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All Journal Jurnal Ilmu Kesehatan Heart Science Journal Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Fransiska Anggreni Sihotang
Laboratorium Fisiologi Fakultas Kedokteran Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : heart science journal

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Multimodality imaging in evaluation of cardiac masses Sihotang, Fransiska Anggreni; Handari, Saskia Dyah
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.8

Abstract

Cardiac masses are infrequently encountered in routine cardiology practice but often pose as a diagnostic challenge. Cardiac masses can be categorised as either neoplastic (benign and malignant) or non-neoplastic, and as either primary or secondary. The prognosis is contingent upon the identification of the mass, as treatment choices vary significantly. Histopathology remains the most dependable approach for diagnosing any cardiac tumour. Nevertheless, given its invasive characteristics, cardiac imaging plays a crucial role in diagnosing cardiac masses. The emergence of new imaging tools necessitates a multimodality strategy to assess intracardiac masses. This approach is crucial for non-invasive evaluation before considering surgical planning or oncological treatment. This article aims to compare the different imaging techniques, particularly echocardiography, cardiovascular magnetic resonance, cardiac computed tomography, and nuclear imaging, in terms of their clinical applications in the evaluation of cardiac masses and to determine distinctive features on these modalities for the most prevalent intracardiac masses.
When bones meet blood vessels: BMP-2 expression and vascular calcification in a rat model of metabolic syndrome Sihotang, Fransiska Anggreni; Rohman, Muhammad Saifur; Satrijo, Budi; Sargowo, Djanggan; Rizal, Ardian
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.14

Abstract

Background: Vascular calcification (VC) is a significant contributor to cardiovascular morbidity, particularly in conditions like metabolic syndrome (MetS). Bone Morphogenetic Protein-2 (BMP-2) is implicated in the osteogenic differentiation of vascular cells, potentially linking MetS to VC. Objective: This study aimed to investigate aortic BMP-2 expression and the presence of VC in a rat model of MetS and assess the effects of Metformin, Empagliflozin, and a green tea/green coffee extract combination. Methods: Male Sprague-Dawley rats were induced with MetS using a high-fat, high-sucrose diet combined with a low-dose streptozotocin injection (30 mg/kgBW). Rats were divided into five groups (n=5): Normal control (NORM), MetS (METS), MetS + Metformin (MFN, 500 mg/kgBW), MetS + Empagliflozin (EMP, 30 mg/kgBW), and MetS + GTCE (300 mg/kgBW green tea + 200 mg/kgBW green coffee). Treatments were administered daily via oral gavage for 9 weeks. Result: Aortic tissue was collected for histological analysis and qRT-PCR to measure relative BMP-2 mRNA expression. Histological analysis revealed calcification in the aortic wall of the METS group rats. Compared to the NORM group, BMP-2 mRNA expression was significantly upregulated in the METS group (p<0.001). Treatment with MFN, EMP, and GTCE significantly downregulated BMP-2 mRNA expression compared to the METS group (p<0.001 for all). Conclusion: This study demonstrates that MetS induction in this rat model might promotes aortic calcification and significantly increases BMP-2 mRNA expression. Pharmacological interventions with Metformin, Empagliflozin, and green tea/coffee extract attenuated the MetS-induced upregulation of BMP-2 expression. These findings suggest a potential role for BMP-2 in MetS-associated vascular changes.
Co-Authors Djanggan Sargowo Doni Suryadi Doni Suryadi Fadillah Hana Hafifah Kalalo, Lily Pertiwi Lily Pertiwi Kalalo Loly Rotua Dharmanita Siagian Mudinillah, Adam Muhammad Saifur Rohman Novia Fransiska Ngo Nur Khoma Fatmawati Rizal, Ardian Saskia Dyah Handari Satrijo, Budi Siagian, Loly Rotua Dharmanita Siti Khotimah Vera Madonna Lumban Toruan Winda Puspita Salim Yetty Octavia Hutahaean