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All Journal Media Farmasi Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Nurse
Adjeg Tarius
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Other

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Chronic Diarrhea Caused by Amebic Colitis and Inflammatory Bowel Disease Hery Djagat Purnomo; Adjeg Tarius; Marcellus Simadibrata; Ari Fahrial Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 8, ISSUE 3, December 2007
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/83200795-99

Abstract

The diagnosis of intestinal amebiasis is easily established based on colonoscopy, i.e. there is a specific characteristic of ulcer/lesion “discrete flask-shape ulcer” with normal mucosa among the ulcers. However, most patients with amebic colitis have non-specific clinical manifestations and their colonoscopy findings are hardly distinguished from inflammatory bowel disease. In the present case, the patient had a chief complaint of chronic bleeding diarrhea and abdominal pain. The fecal analysis found trophozoites of Entamoeba histolytica. Serology test (sero-amebic) revealed negative result. The colonoscopy examination reveals hyperemic mucosa, edema, and multiple ulcers with various sizes covered with fragile and easily bleed debris, from the rectum to ascending colon, rigid colon, narrowing lumen and tumor/mass appearance on ascending colon. The differential diagnosis was severe amebic colitis and inflammatory bowel disease. Based on the colonoscopy biopsy, we found an active chronic colitis along with dysplasia. The patient received management and treatment of severe amebic colitis and inflammatory bowel disease. Keywords: amebic colitis, bleeding diarrhea, fecal analysis, colonoscopy, biopsy, inflammatory bowel disease
Pemanfaatan Belimbing Wuluh Sebagai Alternatif Larutan Deparafinisasi Mikro Pada Jaringan Mammae Fransiska Ayuningtyas Widyastani; Nadilla Apriliyani Widyaningtyas; Adjeg Tarius
Jurnal Nurse Vol. 4 No. 2 (2021): Juli : Jurnal Nurse
Publisher : STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/nurse.v4i2.228

Abstract

The deparaffinization stage in HE staining usually using xylol, but xylol has a toxic, volatile and flammable effect. An alternative solvent that can be used as a substitute for xylol is Averrhoa bilimbi solution which contains citric acid and has characterized that are easy to obtain, derived from nature and safe to use. This study aims to determine whether there are differences in the microscopic image (shape, color and cell background) of mammary tissue micro-deparaffinized with xylol and Averrhoa bilimbi solution. This type of research is an experimental study using mammae tissue samples with saturated samples using 2 variations of micro deparaffinization treatment, namely deparaffinization with Averrhoa bilimbi solution and deparaffinization using xylol. The results obtained were carried out by descriptive test, then the normality test using two pairs of data with the results on the shape, color and background are not normal, namely 0.000. The Wilcoxon test was carried out further with the results of cell shape, cell color and background p <0.05, which indicated that the shape, color and background of the two treatments had significant difference.
EFEK GASTROPROTEKTOR SENYAWA ANALOG KURKUMIN TERHADAP JARINGAN LAMBUNG TIKUS YANG DIINDUKSI PARASETAMOL Rinihapsari, Elisa; Widyayastani, Fransiska Ayuningtyas; Tarius, Adjeg
Media Farmasi Indonesia Vol. 13 No. 1 (2018): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.104 KB)

Abstract

Abstrak Senyawa 2,5-bis-(4-nitrobenzilidin) siklopentanon merupakan salah satu senyawa analog kurkumin yang telah berhasil disintesis dan memiliki struktur kimia yang menyerupai struktur kurkumin. Penelitian ini bertujuan untuk mengetahui aktivitas gastroprotektif dari senyawa analog kurkumin tersebut. Penelitian dilakukan dengan menggunakan tiga puluh lima ekor tikus putih galur Wistar yang dibagi menjadi lima kelompok perlakuan, yaitu : kontrol negatif, kontrol positif, diberi senyawa kurkumin dosis 25 mg/kg BB tikus, diberi senyawa analog kurkumin dosis 12,5 mg/kg BB dan diberi senyawa analog kurkumin dosis 25 mg/kg BB tikus. Senyawa kurkumin dan analog kurkumin diberikan secara per oral selama 7 hari sebelum tikus diinduksi parasetamol dosis tinggi. Tikus yang telah diinduksi parasetamol, selanjutnya dilakukan pemeriksaan mikroskopis jaringan lambung dengan pewarnaan Hematoxylin Eosin. Hasil pengamatan berupa data skoring derajat erosi lambung, selanjutnya dilakukan uji statistik dan diperoleh hasil bahwa tidak terdapat perbedaan yang bermakna antara kelompok yang diberi kurkumin dengan yang diberi senyawa analog kurkumin dosis 25 mg/kgBB. Senyawa analog kurkumin dosis 25 mg/kgBB memiliki efek gastroprotektor sama kuat dengan senyawa kurkumin dosis 25 mg/kgBB terhadap jaringan lambung yang diinduksi parasetamol dosis tinggi.
Co-Authors Ari Fahrial Syam Elisa Rinihapsari Elisa Rinihapsari Fransiska Ayuningtyas Widyastani Hery Djagat Purnomo Hery Djagat Purnomo Marcellus Simadibrata Marcellus Simadibrata Nadilla Apriliyani Widyaningtyas Widyayastani, Fransiska Ayuningtyas