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Oral Hairy Leukoplakia: Clinical Indicator of an Immunosuppressive Condition and Challenges in Patient Management Agustina, Yohana Alfa; Wardhany, Indriasti Indah; Wimardhani, Yuniardini Septorini; Krisnuhoni, Ening; Iamaroon, Anak
Journal of Dentistry Indonesia Vol. 23, No. 2
Publisher : UI Scholars Hub

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Oral hairy leukoplakia (OHL) is defined as an asymptomatic white patch with vertical corrugation pattern the lateral borders of the tongue, that is associated with Epstein-Barr Virus (EBV) infection. Generally, it is related to immunosuppressive condition found in HIV-positive patients and patients undergoing immunosuppressive therapy. Sometimes, its clinical appearances could mimic other white lesions. Although most OHL cases are found in HIV seropositive individuals, finding in the immunocompetent individuals has also been reported. Appropriate clinical evaluations and laboratory investigations are important for patient’s comprehensive management. Objective: To report a finding of oral hairy leukoplakia as a clinical indicator of an immunosuppressive condition in otherwise a clinically healthy-looking individual and to discuss the challenges on patient management. Case Report: A 40 yearold man presented with asymptomatic, bilateral homogenous white hyperkeratotic plaques with a hairy appearance located on the dorsal of the tongue, extended to the lateral tongue mucosa. The patient failed to remember the lesion’s first appearance, until three weeks before a visit. Working diagnosis of OHL was made with differential diagnoses including white sponge nevus, leukoplakia and oral lichen planus. Histopathological assessment was consistent with OHL. Challenges on patient management include identifying possible risk factors and assuring patient for HIV testing. Conclusion: This case reported findings of OHL as the first clinical indicator of immunosuppressive condition that might be related to HIV-infection.

Role of Dentists in the Management of Behcet’s Disease: A Case Report Patoni, Nurfianti Ahmad; Sitheeque, Mohaideen AM.; Sarsito, Afi Savitri; Soegyanto, Anandina Irmagita; Wimardhani, Yuniardini Septorini
Journal of Dentistry Indonesia Vol. 25, No. 2
Publisher : UI Scholars Hub

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Behcet’s disease (BD) is a multi-system recurrent inflammatory disorder occurring in the form of vasculitis of an unknown etiology. It most frequently affects oral and genital mucosa, skin, eyes, joints, and blood vessels. The definitive diagnosis of BD is based on major symptoms such as recurrent oral and genital ulcers and recurrent skin and ocular lesions, accompanied by symptoms related to various systems. However, early BD manifestations are very similar to recurrent aphthous stomatitis (RAS). Several years from its first appearance are often required for a definitive diagnosis. Objective: To describe a dentist’s role in BD management in a patient with a history of highly recurrent RAS. Case Report: We evaluated a 38-year-old man with a 10-year history of recurrent oral ulcers, accompanied by skin and eyes lesions. His intraoral examination revealed multi-sized ulcers with a yellowish-white base and regular edges, surrounded by an erythematous halo. Ulcers were located on the tongue, floor of the mouth, and gingival mucosa. Although BD diagnosis was not histopathologically confirmed, the patient’s lesions met the International Criteria for Behcet’s disease with a score of 5. Oral ulcers were managed with chlorhexidine mouthwash 2 times/day and supportive measures. A multidisciplinary approach was used for this patient to provide comprehensive treatment. Conclusion: Dentists can be the first clinicians to detect the possible development of BD in patients with symptoms similar to RAS, but additionally having skin and eye lesions.

An experimental model of chemically-induced ulceration of the buccal mucosa of Mus musculus Idrus, Erik; Hartanti, Pratiwi Dwi; Suniarti, Dewi Fatma; Prasetyo, Sri Redjeki; Wimardhani, Yuniardini Septorini; Subarnbhesaj, Ajiravudh
Makara Journal of Health Research Vol. 23, No. 3
Publisher : UI Scholars Hub

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Background: Ulceration caused by chemical agents used in dental practice for in-office or home-used is a common event, resulting in discomfort and pain. Treatments for such conditions are still being developed, requiring extensive experiments both in vitro and in vivo studies. At present, a standardized experimental mouse model for mucosal ulceration caused by a chemical inducer to study the pathogenesis of ulceration and to develop medications for treatment of ulceration is still not available. The aim of this study was to create a chemically induced model of ulceration of the buccal mucosa of mice. Methods: An in vivo study model of ulceration using a total of 9 mice (Swiss Webster) was performed. All mice received 70% acetic acid application on the left buccal mucosa, while the right buccal mucosa received only saline. Clinical and histological observations of ulcer formation and healing were performed, including the presence of redness and swelling, ulcer diameter, bodyweight as well as epithelial disintegration, dilation of blood vessels, and infiltration of inflammatory cells. Results: Buccal mucosa application of 70% acetic acid generated ulcers on day 2, reached its peak on day 3 and recovered by day 14. The histological features of inflammation were also seen in the ulcer model, and the degree of inflammation was consistent with the day of ulcers. Conclusion: Chemical trauma by the administration of 70% acetic acid effectively induce ulceration on buccal mucosa in mice, and this method can be considered as a novel, reproducible, and clinically relevant model to study pathogenesis and therapeutic approach for treating oral mucosal ulceration.

Contents of Vol. 31, No.1, April 2024 Wimardhani, Yuniardini Septorini
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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This is the Cover and the Contents of the Vol. 31 No. 1 2024

The Effectiveness of Moringa Oleifera Lam Extract as an Oral Antimicrobial: a Systematic Literature Review Indrastiti, Ratna Kumala; Rahmayanti, Febrina; Wimardhani, Yuniardini Septorini
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.39-47

Background: The use of mouthwash to maintain oral hygiene has been carried out for many years. However, long-term use of mouthwash can cause side effects such as tooth discoloration, burning sensation and the death of normal oral flora. The use of herbal plant, such as Moringa oleifera lam has been studied as an alternative medicine because of its pharmacological properties and it is hoped to have minimum side effect. In this systematic literature review, we included the studies that have been investigate the antimicrobial capacity of Moringa oleifera lam as a basic knowledge to develop a preparation for oral hygiene maintenance.Method: A comprehensive literature search was performed utilizing four different electronic databases: PubMed, Scopus, Cochrane library, and EBSCO. Articles included in this study were published from 2013 to September 2023, with broad search criteria comprising MeSH-terms and free-text keywords Moringa Oleifera, Oral Antimicrobial, and Mouthwash.Result: At the beginning our search resulted in 17 articles, with 14 articles remaining after removal of duplication. We exclude five studies that do not meet the PICO criteria, resulting seven articles which included to this study.Conclusion: According to the literature review that has been carried out, Moringa oleifera lam has antimicrobial capacity which allows it to be used as a material in medicinal preparations. Further research, both in vitro and clinical research, will determine the effectiveness of Moringa oleifera lam in suppressing microorganisms.

The Effectiveness of Moringa Oleifera Lam Extract as an Oral Antimicrobial: a Systematic Literature Review Indrastiti, Ratna Kumala; Rahmayanti, Febrina; Wimardhani, Yuniardini Septorini
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.39-47

Background: The use of mouthwash to maintain oral hygiene has been carried out for many years. However, long-term use of mouthwash can cause side effects such as tooth discoloration, burning sensation and the death of normal oral flora. The use of herbal plant, such as Moringa oleifera lam has been studied as an alternative medicine because of its pharmacological properties and it is hoped to have minimum side effect. In this systematic literature review, we included the studies that have been investigate the antimicrobial capacity of Moringa oleifera lam as a basic knowledge to develop a preparation for oral hygiene maintenance.Method: A comprehensive literature search was performed utilizing four different electronic databases: PubMed, Scopus, Cochrane library, and EBSCO. Articles included in this study were published from 2013 to September 2023, with broad search criteria comprising MeSH-terms and free-text keywords Moringa Oleifera, Oral Antimicrobial, and Mouthwash.Result: At the beginning our search resulted in 17 articles, with 14 articles remaining after removal of duplication. We exclude five studies that do not meet the PICO criteria, resulting seven articles which included to this study.Conclusion: According to the literature review that has been carried out, Moringa oleifera lam has antimicrobial capacity which allows it to be used as a material in medicinal preparations. Further research, both in vitro and clinical research, will determine the effectiveness of Moringa oleifera lam in suppressing microorganisms.

Mapping the Anticancer Mechanism of Asiatic Acid : A systematic review of preclinical evidence Sari, Rina Kartika; Dalimunthe, Rahmi Syaflida; Amir, Lisa Rinanda; Wimardhani, Yuniardini Septorini; Musfiroh, Ida; Sastradipura, Dewi Fatma Suniarti
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.62028

Studies have demonstrated that Asiatic acid (AA) from Centella asiatica has anticancer properties in cancer cell lines, but translating these findings into clinical research remains challenging. This review aims to provide a robust scientific foundation for enhancing the translational potential of AA-based anticancer therapy. The PubMed, Scopus, and ScienceDirect databases were searched electronically using specific keywords and screened in accordance with the PRISMA 2020 guidelines. Fourteen studies meet the criteria. All research was conducted in vitro; four studies were conducted both in vitro and in vivo, and three were conducted in silico.Asiatic acid (AA) demonstrates potent anticancer activity by modulating key signaling pathways, including PI3K/Akt and NF-κB, thereby inhibiting proliferation, promoting apoptosis, and reducing metastasis. Its cytotoxic effects are time- and dose-dependent (1–50 µM) and minimal in normal cells. While AA and its derivatives consistently outperform controls, limitations such as missing control dose data warrant further investigation. Future studies should focus on in vivo validation, clinical translation, and advanced strategies such as targeted delivery and AI-assisted drug development to fully realize AA’s therapeutic potential.

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