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THE EFFECTIVENESS OF CEMCEM (Spondiaspinnata (L.f) Kurz) LEAF EXTRACT IN INHIBITING THE GROWTH OF Streptococcus mutans Putu Sulistiawati Dewi; I Made Merta Suparka
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 19 No. 2 (2023): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v19i2.7704

Introduction: Dry socket is post-tooth extraction pain characterized by partial or complete loss of blood clots in the alveolar socket. One of the management of dry socket is by using antibiotic therapy. Inappropriate use of antibiotics in addition to being economically wasteful can also cause bacterial resistance to antibiotics. The use of herbal ingredients such as Cemcem (Spondiaspinnata (L.f) Kurz) is one solution. Cemcem leaves are thought to have antibacterial effects because they contain flavonoids, tannins and saponins. This study aims to determine the inhibition of cemcem leaf extract (Spondias pinnata (L.f) Kurz) against the growth of Streptococcus mutans. Materials and methods: The research method used is the Kirby Bauer method which is a sensitivity test with the agar diffusion method using the disc diffusion technique. In the Kirby Bauer sensitivity test using selective media, namely Muller Hinton Blood Agar media, the inhibition zone created is characterized by a clear zone around the disc. The data obtained were analyzed using the Kruskall Wallis test to determine whether or not there was a significant difference then continued with the Mann Whitney U - Test. Results: Cemcem leaf extract (Spondias pinnata (L.f) Kurz) with a concentration of 60% and 70% can inhibit the growth of Streptococcus mutans better than positive control and 80% concentration. Conclusion: 60% concentration of cemcem leaf extract is more effective in inhibiting the growth of Streptococcus mutans than 70% and 80% concentrations.

PEMBUATAN JAMU TRADISIONAL DARI DAUN KELOR YANG DAPAT DIMODIFIKASI DALAM BENTUK PUDDING DI DUSUN SILADAN, DESA TAMANBALI, BANGLI Putu Sulistiawati Dewi; Manek, Daniel; Anggi, Luh Nik Pradnya; Arandika, I Wayan Wisma
Jurnal Abdi Dharma Masyarakat (JADMA) Vol. 5 No. 1 (2024): April 2024
Publisher : LPPM Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/jadma.v5i1.9034

Indonesia mempunyai kekayaan alam yang melimpah dan beraneka ragam tanaman obat tumbuh di Indonesia. Kekayaan alam ini bermanfaat besar bagi kesehatan masyarakat. Beberapa penelitian membuktikan bahwa Indonesia sangat berpotensi sebagai tempat tumbuh dan berkembangnya bahan obat terhadap masyarakat. Salah satu tumbuhan yang dapat dimanfaatkan baik sebagai bahan makanan maupun obat-obatan ialah tanaman kelor (Moringa oleifera L.). Tanaman kelor termasuk ke dalam familia Moringaceae dan memiliki banyak sebutan seperti kelor, marangghi, moltong, kelo, keloro, kawano, dan ongge. Tanaman kelor mengandung lebih dari 90 jenis nutrisi berupa vitamin esensial, mineral, asam amino, antipenuaan, dan antiinflamasi. Tujuan pengabdian ini yaitu agar warga bisa mengubah hidupnya dapat gemar dan rutin akan mengkonsumsi minuman obat tradisional khususnya jamu untuk menambah zat gizi dan nutrisi serta menjaga kesehatan daya tahan tubuh. Metode pelaksanaan yang dilakukan melalui 4 tahapan yaitu : observasi, persiapan dan perancangan, pelaksanaan, dan evaluasi. Hasil dari program kerja pengabdian masyarakat terkait dengan pembuatan jamu tradisional dalam bentuk pudding di Pondok Harmoni berjalan cukup baik, warga mengapresiasikan kegiatan yang kami selenggarakan. Setelah dilakukannya kegiatan ini diharapkan masyarakat di wilayah pondok harmoni di Dusun Siladan mulai memanfaatkan hasil alam sehingga dapat dimanfaatkan sebagai produk yang menyehatkan.

Sub-Acute Toxicity and Allergy Studies of Bidara Leaf (Ziziphus Mauritiana) Extract as A Wound Healing Material Ma'ruf, Mochammad Taha; Dewi, Putu Sulistiawati; Poernomo, Hendri
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.194-201

Background: In dentistry, the wound healing process is often encountered in tooth extractions, incisions, oral and facial surgery, gingival flaps and biopsies. Post-tooth extraction wound is a medium that allows pathogenic microbes to breed and infect the wound. Wound management must be carried out as soon as possible to restore mucosal integrity so as to prevent bacterial infections penetrates the body. Bidara (Ziziphus mauritiana) is one of the plants used as traditional medicine by the community. Research on this plant as a medicinal raw material is increasing, so further research needs to be carried out to prove the safety of this medicinal plant. This study aims to determine the effects of sub-acute toxicity and allergic reactions caused after administering bidara leaf extract on the liver histopathology of mice. Methods: In vivo laboratory experimental study using a post-test only control group design with 24 mice (Mus musculus). The research sample consisted of 4 groups, namely the control group given 0.3% Na-CMC, the treatment group given bidara leaf extract at a dose of 500 mg/kg BW, 600 mg/kg BW, and 700 mg/kg BW. The treatment extract was given orally for 28 days. Results: The results of the study showed that the dose of bidara leaf extract had an effect on the liver histopathology of mice, namely at doses of 600 mg/kg BW and 700 mg/kg BW it had a toxic effect that was visible from changes in liver cell structure. Allergy tests showed that bidara leaf extract did not cause allergic reactions in mice. Conclusion: It can be concluded that bidara leaf extract (Ziziphus mauritiana) does not cause allergies and at certain doses does not have toxicity in the liver of animals study.

Sub-Acute Toxicity and Allergy Studies of Bidara Leaf (Ziziphus Mauritiana) Extract as A Wound Healing Material Ma'ruf, Mochammad Taha; Dewi, Putu Sulistiawati; Poernomo, Hendri
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.194-201

Background: In dentistry, the wound healing process is often encountered in tooth extractions, incisions, oral and facial surgery, gingival flaps and biopsies. Post-tooth extraction wound is a medium that allows pathogenic microbes to breed and infect the wound. Wound management must be carried out as soon as possible to restore mucosal integrity so as to prevent bacterial infections penetrates the body. Bidara (Ziziphus mauritiana) is one of the plants used as traditional medicine by the community. Research on this plant as a medicinal raw material is increasing, so further research needs to be carried out to prove the safety of this medicinal plant. This study aims to determine the effects of sub-acute toxicity and allergic reactions caused after administering bidara leaf extract on the liver histopathology of mice. Methods: In vivo laboratory experimental study using a post-test only control group design with 24 mice (Mus musculus). The research sample consisted of 4 groups, namely the control group given 0.3% Na-CMC, the treatment group given bidara leaf extract at a dose of 500 mg/kg BW, 600 mg/kg BW, and 700 mg/kg BW. The treatment extract was given orally for 28 days. Results: The results of the study showed that the dose of bidara leaf extract had an effect on the liver histopathology of mice, namely at doses of 600 mg/kg BW and 700 mg/kg BW it had a toxic effect that was visible from changes in liver cell structure. Allergy tests showed that bidara leaf extract did not cause allergic reactions in mice. Conclusion: It can be concluded that bidara leaf extract (Ziziphus mauritiana) does not cause allergies and at certain doses does not have toxicity in the liver of animals study.

Effectiveness of Banana Tree Sap Extract (Musa paradisiaca) on Collagen Density After Incision in Wistar Rats (Rattus novergicus) Infected with Staphylococcus aureus Dewi, Putu Sulistiawati; Setiawan; Pajajaran, Tu Bagus Satria
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 3 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i3.11732

Introduction: wounds in the oral cavity are at high risk of infection because of the large number of normal flora in the oral cavity that can be opportunistic, one of which is Staphylococcus aureus. Wound care is crucial, particularly the use of medications or materials that can aid in accelerating wound healing. One of the plants that can be used to heal wounds is the banana tree sap. The objective of this study is to determine the effectiveness of banana tree sap extract on collagen density in wound healing of Wistar rats infected with Staphylococcus aureus bacteria. Materials and Methods: This study is a laboratory experimental study conducted in vivo with a post-test only control group design, using 24 rats divided into four groups. Namely, the negative control group, the group that was given the banana tree sap extract gel at concentrations of 30%, 40%, and 50%. The in vivo test involved creating an incision wound in Wistar rats and subsequently infecting them with Staphylococcus aureus bacteria. The wound was then treated with gel extract twice daily. On the 7th day, specimens were decapitated to observe collagen density. The research data were analyzed using one-way ANOVA, followed by the Games-Howell post hoc test. Results and Discussion: The administration of banana tree sap extract was effective in the wound healing process, as evidenced by an increase in collagen density in the treatment at all concentrations. The increase in collagen density is due to the banana tree sap extract gel containing active substances, namely flavonoids, saponins, tannins, and alkaloids, which have anti-inflammatory, antibacterial roles, ward off free radicals, and stimulate collagen formation. Conclusion: 50% concentration of banana tree sap extract gel was more effective in increasing collagen density in the incision wound of Wistar rats infected with Staphylococcus aureus than concentrations of 30% and 40%.

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