Yuniardini Septorini Wimardhani
Department Of Oral Medicine, Faculty Of Dentistry, Universitas Indonesia

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SALIVARY PROFILE AND IDENTIFICATION OF EXISTING CANDIDA sp OF AN INSTITUTIONALIZED ELDERLY POPULATION IN JAKARTA: PROFIL SALIVA DAN IDENTIFIKASI KEBERADAAN CANDIDA sp PADA LANSIA DI PANTI JOMPO DI JAKARTA Febrina Rahmayanti; Yuniardini Septorini Wimardhani; Indriasti Wardhany
Dentika: Dental Journal Vol. 17 No. 4 (2013): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.57 KB) | DOI: 10.32734/dentika.v17i4.1783

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Saliva plays an important role to protect oral and dental health, in maintenance oral microflora balance. In elderly, disease, and medications usually influence the saliva. The purpose of this preliminary study was to investigate salivary profile, oral symptoms of dryness, and existing of Candida sp of an institutionalized elderly in Jakarta, Twenty seven (27) elderly (17 men and 10 women) were examined in a cross sectional study. Unstimulated whole saliva was collected for 5 minutes, according to published protocol, and then salivary flow rate and pH were measured. Candida sp were cultured in CHROM agar. The yeasts were counted and identified. Oral symptom or complaints of oral dryness, and burning or itching were recorded with an interview. Data of systemic conditions and medication the used were obtained from the medical record. Eighteen (66.7%) CHROM agar plates were Candida sp positive cultured, and about 61.1% subjects’ salivary pH were below normal range. Twenty one (77.8%) subjects had oral symptom and complain about oral dryness, even thought the salivary flow rate were in normal range. In this study, C.albicans is not the most frequently found colonized. About 72% were identified not C.albicans. This study suggests that, in elderly which salivary pH was below normal range have greater opportunistic infected by Candida sp. It can be concluded that, the result did not confirm a significant difference between subjects’ data and salivary profile concentration. The mycological finding Candida albicans is not the most frequently found colonized in this elderly population. Further study which lagger elderly population and might give deeper insights of salivary profile in this population.
Oral Hairy Leukoplakia: Clinical Indicator of an Immunosuppressive Condition and Challenges in Patient Management Agustina, Yohana Alfa; Wardhany, Indriasti Indah; Wimardhani, Yuniardini Septorini; Krisnuhoni, Ening; Iamaroon, Anak
Journal of Dentistry Indonesia Vol. 23, No. 2
Publisher : UI Scholars Hub

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Oral hairy leukoplakia (OHL) is defined as an asymptomatic white patch with vertical corrugation pattern the lateral borders of the tongue, that is associated with Epstein-Barr Virus (EBV) infection. Generally, it is related to immunosuppressive condition found in HIV-positive patients and patients undergoing immunosuppressive therapy. Sometimes, its clinical appearances could mimic other white lesions. Although most OHL cases are found in HIV seropositive individuals, finding in the immunocompetent individuals has also been reported. Appropriate clinical evaluations and laboratory investigations are important for patient’s comprehensive management. Objective: To report a finding of oral hairy leukoplakia as a clinical indicator of an immunosuppressive condition in otherwise a clinically healthy-looking individual and to discuss the challenges on patient management. Case Report: A 40 yearold man presented with asymptomatic, bilateral homogenous white hyperkeratotic plaques with a hairy appearance located on the dorsal of the tongue, extended to the lateral tongue mucosa. The patient failed to remember the lesion’s first appearance, until three weeks before a visit. Working diagnosis of OHL was made with differential diagnoses including white sponge nevus, leukoplakia and oral lichen planus. Histopathological assessment was consistent with OHL. Challenges on patient management include identifying possible risk factors and assuring patient for HIV testing. Conclusion: This case reported findings of OHL as the first clinical indicator of immunosuppressive condition that might be related to HIV-infection.
Role of Dentists in the Management of Behcet’s Disease: A Case Report Patoni, Nurfianti Ahmad; Sitheeque, Mohaideen AM.; Sarsito, Afi Savitri; Soegyanto, Anandina Irmagita; Wimardhani, Yuniardini Septorini
Journal of Dentistry Indonesia Vol. 25, No. 2
Publisher : UI Scholars Hub

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Behcet’s disease (BD) is a multi-system recurrent inflammatory disorder occurring in the form of vasculitis of an unknown etiology. It most frequently affects oral and genital mucosa, skin, eyes, joints, and blood vessels. The definitive diagnosis of BD is based on major symptoms such as recurrent oral and genital ulcers and recurrent skin and ocular lesions, accompanied by symptoms related to various systems. However, early BD manifestations are very similar to recurrent aphthous stomatitis (RAS). Several years from its first appearance are often required for a definitive diagnosis. Objective: To describe a dentist’s role in BD management in a patient with a history of highly recurrent RAS. Case Report: We evaluated a 38-year-old man with a 10-year history of recurrent oral ulcers, accompanied by skin and eyes lesions. His intraoral examination revealed multi-sized ulcers with a yellowish-white base and regular edges, surrounded by an erythematous halo. Ulcers were located on the tongue, floor of the mouth, and gingival mucosa. Although BD diagnosis was not histopathologically confirmed, the patient’s lesions met the International Criteria for Behcet’s disease with a score of 5. Oral ulcers were managed with chlorhexidine mouthwash 2 times/day and supportive measures. A multidisciplinary approach was used for this patient to provide comprehensive treatment. Conclusion: Dentists can be the first clinicians to detect the possible development of BD in patients with symptoms similar to RAS, but additionally having skin and eye lesions.
Medication intake and its influence on salivary profile of geriatric outpatients in Cipto Mangunkusumo Hospital Yuniardini Septorini Wimardhani; Winanda Annisa; Febrina Rahmayanti
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 3 (2012): September 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (467.557 KB) | DOI: 10.20473/j.djmkg.v45.i3.p138-143

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Background: It has been well documented that several diseases or conditions and their related medications could be the risk factors for several ailments found in the oral cavity. Increased usage of medication in elderly could have impact on quality of saliva that affects oral health, eventually cause deterioration in quality of life. Purpose: examine the salivary pH, buffering capacity, stimulated- and unstimulated salivary flow rate profile in elderly using medications. Methods: Seventy-six elderly were consented and agreed to participate in this study. Interview and medical record analysis were performed to get data about their health status, chronic use of medications and complaints related to xerostomia. Collection of unstimulated and stimulated saliva samples were completed in parallel with measurement of salivary pH and buffering capacity. Results: The mean salivary pH was moderately acidic while having low salivary buffering capacity. The mean unstimulated salivary flow rate (USSFR) was 0.24 ± 1.8ml/min and 41of subjects (53%) were classified hyposalivation, while the stimulated salivary flow rate (SSFR) was 0.86 ± 0.49ml/min and 31 (40%) classified hyposalivation. Number of drugs-induced xerostomia intake significantly correlated with the reduction in the USSFR of subjects (p<0.0001), however it was not the case with salivary pH and buffering capacity (p>0.05). It also showed correlation with complaints related to xerostomia. The mean USSFR did not correlate with xerostomia complaints. Conclusion: Medications intake influenced salivary profile and had more effect in changes in xerostomia complaints and salivary quantity than to salivary pH and buffering capacity in Indonesian elderly population.Latar belakang: Telah lama diketahui bahwa beberapa penyakit atau kondisi sistemik dan medikasinya dapat menjadi faktor resiko terjadinya beberapa kelainan dalam rongga mulut. Meningkatnya penggunaan medikasi sistemik pada lansia dapat mempengaruhi kualitas saliva sehingga berpengaruh pada kesehatan mulut yang akhirnya menyebabkan menurunnya kualitas hidup. Tujuan: Mengetahui profil pH saliva, kapasitas dapar, laju aliran saliva terstimulasi (LAST) dan tanpa stimulasi (LASTS) pada lansia yang mendapatkan medikasi sistemik. Metode: Tujuh puluh enam lansia telah menandatangani inform consent dan setuju untuk berpartisipasi. Wawancara dan analsis rekam medis dilakukan untuk mendapatkan data tentang status kesehatan, penggunaan medikasi sistemik jangka panjang dan keluhan xerostomia. Pengumpulan saliva tanpa stimulasi dan terstimulasi dilakukan bersama-sama dengan pengukuran pH dan kapasitas dapar. Hasil: pH saliva subyek adalah berada dalam kelompok asam sedang dengan kapasitas dapar yang rendah. Rerata LASTS adalah 0,24 ± 1,8ml/menit dan 41 subyek (53%) mengalami hiposalivasi, sementara LAST adalah 0,86 ± 0,49ml/menit dan 31 subyek (40%) mengalami hiposalivasi. Jumlah medikasi yang dapat menginduksi xerostomia secara bermakna berhubungan dengan penurunan LASTS (p < 0,0001), namun tidak demikian dengan pH dan kapasitas dapar (p>0,05). Medikasi sistemik juga berhubungan dengan keluhan yang terkait xerostomia. Rerata LASTS tidak berhubungan dengan keluhan xerostomia. Kesimpulan: Medikasi sistemik pada populasi lansia Indonesia mempengaruhi profil saliva dan mempunyai pengaruh yang lebih besar pada keluhan xerostomia dan kuantitas saliva dibandingkan pH dan kapasitas dapar.
An experimental model of chemically-induced ulceration of the buccal mucosa of Mus musculus Idrus, Erik; Hartanti, Pratiwi Dwi; Suniarti, Dewi Fatma; Prasetyo, Sri Redjeki; Wimardhani, Yuniardini Septorini; Subarnbhesaj, Ajiravudh
Makara Journal of Health Research Vol. 23, No. 3
Publisher : UI Scholars Hub

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Background: Ulceration caused by chemical agents used in dental practice for in-office or home-used is a common event, resulting in discomfort and pain. Treatments for such conditions are still being developed, requiring extensive experiments both in vitro and in vivo studies. At present, a standardized experimental mouse model for mucosal ulceration caused by a chemical inducer to study the pathogenesis of ulceration and to develop medications for treatment of ulceration is still not available. The aim of this study was to create a chemically induced model of ulceration of the buccal mucosa of mice. Methods: An in vivo study model of ulceration using a total of 9 mice (Swiss Webster) was performed. All mice received 70% acetic acid application on the left buccal mucosa, while the right buccal mucosa received only saline. Clinical and histological observations of ulcer formation and healing were performed, including the presence of redness and swelling, ulcer diameter, bodyweight as well as epithelial disintegration, dilation of blood vessels, and infiltration of inflammatory cells. Results: Buccal mucosa application of 70% acetic acid generated ulcers on day 2, reached its peak on day 3 and recovered by day 14. The histological features of inflammation were also seen in the ulcer model, and the degree of inflammation was consistent with the day of ulcers. Conclusion: Chemical trauma by the administration of 70% acetic acid effectively induce ulceration on buccal mucosa in mice, and this method can be considered as a novel, reproducible, and clinically relevant model to study pathogenesis and therapeutic approach for treating oral mucosal ulceration.
Contents Vol 30 No 2 2023 Septorini Wimardhani, Dr. Yuniardini Septorini
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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This is the contents of the 2nd number of the Volume 30 December 2023 edition of the Journal of Dentistry Indonesia.
Contents Vol 30 No 3 2023 Septorini Wimardhani, Dr. Yuniardini Septorini
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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This is the content of Vol. 30 number 3 2023.
Contents of Vol. 31, No.1, April 2024 Wimardhani, Yuniardini Septorini
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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This is the Cover and the Contents of the Vol. 31 No. 1 2024
Contents of Vol. 31, No.2, August 2024 Septorini Wimardhani, Dr. Yuniardini Septorini
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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This is the Cover and the Contents of the Vol. 31 No. 2 2024
The Effectiveness of Moringa Oleifera Lam Extract as an Oral Antimicrobial: a Systematic Literature Review Indrastiti, Ratna Kumala; Rahmayanti, Febrina; Wimardhani, Yuniardini Septorini
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.39-47

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Background: The use of mouthwash to maintain oral hygiene has been carried out for many years. However, long-term use of mouthwash can cause side effects such as tooth discoloration, burning sensation and the death of normal oral flora. The use of herbal plant, such as Moringa oleifera lam has been studied as an alternative medicine because of its pharmacological properties and it is hoped to have minimum side effect. In this systematic literature review, we included the studies that have been investigate the antimicrobial capacity of Moringa oleifera lam as a basic knowledge to develop a preparation for oral hygiene maintenance.Method: A comprehensive literature search was performed utilizing four different electronic databases: PubMed, Scopus, Cochrane library, and EBSCO. Articles included in this study were published from 2013 to September 2023, with broad search criteria comprising MeSH-terms and free-text keywords Moringa Oleifera, Oral Antimicrobial, and Mouthwash.Result: At the beginning our search resulted in 17 articles, with 14 articles remaining after removal of duplication. We exclude five studies that do not meet the PICO criteria, resulting seven articles which included to this study.Conclusion: According to the literature review that has been carried out, Moringa oleifera lam has antimicrobial capacity which allows it to be used as a material in medicinal preparations. Further research, both in vitro and clinical research, will determine the effectiveness of Moringa oleifera lam in suppressing microorganisms.