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arniat christiani telaumbanua
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Membandingkan Jumlah Retikulosit pada Penderita Anemia Defisiensi Besi Sebelum dan Sesudah Pengobatan dengan Preparat Fe arniat christiani telaumbanua
Jurnal Kesehatan Saintika Meditory Vol 2, No 2 (2020): Mei 2020
Publisher : Stikes Syedza Saintika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v2i2.538

Abstract

Retikulosit adalah  sel eritrosit muda yang  kehilangan inti sel, dan mengandung sisa – sisa asam ribonukleat di dalam sitoplasmanya, serta masih dapat mensintesis hemoglobin. Hitung retikulosit merupakan indikator aktivitas sumsum tulang. Penelitian ini bertujuan untuk mengetahui  perbandingan jumlah  retikulosit pada penderita anemia defesiensi besi sebelum dan sesudah pengobatan. Besi merupakan bagian dari molekul hemoglobin, dengan berkurangnya besi maka sintesa hemoglobin akan berkurang. Penelitian  ini dilaksanakan mulai Juni 2012 sampai Juli 2013 terhadap pasien anemia defisiensi besi di RSUP. DJAMIL Padang. Jumlah sampel 30 orang. Penelitian ini bersifat deskriptif, retikulosit di hitung secara langsung. Analisis data menggunakan uji T. Dan penelitian yang telah dilakukan didapatkan hasil adanya perbedaan yang bermakna antara jumlah retikulosit sebelum dan sesudah pengobatan. Pemeriksaan menunjukkan terdapat peningkatan retikulosit setelah pemberian preparat Fe setelah 5-7 hari pengobatan. Nilai retikulosit sebelum pengobatan normal atau rendah.
The Effect of Wharton’s Jelly Mesenchymal Stem Cells on Nestin Gene Expression in Alzheimer's Rat Models Annita Annita; Arniat Christiani Telaumbanua; Yanti Rahayu; Putri Dafriani; Hendri Panus
Jurnal Kesehatan Saintika Meditory Vol 9, No 1 (2026): Mei 2026
Publisher : STIKES Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v9i1.30890

Abstract

Alzheimer's disease (AD) is characterized by neurodegeneration and decreased neurogenesis due to neuroinflammation and free radical accumulation. Nestin is an intermediate filament protein that serves as a primary marker for neural progenitor cells in the neurogenesis process. This study aimed to analyze the effect of Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs) administration on Nestin gene expression in an Alzheimer's rat model. This experimental study with a posttest-only control group design utilized male white rats (Rattus norvegicus) induced by Aluminum chloride (AlCl3) at a dose of 300 mg/kg BW orally for 5 days to model Alzheimer's pathology. A dose of 1×106 WJ-MSCs was injected intraperitoneally in the treatment group. One month post-therapy, Nestin gene expression from brain tissue was analyzed using quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) and statistically tested with One-Way ANOVA. The results showed a statistically significant difference (p < 0.05), with a significant increase in Nestin gene expression in the WJ-MSCs treated group compared to the positive control group. It is concluded that the administration of WJ-MSCs effectively increases Nestin gene expression, indicating an improvement in the regeneration and neurogenesis processes in the brain tissue of Alzheimer's rat models.
Co-Authors Annita Annita Hendri Panus Putri Dafriani Rahayu, Yanti