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All Journal Jambura Journal of Chemistry JPP Jurnal Kesehatan Poltekkes Palembang Jurnal Medikes (Media Informasi Kesehatan) Bantenese Jurnal Pengabdian Masyarakat SANITAS: Jurnal Teknologi dan Seni Kesehatan Journal of Medical Laboratory Research
Rachmawati, Nurmeily
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Activity Of Ethanol Extract Namnam (Cynometra cauliflora L.) Leaves Toward Antioxidant Anliza, Syarah; Rachmawati, Nurmeily
SANITAS: Jurnal Teknologi dan Seni Kesehatan Vol 14 No 1 (2023): SANITAS Volume 14 Nomor 1 Tahun 2023
Publisher : Politeknik Kesehatan Kemenkes Jakarta II

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36525/sanitas.2023.1

Abstract

One of the natural defense systems that an organism had to prevent exposure from free radicals is by forming a number of compounds that act as antioxidants. One of the substances that can prevent these free radicals are enzymes produced in the body such as glutathione peroxidase enzymes, catalase, and others. The amount of these antioxidants can be added with intake from outside the body. This antioxidant is a type of natural antioxidant that can be found in plants. Namnam plants contain phytochemical compounds such as flavonoids, tannins, phenolics, and terpenoids. These compounds can act as antioxidants. To obtain these antioxidants, the extraction process was carried out by using ethanol in a ratio of 1:5 through a maceration process for 3x24 hours. The samples used were young and old Namnam leaves each for 100 gram. The extract obtained was then tested for antioxidant activity using the DPPH method with measurements using an ELISA spectrophotometer at a wavelength of 517 nm. The positive control used was ascorbic acid. After that, the absorbance measurement results obtained will be used to measure the IC50 value. This value shows the antioxidant activity from the extract that has been made. Old Namnam leaves generate IC50 results of 9.58 ppm, while young Namnam leaves generate IC50 results of 28.93 ppm. Based on this data, the antioxidants in old Namnam leaves give a greater IC50 value than young Namnam leaves.
PENENTUAN KADAR LOGAM TIMBAL PADA RAMBUT SUPIR BUS RUTE TANGERANG-PADANG-SURABAYA-YOGYAKARATA DI TERMINAL PORIS TANGERANG Rachmawati, Nurmeily
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 15 No 2 (2020): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v15i2.531

Abstract

ABSTRAK Latar Belakang : Pencemaran di udara salah satunya dapat disebabkan oleh emisi buangan gas kendaraan yang dapat melepaskan zat timbal ke udara. Salah satu orang yang dapat beresiko terpapar logam timbal adalah pekerja supir bus. Pajanan logam timbal dapat terakumulasi di dalam rambut dan dapat menyebabkan efek toksisitas. Tujuan penelitan untuk mengetahui kadar logam timbal (Pb) pada rambut supir bus di tiga rute berbeda yang berangkat dari Terminal Poris, Tangerang. Ketiga rute tersebut adalah Tangerang-Padang, Tangerang-Surabaya, Tangerang-Yogyakarta. Metode : Penelitian yang digunakan adalah penelitian eksperimental dengan jumlah korespondensi setiap rute bis sebanyak 8 orang. Penentuan kadar logam timbal pada rambut supir bus menggunakan spektrofotometer ICP-OES. Hasil : Penelitian ini memberikan hasil bahwa semua sampel rambut supir bus diketiga rute teridentifikasi logam timbal. Kadar logam timbal terbesar pada rambut supir bus rute Tangerang-Padang yaitu 2,28 mg Pb/100 g dengan masa kerja 25 tahun. Sedangkan kadar logam timbal terendah pada rambut supir bus rute Tangerang-Surabaya yaitu 0,17 mg Pb/100 g dengan masa kerja 3 tahun. Berdasarkan uji statistic analisis korelasi diperoleh nilai r = 0,82 mendekati 1 yang menunjukkan adanya korelasi positif yang kuat antara masa bekerja supir bis dengan paparan logam timbal yang terdeteksi. Kesimpulan : Seluruh supir bus diketiga rute teridentifikasi logam timbal dengan konsentrasi yang berbeda-beda dengan masa kerja yang bervariasi. Kata kunci : Logam timbal, rambut supir bis, spektrofotometer ABSTRACT Background : One of the causes of air pollution is vehicle exhaust emissions which can release lead metal into the air. One of the people who can be at risk to the exposure of lead metal is bus driver workers. Lead metal exposure can accumulate in the hair and can cause toxicity effects. The objective of this research is to determine the level of lead (Pb) in the hair of bus drivers on three different routes departing from Terminal Poris, Tangerang. The three routes are Tangerang-Padang, Tangerang-Surabaya, Tangerang-Yogyakarta. Methods : The method used in this research is experimental research with 8 correspondences for each of bus route. Determination of the level of lead metal in the bus driver's hair is using an ICP-OES spectrophotometer. Results : The results showed that all the hair samples of the bus drivers in the three routes were contaminated as lead metal. The largest concentration of lead metal in the hair of bus drivers on the Tangerang-Padang route is 2.28 mg Pb / 100 g with 25 years of working periods. Meanwhile, the lowest level of lead in the hair of bus drivers on the Tangerang-Surabaya route is 0.17 mg Pb / 100 g with 3 years working periods. Based on statistics result corelation analysis showed value r=0,82 approximately 1 indicate positif corellation between working periods and level of lead metal that detected in driver bus body. Conclusion : The samples hair of the three bus drivers was contaminated with lead metal with different concentrations in various working periods Keywords : Lead metal, bus driver’s hair, spectrophotometer
Hubungan Kekeruhan, pH dan Suhu terhadap Konsentrasi Logam Berat pada Air Sungai di Tangerang Rinawati, Diana; Rachmawati, Nurmeily; Annisa, Istiana; Meilina, Meilina
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 17 No 1 Juni (2022): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v17i1.1247

Abstract

Rapid industrial growth can cause environmental pollution if not balanced with good environmentalmanagement. To determine the concentration of heavy metals in polluted water, it is better tomeasure turbidity, pH and temperature as other factors in determining the concentration of heavymetals in water bodies. For this reason, it is necessary to know the relationship between turbidity,pH, temperature and the concentration of heavy metals (Pb, Cd, Hg) in river water in Tangerang.The design of this study is a descriptive correlational study, with a total sample of 36 samples ofCirarab, Cimanceuri, Cidurian and Cisadane rivers in kabupaten Tangerang. The sample pointsare on the left, middle and right of the river with measurement times in the morning, afternoon andevening. Examination of Pb and Cd using a Non-flame Atomic Absorption Spectrophotometer(Graphite Furnace AAS). While for Hg using a Mercury Analyzer. The working principle of the AASfurnace is the process of breaking molecules into atoms using electricity. The working principle ofthe Hg probe is the process of breaking molecules into atoms using cold steam. The results showedthat the concentrations of Mercury and Cadmium were both below the quality standard with a valueof 10-4 (0.0002 mg/L). Lead concentrations varied mostly below the quality standard (0.03 mg/L).pH, temperature according to environmental conditions and turbidity below the quality standard.(400 NTU) The results of statistical tests with P values of 0.571, 0.440, 0864. It was obtained thatthere was no relationship between turbidity, pH and temperature with the concentration of Lead.The conclusion is that there is no relationship between turbidity, temperature, pH with heavy metalconcentrations expecially Lead in rivers in kabupaten Tangerang.
Pemberdayaan Tokoh Masyarakat Dalam Adaptasi Kebiasaan Baru dan Penerapan Pola Hidup Bersih dan Sehat di Kecamatan Periuk Aminah, Aminah; Rachmawati, Nurmeily; Trisna, Citra; Anliza, Syarah; Wijonarko, Bangun
BANTENESE : JURNAL PENGABDIAN MASYARAKAT Vol. 6 No. 2 (2024): Bantenese: Jurnal Pengabdian Masyarakat
Publisher : Pusat Studi Sosial dan Pengabdian Masyarakat Fisipkum Universitas Serang Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30656/ps2pm.v6i2.9055

Abstract

Perkembangan pandemic covid-19 menjadikan pola hidup yang berbeda dari masa sebelumnya. Pada masa pandemic ini masyarakat diminta untuk menerapkan protokol kesehatan yang ketat guna memutus rantai perkembangan virus tersebut. Berbagai program dilakukan pemerintah salah satunya adalah Pola Hidup Bersih dan Sehat (PHBS). Kegiatan pengabdian masyarakat ini bertujuan untuk memberdayakan Ketua RW se-Kecamatan Periuk dalam membangun kesadaran masyarakat tentang peran strategis adaptasi kebiasaan baru dan penerapan PHBS untuk meningkatkan taraf kesehatan dan pencegahan penyakit menular. Kegiatan diawali dengan edukasi tentang adaptasi kebiasaan baru dan PHBS untuk meningkatkan pengetahuan, sikap, dan perilaku para peserta. Semua peserta diajak untuk melanjutkan kebiasan memakai masker dan mencuci tangan terutama ketika melakukan kegiatan yang melibatkan banyak orang di dalam ruangan. Hasil pemberian edukasi menunjukkan peningkatan pengetahuan, sikap, dan perilaku para peserta berdasarkan hasil kuesioner pre dan posttest. Dalam monitoring dan evaluasi yang dilakukan saat penyelenggaraan rapat pengurus RT/RW di RW 13 Kelurahan Gebang Raya, Ketua RW dapat menjadi contoh yang menggerakkan pada peserta rapat untuk tertib mengikuti protokol kesehatan. Keberlanjutan adaptasi kebiasaan baru dan penerapan PHBS untuk mencegah penularan penyakit bergantung pada keberadaan anggota masyarakat yang dapat menginspirasi dan menjadi teladan.
SINTESIS DAN KARAKTERISASI EKSTRAK DAUN NAMNAM SEBAGAI ANTIMIKROBA Rachmawati, Nurmeily; Syarah Anliza; Dian Pratiwi; Digna Renny Panduwati
Jurnal Medikes (Media Informasi Kesehatan) Vol. 12 No. 1 (2025)
Publisher : Politeknik Kesehatan Kementerian Kesehatan Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The biodiversity owned by a country is a gift that must be appreciated. The potential of these natural resources can be used as research material to overcome existing problems. One of them is about how to answer the challenges of the effects caused by the use of chemicals that can harm the environment and surrounding living things. Therefore, it is necessary to modify the use of chemicals to be more optimal and of course safe both in use and effects. Modification of the particle size of a substance provides benefits because the size of a substance becomes smaller (nanoparticles) so that it will expand the surface of the contact substance. Several applications of the use of nanoparticles of a substance as a drug target carrier agent, sensor, increased bioavailability, and reduced effects of a substance have been carried out by several researchers. This study aims to evaluate the continuation of the potential of namnam leaves which have quite good bioactivity as antimicrobials. The method used is laboratory experimental. The research stages include the manufacture of namnam leaf extract, phytochemical test of the extract, and antimicrobial activity test. The extract was made by maceration using methanol for 3x24 hours and produced a yield of 11.2%. The results of the phytochemical test showed that the methanol extract of namnam leaves contains active compounds such as flavonoids, saponins, phenolics, steroids, and tannins. The content of these active substances has the potential as antimicrobials. The preliminary bioactivity test was carried out using the well method which produced inhibition zones of 15 mm, 18 mm, and 18 mm. The value of this inhibition zone is included in the sensitive category according to the CLSI data division.
Efektivitas Ekstrak Metanol Daun Namnam (Cynometra Cauliflora L.) Terhadap Daya Hambat Pertumbuhan Bakteri Vibrio Cholerae Zulkifli, M. Zidan; Anliza, Syarah; Rachmawati, Nurmeily; Fadillah, M.Arief
Journal of Medical Laboratory Research Vol. 3 No. 1 (2025): Journal of Medical Laboratory Research
Publisher : Politeknik Kesehatan Kementerian Kesehatan Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36743/jomlr.v3i1.805

Abstract

Saat ini peningkatan kasus resistensi bakteri pada sejumlah antibiotik sintetis kian meningkat tidak terkecuali bakteri Vibrio cholerae, oleh karena itu banyak sekali penelitian yang beralih untuk memanfaatkan bahan alam. Daun namnam (Cynometra cauliflora L.) merupakan daun yang banyak dijumpai di Indonesia. Daun namnam memiliki senyawa seperti fenolik, flavonoid, saponin, Steroid, dan tanin. Senyawa-senyawa tersebut merupakan senyawa yang berpotensi sebagai antibakteri. Penelitian ini bertujuan mengetahui konsentrasi hambat minimum (KHM) ekstrak daun namnam (Cynometra cauliflora L.) terhadap bakteri Vibrio cholerae. Penelitian ini menggunakan metode eksperimental dengan mengekstrak daun namnam menggunakan metode maserasi dengan pelarut metanol. Metode uji daya hambat menggunakan metode mikrodilusi dengan DMSO 10% sebagai kontrol negatif dan tetrasiklin sebagai kontrol positif. Variasi konsentrasi daun namnam yang digunakan pada penelitian ini yaitu 50.000, 100.000, 150.000, 200.000, dan 300.000 ppm. Massa simplisia yang digunakan pada penelitian ini sebanyak 255 gram dan diperoleh rendemen ekstrak sebanyak 10,1%. Hasil penelitian ini menunjukkan nilai konsentrasi hambat minimum (IC50) ekstrak daun namnam yang dapat menghambat pertumbuhan bakteri Vibrio cholerae ada pada konsentrasi 262.421 ppm.
Uji Daya Hambat Kombinasi Ekstrak Daun Handeuleum Dan Daun Jarak Pagar Terhadap Bakteri Staphylococcus aureus Audina, Gina; Rachmawati, Nurmeily; Yani, Ahmad; Fadillah, Muhammad Arief
Journal of Medical Laboratory Research Vol. 3 No. 1 (2025): Journal of Medical Laboratory Research
Publisher : Politeknik Kesehatan Kementerian Kesehatan Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36743/jomlr.v3i1.847

Abstract

Penyakit infeksi meupakan penyakit akibat proses masuknya mikroorganisme ke dalam host. Penyakit infeksi di Indonesia dapat disebabkan oleh satu bakteri yaitu Staphylococcus aureus. Pemberian antibiotik yang tidak tepat mengakibatkan terjadinya antimicrobial resistance (AMR). Pengembangan bahan alami sebagai bahan pengobatan akibat penyakit infeksi dapat dilakukan dengan memanfaatkan tanaman daun handeuleum (Graptophyllum pictum (L.) Griff) dan daun jarak pagar (Jatropha curcas L.) sebagai antibakteri terhadap Staphylococcus aureus. Tujuan penelitian ini untuk mengetahui aktivitas antibakteri yang dihasilkan dari kombinasi kedua ekstrak tanaman tersebut terhadap Staphylococcus aureus. Metode yang digunakan adalah ekperimental laboratorium secara invitro. Metode maserasi digunakan dalam pembuatan ekstrak menggunakan etanol 70% dan metode uji daya hambat menggunakan metode cakram dengan kontrol positif adalah gentamicin 10 μg dan kontrol negatif adalah DMSO 10%. Hasil uji daya hambat yang dihasilkan dari perbandingan konsentrasi ekstrak dengan ratio 25%:75%, 50%:50%, dan 75%:25% mendapatkan zona hambat berturut turut 12.4 mm, 10.1 mm, dan 15. 5 mm. Berdasarkan hasil tersebut kombinasi ekstrak daun handeuleum dan daun jarak pagar pada konsentrasi 25%:75% dan 50%:50 masuk dalam katagori resisten dan pada konsentrasi 75%:25% masuk kedalam katagori intermediat yang mengacu pada CLSI.
Bioaktivitas Ekstrak Daun Namnam (Cynometra cauliflora L.) Terhadap Antidiabetes Secara In Vitro Anliza, Syarah; Rachmawati, Nurmeily
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.13379

Abstract

Every day our bodies produce free radicals and every organism has a natural defense system to reduce free radicals. In a healthy state the amount of antioxidants in the body can balancing the amount of free radicals. However, in certain circumstances it can interfere with the body's defense against free radicals. This situation underlies the occurrence of various diseases caused by radicals, one of which is non-communicable (degenerative) diseases. Many therapies are available for the treatment of diabetes, do not completely cure the disease but cause many side effects. Namnam plant is predict to have the ability as an anti-diabetic agent. The purpose of this study was to determine the in vitro bioactivity of Namnam leaves extract against antidiabetic. This research conducted extraction, phytochemical test, total phenol test, total flavonoid test, and in vitro -glucosidase enzyme inhibition test as an antidiabetic. The results of the study showed that the ethanol extract produced secondary metabolites, namely flavonoids and steroids. The results of the α-glucosidase inhibition test resulted in an IC50 value of 30,89 ppm. The comparison that has been used is acarbose which produces IC50 of 0.22 ppm. Ethanol extract and ethyl acetate extract have inhibitory ability due to the presence of flavonoid and steroid compounds contained in the extract
Co-Authors ahmad yani Aminah Aminah Anliza, Syarah Annisa, Istiana Audina, Gina Bangun Wijonarko, Bangun Dian Pratiwi Digna Renny Panduwati Fadillah, M.Arief Fadillah, Muhammad Arief Meilina, Meilina Rinawati, Diana Syarah Anliza Trisna, Citra Zulkifli, M. Zidan