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All Journal Majalah Kedokteran Bandung Sari Pediatri Jurnal Sistem Kesehatan Paediatrica Indonesiana Jurnal Perspektif Manajerial dan Kewirausahaan (JPMK)
Novina Novina
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin Bandung
Humanities Economics, Econometrics & Finance Environmental Science Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences

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Journal : Paediatrica Indonesiana

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Subclinical hypothyroidism in pediatric nephrotic syndrome: the correlations with albumin, globulin, and proteinuria Erni Nuraeni; Faiisal Faisal; Ahmedz Widiasta; Novina Novina
Paediatrica Indonesiana Vol 60 No 2 (2020): March 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.05 KB) | DOI: 10.14238/pi60.2.2020.91-5

Abstract

Background Nephrotic syndrome causes loss of medium-sized plasma proteins and binding proteins, resulting in thyroid hormone deficiency. Objective To assess for potential correlations between subclinical hypothyroidism in pediatric nephrotic syndrome with albumin, globulin, and proteinuria. Methods This cross-sectional study was conducted in the Department of Pediatrics, Hasan Sadikin General Hospital, Bandung, West Java. All types of nephrotic syndrome patients aged 1 month to < 18 years were included. Blood and urine specimens were collected from the patients for albumin, globulin, thyroid function (T3, fT4 and TSH), and proteinuria tests and analyzed with standard techniques. Results There were 26 subjects, 20 males and 6 females. Ten subjects developed subclinical hypothyroidism, with mean albumin and thyroid-stimulating hormone (TSH) levels of 0.92 g/dL and 6.9 mIU/L, respectively. There was a negative correlation between albumin level and subclinical hypothyroidism (rpb=-0.702; P<0.001) and a positive correlation between proteinuria and subclinical hypothyroidism (r=0.573; P=0.003). Univariate logistic regression analysis revealed that globulin had no impact on the presence of subclinical hypothyroidism, but albumin and proteinuria did have such an impact. The odds ratios of albumin and proteinuria with subclinical hypothyroidism were 27.00 (95%CI 1.69 to 17.7) and 19.80 (95%CI 1.94 to 201.63), respectively. Conclusion Subclinical hypothyroidism correlates with serum albumin level and proteinuria in nephrotic syndrome patients. Tha low serum albumin level has a high likelihood of subclinical hypothyroidism.
Recurrent impending thyroid storm in a girl with Graves’ disease: a case report Novina, Novina; Putri, Nisa Hermina; Pramudani, Nadia; Faisal, Faisal
Paediatrica Indonesiana Vol. 63 No. 6 (2023): November 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.6.2023.517-20

Abstract

Thyroid storm is an acute, life-threatening, hypermetabolic state in children with thyrotoxicosis. Before the thyroid storm occurs, the patient falls into a “warning stage” called impending thyroid storm. Rapid diagnosis and prompt treatment of an impending thyroid storm are crucial to prevent further life-threatening impacts. We describe a pediatric patient who experienced two episodes of impending thyroid storm with negative COVID-19 tests during the COVID-19 pandemic.
Co-Authors Adhitya Agung Pratama Ahmedz Widiasta Alex Chairulfatah Apriani, Ari Dida Akhmad Gurnida Eddy Fadlyana Erni Nuraeni Faiisal Faisal Faisal Faisal Faisal Faisal Faisal Faisal Lulu Eva Rakhmilla Nanan Sekarwana Nova Sylviana Pramudani, Nadia Putri, Nisa Hermina Renita Dewi Supyana