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All Journal Farmaka Indonesian Journal of Applied Sciences Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Pharmacology and Clinical Pharmacy Research KACANEGARA Jurnal Pengabdian pada Masyarakat Journal of Maternal and Child Health Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa Indian Journal of Forensic Medicine & Toxicology Medical Sains : Jurnal Ilmiah Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian
Keri Lestari
Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Monitoring Terapi Warfarin pada Pasien Pelayanan Jantung pada Rumah Sakit di Bandung Putri, Norisca A.; Lestari, Keri; Diantini, Ajeng; Rusdiana, Taofik
Indonesian Journal of Clinical Pharmacy Vol 1, No 3 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (655.259 KB)

Abstract

Penelitian ini bertujuan untuk mengetahui monitoring terapi warfarin untuk menjamin ketepatan dosis,keamanan terapi, dan mengetahui apakah dosis terapi warfarin yang digunakan telah memenuhi kriteria  penggunaan obat warfarin yang rasional. Derajat antikogulasi setiap pasien diukur dengan parameter waktu protrombin yang dinyatakan dengan International Normalized Ratio (INR). Metode Penelitian meliputi monitoring terapi warfarin terhadap 80 pasien di pelayanan jantung melalui PT-INR, pendataanklinis pasien meliputi, usia, jenis kelamin, berat badan, tinggi badan, jenis penyakit, dosis yang digunakan dan obat lain yang dikonsumsi secara bersamaan. Hasil monitoring menunjukkan rata-rata INR pasien yaitu 1,38± 0,42 hasil ANAVA (α = 0,05) menunjukkan tidak ada pengaruh dosis terhadap INR(p=0,13) tetapi ada pengaruh pada umur (p =0,014), hasil uji beda (α = 0,05) menunjukkan tidak ada perbedaan terhadap rata-rata INR berdasarkan jenis kelamin (p =0,051), umur (p =0,397), dan variasi dosis (p = 0,057). Hasil tersebut menunjukkan bahwa dosis warfarin belum mencapai target terapi INR (2–3).Kata kunci: Warfarin, penyakit trombotik, PT-INR Warfarin Therapy Monitoring of Cardiac Care Patients in Hospital in BandungAbstractThe aims of this study were to identify the rational warfarin monitoring therapy to guarantee the rightdose, therapy security, and whether the dose of warfarin therapy has completed the rational criteria ornot. Degree of antikoagulasi for each patient is measured with protombin time as International Normalized Ratio (INR). The methods consist of warfarin monitoring therapy towards 80 patients at the heart service through the PT-INR constant, medical data, such as age, gender, weight, height, type of the disease, dose usage and another medicine which is used together, and statistical test of the average of INR. The monitoring result shows that patient’s INR average is 1,38 ±0,42, the result of ANAVA (α=0,05)shows that there’s no impact of dose towards INR (p=0,13) but there’s an INR average impact basedon gender (p=0,051), age (p=0,397) and dose variation (p=0,057). The results shown that warfarin dose which used is not bleeding risk.Key words: Warfarin, trombotic disease, PT-INR
Korelasi Faktor Usia, Cara Minum, dan Dosis Obat Metformin terhadap Risiko Efek Samping pada Penderita Diabetes Melitus Tipe 2 Riwu, Magdarita; Subarnas, Anas; Lestari, Keri
Indonesian Journal of Clinical Pharmacy Vol 4, No 3 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.662 KB) | DOI: 10.15416/ijcp.2015.4.3.151

Abstract

Metformin merupakan obat antidiabetes oral yang umumnya direkomendasikan sebagai pengobatan lini pertama pada diabetes melitus tipe 2 apabila kadar glukosa darah tidak terkontrol dengan modifikasi gaya hidup. Pada penggunaan metformin sebagai kontrol glikemia sering terjadi reaksi obat yang merugikan (ROM) berupa gangguan gastrointestinal seperti diare, mual, dan perut kembung. Penelitian ini bertujuan untuk menganalisis korelasi faktor usia, cara minum, dan dosis metformin terhadap risiko efek samping gangguan gastrointestinal pada penderita rawat jalan BPJS Kesehatan yang baru terdiagnosis diabetes melitus tipe 2 di RSAU Dr. M. Salamun Bandung. Penelitian ini adalah analitik observasional dengan desain potong lintang. Data dikumpulkan dari bagian poliklinik penyakit dalam, rekam medis, dan form check penderita yang mendapat pengobatan dengan metformin yang dilakukan sejak April–Juni 2014. Jumlah penderita yang memenuhi kriteria penelitian sebanyak 65 orang dengan rentang usia rata-rata 48 tahun. Keluhan efek samping yang dialami penderita berupa kembung (58,46%) dan mual (41,54%). Cara minum dan dosis metformin berkorelasi terhadap risiko efek samping berupa mual dan kembung pada penderita diabetes melitus tipe 2 (p<0,05) sedangkan faktor usia tidak berkorelasi (p>0,05). Penggunaan metformin dianjurkan sesudah makan dan dengan dosis awal rendah yang dititrasi perlahan untuk mengurangi dan menghindari terjadinya efek samping mual dan perut kembung pada penderita diabetes melitus tipe 2.Kata kunci: Diabetes melitus tipe 2, efek samping, metforminThe Correlation of Age Factor, Administration, and Metformin Dose Against Risk of Side Effect on Type 2 Diabetes MellitusMetformin is an antidiabetic oral medicine commonly recommended as first line treatment on type 2 diabetes mellitus. Metformin can caused drug related problems (DRPs) such as gastrointestinal disorders, e.g. diarrhea, nausea, and flatulence. This study aimed to analyze correlation profiles on age, administration, and metformin dosage factors against risk of gastrointestinal disorders among newlydiagnosed diabetic outpatients of National Health Insurance in RSAU Dr. M. Salamun Bandung. This study was an analytic observational study with a cross sectional method. The study was carried out in the internal medicine outpatient clinic and data were extracted from patients medical records from April to June 2014. Metformin-treated patients were interviewed using a form check. The number of patients were 65 with the median rate was 48 years old. Side effect reported were flatulence (58.46%) and nausea (41.54%). Administration and metformin dosage factors were correlated to the risk of side effects such as nausea and flatulence on type 2 diabetes mellitus (p<0.05), while age was not correlated (p>0.05). The administration of metformin is recommended after meals and with a lower initial dose titrated slowly to reduce and avoid the side effects of nausea and flatulence in patients with type 2 diabetes mellitus.Keywords: Metformin, side effect, type 2 diabetes mellitus
Pengaruh Konseling Apoteker terhadap Pengetahuan dan Persepsi Pasien Penyakit Jantung Terapi Warfarin di RSUP Dr. Hasan Sadikin Bandung Putriana, Norisca A.; Barliana, Melisa I.; Lestari, Keri
Indonesian Journal of Clinical Pharmacy Vol 6, No 4 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (587.367 KB) | DOI: 10.15416/ijcp.2017.6.4.282

Abstract

Warfarin merupakan turunan dari kumarin, yang sudah biasa diresepkan sebagai antikoagulan oral untuk mengobati atau mencegah penyakit-penyakit trombotik. Tujuan dari penelitian ini yaitu untuk menganalisis pengaruh konseling apoteker terhadap pengetahuan dan persepsi pada pasien penyakit jantung pengguna warfarin. Penelitian ini dilaksanakan pada bulan Juli 2012–Februari 2014 di Poli Jantung RSUP Dr. Hasan Sadikin, Bandung. Desain penelitian berupa mixed method. Data kualitatif digunakan untuk mendukung data kuantitatif, dengan metode kualitatif berupa analisis konten dengan cara wawancara. Metode kuantitatif berupa quasi-eksperimental dengan kelompok kontrol pre-post test design. Analisis data penelitian menggunakan uji Wilcoxon dan uji Mann-Whitney dengan level signifikansi p≤0,05 dan analisis multivariat. Hasil penelitian menunjukkan bahwa terdapat pengaruh konseling apoteker terhadap pengetahuan (p<0,05) dan persepsi (p<0,05). Konseling apoteker dapat memperbaiki pengetahuan dan persepsi pasien terapi warfarin.Kata kunci: Konseling, pengetahuan, persepsi, warfarin The Influence of Pharmacist’s Counseling on Knowledge and Perception on Cardiac Patient Warfarin Management at Dr. Hasan Sadikin Hospital BandungWarfarin is a derivate of coumarin, which is usually prescripted as an oral anti-coagulant for treatment and prevention of thromboembolic disorders. The aim of this research was to analyse the influence of pharmacist’s counseling on knowledge and perception on warfarin management. This research was conducted from July 2012 until February 2014 in Cardiac Polyclinic Dr. Hasan Sadikin General Hospital, Bandung. This research used mixed method design. Qualitative data was obtained using content analysis with interview method and used to complete quantitative data. Quantitative method used a quasi-experimental method with control groups and pre-post test design. Data was collected by prospective method and analysed using Wilcoxon and Mann-Whitney test at significance level p≤0.05 and multivariate analysis covariate. The result of this research is pharmacist’s counseling affected knowledge (p<0.05) and perception (p<0.05). Pharmacist’s counseling can improve knowledge and perception on warafarin therapy.Keywords: Counseling, knowledge, perception, warfarin
Permasalahan Terkait Obat (Drug Related Problems/DRPs) pada Penatalaksanaan Penyakit Ginjal Kronis dengan Penyulit Penyakit Arteri Koroner Furqani, Winda H.; Zazuli, Zulfan; Nadhif, Nabilah; Saidah, Siti; Abdulah, Rizky; Lestari, Keri
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.176 KB) | DOI: 10.15416/ijcp.2015.4.2.141

Abstract

Masalah terkait obat (DRPs) didefinisikan sebagai setiap kondisi dalam penatalaksanaan terapi pasien yang menyebabkan atau berpotensi menyebabkan tidak tercapainya hasil terapi yang optimal. Penelitian ini dilakukan di salah satu rumah sakit di Kota Cimahi pada bulan Mei 2014. Pada penelitian ini dilakukan identifikasi DRPs pada pasien wanita berusia 59 tahun yang didiagnosis penyakit ginjal kronis dengan penyulit penyakit arteri koroner dan gangren di tangan kiri (jari ke-3). Pasien diketahui mempunyai riwayat diabetes melitus sejak dua hingga tiga tahun yang lalu. Melalui kajian DRPs ditemukan permasalahan terkait obat, yaitu adanya terapi obat yang tidak diperlukan (pemberian kalsium polistiren sulfonat), ketidaktepatan pemilihan antibiotik, Ketidaktepatan dosis (pemberian amoksisilin dan kaptopril), dan risiko interaksi obat-obat merugikan (interaksi kaptopril–furosemid, kaptopril–isosorbid dinitrat, dan kaptopril–natrium bikarbonat). Pasien penyakit ginjal kronis dengan penyulit penyakit arteri koroner menerima terapi obat yang kompleks sehingga meningkatkan risiko terjadinya DRPs. Keterlibatan apoteker klinis di rumah sakit dalam penatalaksanaan penyakit yang kompleks diperlukan untuk mengoptimalkan terapi, meminimalisir risiko DRPs, dan meningkatkan kualitas hidup pasien.Kata kunci: Drug related problems, penyakit ginjal kronis, penyakit arteri koronerDrug Related Problems in the Management of Chronic Kidney Disease with Coronary Artery DiseaseDrug related problems were defined as conditions on patient’s therapy management that caused, or potentially caused unsuccessful therapy. This study was conducted at a hospital in Cimahi City in May 2014. In this study, DRPs were identified on a 59 years old woman who was diagnosed with chronic kidney disease and coronary artery disease with gangrene on the left hand (the third finger). The patient also had a diabetes mellitus for two until three years ago. Drug related problems (DRPs) were found in this patient. Unnecessary drug therapy (administration of calsium polystirene sulfonate), inappropriate choosen antibiotic, inappropriate dosing (administration of amoxicillin and captopril), and risks drug interactions (captopril–furosemide, captopril–isosorbide dinitrate, and captopril–sodium bicarbonate). Patients with chronic kidney disease and coronary artery disease received complex drug therapy. These condition lead to higer risk of DRPs. The involvement of clinical pharmacist in interdisciplinary team for management of complex diseases was needed to monitor drug therapy to optimizing the therapy, minimalizing the risk of DRPs, and improving patient’s quality of life.Key words: Chronic kidney disease, coronary artery disease, drug related problems
Pengukuran Tingkat Pengetahuan tentang Hipertensi pada Pasien Hipertensi di Kota Bandung: Sebuah Studi Pendahuluan Sinuraya, Rano K.; Siagian, Bryan J.; Taufik, Adit; Destiani, Dika P.; Puspitasari, Irma M.; Lestari, Keri; Diantini, Ajeng
Indonesian Journal of Clinical Pharmacy Vol 6, No 4 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (628.091 KB) | DOI: 10.15416/ijcp.2017.6.4.290

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Hipertensi merupakan penyebab umum dalam peningkatan angka mortalitas dan mobiditas di masyarakat. Selain merupakan silent killer, prevalensi penyakit ini semakin meningkat di seluruh dunia. Prevalensi hipertensi di Indonesia 25,8% dan Jawa Barat berada di peringkat keempat dengan prevalensi 29,4%. Penelitian ini bertujuan untuk mengukur tingkat pengetahuan pasien hipertensi terkait penyakit yang dideritanya. Studi ini merupakan penelitian observasional menggunakan rancangan potong lintang dan dilakukan pada bulan Juni–Oktober 2017 di Apotek Pendidikan Universitas Padjadjaran, Kota Bandung. Sejumlah seratus lima puluh responden mengisi kuesioner yang telah divalidasi setelah menandatangani informed consent terlebih dahulu. Hasil penelitian menunjukkan bahwa sebanyak 56,7% dari responden memiliki tingkat pengetahuan baik, 40% dari responden memiliki tingkat pengetahuan cukup, dan 3,3% dari responden memiliki tingkat pengetahuan kurang. Data kemudian diolah secara statistik sehingga diperoleh hasil bahwa tidak terdapat perbedaan bermakna (p>0,05) antara setiap kelompok responden terhadap sosiodemografi dan karakteristik klinis pasien. Hanya sekitar 50% responden yang memiliki tingkat pengetahuan baik, pasien yang memiliki tingkat pengetahuan cukup dan kurang umumnya adalah pasien dengan tingkat pendidikan rendah dan menderita hipertensi kurang dari lima tahun.Kata kunci: Fasilitas kesehatan primer, hipertensi, tingkat pengetahuan Assessment of Knowledge on Hypertension among Hypertensive Patients in Bandung City: A Preliminary StudyHypertension is a common health problems that can increase the mortality and mobility rate in the community. As a silent killer, the prevalence of this disease is increasing worldwide. The prevalence of hypertension in Indonesia is 25.8% and West Java is ranked at top four with prevalence of 29.4%. This study aimed to measure the level of knowledge of hypertensive patients about their disease. This study was an observational study using cross-sectional design in June–October 2017 at Apotek Pendidikan Universitas Padjadjaran, Bandung City. A total of one hundred and fifty respondents completed a validated questionnaire after signing informed consent. The results showed that 56.7% of respondents have “good” level of knowledge, 40% of respondents have “moderate” level of knowledge, and 3.3% of respondents have “poor” level of knowledge. Data were analyzed statistically, the results showed that there was no significant difference (p>0.05) between each group of respondents to sociodemographic and clinical characteristics of the patients. Only fifty percent of respondents have “good” level of knowledge, patients who have “moderate” and “poor” level of knowledge generally are patients with low levels of education and suffer from hypertension less than five years.Keywords: Hypertension, level of knowledge, primary health care
Pengaruh Pelayanan Informasi Obat terhadap Keberhasilan Terapi Pasien Diabetes Melitus Tipe 2 Insani, Widya N.; Lestari, Keri; Abdulah, Rizky; Ghassani, Salma K.
Indonesian Journal of Clinical Pharmacy Vol 2, No 4 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

pemahaman mengenai instruksi pengobatan merupakan permasalahan utama dalam pengobatan DMT2. Ketidakpatuhan pasien terhadap regimen obat hipoglikemik oral yang kompleks serta ketidaktepatan dalam cara dan waktu pengonsumsiannya merupakan barrier tercapainya keberhasilan terapi DMT2. Hal ini sangat berkaitan dengan kualitas pelayanan kefarmasian yang diberikan kepada pasien, khususnya pelayanan informasi obat. Penelitian ini bertujuan untuk mengevaluasi pengaruh intervensi pelayanan informasi obat terhadap parameter keberhasilan terapi diabetes yaitu glukosa 2 jam postprandial, HDL dan trigliserida. Penelitian ini merupakan nonrandomized concurrent control trial secara prospektif. 14 subjek uji direkrut selama 4 bulan selama Mei–Agustus 2013 kemudian dibagi menjadi dua grup. Kedua grup mendapat terapi pengobatan diabetes berupa hipoglikemik oral. Grup intervensi mendapatkan pelayanan informasi obat dan edukasi mengenai diabetes, sedangkan grup kontrol tidak mendapatkannya. Data dianalisis menggunakan uji t independen dengan α 0,05. Walau belum berbeda signifikan, nilai keberhasilan terapi dengan intervensi pelayanan informasi obat pada parameter glukosa 2 jam postprandial, HDL dan trigliserida memberikan hasil yang lebih tinggi 17,01%; 6,73%; dan 6,31% untuk masing-masing parameter dibandingkan terapi tanpa pelayanan kefarmasian tersebut.Kata kunci: Pelayanan informasi obat, diabetes, obat hipoglikemik oral Effect of Pharmaceutical Information Care on Clinical Outcomes of Patients With Type 2 Diabetes MellitusPoor adherence to medication and lack of understanding about medication instructions are the main problems in the treatment of type 2 diabetes mellitus. Poor adherence to oral hypoglicemic drugs which have complex regiment and unappropriate consumption of them are the obstacles to reach good clinical outcomes. These problems are highly related to the quality of pharmaceutical care given to patients. The aim of this study was to evaluate the effect of pharmaceutical information care towards the outcome of type 2 diabetes mellitus including 2 hours postprandial glucose, HDL and tryglicerides. This study used nonrandomized concurrent control trial prospectively. 14 subjects were recruited during 4 months from May–August 2013 and were divided into two groups. Both of group were given oral hypoglycemic drugs. The intervention group received pharmaceutical information care and diabetes education, whilecontrol group did not receive these. Data were then analysed with independent t test using α 0,005. Although the difference were not significant yet, pharmaceutical information care intervention on diabetes treatment gave higher improvement by 17,01%; 6,73%; and 6,31% respectively in 2 hours postprandial glucose, HDL and tryglicerides parameters, compared with the treatment without pharmaceutical care.Key words: Pharmaceutical information care, diabetes, oral hypoglicemic drugs
Consumption Time of Captopril Influenced the Outcomes of Patients with Stage 1 Hypertension Herdaningsih, Sulastri; Muhtadi, Ahmad; Lestari, Keri
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.853 KB) | DOI: 10.15416/pcpr.v2i1.16213

Abstract

Differences in drugs consumption time may affect its absorption and metabolism in the bodywhich could lead to differences in its efficacy. For hypertension patients, one of the mostfrequently used drugs for lowering blood is captopril. However, information regarding theinfluence of consumption time on captopril efficacy was limited. Therefore, this study wasconducted to compare the efficacy of captopril in lowering blood pressure when administeredbefore and after meal. This was an experimental study with two treatment groups,conducted at Dr. Soedarso General Hospital, Pontianak, Indonesia, during April-June 2015.Statistical analysis was performed using Mann-Whitney, Exact-Fisher, and T-test. We foundout that the reduction of systolic blood pressure in group who consumed captopril beforeand after meal was 30 mmHg and 25 mmHg, respectively (p<0.05). The similar reduction indiastolic bloos pressure was observed in both groups (10 mmHg, p>0.05). In conclusion, itis recommended to take captopril on an empty stomach since it showed better efficacy whenadministered before meal compared to after meal consumption.Keywords: hypertension, captopril, absorption
Hypoglicemia Risk Factors on Hospitalized Type 2 Diabetes Mellitus Patients Jayanti, Meilani; Lestari, Keri; Abdulah, Rizky
Pharmacology and Clinical Pharmacy Research Vol 3, No 2 (2018)
Publisher : Universitas Padjadjaran, Indonesia

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Abstract

Hypoglycemia is one of the most important complications of diabetes treatment and it becomes an obstacle in hypoglycemia medication. Besides, hypoglycemia can cause nerve damage and impaired cognitive function so that it influences the patients mortality, morbidity, and quality of life. Recognition of hypoglycemia risk factors, blood glucose monitoring, selection of appropriate regimens and educational programs for healthcare professionals and patients with diabetes are the major issues to maintain good glycemic control, minimize the risk of hypoglycemia, and prevent long-term complications. This research employs retrospective method and the design of the research is case control.  The sample of this research is 72 patients with type 2 diabetes which is divided into two groups.  The first group is case and It consists of 23 patients (31,9%) getting hypoglycemia. Then, the second group is control and it consists of 49 patients (68,1%). In the second group the 49 patients do not get hypoglycemia and they do not receive any hypoglycemia medication in the hospital. The Results of multivariate logistic regression analysis shows that there is a significant different between the variables reduction in food intake (p 0,011) and lower laboratory result of HbA1C (p 0,003) on the incidence of hypoglycemic, where the variable reduction in food intake has the strong relationship with most major hypoglycemic (OR 9,329). On the other hand, other variables such as the use of antidiabetic drugs, diabetes duration, age, comorbidities and polypharmacy showed no significant association with hypoglycemic events. Thus, the hypoglycemic risk factors in patients with type 2 diabetes receiving antidiabetic therapy due to reduction in food intake and lower laboratory results of HbA1C. Patients with reduction in food intake at risk of hypoglycemic events nine times greater than patients with normal food intake. Keywords: type 2 diabetes mellitus, hypoglycemia, food intake, HbA1C
Pharmaceutical Counseling Has a Positive Impact on Quality of Life of Hypertension Patients Aulia, Gina; Halimah, Eli; Lestari, Keri
Pharmacology and Clinical Pharmacy Research Vol 3, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.668 KB) | DOI: 10.15416/pcpr.v3i1.16449

Abstract

Pharmacists play a major role in educating patients regarding drug therapy, in order to achieve optimal health outcomes. The aim of this study was to investigate the effect of pharmaceutical counseling on quality of life (QoL) of hypertensive patients with renal impairment at one of public hospital in Bandung, Indonesia. This study used a prospective experimental design with pretest-posttest design for 2 months. Inclusion criteria in this study were hypertensive patients with renal impairment who received antihypertensive drugs, aged >18 years, and signed the informed consent. Exclusion criteria were patients who were not able to fill in the questionnaire, patients with end stage renal diseases, diabetes, and pregnant or lactating patients. Pharmaceutical counseling was given during 2 months of the therapy. Pharmaceutical counseling consisted of education on the appropriate use of drugs and disease management. Schedule of their own medication and leaflet containing educational information were given to the subjects. QoL was assessed using a previously validated Mini-Questionnaire of QoL in Arterial Hypertension (MINICHAL). The questionnaire consisted of 16 two dimensions questions, i.e., mental health and somatic manifestation. We found that the mean increase in mental health status (49.5±5.3) was higher than that of somatic dimension (32.7±3.6). Both dimensions had statistically significant improvement (P value <0.05). In conclusion, pharmaceutical counseling is beneficial to improve QoL of hypertension patients.Keywords: hypertension, renal impairment, quality of life 
Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children Rindarwati, Asti Y.; Diantini, Ajeng; Lestari, Keri
Pharmacology and Clinical Pharmacy Research Vol 1, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.813 KB) | DOI: 10.15416/pcpr.v1i3.15218

Abstract

Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients. The most commonly used chelating agents are deferasirox and deferiprone. However, information regarding their effectiveness and side effects in Indonesian children population with TM were limited. This study was conducted to assess the effectiveness and side effects of deferasirox and deferiprone in pediatric patients with TM. This was an observational study with prospective analysis which was conducted during April-August 2015. We included pediatric patients with TM who visited a hospital in Bandung, Indonesia, using consecutive sampling method. Thirty two subjects were divided into two groups, i.e., deferasirox and deferiprone group. Review of medical records and interview were performed for each participants. Effectiveness was defined as reduction in ferritin level. Side effects were assessed using Naranjo scale. Data were analyzed using Mann-Whitney test, Wiloxon test and Chi square test. P value < 0.05 defined statistical significance. We found that deferasirox was more effective than deferiprone for the treatment of TM in pediatric patiens, with less side effects. The use of deferasirox as iron chelating agent is recommended for patients with TM.Keywords: deferasirox, deferiprone, ferritin, thalassemia major
Co-Authors Abdurahman Ridho ADIRA RAHMAWATY Adit Taufik Ahmad Muhtadi AJENG DIANTINI Ajeng Diantini, Ajeng Anas Subarnas Andi Wijaya ANISA MARIETA Anna Meiliana Arifin, Arief Riadi Asti Y. Rindarwati Aulia, Gina Auliya A. Suwantika Babikian, Haig Barliana, Melisa I. BERLIAN HANUTAMI N.P. Bryan J. Siagian Budi Setiabudiawan Catharina A. P. Utami Chandra Agung Purnama Destiani, Dika P. Desyandri Desyandri DIANTINI, AJENG - Dika P. Destiani DILA TRIARINI, DILA Dwi Lestari Sulistyaningsih Eli Halimah Eli Halimah, Eli Erizal Sugiono, Erizal Fadila Nur Annisa Fadlilah, Aida Roja Fajriansyah Fajriansyah FATHYA ULFA Ferdy Ferdian Fitriah Nurhayani Florencia, Carla Furqani, Winda H. Ganis Fitria Fauziyyah Ghassani, Salma K. Gina Aulia Herdaningsih, Sulastri Herdaningsih, Sulastri Iceu Dimas Kulsum Ida Paulina Sormin Iis Rukmawati Iis Rumawati Imam Adi Wicaksono Insani, Widya N. Irma M. Puspitasari Irma M. Puspitasari Irma M. Puspitasari, Irma M. Iskandarsyah, Aulia Ismail, Efriadi Jutti Levita Khaerani, Fitri Azlia Khoirunnisa, Izzatul Kusnendar, Ahmad Nada Magdarita Riwu Maharani, Devita Salsa Meilani Jayanti Melisa I. Barliana Melisa Intan Barliana Melisa Intan Barliana MICHELLE FERDINAND Miswar Fattah Mulyana Mulyana Mulyanto, Sangkan Mutakin Mutakin Nabilah Azka Nihlah Nabilah Nadhif Nabilah Nadhif Nimas T. I. Tarina Norisca A. Putriana Nuning Nurcayani Nyai Ayu Sylfia Stannia Puspitasari Helmi Oktavelia, Wanda Pradana, Eky Septian Prayudi Santoso Putri Kholilah Maulida Putri, Adinda Naswa Putri, Norisca A. Putri, Norisca A. Putriana, Norisca A. Ramadhan, Iqbal Sujida Rano K. Sinuraya Rindarwati, Asti Y. Rini Hendriadi Rizky Abdulah Rizky H. Rambe Salma K. Ghassani Setiawan Setiawan Siagian, Bryan J. Sinuraya, Rano K. Siti Saidah Siti Saidah Soemita, Nanang Sumalim, Yelsen Taofik Rusdiana Taufik, Adit TIANA MILANDA Triatmaja, Dendy Vani Rahmasari Wahyu P. Sari Widya N. Insani Winda H. Furqani Yovita Hartantri YUSUF, RAMAYANI Zaerani, Rani Zelika Mega Ramadhania Zulfan Zazuli