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Faktor Pendukung dan Penghambat Penderita Diabetes Melitus dalam Melakukan Pemeriksaan Glukosa Darah Rizana Fajrunni'mah; Diah Lestari; Angki Purwanti
Global Medical & Health Communication (GMHC) Vol 5, No 3 (2017)
Publisher : Universitas Islam Bandung

Diabetes melitus (DM) adalah sekelompok gangguan metabolisme bersifat kronik yang ditandai peningkatan kadar glukosa darah serta gangguan metabolisme karbohidrat, lemak, dan protein. Setiap tahun lebih dari empat juta orang meninggal akibat DM, dan jutaan orang mengalami efek buruk atau kondisi yang mengancam jiwa seperti serangan jantung, strok, gagal ginjal, kebutaan, dan amputasi. Kemampuan individu mengelola kehidupan sehari-hari serta mengendalikan dan mengurangi dampak penyakit yang dideritanya dikenal dengan self-management, yaitu mengikuti pola makan sehat, meningkatkan kegiatan jasmani, menggunakan obat DM dan obat pada keadaan khusus secara aman dan teratur, melakukan pemantauan kadar gula darah, serta perawatan kaki secara berkala. Beberapa penelitian melaporkan bahwa masih sedikit penderita DM melakukan pemantauan gula darah dengan baik. Penelitian ini bertujuan memperoleh pemahaman mendalam tentang pengalaman penderita DM dalam pemeriksaan kadar glukosa darah dengan menggunakan metode penelitian kualitatif pendekatan fenomenologi. Penelitian dilaksanakan pada bulan Juli–September 2016 di wilayah kerja Puskesmas Jatiwarna, Bekasi. Hasil analisis data teridentifikasi faktor pendukung pemeriksaan glukosa darah adalah faktor psikologis, sosial, edukasi, ekonomi, dan akses. Faktor penghambatnya adalah faktor psikologis, sosial, edukasi, penggunaan obat, sikap terhadap penyakit, dan persepsi terhadap jaminan kesehatan. Hasil penelitian diharapkan dapat menjadi masukan dalam meningkatkan kualitas edukasi dan pendampingan tenaga kesehatan kepada pasien sehingga pasien terbantu meningkatkan adaptasi dan kemampuannya memantau glukosa darah secara mandiri.SUPPORTING AND INHIBITING FACTORS OF DIABETES MELLITUS PATIENTS IN PERFORMING BLOOD GLUCOSE EXAMINATIONDiabetes mellitus (DM) is a chronic metabolic disorder marked by an increase in blood glucose levels and impaired metabolism of carbohydrates, fats, and proteins. Every year more than four million people die because diabetes and millions of people experience the ill effects of diabetes or life-threatening conditions such as heart attack, stroke, kidney failure, blindness, and amputation. The individual's ability to manage life, control and reduce the impact of the disease known as self-management is to follow a healthy diet, increasing physical activity, using the drug safely and regularly, monitoring blood sugar levels as well as maintenance feet regularly. Several studies reported only small number of DM patients examined blood glucose levels routinely. This study aim to gain a thorough understanding of individual experience with DM in examining blood glucose levels. This study used qualitative research with a phenomenological approach from July to September 2016 at Jatiwarna, Bekasi. The results identified factors supporting blood glucose examination were: psychological factors, social, educational, economic, and access to health care. The inhibiting factors were psychological factors, social, educational, drug use, attitudes toward the disease, and perceptions of health insurance. The results expected to improve the quality of education and mentoring for health workers. It will help patients improving the adaptability and the ability to blood glucose self-monitoring.

HUBUNGAN HIGIENITAS PERSONAL SISWA DENGAN KEJADIAN KECACINGAN NEMATODE USUS Diah Lestari Lestari
Jurnal Ilmu dan Teknologi Kesehatan Vol 4 No 1 (2016): september
Publisher : Poltekkes Kemenkes Jakarta III

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Intestinal worm infection by nematode worms also referred to as the stomach, is a group of worms that are transmitted through the soil (soil-transmitted Helminths). Worm infection in children in Indonesia prevalence reached 60-80% . Many studies worm disease in children occur during primary school age. Important species that commonly infects humans are kind of Ascaris lumbricoides, Trichuris trichiura, Strongyloides stercoralis and hookworm (Ancillostoma duodenale and Necator americanus). Genesis worm disease on Primary School Children can occur by factors such as students' personal hygiene habits play on the ground, hand washing, use of footwear, sucking fingers, and the physical condition of the students. The research objective was to determine the relationship between personal hygiene students with the incidence of intestinal nematode worm infection. Design studies using cross-sectional study with a sample of 160 through primary data through interview, observation and the eggs and larvae of intestinal nematode worms in the stool with Kato- Katz method.The results showed significant relationship between hand washing habits in students with the incidence of worm infection (p value 0.033). The prevalens of infection in students of 57.5%, by worms A.lumbricoides 74.8% and 25.2% by T.trichiura, infection does not occur by hookworm.

Pengaruh Penambahan Saffron (Crocus sativus) Pada Yoghurt Terhadap Pertumbuhan Pseudomonas aeruginosa Retno Martini Widhyasih; Nunu Suminar; Diah Lestari
Anakes : Jurnal Ilmiah Analis Kesehatan Vol 8, No 1 (2022): Anakes: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v8i1.800

Saffron (Crocus sativus) merupakan tumbuhan yang dapat digunakan sebagai obat tradisional dan juga digunakan dalam produk olahan makanan. Bahan aktif saffron, seperti flavonoid, saponin, dan tanin, diketahui merupakan senyawa antibakteri. Saffron dapat digunakan dalam produk fermentasi seperti yoghurt yang berperan sebagai prebiotik untuk zat aktif yang terkandung dalam yoghurt, yaitu bakteri asam laktat (BAL). Bakteri patogen dapat menyebabkan beberapa penyakit, diantaranya Pseudomonas aeruginosa. Bakteri ini diketahui menyebabkan infeksi pneumonia nosokomial yang ditularkan melalui pernapasan. Penelitian ini bertujuan untuk mengetahui nilai zona hambat, volume hambat minimum dan pengaruh penambahan saffron yoghurt terhadap Pseudomonas aeruginosa. Penelitian ini dilakukan dengan menggunakan metode true experimen dengan desain post test only control group. Uji daya hambat dilakukan dengan metode difusi sumur dengan lima kelompok perlakuan yaitu 5 helai dan 10 helai saffron dalam yoghurt dengan volume 25 µl, 50 µl, 100 µl, 150 µl, dan 200 µl. Setiap perlakuan diulangi lima kali. Sebagai kontrol positif larutan ciprofloxacin 0,25% dan akuades sebagai kontrol negatif. Pengujian dilakukan di Laboratorium Bakteriologi Politeknik Kemenkes Jakarta III pada bulan Juni 2020. Data yang diperoleh dianalisis secara statistik dengan uji Kruskal-Wallis dan dilanjutkan dengan uji Mann-Whitney pada tingkat kepercayaan 95% dengan α = 0,05 (5%). Hasil statistik diperoleh nilai p 0,05 (p = 0,000). Maka dapat disimpulkan penambahan saffron pada yoghurt berpengaruh terhadap pertumbuhan bakteri Pseudomonas aeruginosa.Kata kunci: Crocus sativus, Pseudomonas aeruginosa, Saffron, Yoghurt.

PENINGKATAN KADAR AMINOTRANSFERASE SERUM PEROKOK AKTIF AKIBAT AKTIVITAS MEROKOK (Suatu Studi Kepustakaan) Diah - Lestari; Tri - Prasetyorini; Ghefira - Widayanti
Jurnal Kesehatan Saintika Meditory Vol 4, No 2 (2021): November 2021
Publisher : Stikes Syedza Saintika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v4i2.1199

Merokok menimbulkan dampak negatif bagi kesehatan tubuh salah satunya menyebabkan kerusakan pada struktur sel hati, ditandai dengan keluarnya enzim yang paling baik dalam menilai fungsi hati yaitu kelompok aminotransferase serum yang meliputi AST dan ALT, dan kadarnya meningkat pada peredaran darah. Aktivitas merokok dapat dilihat dari usia perokok, jenis rokok, jumlah rokok dalam sehari, lama merokok, dan derajat merokok. Tujuan penelitian ini untuk melihat hubungan antara aktivitas merokok dengan kadar aminotransferase serum pada perokok aktif. Metode penelitian menggunakan metode studi kepustakaan (library research). Data yang digunakan adalah data skunder berasal dari penelitian yang telah dipublikasi pada jurnal ilmiah. Hasil penelitian diperoleh usia perokok termuda pada usia 21 tahun, jenis rokok terbanyak rokok filter dan kretek, jumlah rokok dikonsumsi sebanyak 1-10 batang/hari, lama merokok terbanyak lebih dari 5 tahun, dan derajat merokok terbanyak dalam kelompok ringan-sedang. Kadar aminotransferase serum sebagian besar mengalami peningkatan, baik kadar AST maupun ALT. Kesimpulan ada hubungan aktivitas merokok dengan kadar aminotransferase serum, dan tidak ada hubungan usia perokok dengan kadar aminotransferase serum. Peningkatan kadar aminotransferase serum pada perokok terjadi < 2x nilai normal, peningkatan yang terjadi hanya dalam batas 2-70 % dari normal.Kata kunci : Aktivitas merokok; aminotransferase serum; AST dan ALT

PROFILE KEBERADAAN EXTENDED SPECTRUM BETA LACTAMASE BERDASARKAN JENIS BAKTERI, JENIS SPESIMEN DAN SUMBER RUANGAN Diah - Lestari
Jurnal Kesehatan Saintika Meditory Vol 5, No 1 (2022): Mei 2022
Publisher : STIKES Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v5i1.1341

Pengobatan penyakit infeksi umumnya dengan pemberian antibiotik. Antibiotik yang dijual bebas dan penggunaan secara tidak tepat menimbulkan resistensi antibiotik. Golongan β-laktam adalah antibiotik yang sering digunakan dan adanya resistensi menyebabkan bakteri terus berkembang biak dan mengakibatkan munculnya enzim Extended spectrum beta-lactamase (ESBL) yang dihasilkan oleh kuman famili Enterobacteriaceae, terutama Klebsiella pneumoniae dan Escherichia coli. Tujuan penelitian untuk mengetahui profile keberadaan extended spectrum beta lactamase (ESBL) berdasarkan jenis bakteri, jenis specimen dan sumber ruangan di RSUD dr. Chasbullah Abdulmadjid Kota Bekasi. Metode penelitian dilakukan berdasarkan analitik deskriptif cross sectional menggunakan data sekunder hasil pemeriksaan kultur mikroorganisme dan resistensi antibiotik. Sampel penelitian adalah spesimen sputum, urin, pus, darah dan cairan tubuh lain berjumlah 98 isolat E. coli dan K. pneumoniae. Hasil penelitian dari 98 isolat E. coli dan K. pneumoniae ditemukan ESBL positif sebanyak 56,1%. Spesies E. coli ESBL positif ditemukan pada spesimen pus dan urin sebanyak 33,3% dan K. pneumoniae ESBL positif pada spesimen pus sebanyak 48,0%. Isolat E. coli ESBL positif banyak berasal dari ruang ICU dan ruang inap bedah (Tulip) 20,0% dan isolat K. pneumoniae ESBL positif sebanyak 12,0% berasal dari rujukan luar. Isolat E. coli ESBL menunjukkan sensitifitas tinggi terhadap antibiotik ertapenem, meropenem, amikacin dan tigecycline (100%). Isolat K. pneumoniae ESBL menunjukkan sensitifitas yang baik terhadap meropenem (96%), ertapenem (88%), amikacin (88%) dan tigecycline (84%). Kata kunci : ESBL, resistensi antibiotik, β-laktam, isolat E. coli, isolat K. pneumoniae.

SIGNIFICANT CORRELATION BETWEEN LACK OF VITAMIN D LEVELS 25 OH IN PREGNANT WOMEN WITH LOW BIRTH WEIGHT Diah Lestari; Dwi Rahmawati; Yosanti Elsa
Jurnal Delima Harapan Vol 10 No 1 (2023): Maret
Publisher : AKADEMI KEBIDANAN HARAPAN MULYA PONOROGO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31935/delima.v10i1.208

Pregnant women who lack in vitamin D will increase the risk of fetal growth and development, one of which is births with low birth weight (LBW). Vitamin D functions for calcium absorption up to 60% during pregnancy for fetal bone growth. This study aims to determine the correlation between vitamin D levels in pregnant women and low birth weight babies at RSAB Harapan Kita. The research method uses a cross-sectional design. The population was pregnant women who checked levels of Vitamin D (Vit D 25 (OH)) in the first trimester and third trimester with sample size of 80. The data analysis used is the Chi-Square test. Examination of vitamin D levels with the ELISA method. The results showed that the average level of vitamin D content was abnormal (Insufficient and Deficient) 73.8%, and normal vitamin D content (Sufficient) 26.2%. The mean of extremely low birth weight (ELBW) was 13.8%, very low birth weight (VLBW) was 26.2% and low birth weight (LBW) was 60.0%. There was a significant correlation between vitamin D levels in pregnant women and low birth weight (Sig = 0.025), (p < 0.05). Conclusions vitamin D intake in pregnant women is needed for fetal development to reduce the risk of low birth weight (LBW).

Sensitivitas Antara Antibiotik Meropenem dan Seftazidin Terhadap Pseudomonas aeruginosa Strain ATCC 15442 Pada Pasien Pneumonia di RSUP dr. Cipto Mangunkusumo Jakarta Pusat Diah Lestari; Husyain Djajaningrat; Febri Wulan Dari; Dean Handimulya
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 11 No. 1 (2025): ANAKES: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v11i1.2500

Pneumonia is an acute lower respiratory tract infection in the lung parenchyma that has a high level of treatment resistance and is a nosocomial bacterial transmission. One of the nosocomial bacteria in hospitals is Pseudomonas aeruginosa, which is a Multi Drug Resistant (MDR) bacteria, a pathogen that causes infections that are resistant to at least three antimicrobial agents. The antimicrobials included are meropenem and ceftazidime, these two antibiotics are the best choice of last-line drugs in the treatment of MDR bacteria. Effective prevention and treatment of bacterial colonization and infection in pneumonia patients needs to be done to reduce the negative impact of antibiotic use. The aim of this study was to determine the sensitivity between the antibiotics meropenem and ceftazidime against Pseudomonas aeruginosa bacteria in pneumonia patients at RSUPN dr. Cipto Mangunkusumo, Central Jakarta. The research method was analytical observational using a cross sectional design with medical record data sources on 105 pneumonia patients who underwent sputum culture examination. Data analysis using the Mann-Whitney Test at 95% CI (α = 0.05). The research results showed that the majority of patients were male, 69 people with an elderly age category of 51 people (48.6%). The results of the antibiotic sensitivity of meropenem were 76.25% and ceftazidime were 69.5%, with a p-value of 0.000. The average sensitivity of the antibiotic meropenem is 20.59, more sensitive than the antibiotic ceftazidime, an average of 20.50 with a difference in sensitivity of 9%. The conclusion is that there is a difference in the sensitivity of the antibiotics meropenem and ceftazidime against Pseudomonas aeruginosa bacteria in pneumonia patients at RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, the antibiotic meropenem is more sensitive than the antibiotic ceftazidime. Keywords: Meropenem, Pneumonia, Pseudomonas aeruginosa, Seftazidim.

Effect of pH Variations in Eosin Methylene Blue Agar (EMBA) Medium on E. coli Growth Lestari, Diah; Haliza, Eva Nur; Setiawan, Heru
JURNAL INFO KESEHATAN Vol 22 No 1 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss1.1298

The growth of E. coli is influenced by several factors, including environmental pH. Environmental pH unsuitable for bacterial growth conditions will interfere with the enzyme activity and influence bacterial growth. This study aimed to determine the effect of pH variations (5.3, 5.8, 6.3, 7.3, 7.8, 8.3) in EMBA medium on E. coli growth. The research method used was true experiment post-test-only control design. The samples in this study were suspensions with dilutions of 10-4, 10-5, 10-6, and 10-7, inoculated using the duplo test to EMBA with various pH conditions, so that the total sample size is 48. The results showed that the mean number of E. coli bacteria on EMBA with pH 5.3 was 9.1 x 106 CFU/mL; with pH 5.8 was 9.6 x 106 CFU/mL; with pH 6.3 was 1.2 x 107 CFU/mL; with pH 7.3 was 1.1 x 107 CFU/mL; with pH 7.8 was 9.7 x 106 CFU/mL; and with pH 8.3 was 7.1 x 106 CFU/mL. Growth in positive control showed the mean number 1.4 x 107 CFU/mL; negative control showed no growth of E. coli or other microorganisms. Based on the One-Way ANOVA statistical test with a 95% confidence level, there was no difference in the mean number of E. coli bacteria in the six pH variations of EMBA medium (p-value > 0.05). E. coli bacteria grew best at neutral pH. Its growth decreases in slightly acidic and slightly alkaline pH, but it can still be observed. This allows E. coli to survive in extreme pH. Pathogenic E. coli have developed the potential to live inside the human body. They will experience temporary stress in unfavourable conditions before finally adapting. The advice for future researchers is to test the effect of pH on E. coli growth by using other E. coli growth media or with a wider range of pH (more acidic and more basic). It is also recommended to conduct further research about the effect of various environmental conditions such as temperature, nutrients, and others on bacterial growth.

THE RELATIONSHIP BETWEEN THE LENGTH OF FEVER AND THE NUMBER OF LEUKOCYTES ON THE RESULTS OF TUBEX TF EXAMINATION IN TYPHOID FEVER PATIENTS Diah Lestari; Tika Melani; Retno Martini Widhyasih
Klinikal Sains : Jurnal Analis Kesehatan Vol. 13 No. 2 (2025): Desember
Publisher : LPPM Universitas Abdurrab

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Typhoid fever is a systemic disease caused by Salmonella typhi bacteria with LPS-09 antigens that can stimulate an immune response in the form of IgM antibodies, so it can be detected through Tubex TF and leukocyte counts as predictors to reduce morbidity and mortality. This study aims to determine the relationship between fever duration and leukocyte count based on Tubex TF examination results in diagnosing typhoid fever. The type of research used was associative analytical observational with secondary data from 70 typhoid fever patients at Pasar Rebo Hospital from March 2023 to February 2024. The results showed that most patients were female (41 or 58.6%) and the largest age group was children (6-11 years) with 20 patients (28.6%). Based on the Fisher’s Exact test, there was a significant association between fever duration and Tubex TF result (p=0.000), while there was no association between leucocyte count and Tubex TF result (p=0.645). In conclusion, fever duration can be used as an indicator in the diagnosis of typhoid fever with Tubex TF, while leucocyte count cannot always be used as a specific marker. These results are expected to improve individual health information of typhoid fever patients through early detection and intervention.

WAKTU GENERASI BAKTERI Escherichia coli BERDASARKAN VARIASI PH MEDIA EOSIN METHYLENE BLUE AGAR MEDIA Diah Lestari; Indah Prasetyowati; Mega Mirawati
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 17 No 2 (2023): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v17i2.6405

Bacteria require optimum environmental conditions to support cell growth and reproduction. States that are less than optimal cause bacteria to adapt and can infect humans for invasion of other organs. The speed of bacteria to infect is influenced by the rate and time of generation of bacteria in multiplying cells. This study aims to determine the effect of variations in pH (4,8; 5,8; 6,8; 7,8; and 8,8) in Eosin Methylene Blue Agar (EMBA) media on the generation time of Escherichia coli bacteria. Researchers used the True Experiment Post Only Control Design and One Way ANOVA test. The results showed that at a variation of pH 4,8 there was no growth; pH 5,8 with a generation time of 1,5-24,9; pH 6,8 with a generation time of 1,5-21,7 minutes; pH 7,8 with a generation time of 1,6-22,3 minutes; and pH 8,8 with a generation time of 1,6-22,8 minutes. The study concludes is that there is a significant effect of the variation in pH of the EMBA media on the generation time of Escherichia coli bacteria with a p-value of 0,000 < α 0,05, with the fastest generation time at pH 6,8.

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