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Fanny Adhy Putri
Universitas Andalas
Health Professions Medicine & Pharmacology Nursing

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Terapi plasma exchange pada krisis miastenik Yulia Trisna; Fanny Adhy Putri; Reno Bestari
Jurnal Kedokteran Syiah Kuala Vol 22, No 1 (2022): Volume 22 Nomor 1 Maret 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v22i1.23336

Abstract

Krisis miastenik adalah perburukan gejala yang terjadi pada pasien miastenia gravis, ditandai dengan kondisi gagal nafas. Sebanyak 15-20 % pasien miastenia gravis mengalami krisis miastenik dalam kehidupannya. Mortalitas akibat krisis miastenik pada saat ini mulai menurun, salah satunya adalah karena peran terapi plasma exchange (PE). Terapi PE dapat menghilangkan substansi seperti antibodi yang bersifat patologis, kompleks imun, dan sitokin, dari plasma, kemudian diganti dengan cairan pengganti. Pada laporan ini, kami membahas kasus seorang perempuan 21 tahun yang telah menderita miastenia gravis tipe okular (sejak tahun 2016), masuk ke unit gawat darurat dengan diagnosis  krisis miastenik yang dipicu infeksi saluran nafas nafas atas.  Pasien dirawat di unit perawatan intensif dan mendapat dukungan ventilator mekanikal, kemudian dilakukan tindakan terapi plasma exchange dengan hasil perbaikan luaran klinis.
Hubungan Kadar Apolipoprotein B dengan Tingkat Keparahan Stroke Iskemik Ridho Ahmad Jabbar; Syarif Indra; Dedi Sutia; Yuliarni Syafrita; Restu Susanti; Fanny Adhy Putri
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.49865

Abstract

Background: Stroke is a leading cause of disability and the second leading cause of death worldwide. Ischemic stroke occurs due to vascular occlusion that restricts blood supply to the brain. Apolipoprotein B (ApoB) is the main component of atherogenic lipoprotein particles, which plays a role in the pathogenesis of atherosclerosis. The NIHSS is recommended as a valid and accessible tool for assessing the severity of acute stroke. Although ApoB has been studied as a lipid biomarker, evidence regarding its association with the severity of ischemic stroke remains limited. Methods: This cross-sectional study included 72 ischemic stroke patients with onset <72 hours who were admitted to Dr. M. Djamil General Hospital, Padang, from February 2025 to July 2025. Data were collected through interviews, physical examinations, supporting investigations, and laboratory tests. ApoB levels were measured using the ELISA method, and stroke severity was assessed using the NIHSS. Data analysis was performed using SPSS version 30.0, with statistical significance set at p < 0.05. Results: The mean Apolipoprotein B level was 105.25 mg/dL. Based on NIHSS assessment, patients with moderate stroke severity accounted for 43.1%, followed by mild stroke (37.5%) and severe stroke (19.4%). Statistical analysis showed no significant association between Apolipoprotein B levels and ischemic stroke severity (p = 0.614). Conclusion: There was no association between Apolipoprotein B levels and ischemic stroke severity.
The Association between NLR and TGF-β with Acute Ischemic Stroke Severity with and without Thrombolysis Lesti Marliana; Syarif Indra; Dedi Sutia; Yuliarni Syafrita; Restu Susanti; Fanny Adhy Putri
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.49866

Abstract

Acute ischemic stroke is a leading cause of mortality worldwide. Thrombolysis is the main treatment in the acute phase; however, clinical outcomes remain variable. Inflammatory markers such as the NLR and TGF-β1 may reflect inflammatory activity and tissue repair, yet their relationship with stroke severity is not fully established. This study aimed to evaluate the association of NLR and TGF-β1 with acute ischemic stroke severity in patients with and without thrombolysis. A cross-sectional study was conducted in the neurology ward of Dr. M. Djamil General Hospital, Padang. Patients with acute ischemic stroke, either treated with thrombolysis or not, were included. NLR and TGF-β1 were measured at 24 hours after onset, while stroke severity was assessed using the NIHSS at 24 hours. A total of 25 thrombolyzed and 25 non-thrombolyzed patients were enrolled. The results showed no significant association between NLR and stroke severity in either the thrombolysis (p=0.123) or non-thrombolysis group (p=0.257). In contrast, TGF-β1 was significantly associated with stroke severity in both groups (p<0.001 and p=0.002, respectively). In conclusion, TGF-β1 correlates with acute ischemic stroke severity regardless of thrombolysis, while NLR shows no significant association.
Hubungan Kadar Neuron Specific Enolase Serum dengan Subtipe dan Tingkat Keparahan pada Pasien Stroke Iskemik Akut Dhani Arief Prandana; Syarif Indra; Dedi Sutia; Restu Susanti; Fanny Adhy Putri; Gunawan Septa Dinata
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.49867

Abstract

Background: Acute ischemic stroke is a serious medical condition with potentially life-threatening consequences. It occurs when cerebral blood flow is obstructed by vascular occlusion, resulting in brain tissue injury. Neuron Specific Enolase (NSE) is a biomarker used to assess the extent of neuronal damage in patients with ischemic stroke. This study aims to evaluate the association between serum NSE levels, stroke subtypes, and stroke severity in patients with acute ischemic stroke. Methods: This observational study employed a cross-sectional design and included 67 patients with acute ischemic stroke. Serum NSE levels were measured using the ELISA method. Stroke subtypes were determined according to the TOAST classification, and stroke severity was assessed using the NIHSS score. Statistical analysis was performed to evaluate the association between serum NSE levels, stroke subtypes, and severity. Results: The mean serum NSE level was 14.038 ng/ml. Large artery atherosclerosis (LAA) was the most prevalent subtype with a moderate severity level. Statistical analysis showed a significant association between serum NSE levels and stroke subtype (p = 0.021) and severity (p = 0.034) in patients with acute ischemic stroke. Conclusion: Serum NSE levels are significantly associated with both stroke subtype and severity in patients with acute ischemic stroke.
Characteristics of Tuberculous Meningitis Patients at M.Djamil Padang Hospital in 2024 Fanny Adhy Putri; Yuliarni Syafrita; Djong Hon Tjong; Dwitya Elvira; Nurvalinda Nurvalinda
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.50224

Abstract

Tuberculous meningitis (TBM) is the most severe form of extrapulmonary TB, causing high morbidity and mortality. The Global TB 2022 report estimates that there are at least 100,000 people with MTB each year. In 2021, there were at least 13,400 MTB cases in Indonesia, or about 8% of the global estimate. To determine the characteristics of tuberculous meningitis patients at M. Djamil Padang Hospital in 2024. A descriptive study with cross-sectional method. The sampling technique used was purposive sampling by collecting medical record data of TBM patients at Dr. M. Djamil Padang Hospital in 2024. The number of samples that met the inclusion and exclusion criteria was 45 sample. Data were analyzed using SPSS. Univariate analysis was used to assess the characteristics of patient and presented in the form of a frequency distribution table. The average age of TBM patients in this study was 31 years, dominated by male gender (55.6%). Most of the TBM patients had normal nutritional status (64.4%) and only 17.8% of patients were underweight. Only 13.3% of TBM patients had a history of TB and 6.7% of patients had positive HIV status. Around 4.76% and 11.1% of patients had comorbid DM and hypertension. Most patients were in stage II BMRC (71.1%). Hydrocephalus was the most common CT Scan finding, which was 46.7%. Only 26.7% of patients died during treatment. Tuberculous meningitis is more common in men, with stage II BMRC, has hydrocephalus, and more than a quarter of MTB patients died during treatment.
Co-Authors Dedi Sutia Dhani Arief Prandana Djong Hon Tjong Dwitya Elvira Gunawan Septa Dinata Lesti Marliana Nurvalinda Nurvalinda Reno Bestari Restu Susanti Ridho Ahmad Jabbar Syarif Indra Yulia Trisna Yuliarni Syafrita