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All Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian Parapemikir Jurnal Ilmiah Farmasi Jurnal Pengabdian Ikifa JIFTK (Jurnal Ilmu Farmasi Terapan dan Kesehatan)
Pra Panca Bayu Chandra
Sekolah Tinggi Ilmu Kesehatan IKIFA
Chemistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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Pengaruh Gel Ekstrak Buah Okra (Abelmoschus esculentus L.) Pada Luka Mencit Hiperglikemik Pra Panca Bayu Chandra; Dian Ratih Laksmitawati; Deni Rahmat
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.9252

Abstract

ABSTRAKPenelitian ini bertujuan untuk melihat pengaruh pemberian gel ekstrak buah okra (Abelmoschus esculentus L.) pada luka mencit dengan kondisi hiperglikemik berdasarkan parameter diameter luka dan pertumbuhan keropeng. Mencit jantan galur Mus musculus dikondisikan hiperglikemik dengan STZ dosis 0,06 mg/gBB. Mencit dibagi menjadi 8 kelompok, yaitu kelompok 1 (kontrol Non-DM/oral CMC Na+gel plasebo), kelompok 2 (kontrol DM/oral CMC Na+gel plasebo), kelompok 3 (uji I/oral CMC Na+gel ekstrak buah okra 12%), kelompok 4 (uji II/oral glibenclamide+gel plasebo), kelompok 5 (uji III/oral glibenclamide+gel ekstrak buah okra 12%), kelompok 6 (uji IV/oral ekstrak buah okra+gel plasebo), kelompok 7 (uji V/oral ekstrak buah okra+gel ekstrak buah okra 6%), kelompok 8 (uji VI/oral ekstrak buah okra+gel ekstrak buah okra 12%). Dosis glibenclamide 5 mg/KgBB, dosis ekstrak buah okra 400 mg/KgBB serta dosis CMC Na 5 mL/KgBB. Terapi diberikan 1 kali sehari (oral dan topikal) selama 15 hari terapi yang dilihat pada hari ke-0, 5, 11 dan 15. Hasil penelitian diameter luka mengalami penurunan dan pertumbuhan  keropeng meningkat pada mencit yang diberikan terapi kombinasi gel ekstrak buah okra dengan terapi oral dengan pengobatan. Pemberian kombinasi gel ekstrak buah okra secara topikal dengan ekstrak buah okra secara oral selama 15 hari terapi mampu menurunkan diameter luka dan meningkatkan pertumbuhan keropeng dibandingkan dengan pemberian tanpa kombinasi atau hanya secara oral. Kata kunci : Gel Ekstrak Buah Okra; Diameter Luka; Pertumbuhan Keropeng; Luka Mencit Hiperglikemik.ABSTRACTThis study aimed to examine the effect of giving okra fruit extract gel (Abelmoschus esculentus L.) in mice with hyperglycemic conditions based on wound diameter and scab growth parameters. Mus musculus male mice were hyperglycemic with STZ at a dose of 0.06 mg/gBW. Mice were divided into 8 groups, namely group 1 (non-DM control/oral CMC Na+gel placebo), group 2 (DM control/oral CMC Na+gel placebo), group 3 (test I/oral CMC Na+gel fruit extract okra 12%), group 4 (test II/oral glibenclamide+placebo gel), group 5 (test III/oral glibenclamide+okra fruit extract gel 12%), group 6 (test IV/oral okra fruit extract+placebo gel), group 7 (test V/oral okra fruit extract + okra fruit extract gel 6%), group 8 (test VI/oral okra fruit extract + okra fruit extract gel 12%). The dose of glibenclamide is 5 mg/KgBW, the dose of okra fruit extract is 400 mg/KgBW and the dose of CMC Na is 5 mL/KgBW. Therapy was given once a day (oral and topical) for 15 days of therapy which was seen on days 0, 5, 11 and 15. The results of the study decreased wound diameter and increased scab growth in mice given combination therapy of okra fruit extract gel with therapy orally with treatment. Administration of a combination of topical okra fruit extract gel with okra fruit extract orally for 15 days of therapy was able to reduce wound diameter and increase scab growth compared to administration without the combination or only orally.Keywords : Okra Fruit Extract Gel; Wound Diameter; Scab Growth;Hyperglycemic Mice; Wound.
Formulasi dan Evaluasi Gel Ekstrak Buah Okra (Abelmoschus esculentus L.Moench) Menggunakan Gelling Agent Carbophol Pra Panca Bayu Chandra
Parapemikir : Jurnal Ilmiah Farmasi Vol 11, No 3 (2022): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v11i3.3985

Abstract

Buah okra mengandung senyawa kimia yang terdiri dari hyperin, flavonoid glikosida, kumarin skopoletin, uridine, tannin, saponin, triterpenoid, steroid, alkaloid dan karbohidrat. Pengembangan dilakukan dengan membuat formulasi gel ekstrak buah okra dengan formula carbophol, trietanolamin, propilenglikol, fenoksietanol dan akuades. Penelitian ini bertujuan untuk membuat formulasi sediaan gel ekstrak buah okra dengan variasi konsentrasi carbophol sebagai gelling agent serta evaluasi gel terhadap formula gel ekstrak buah okra. Konsentrasi  ekstrak pada 3 formula gel yaitu konsentrasi ekstrak  6% untuk F1, F2, F3 (Carbophol 1%, 2%, 1,5%) dan konsentrasi ekstrak  12% untuk F4, F5, F6 (Carbophol 1,2%, 2%, 1,5%). Formula gel ekstrak dievaluasi berdasarkan pengamatan organoleptis, homogenitas, daya sebar, viskositas, daya lekat dan pH. Data Uji organoleptis, homogenitas, daya sebar, daya lekat dan pH dilakukan secara deskriptif serta data uji viskositas dilakukan menggunakan metode analisis Kruskal-Wallis. Hasil pengujian evaluasi sediaan gel memiliki warna hijau tua, bau khas dan konsistensi kental, lebih padat dan padat, homogen, serta daya sebar, daya lekat dan pH memenuhi syarat, tidak terdapat perbedaan viskositas yang signifikan antara F1 dengan konsentrasi 6% dengan F4 dengan konsentrasi 12%. Formula terbaik pada konsentrasi 6% adalah F1 dengan carbophol 1% serta pada konsentrasi 12% adalah F4 dengan carbophol 1,2%.
POTENSI BAHAN ALAM UNTUK DIABETES MELLITUS DI WILAYAH RW 03 KELURAHAN KLENDER JAKARTA TIMUR Pra Panca Bayu Chandra; Pricillya Maria Loimalitna; Rohima Robby
Jurnal Pengabdian IKIFA Vol. 3 No. 3 (2024): Jurnal Pengabdian IKIFA
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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Abstract

Hyperglycemia is a medical condition characterized by elevated blood glucose levels above normal, often associated with diseases such as Diabetes Mellitus (DM). According to data from the Indonesian health Survey in 2023, the prevalence of DM based on doctor's diagnoses in the population of all ages in DKI Jakarta Province ranked 4th. Using natural ingredients to help regulate blood glucose levels is a cost-effective and minimally side-effect approach, as these raw materials are readily available. The aim of the Community Service (PkM) activity in the RW 03 area of Klender Village, East Jakarta, was to educate the public on the use of natural ingredients for blood glucose control. The PkM activity was attended by 18 residents from RW 03 in Klender Village and the results showed a 22% increase in respondents' knowledge about natural ingredients for blood glucose control.
Penetapan Kadar Formalin pada Tahu Putih yang Dijual di Pasar Kranggan Bekasi dengan Metode Spektrofotometri UV-Vis pada April 2025 Ivan Santoso; Pricillya Maria Loimalitna; Wulan Sucianingrum; Pra Panca Bayu Chandra; Indri Astuti Handayani
Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol. 3 No. 3 (2025): Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol.3 No.3 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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Abstract

The misuse of formalin as a preservative in food products, particularly white tofu, is still frequently found, despite its prohibition due to harmful health effects such as respiratory tract irritation, internal organ damage, and even cancer risk. White tofu is one of the food items that is vulnerable to formalin addition to extend its shelf life and improve texture. The aim of this study was to identify and determine the formalin content in white tofu sold at Kranggan Market, Bekasi, using the UV-Vis spectrophotometry method. This research employed a descriptive quantitative method. The analysis was carried out through both qualitative and quantitative testing on 14 white tofu samples obtained from Kranggan Market. The qualitative test, using Schiff reagent, KMnO₄, and Fehling’s solution, showed that 7 samples gave positive reactions indicating the presence of formalin. The quantitative test was conducted using UV-Vis spectrophotometry at a maximum wavelength of 550 nm, and a standard curve was obtained with a correlation coefficient (R) of 0.991. The results showed that 8 samples contained formalin, with concentrations ranging from 0.00018% w/w to 0.00104% w/w. The UV-Vis spectrophotometry method proved to be sensitive and accurate in detecting formalin in food samples. These findings indicate that some white tofu sold at Kranggan Market still contains formalin, highlighting the need for stricter food safety monitoring in traditional markets.
Co-Authors Deni Rahmat Dian Ratih Laksmitawati Indri Astuti Handayani Ivan Santoso Pricillya Maria Loimalitna Rohima Robby Wulan Sucianingrum