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All Journal Jurnal Farmasi Klinik Indonesia Acta Biochimica Indonesiana Jurnal Media Tropika: Jurnal Pengabdian Kepada Masyarakat
Magdarita Riwu
Universitas Nusa Cendana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Korelasi Faktor Usia, Cara Minum, dan Dosis Obat Metformin terhadap Risiko Efek Samping pada Penderita Diabetes Melitus Tipe 2 Riwu, Magdarita; Subarnas, Anas; Lestari, Keri
Indonesian Journal of Clinical Pharmacy Vol 4, No 3 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.662 KB) | DOI: 10.15416/ijcp.2015.4.3.151

Abstract

Metformin merupakan obat antidiabetes oral yang umumnya direkomendasikan sebagai pengobatan lini pertama pada diabetes melitus tipe 2 apabila kadar glukosa darah tidak terkontrol dengan modifikasi gaya hidup. Pada penggunaan metformin sebagai kontrol glikemia sering terjadi reaksi obat yang merugikan (ROM) berupa gangguan gastrointestinal seperti diare, mual, dan perut kembung. Penelitian ini bertujuan untuk menganalisis korelasi faktor usia, cara minum, dan dosis metformin terhadap risiko efek samping gangguan gastrointestinal pada penderita rawat jalan BPJS Kesehatan yang baru terdiagnosis diabetes melitus tipe 2 di RSAU Dr. M. Salamun Bandung. Penelitian ini adalah analitik observasional dengan desain potong lintang. Data dikumpulkan dari bagian poliklinik penyakit dalam, rekam medis, dan form check penderita yang mendapat pengobatan dengan metformin yang dilakukan sejak April–Juni 2014. Jumlah penderita yang memenuhi kriteria penelitian sebanyak 65 orang dengan rentang usia rata-rata 48 tahun. Keluhan efek samping yang dialami penderita berupa kembung (58,46%) dan mual (41,54%). Cara minum dan dosis metformin berkorelasi terhadap risiko efek samping berupa mual dan kembung pada penderita diabetes melitus tipe 2 (p<0,05) sedangkan faktor usia tidak berkorelasi (p>0,05). Penggunaan metformin dianjurkan sesudah makan dan dengan dosis awal rendah yang dititrasi perlahan untuk mengurangi dan menghindari terjadinya efek samping mual dan perut kembung pada penderita diabetes melitus tipe 2.Kata kunci: Diabetes melitus tipe 2, efek samping, metforminThe Correlation of Age Factor, Administration, and Metformin Dose Against Risk of Side Effect on Type 2 Diabetes MellitusMetformin is an antidiabetic oral medicine commonly recommended as first line treatment on type 2 diabetes mellitus. Metformin can caused drug related problems (DRPs) such as gastrointestinal disorders, e.g. diarrhea, nausea, and flatulence. This study aimed to analyze correlation profiles on age, administration, and metformin dosage factors against risk of gastrointestinal disorders among newlydiagnosed diabetic outpatients of National Health Insurance in RSAU Dr. M. Salamun Bandung. This study was an analytic observational study with a cross sectional method. The study was carried out in the internal medicine outpatient clinic and data were extracted from patients medical records from April to June 2014. Metformin-treated patients were interviewed using a form check. The number of patients were 65 with the median rate was 48 years old. Side effect reported were flatulence (58.46%) and nausea (41.54%). Administration and metformin dosage factors were correlated to the risk of side effects such as nausea and flatulence on type 2 diabetes mellitus (p<0.05), while age was not correlated (p>0.05). The administration of metformin is recommended after meals and with a lower initial dose titrated slowly to reduce and avoid the side effects of nausea and flatulence in patients with type 2 diabetes mellitus.Keywords: Metformin, side effect, type 2 diabetes mellitus
Korelasi Faktor Usia, Cara Minum, dan Dosis Obat Metformin terhadap Risiko Efek Samping pada Penderita Diabetes Melitus Tipe 2 Magdarita Riwu; Anas Subarnas; Keri Lestari
Indonesian Journal of Clinical Pharmacy Vol 4, No 3 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (8009.124 KB) | DOI: 10.15416/ijcp.2015.4.3.151

Abstract

Metformin merupakan obat antidiabetes oral yang umumnya direkomendasikan sebagai pengobatan lini pertama pada diabetes melitus tipe 2 apabila kadar glukosa darah tidak terkontrol dengan modifikasi gaya hidup. Pada penggunaan metformin sebagai kontrol glikemia sering terjadi reaksi obat yang merugikan (ROM) berupa gangguan gastrointestinal seperti diare, mual, dan perut kembung. Penelitian ini bertujuan untuk menganalisis korelasi faktor usia, cara minum, dan dosis metformin terhadap risiko efek samping gangguan gastrointestinal pada penderita rawat jalan BPJS Kesehatan yang baru terdiagnosis diabetes melitus tipe 2 di RSAU Dr. M. Salamun Bandung. Penelitian ini adalah analitik observasional dengan desain potong lintang. Data dikumpulkan dari bagian poliklinik penyakit dalam, rekam medis, dan form check penderita yang mendapat pengobatan dengan metformin yang dilakukan sejak April–Juni 2014. Jumlah penderita yang memenuhi kriteria penelitian sebanyak 65 orang dengan rentang usia rata-rata 48 tahun. Keluhan efek samping yang dialami penderita berupa kembung (58,46%) dan mual (41,54%). Cara minum dan dosis metformin berkorelasi terhadap risiko efek samping berupa mual dan kembung pada penderita diabetes melitus tipe 2 (p<0,05) sedangkan faktor usia tidak berkorelasi (p>0,05). Penggunaan metformin dianjurkan sesudah makan dan dengan dosis awal rendah yang dititrasi perlahan untuk mengurangi dan menghindari terjadinya efek samping mual dan perut kembung pada penderita diabetes melitus tipe 2.Kata kunci: Diabetes melitus tipe 2, efek samping, metforminThe Correlation of Age Factor, Administration, and Metformin Dose Against Risk of Side Effect on Type 2 Diabetes MellitusMetformin is an antidiabetic oral medicine commonly recommended as first line treatment on type 2 diabetes mellitus. Metformin can caused drug related problems (DRPs) such as gastrointestinal disorders, e.g. diarrhea, nausea, and flatulence. This study aimed to analyze correlation profiles on age, administration, and metformin dosage factors against risk of gastrointestinal disorders among newlydiagnosed diabetic outpatients of National Health Insurance in RSAU Dr. M. Salamun Bandung. This study was an analytic observational study with a cross sectional method. The study was carried out in the internal medicine outpatient clinic and data were extracted from patients medical records from April to June 2014. Metformin-treated patients were interviewed using a form check. The number of patients were 65 with the median rate was 48 years old. Side effect reported were flatulence (58.46%) and nausea (41.54%). Administration and metformin dosage factors were correlated to the risk of side effects such as nausea and flatulence on type 2 diabetes mellitus (p<0.05), while age was not correlated (p>0.05). The administration of metformin is recommended after meals and with a lower initial dose titrated slowly to reduce and avoid the side effects of nausea and flatulence in patients with type 2 diabetes mellitus.Keywords: Metformin, side effect, type 2 diabetes mellitus
PENYULUHAN MENGENAI PENCEGAHAN DAN PENGOBATAN MALARIA DI DESA CAMPLONG, KABUPATEN KUPANG, NTT Lidia, Kartini; Setianingrum, Elisabeth Levina Sari; Riwu, Magdarita; Lada, Christina Olly; Pasa, Irene Rosario Mala; Pakaenoni, Agnes Tiara Maharani D.; Stevanovic, Claudio; Suryanta, Andrie; Wibawa, Krisanty Lintang
Jurnal Media Tropika Vol 3 No 2 (2023): Jurnal Media Tropika
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/mediatropika.v3i2.11200

Abstract

Malaria is one of the parasitic infectious diseases that is still a world health problem, especially in tropical countries including Indonesia. Malaria is still one of the causes of death in both adults and children. According to the World Health Organization (WHO) malaria report in 2020, the estimated number of malaria cases in the world in 2019 reached 229 million cases in 87 malaria-endemic countries, down from 238 million in 2000. Data from the Indonesian Ministry of Health regarding the achievement of Malaria Elimination Districts / Cities shows that Indonesia's Annual Paracite Incidence (API) rate in 2020 reached 0.87. Data from the 2021 NTT Malaria Report from the NTT Provincial Health Office shows that in 2021, the number of positive malaria cases in NTT Province was 9,419 cases with an API of 1.72 per 1000 population and 10 cases of death due to malaria. In addition, in 2021 there are 14 districts/cities in NTT classified as low endemic areas, and there are still 3 districts/cities classified as high endemic areas with the dominant species being plasmodium falciparum. Kupang Regency is one of the areas targeted for malaria elimination in 2020. Camplong Village, Fatuleu District, is included in Kupang Regency which is the target of elimination in 2022. Aims and objectives: Increase awareness of the people of Camplong village on the dangers of malaria, malaria prevention and treatment so that the 2030 NTT malaria elimination target can be achieved. Method of implementation of activities: Counseling and treatment Output indicators produced: The implementation of counseling for the community in the Camplong Village area of Hamlet 2 totaling 88 residents consisting of 45 women and 43 men. Conclusion: The activities of malaria counseling and treatment services in Camplong village 2 hamlet 2 RT 5,6,7 are one of the programs that can provide benefits to the community, namely increasing knowledge about malaria, how to prevent and treat malaria. This is very important to improve the health of the Camplong community while helping the malaria elimination program carried out by the government. Similar activities must continue to be carried out and in collaboration with local Puskesmas so that the target of malaria elimination in 2030 for Kupang district in particular and Indonesia in general can be achieved.
The effect of green tea consumption on cholesterol reduction: a study among social service employees in East Nusa Tenggara Mukin, Patricia Flamli Uma; Amat, Anita Lidesna Shinta; Setianingrum, Elisabeth Levina Sari; Riwu, Magdarita
Acta Biochimica Indonesiana Vol. 7 No. 1 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.153

Abstract

Background: Hypercholesterolemia is a major risk factor for cardiovascular diseases, with elevated cholesterol levels prevalent in Indonesia. While pharmaceutical treatments are effective, they can be costly and cause side effects, prompting interest in natural remedies. Green tea, rich in bioactive compounds such as catechins, has shown potential in reducing cholesterol levels through its lipid-lowering and antioxidant properties. Objective: This study aimed to evaluate the effect of green tea consumption on total cholesterol levels in employees of the Social Service Office, East Nusa Tenggara Province, Indonesia. Method: An experimental study was conducted involving 38 participants aged 25–55 years, divided into a treatment group (n = 19) and a control group (n = 19). The treatment group consumed 240 ml of green tea twice daily for one week, while the control group received no intervention. Total cholesterol levels were measured using capillary blood and cholesterol test strips pre- and post-intervention. Data analysis was performed using the paired t-test. Results: The treatment group exhibited a significant reduction in total cholesterol levels (mean pre-treatment: 210.95 mg/dL; post-treatment: 188.26 mg/dL; p = 0.003). The control group showed no significant change (pre-treatment: 208.11 mg/dL; post-treatment: 214.37 mg/dL; p = 0.42). Conclusion: Green tea consumption for one week significantly reduced total cholesterol levels, demonstrating its potential as a natural remedy for managing hypercholesterolemia.
Co-Authors Amat, Anita Lidesna Shinta Anas Subarnas Christina Olly Lada Keri Lestari Lidia, Kartini Mukin, Patricia Flamli Uma Pakaenoni, Agnes Tiara Maharani D. Pasa, Irene Rosario Mala Setianingrum, Elisabeth Levina Sari Stevanovic, Claudio Suryanta, Andrie Wibawa, Krisanty Lintang