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All Journal INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Buletin Udayana Mengabdi Jurnal Farmasi Udayana
I.N.K. Widjaja
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Chemistry Dentistry Education Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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Journal : Jurnal Farmasi Udayana

 1 
TINGKAT KEPUASAN PASIEN TERHADAP PENGGUNAAN OBAT GENERIK DAN OBAT GENERIK BERMEREK (BRANDED GENERIC) PADA PASIEN RAWAT JALAN DI BADAN RUMAH SAKIT UMUM TABANAN L.P.F. Larasanty,; I.N.K. Widjaja; N.K.W Prasminda; N.L.P.U Antari; N.L.P.D. Wulandari; R.A.D. Puspitasari; N.M.F Irmayanti; P.P. Andiani
Jurnal Farmasi Udayana Vol. 5, No. 1, Tahun 2016
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Perbedaan jumlah penggunaan obat generik dan obat generik bermerek salah satunya dapat disebabkan oleh adanya perbedaan kepuasan pasien. Kaptopril merupakan jenis obat antihipertensi lini pertama yang ada dipasaran dalam bentuk produk generik dan produk generik bermerek. Kaptopril digunakan secara luas dan digunakan dalam jangka waktu panjang oleh pasien hipertensi. Penelitian ini bertujuan untuk mengetahui tingkat kepuasan pasien hipertensi di Badan Rumah Sakit Umum Tabanan terhadap penggunaan obat kaptopril generik dan obat kaptopril generik bermerek. Kepuasan pasien diukur dengan menggunakan skor gap. Skor gap diperoleh dengan membandingkan antara harapan dan persepsi pasien terhadap penggunaan obat kaptopril generik dan kaptopri generik bermerek. Harapan dan persepsi pasien diukur menggunakan skala likert dalam kuisioner yang berisi pernyataan tentang core product, actual product dan augmented product. Data yang diperoleh dianalisis dengan uji statistik parametrik menggunakan uji t berpasangan dengan taraf kepercayaan 95%. Empat puluh sembilan orang responden ikut serta dalam penelitian. Hasil penelitian menunjukkan harapan pasien yang tinggi baik pada penggunaan kaptopril generik maupun kaptopril generik bermerek. Tingkat kepuasan pasien hipertensi di Badan Rumah Sakit Umum Tabanan terhadap penggunaan obat kaptopril generik dan kaptopril generik bermerek termasuk dalam kategori sedang dan tidak terdapat perbedaan yang signifikan antara kepuasan pasien terhadap penggunaan kedua jenis obat tersebut (p > 0,05).
STUDI PENDAHULUAN DERIVATISASI BEBERAPA SENYAWA DENGAN GUGUS AMIN MENGGUNAKAN DANSIL KLORIDA PADA KLT-SPEKTROFOTODENSITOMETER Dewi Puspita Apsari; Ni Putu Linda Laksmiani; I.N.K. Widjaja
Jurnal Farmasi Udayana Vol. 1, No. 1, Tahun 2012
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Advance derivatization study of several amines with dansyl chloride has been carried out. The aim of this study was to determine influence of molecul structures compound toward dansylation. Derivatization was done by reacting  4000 ng drugs which contain primary or secondary amine group with 100 ng dansyl chloride at a temperature 450 C and pH 9 for a hour. Interference was separated using stationary phase silica G60 and mobile phase  etyl acetat : methanol : ammonia (85:10:5), detection on spectrophotodensytometer ?eks 312 nm mode fluorescence with filter K400. Compounds that have a primary or secondary amine groups can be derivatized using  dansyl chloride though that most affects  of  the reaction is  rigidity of molecul structure. Differences fluorescence intensity between each derivatives influenced by the reactivity amine groups and steric hindrance of the compound.
PENGARUH VARIASI KEPOLARAN FASE GERAK ASETON-DIKLOROMETANA: METANOL-ASAM ASETAT TERHADAP % DISTRIBUSI (+)-KATEKIN DARI GAMBIR DENGAN METODE KROMATOGRAFI CAIR VAKUM Era S.Y.,; Eka L; I.N.K. Widjaja
Jurnal Farmasi Udayana Vol. 1, No. 1, Tahun 2012
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

The research was conducted to determine the influence of mobile phase polarity of acetone-dichloromethana : methanol-acetic acid on the percent distribution of (+)-catechin from gambier by vacuum liquid chromatography and to determine the polarity mobile phase required to obtain the largest amount of (+)-catechin percent distribution. Gambier extract was fractionated using vacuum liquid chromatography with several variations of polarity of acetone-dichloromethane : methanol-acetic acid mobile phase expressed by the dielectric constant value (?) of 13.74 to 17.51. Fractions were analyzed by TLC-spectrophotodensitometer to calculate the concentration and the percent distribution of (+)-catechin. To know the effect of variations in mobile phase polarity on the percent distribution of (+)-catechin performed statistical analysis using one-way ANOVA test (? = 0.05). The results show that the variation of polarity of acetone-dichloromethane : methanol-acetic acid mobile phase (? = 13.74 to 17.51) had a significant influence on percent distribution of (+)-catechin from gambier by vacuum liquid chromatography method (p <0.05). Fraction with a mobile phase of acetone-dichloromethane (4:6) 50% : methanol-acetic acid (3:4) 50%, which had a value of dielectric constant of 15.62 yield the largest amount of (+)-catechin percent distribution value (45.40%).
UJI AKTIVITAS PENANGKAPAN RADIKAL DPPH EKSTRAK PRODUK TEH HITAM (Camellia sinensis (L.) O.K.) DAN GAMBIR (Uncaria gambir (Hunter) Roxb) SERTA PROFIL KLT-DENSITOMETERNYA Jaya, I. G. N. I. P; Leliqia N. P. E; I.N.K. Widjaja
Jurnal Farmasi Udayana Vol. 1, No. 1, Tahun 2012
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

The purpose of this research was to compare the DPPH scavenging activity of black tea (Camellia sinensis (L.) OK) and gambier (Uncaria gambir (Hunter) Roxb) product extract and to determine their TLC-densitometer profile. This research was conducted in two stages, first stage was to examine the DPPH scavenging activity of black tea and gambier product extract. This assay used some concentrations of black tea product extract, gambier product extract, and standard vitamin C (10, 20, 40, 80, 160, 200, and 320 µg/mL). The second stage was to determine the extracts profile by TLC-densitometer. The result of this research showed that the DPPH scavenging activity of gambier product extract was greater (IC50 = 88,57±0,64 µg/mL) than black tea product extract (IC50 = 311,54±2,79 µg/mL). The result of profile determination of black tea product extract at a mobile phase of MeOH:toluene (50:50) showed that no spot was supposed a volatile oil group; at mobile phase of ethyl acetate:formic acid:acetic acid:H2O (100:11:11:26) showed two spots that was supposed a flavonoid group, spot with Rf 0,41 (?max 365 nm) and spot with Rf 0,97 (?max 280 nm); at mobile phase of CHCl3:MeOH (90:10) showed that spot with Rf 0,87 (?max 275 nm) was supposed an alkaloid group; at mobile phase of acetic acid:diethyl ether:n-hexane:ethyl acetate (20:20:20:40) showed that spot with Rf 0,62 (?max 290 nm) was supposed a tannin group. While the result of profile determination of gambier product extract at mobile phase of ethyl acetate:formic acid:acetic acid:H2O (100:11:11:26) showed two spots that was supposed a flavonoid group, spot with Rf 0,81 (?max 280 nm) and spot with Rf 0,92 (?max 280 nm); at mobile phase of acetic acid:diethyl ether:n-hexane:ethyl acetate (20:20:20:40) showed that spot with Rf 0,42 (?max 285 nm) was supposed a tannin group.
DERIVATISASI MORFIN MENGGUNAKAN DANSIL KLORIDA UNTUK MENINGKATKAN KEPEKAAN DETEKSI MORFIN PADA METODE KLT- SPEKTROFOTODENSITOMETER L.P. Ari Chandrayan; N.P. Linda L.; I.N.K. Widjaja
Jurnal Farmasi Udayana Vol. 1, No. 1, Tahun 2012
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Fluorescence detection could be used for enhance  the  sensitivity of morphine  detection  by TLC-Spectrophotodensytometry. Morfin is a compound  that fluoresces intrinsically incapable. ence, morphine  was derivatized using dansyl chloride. Morphine was derivatized by two methods, derivatization in solution and overspotting method. The derivatization reaction was kept at pH 9 and 450  C for 20 minute. The ratio between dansyl chloride and analyte concentration was 6:1. The derivatization result was separated from the interference using TLC. The TLC method was using Al-TLC silica G60 plate as a stationary phase and etyl acetate : methanol : amonia (85:10:5) as the mobile phase. The dansyl derivative was detected at ?eks 365 nm and K540 filter for fluoresence. Derivatization  of  morphine-dansyl chloride capable  to  enhancing  the  sensitivity of  morphine detection using TLC-Spectrophotodensytometry. Derivatization in solution and overspotting method took the same time in procedure  but  they  gave  different sensitivity. Derivatization in solution method gave more quantity  than derivatization of overspotting.
Co-Authors A.A.M.A.M. Putra A.A.R.P Dewi D.A.F Sari Dewi Puspita Apsari Era S.Y., Ida Bagus Gde Agung Raditya Eka Putra Jaya, I. G. N. I. P L.P. Ari Chandrayan Luh Putu Febryana Larasanty M. Oka N.K.D Triastuti N.K.W Prasminda N.L.P.D. Wulandari N.L.P.U Antari N.M.F Irmayanti N.P. Linda L. Ni Putu Eka Leliqia Ni Putu Linda Laksmiani P.P. Andiani R.A.D. Puspitasari