadaran dan partisipasi jemaat Gereja GBKP Runggun dalam deteksi dini kanker serviks melalui Inspeksi Visual Asam Asetat (IVA) test, serta mendorong kepedulian terhadap donor darah sukarela. Kegiatan dilaksanakan pada bulan April 2025 melalui tahapan persiapan, penyuluhan, pelayanan, dan evaluasi. Sebanyak 14 perempuan mengikuti IVA test, dengan hasil 13 peserta (92,9%) negatif dan 1 peserta (7,1%) menunjukkan adanya infeksi ringan yang memerlukan pengobatan. Sementara itu, kegiatan donor darah diikuti oleh 40 peserta dengan rentang usia 20–60 tahun, menunjukkan kadar hemoglobin bervariasi sesuai dengan jenis kelamin dan usia. Hasil kegiatan menunjukkan peningkatan pemahaman masyarakat terhadap pentingnya deteksi dini kanker serviks dan manfaat donor darah. Edukasi yang berkelanjutan, pendekatan empatik, serta penyediaan layanan kesehatan yang terjangkau terbukti efektif dalam meningkatkan kesadaran. Kegiatan ini memberikan dampak positif dalam membangun budaya hidup sehat dan mendorong keterlibatan aktif masyarakat dalam upaya promosi kesehatan.
Bioaktivitas Andaliman (Zanthoxylum acanthopodium) Sebagai Tanaman Endemik Sumatera Utara Pratiwi, Dian; Panduwati, Digna Renny; Mutia, Liza; Ningsih, Sri Widia; Setiyawati, Dewi; Suparni, Suparni
Jurnal Sains Kesehatan Vol 31, No 2 (2024)
Publisher : Sekolah Tinggi Ilmu Kesehatan Tri Mandiri Sakti Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37638/jsk.31.2.67-74

Abstract

Andaliman (Zanthoxylum acanthopodium) merupakan salah satu tanaman endemik Sumatera Utara yang pemanfaatannya masih sangat minim. Dengan adanya berbagai macam senyawa metabolit sekunder pada bahan alam, tidak menutup kemungkinan bahwa andaliman bisa berpotensi sebagai senyawa antioksidan. Senyawa antioksidan dapat mencegah radikal bebas disebabkan karena adanya donor elekron dari senyawa antioksidan yang dapat mengikat elektron bebas pada senyawa radikal.. Tujuan penelitian ini adalah untuk mendapatkan senyawa antioksidan melalui ekstraksi andaliman, karakterisasi dengan beberapa instrumen, dan uji 1,1-difinil-2-pikrilhidrazil (DPPH). Metode yang digunakan adalah secara eksperimental di laboratorium dengan sampel bahan alam yaitu buah andaliman (Zanthoxylum acanthopodium). Berdasarkan uji FT-IR dapat dilihat bahwa peak yang muncul pada 3300 cm-1 menunjukkan adanya gugus -OH (hidroksil) pada sampel. Pada  2900 cm-1 menunjukkan adanya gugus C-H alifatik. Pada 1700 dan 1600 cm-1 menunjukkan adanya gugus karbonil. Berdasarkan uji menggunakan GC-MS diperoleh hasil ekstrak andaliman (Zanthoxylum acanthopodium) mengandung senyawa 3-karen, D-limonen, 2-karen-4-ol, Geraniol, Geranil asetat, naftol, dodekatrienol trimetil asetat, asam heksadekanoat, asam suksinat, dan oktadekadienoil klorida. Berdasarkan uji DPPH dapat disimpulkan bahwa kekuatan antioksidan dari andaliman (Zanthoxylum acanthopodium) menunjukkan hasil yang sedang sebesar 149 ppm dan dapat dimanfaatkan sebagai antioksidan. Saran dari penelitian ini adalah menvariasikan pelarut dalam pengujian DPPH.Kata Kunci: Andaliman, bioaktivitas, antioksidan, uji DPPH                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
Potential Bioactivity of Carrot (daucus carota L) as a Health Protector Through Antioxidant, Antibacterial, and Antifungal Activities Digna Renny Panduwati; Dian Pratiwi; Liza Mutia; Suryani MF Situmeang; Karolina Br Surbakti; Wardati Humaira; Sahala Fransiskus Marbun
Jurnal Penelitian Pendidikan IPA Vol 11 No 4 (2025): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i4.9441

Abstract

Carrots are one of the most popular plants in Indonesia. In addition to being a plant with a flavor favored, carrots also contain various bioactivities that can be utilized for health. This study aims to investigate the bioactivity of carrot extract, which includes antioxidant, antibacterial, and antifungal. The method used in this study is DPPH, which aims to determine antioxidant activity, and the disc diffusion method to determine antibacterial and antifungal activity. Carrot extract was obtained using the maceration method with a ratio of 1:10 using ethanol solvent 96% for the antioxidant test, while for the antibacterial and antifungal tests, acetone solvent was used. The extracted carrots yielded a yield of 10.1% (v/b). Based on the results of phytochemical screening, it is known that carrots contain flavonoids, saponins, tannins, and alkaloids, as well as functional groups indicating the presence of beta-carotene in carrots through FTIR. Carrots show weak antioxidant activity with an IC50 value of 125.944 ppm. The inhibitory activity of carrot extract during 24 hours of observation are concentration 40% (0.7 mm), 60% (0.77 mm) and 80% (0.85 mm). Meanwhile, in the antifungal test, carrot extract showed negative results at concentrations 60 and 80%, while at a concentration of 100% showed an inhibition zone of 0.835 mm.
SINTESIS DAN KARAKTERISASI EKSTRAK DAUN NAMNAM SEBAGAI ANTIMIKROBA Nurmeily Rachmawati; Syarah Anliza; Dian Pratiwi; Digna Renny Panduwati
Jurnal Medikes (Media Informasi Kesehatan) Vol. 12 No. 1 (2025)
Publisher : Politeknik Kesehatan Kementerian Kesehatan Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The biodiversity owned by a country is a gift that must be appreciated. The potential of these natural resources can be used as research material to overcome existing problems. One of them is about how to answer the challenges of the effects caused by the use of chemicals that can harm the environment and surrounding living things. Therefore, it is necessary to modify the use of chemicals to be more optimal and of course safe both in use and effects. Modification of the particle size of a substance provides benefits because the size of a substance becomes smaller (nanoparticles) so that it will expand the surface of the contact substance. Several applications of the use of nanoparticles of a substance as a drug target carrier agent, sensor, increased bioavailability, and reduced effects of a substance have been carried out by several researchers. This study aims to evaluate the continuation of the potential of namnam leaves which have quite good bioactivity as antimicrobials. The method used is laboratory experimental. The research stages include the manufacture of namnam leaf extract, phytochemical test of the extract, and antimicrobial activity test. The extract was made by maceration using methanol for 3x24 hours and produced a yield of 11.2%. The results of the phytochemical test showed that the methanol extract of namnam leaves contains active compounds such as flavonoids, saponins, phenolics, steroids, and tannins. The content of these active substances has the potential as antimicrobials. The preliminary bioactivity test was carried out using the well method which produced inhibition zones of 15 mm, 18 mm, and 18 mm. The value of this inhibition zone is included in the sensitive category according to the CLSI data division.
Analisis Pengaruh Perilaku Kebersihan terhadap Risiko Dermatitis pada Kaki Petani Jeruk di Berastagi Suryani Situmeang; Digna Renny Panduwati; Karolina br Surbakti
JURNAL KESEHATAN KARTIKA Vol. 21 No. 1 (2026): Jurnal Kesehatan Kartika
Publisher : Faculty of Health Science and Technology, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkkes.v21i1.471

Abstract

Background: Dermatitis is a common skin health problem among farmers and is associated with personal hygiene practices in humid working conditions and exposure to agricultural chemicals. Objective: This study aims to analyze the relationship between hygiene practices and the risk of dermatitis in the feet of orange farmers in Berastag. Methods: The study design employed a descriptive-analytical approach using a cross-sectional method. The study sample consisted of 30 orange farmers selected via purposive sampling. Data were collected through interviews, observation of hygiene behaviors (foot washing, use of personal protective equipment/PPE, and workplace cleanliness), as well as clinical and mycological laboratory examinations. Results: The study found that 13 respondents (43.3%) had dermatitis, while 17 respondents (56.7%) did not. A total of 19 farmers (63.7%) were in the habit of washing their feet after work, 9 people (30%) used PPE, and 12 people (73.4%) maintained workplace hygiene. Analysis indicated a trend that farmers who did not wash their feet were more likely to experience dermatitis (72.7%) compared to those who did (26.3%). The use of PPE and workplace hygiene were also associated with the occurrence of dermatitis. Laboratory identification revealed pathogenic fungi such as Trichophyton rubrum and Candida albicans, which were implicated in the cases of dermatitis. Conclusion: Hygiene practices are associated with the risk of dermatitis among citrus farmers.
Co-Authors Agustinawati, Agustinawati Dewi Setiyawati Dian Pratiwi Dian Pratiwi Dian Pratiwi Dian Pratiwi Fauzi Romeli Karolina br Surbakti Karolina Br Surbakti Mutia, Liza NINGSIH, SRI WIDIA Nita Andriani Lubis Nurmeily Rachmawati Rahmah, Lestari Sahala Fransiskus Marbun Situmeang, Suryani M Florence Sri Wahyuni SRI WIDIA NINGSIH Suparni Suparni Surbakti, Karolina Br Suryani M.F Situmeang Suryani Situmeang Syarah Anliza Wardati Humaira