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All Journal Majalah Kedokteran Bandung Althea Medical Journal Jurnal Farmasi Klinik Indonesia Majalah Patologi Indonesia JK Unila (Jurnal Kedokteran Universitas Lampung) Indonesian Journal of Cancer
Herry Yulianti
Departemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Histopathologic Distribution of Appendicitis at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, in 2012 Tara Zhafira; Herry Yulianti; Maman Wastaman
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (581.898 KB)

Abstract

Background: Appendicitis is a medical emergency and a common cause of emergency surgeries worldwide. Its frequency is varied based on many factors, including age and sex. Histopathologic examination is a gold standard for diagnosis, and complications like gangrene formation and perforation lead to high mortality and morbidity in almost all age groups. This study was conducted to describe the distribution pattern of appendicitis according to age, sex, and histopathologic type. Methods: This cross-sectional study was carried out in the Department of Pathology Anatomy, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from August–October 2013. Secondary data were obtained from medical records of January 1st to December 31st, 2012. A total of 503 out of 516 cases were included to be reviewed. Age, sex, and histopathologic type from medical records were then evaluated. Any specific case and perforation were also noted.Results: Data showed the highest prevalence of appendicitis occurred in the 10- 19 age group (28.4%) and in the female group (52.3%). Acute appendicitis was more common than chronic appendicitis in both sexes and all age groups. Perforation rate was high (41.4%), and was more prevalent in male (54.9%) and in the 0–9 age group (65.7%).Conclusions: Appendicitis, both acute and chronic, is more distributed in the second decade, and is slightly more prevalent in females. Acute cases are more common than chronic. Perforation rate is significant and peaks in the first decade and in males. [AMJ.2017;4(1):36–41]DOI: 10.15850/amj.v4n1.1017
Effects of White Turmeric Infusion on the Liver Cells in Carbon Tetrachloride-Induced Mice Fitria Oktaviani; RB. Soeherman Herdiningrat; Herry Yulianti
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: The liver is an organ that has important functions in the body. Liver damage can be caused by oxidative stress and free radicals. White turmeric (Curcuma zedoaria L) contains antioxidants that can be used to neutralize the effects of free radicals. This study was conducted to determine the effect of white turmeric infusion on histological appearance of liver cells in male mice induced by carbon tetrachloride (CCl4).Methods: This laboratory experimental study was conducted using male mice (Mus musculus) with Balb/c strain. Thirty-three mice were randomly divided into 3 groups i.e.,group 1 as a control group was given standard food and drink, group 2 was given 10% of CCl4 0.1 ml by intraperitoneal injection on the first day and group 3 was given 10% of CCl4 0.1 mL by  ntraperitoneal injection on the first day, followed by the administration of 50% of white turmeric infusion 0.2 mL. Kruskal-Wallis test method was used to analyse the significant differences of the average percentage of damaged liver cells in the group given CCl4 alone with the group given CCl4 and white turmeric infusion and control group.Results: The percentage of damaged liver cells between groups of mice given CCl4 alone and the group given CCl4 followed by white turmeric infusion were respectively(p <0.05) compared to group1.Conclusions: Administration of white turmeric infusion gave an influence by decreasing the percentage of damaged liver cells in CCl4-induced mice. White turmeric can serve as an alternative antioxidants that can be used to neutralize the effects of free radicals. [AMJ.2015;2(4):506–10] DOI: 10.15850/amj.v2n4.498
Reseptor Vitamin D (VDR) dan Phosphatidylinositol 3-Kinase (PI3K) Secara Independen Memengaruhi Diferensiasi Adenokarsinoma Kolorektal Yulie Erida; Hermin Aminah; Herry Yulianti; Bethy S. Hernowo
Indonesian Journal of Clinical Pharmacy Vol 4, No 4 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3001.36 KB) | DOI: 10.15416/ijcp.2015.4.4.264

Abstract

Terapi target (targeted therapy) pada karsinoma kolorektal merupakan terapi alternatif yang diharapkan memberikan hasil yang lebih baik diantaranya dengan pemberian metabolit aktif vitamin D, yaitu calcitriol dan inhibitor Phosphatidyl Inositol 3 Kinase (PI3K). Penelitian ini bertujuan untuk mengetahui korelasi imunoekspresi VDR dan PI3K terhadap derajat diferensiasi adenokarsinoma kolorektal. Penelitian ini menggunakan desain potong lintang dengan analisis kategorik dari 30 blok parafin adenokarsinoma kolorektal (kelompok low grade dan high grade masing-masing 15 kasus) dari Departemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran/RSUP Hasan Sadikin Bandung. Analisis Lambda menunjukkan bahwa imunoekspresi VDR dan PI3K masing-masing memengaruhi diferensiasi adenokarsinoma kolorektal (p=0,029, p=0,0225, R= 0,533). Berdasarkan nilai p, PI3K lebih kuat daripada VDR dalam memengaruhi derajat diferensiasi. Analisis Spearman menunjukkan imunoekspresi VDR dan PI3K tidak terbukti berkorelasi dengan diferensiasi (p=0,186, p>0,05, R: 0,248) secara bersamaan/simultan. Imunoekspresi VDR dan PI3K berkorelasi positif dengan kelompok low grade. Disimpulkan bahwa VDR tidak menggunakan jalur MAPK bersama-sama dengan PI3K dalam memengaruhi diferensiasi adenokarsinoma kolorektal.Kata kunci: Adenokarsinoma kolorektal, diferensiasi, imunoekspresi PI3K, imunoekspresi VDRVitamin D Receptor (VDR) and Phosphatidylinositol 3-Kinase (PI3K) Independently Affected Colorectal Adenocarcinoma Differentiation Targeted therapy in carcinoma colorectal such as is as calcitriol and Phosphatidyl Inositol 3 Kinase (PI3K) is an alternative therapy for better treatment outcome. The aim of this study was to determine the correlation between VDR and PI3K immunoexpression with the degree of differentiation (grading) in colorectal adenocarcinoma. Cross-sectional, categorical analysis of 30 paraffin blocks of colorectal adenocarcinoma (low and high grade group, 15 cases each) obtained from Department of Pathology Faculty of Medicine, Universitas Padjadjaran/Dr Hasan Sadikin General Hospital Bandung. Analysis of Lambda showed that immunoexpression of VDR and PI3K affected differentiation of colorectal adenocarcinoma (p=0.029, p=0.0225, R=0.533). Based on p value, PI3k is stronger than VDR in influencing the degree of differentiation. Spearman analysis showed that simultaneous immunoexpression of VDR and PI3K was not shown to correlate with differentiation (p= 0186, p<0.05, R: 0.248). Positive immunoexpression of VDR and PI3K correlates with low-grade group. It can be concludes that VDR does not use the MAPK pathway together with PI3K to affect differentiation of colorectal adenocarcinoma.Keywords: Colorectal adenocarcinoma, differentiation, PI3K immunoexpression, VDRImmunoexpression
Imunoekspresi Poly (ADP-Ribose) Polymerase sebagai Petanda Kemoresisten pada Karsinoma Ovarium Retno Westiningrum; Hermin A. Usman; Herry Yulianti; Bethy S. Hernowo
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2794.834 KB) | DOI: 10.15416/ijcp.2018.7.2.115

Abstract

Karsinoma ovarium merupakan keganasan kelima terbanyak dan penyebab kematian ginekologi pertama di dunia. Kemoterapi merupakan modalitas terapi utama karsinoma ovarium dengan stadium lanjut setelah dilakukan pembedahan. Poly (ADP-Ribose) Polymerase (PARP) dan B cell Lymphoma-2 (Bcl-2) merupakan petanda imunohistokimia yang berfungsi dalam proses DNA repair dan anti-apoptosis yang merupakan bagian dari lingkaran mekanisme kerja regimen kemoterapi pada sel tumor. Oleh karena itu dua mekanisme tersebut dianggap memegang peranan penting terhadap terjadinya resisten kemoterapi bahkan rekurensi. Tujuan penelitian ini adalah melihat hubungan imunoekspresi PARP dan Bcl-2 dengan respons kemoterapi pada karsinoma ovarium. Penelitian ini menggunakan desain analisis observasi secara potong lintang dengan menggunakan blok parafin pasien yang didiagnosis sebagai karsinoma ovarium selama periode tahun 2012−2015 di Departemen Patologi Anatomi RSUP Dr Hasan Sadikin Bandung. Jumlah sampel sebanyak 58 kasus yang terdiri atas 30 kasus kemoterapi sensitif dan 28 kasus kemoterapi resisten, keseluruhan sampel dilakukan pulasan imunohistokimia PARP dan Bcl-2. Analisis data menggunakan uji Chi-Square dengan taraf signifikansi 5%. Hasil dari penelitian ini adalah 60% sampel terekspresi PARP kuat dengan proporsi terbesar pada kelompok resisten (p=0,001) dan 74% sampel terekspresi Bcl-2 lemah dengan proporsi sama pada tiap kelompok respon kemoterapi (p=0,45). Respons kemoterapi sangat dipengaruhi oleh proses DNA repair yang dapat dinilai dengan pemeriksaan imunoekspresi PARP. Semakin tinggi imunoekspresi PARP maka semakin tinggi kemampuan DNA repair sehingga semakin tinggi kemungkinan kemoterapi resisten.Kata kunci: Bcl-2, karsinoma ovarium, kemoterapi, PARP Poly (ADP-Ribose) Polymerase Immunoexpression as Chemoresistance Marker in Ovarian CarcinomaAbstractEpithelial ovarian cancer (EOC) is the fifth most common cancer and the main cause of gynecological cancer death worldwide. Chemotherapy is the main therapy in advanced stage of EOC. Poly (ADP-Ribose) Polymerase (PARP) dan B cell Lymphoma-2 (Bcl-2) are immunohistochemistry markers that represent influential factors in chemotherapy response which have roles in DNA repair and anti-apoptosis. The aim of this study was to review the correlation between PARP and Bcl-2 expression with chemotherapy response in EOC. This research was performed as analytic-observational with cross-sectional design using paraffin block of patients diagnosed as EOC in 2012–2015 at Anatomical Pathology Department, Hasan Sadikin Hospital Bandung. Total sample was 58 cases which were divided into chemotherapy sensitive and resistant. All samples were stained by immunohistochemistry PARP and Bcl-2 and analysed using Chi-Square test with significant level of 5%. The results of this study showed that 60% of all samples have strong PARP expression whereas the largest proportion is in chemotherapy resistant group (p=0.001) and 74% of all samples have weak Bcl-2 expression in each group (p=0.45). The conclusion of this study in chemotherapy response was influenced by PARP. Higher PARP immunoexpression showed higher tumour cell ability to repair DNA and higher chemotherapy resistance.Keywords: Bcl-2, chemotherapy, EOC, PARP
Hubungan Imunoekspresi CD44 dengan Metastasis Karsinoma Papilari Tiroid Yasni Iryani Widiasih; Herry Yulianti; Hasrayati Agustina; Bethy S Hernowo
Jurnal Kedokteran Universitas Lampung Vol 3, No 1 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i1.2202

Abstract

Karsinoma tiroid (KT) merupakan keganasan endokrin yang paling sering terjadi dan karsinoma papilari tiroid (KPT) adalah tipe histopatologis terbanyak mencapai 80%. KPT mempunyai perangai yang baik dengan pertumbuhan yang lambat. Namun ditemukan KPT dengan perangai yang agresif, ditandai dengan metastasis ke KGB lebih dari 50% kasus. Cluster of Differentiation 44 (CD44) merupakan penanda imunohistokimia yang berperan dalam memprediksi sifat agresif tumor ganas payudara. Namun peran CD44 pada KPT belum diketahui dengan pasti. Tujuan penelitian ini adalah mengetahui hubungan antara imunoekspresi CD44 dengan metastasis pada KPT.Penelitian ini merupakan penelitian cross sectional terhadap kasus KPT yang didiagnosis secara histopatologis di Departemen Patologi Anatomi RSUP Dr Hasan Sadikin Bandung tahun 2012-2017. Jumlah sampel sebanyak 60 sampel yang terdiri dari 30 kasus KPT non metastasis dan 30 kasus KPT metastasis, keseluruhan sampel dilakukan pulasan imunohistokimia CD44 .Imunoekspresi CD44 pada kelompok metastasis terekspresi lemah pada 6 kasus (20,0%) dan terekspresi kuat pada 24 kasus (80,0%), sedangkan pada kelompok non metastasis terekspresi lemah pada 13 kasus (43,3%) dan terekspresi kuat pada 17 kasus (56,7%) dengan nilai p value 0,052. Hasil dari penelitian ini adalah tidak terdapat hubungan yang signifikan secara statistik antara imunoekspresi CD44 terhadap metastasis. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa CD44 tidak berperan di dalam metastasis dan tidak dapat dijadikan penanda untuk memprediksi metastasis pada kasus KPT serta diperlukan penelitian lanjutan dengan pemilihan penanda yang lebih selektif.Kata Kunci : agresif, CD44, KPT, metastasis
Association of Vascular Endothelial Growth Factor (VEGF) and Mammalian Target of Rapamycin (mTOR) with Radiotherapy Response in High-Grade Sarcomas Eny Soesilowati; Afiati Afiati; Herry Yulianti; Bethy Suryawathy Hernowo; Adji Kusumadjati
Indonesian Journal of Cancer Vol 16, No 2 (2022): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1509.397 KB) | DOI: 10.33371/ijoc.v16i2.868

Abstract

Background: Sarcoma is a rare malignant aggressive tumor originating from mesenchymal elements. High-grade sarcoma has a poor prognosis. The mortality rate of high-grade sarcomas is 50–75%. Radiotherapy is needed in high-grade sarcoma. Radioresistance in the high-grade sarcoma is still common. Vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) are molecular markers that play a role in radioresistance. This study aimed to analyze the association of VEGF and mTOR with radiotherapy response in high-grade sarcoma. Method: This study was an analytic observational study with a cross-sectional design. The minimum samples based on Lameshow’s formula included 40 selected paraffin-embedded tissue blocks from biopsy high-grade sarcoma, consisting of 20 samples of radioresistance and 20 samples of radiosensitive. Immunohistochemistry staining for VEGF and mTOR were performed on all samples. Statistical analysis used the Chi-Square test. The significance of the data was obtained when p-value <0.05.Result: High immunoexpression of VEGF (OR = 17, p < 0.05) and mTOR in high-grade sarcoma showed a significant association with radiotherapy response (OR = 16, p < 0.05). The stepwise logistic regression analysis revealed that both VEGF and mTOR immunoexpression influenced radiotherapy response simultaneously. Conclusion: In this study, which used a minimum sample, it can be concluded that the higher VEGF and mTOR immunoexpression showed the higher radioresistance in high-grade sarcoma.  
Gambaran Klinis dan Histopatologis Limfoma Non Hodgkin Sistem Pencernaan di RSUP Dr. Hasan Sadikin Bandung Tahun 2018-2020 Maharani Tasyandita, Raina; Suryawathy Hernowo, Bethy; Yulianti, Herry
Majalah Patologi Indonesia Vol. 32 No. 1 (2023): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i1.562

Abstract

BackgroundNon-Hodgkin's lymphoma (NHL) is an abnormal growth of lymphocytes that manifests as tumor or enlargement of lymph nodes (lymphadenopathy). New NHL cases in Indonesia in 2020 reached 16.125 cases (4.1%) with 9.024 deaths (3.6%). The WHO classification categorizes NHL into two, B cells and T/NK cells.2 NHL is also divided into low-grade and high-grade based on its progression. The gastrointestinal tract is the most frequently involved extranodal site in NHL. The clinical manifestations of NHL can be non-specific and vary depending on anatomic location. This study aims to determine the clinical and histopathological features in patients with gastrointestinal NHL.MethodsThis research is a descriptive study using medical record data of inpatients at RSUP Dr. Hasan Sadikin Bandung period 2018-2020 diagnosed with gastrointestinal NHL.ResultsPatient characteristics were dominated by patients aged 40 years and male (65.2%), with the most clinical manifestations being enlarged lymph nodes. NHL most often attacks the liver (26.1%) and most patients present at stage IV (34.8%). The most histopathological features were B cells (52.5%) and high-grade (43.5%).ConclusionThe risk of gastrointestinal LNH increases with age and the majority is in men. Clinical manifestations vary and can show local or constitutional symptoms. Most patients are found to be in the late stages and among all gastrointestinal system, most NHL attacks the liver. Many patients were not subjected to further immunohistochemical examination, but the most common histopathological features were B cells and high grade NHL.
Co-Authors Abdul Hadi Hassan Abdul Hadi Hassan, Abdul Hadi Adji Kusumadjati Afiati Afiati Afiati Aminah, Hermin Bethy S Hernowo Bethy S. Hernowo Bethy S. Hernowo Bethy S. Hernowo Bethy Surjawathy Hernowo, PhD, SpPA(K) Bethy Suryawathy Hernowo Bethy Suryawati Hernowo Eny Soesilowati Eny Soesilowati Erida, Yulie Erida, Yulie Fitria Oktaviani Fitria Oktaviani, Fitria Hasrayati Agustina Hermin A. Usman Hermin Aminah Hermin Aminah Hermin Aminah Usman Maharani Tasyandita, Raina Maman Wastaman RB. Soeherman Herdiningrat Retno Westiningrum Sri Dharmayanti Suryawathy Hernowo, Bethy Tara Zhafira Usman, Hermin A. Wastaman, Maman Westiningrum, Retno Yasni Iryani Widiasih Yulie Erida Zhafira, Tara