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All Journal Bioscientist : Jurnal Ilmiah Biologi
Venita Octavia Tambunan
Departemen Mikrobiologi, FK, UPN Veteran Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Social Sciences

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Potensi Daya Hambat Filtrat Zat Metabolit Actinomycetes dari Kebun Raya Bogor terhadap Pertumbuhan Candida albicans dan Malassezia furfur Venita Octavia Tambunan; Meiskha Bahar; Andri Pramono; Cut Fauziah; Hany Yusmaini; Fajriati Zulfa
Bioscientist : Jurnal Ilmiah Biologi Vol 10, No 1 (2022): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v10i1.4792

Abstract

Candida albicans and Malassezia furfur are types of fungi that often cause infections in humans. Widespread fungal infections and lack of therapeutic options can develop fungal resistance and become serious problems in the future. Actinomycetes are Gram-positive bacteria that can produce secondary metabolites such as antifungal, antibacterial, and anticancer. The study aimed to determine the effectiveness of the metabolite filtrate Actinomycetes as an antifungal agent against the in vitro growth of  C.albicans and  M. furfur. This type of research is a laboratory experimental study with a post-test group design only using metabolite concentrations Actinomycetes of 25%, 50%, 75%, 100%, antifungal testing is done using the agar diffusion method on Sabouraud Dextrose Agar Media. Of the four concentrations, the average diameter of the clear zone for C.albicans  is  11.65mm; 12.48mm; 13.63mm and 13.80mm and for M.furfur is  6,025mm; 8,05mm; 9,1mm  and  9,9mm. There was a significant difference between each treatment group with a p-value of < 0.05. The compound Metabolite filtrate  Actinomycetes derived from  Actinomycetes can potentially be antifungal with one of its mechanisms binding to ergosterol in the cell wall that will interfere with the integrity of the fungal cell wall.
Co-Authors Andri Pramesyanti Pramono Cut Fauziah Fajriati Zulfa Hany Yusmaini Meiskha Bahar