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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Cendekia Eksakta Media Farmasi Indonesia Journal of Tropical Pharmacy and Chemistry
Dwi Hadi Setya Palupi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health Other

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PROFIL PENGGUNAAN IMUNOSUPRESAN PADA PASIEN RHEUMATOID ARTHRITIS DI INSTALASI RAWAT JALAN SALAH SATU RUMAH SAKIT DI KOTA SEMARANG Eka Pratiwi, Arik Dian; Setya Palupi, Dwi Hadi; Hanifah, Hananun Zharfa
CENDEKIA EKSAKTA Vol. 9 No. 1 (2024)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v9i1.11021

Abstract

Rheumatoid arthritis (RA) merupakan penyakit autoimun, kronis disertai inflamasi dan kaku sendi. Salah satu kelompok obat yang penting dalam terapi RA adalah imunosupresan seperti golongan DMARD (Disease Modifying Anti Rheumatic Drugs) dan glukokortikoid. Pemilihan dan penggunaan obat yang tepat dan rasional akan menentukan keberhasilan pengobatan walaupun efektivitas dari obat pada pasien sangat bervariasi. Maka dari itu perlu dilakukan penelitian terkait pengkajian terapi imunosupresan pada pasin RA. Tujuan studi ini untuk mengetahui pola penggunaan imunosupresan pada pasien RA di instalasi rawat jalan salah satu rumah sakit di Kota Semarang periode Januari – Desember 2022. Penelitian ini merupakan penelitian non-eksperimental (observasional) bersifat deskriptif dan retrospektif yang memenuhi kriteria inklusi. Penelitian ini menggunakan teknik purposive sampling. Pengambilan data melalui catatan rekam medis pasien kemudian dianalisis secara deskriptif. Total sampel dalam studi ini sejumlah 100 pasien. Hasil penelitian menunjukkan bahwa imunosupresan yang paling banyak diresepkan untuk pasien RA adalah golongan DMARD sintetik konvensional (csDMARD) yaitu methotrexate (MTX) mencapai 94 pasien dengan dosis terapi yang paling banyak diresepkan 7,5 mg/minggu secara per oral (61 pasien). Kombinasi MTX+sulfasalazine termasuk dalam peresepan imunosupresan dengan persentase tertinggi mencapai 23% diikuti MTX monoterapi 20%. MTX menjadi pilihan utama untuk terapi RA baik dalam bentuk monoterapi maupun kombinasi. Kata kunci: DMRAD, imunosupresan, MTX, rheumatoid arthritis
EFEK IMUNOMODULATOR EKSTRAK ETANOL DAUN SOM JAWA (Talinum triangulare (Jacq.) Willd) PADA MENCIT JANTAN GALUR SWISS Wulansari, Rina; Setya Palupi, Dwi Hadi; Puspitaningrum, Ika
Media Farmasi Indonesia Vol. 11 No. 1 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.439 KB)

Abstract

SARIDaun som jawa memiliki beberapa senyawa bioaktif diantaranya flavonoid.Flavonoid dapat mempengaruhi sistem imunitas melalui aktivitasnya padamakrofag. Penelitian ini bertujuan untuk mengetahui efek imunomodulator dandosis efektif dari ekstrak etanol daun som jawa (Talinum triangulare (Jacq.)Willd) terhadap respon imun non spesifik dan respon imun spesifik pada mencitjantan galur Swiss. Hasil pengujian aktivitas fagositik hewan uji berturut-turutpada ekstrak etanol daun som jawa dosis 50, 100, dan 150 mg/kgBB sebesar1,15124; 1,14982; 1,38195. Aktivitas ekstrak etanol daun som jawa juga dapatmeningkatkan berat organ limfoid (hati, limpa, timus) secara bermakna (p< 0,05)dibanding kontrol negatif dan tidak berbeda bermakna dibanding kontrol positif(p> 0,05). Ekstrak etanol daun som jawa mampu mempengaruhi respon imunseluler secara bermakna (p< 0,05) dibanding kontrol negatif dan tidak berbedabermakna dibanding kontrol positif (p> 0,05) pada dosis 100, dan 150 mg/kgBB.Ekstrak etanol daun som jawa ketiga dosis mampu meningkatkan nilai titerantibodi primer dan sekunder. Ekstrak etanol daun som jawa mempunyai efekimunostimulan terhadap respon imun non spesifik dan respon imun spesifik.Dosis efektif dari ekstrak etanol daun som jawa ditetapkan sebesar 100 mg/kgBB.
Imunomodulator Activity of Three Types “Kayu Kuning” Borneo Dwi Hadi Setya Palupi; Riski Sulistiarini; Vita Olivia Siregar
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.375

Abstract

The immune system is a system that plays a role in maintaining the integrity of the body against the dangers that various foreign objects can cause. Immunomodulators are substances or substances that can change/modify the immune system. Empirically, Kayu Kuning or Yellow Wood is used as a cleaner for post-partum conditions. Yellow wood in East Kalimantan is the name for three species, namely Arcangelisia Flava, Fibraurea tinctoria, and Coscinium fensteratum. With the approach of improving the immune system and metabolism, immunomodulatory tests carried out on three types of yellow wood found in Borneo Island. The immunomodulatory activity of Yellow wood steam extract in the non-specific immune response test used phagocytic index and organ index parameters where BALB/c female mice were randomly divided into 16 treatment groups which included a normal group, an immunostimulant comparison group (Levamisole 2.5 mg/kg body weight), an immunosuppressant comparison group (Methylprednisolone 40mg/kg BW), a test extract group with a dose of 100 mg/kg body weight, for the ethanolic extracts of A. Flava, F. tinctoria and C. fenestratum, respectively. Based on the study results, it means that the methanol extract of A. Flava methanol extract had immunostimulating activity, while the methanol extract of F. tinctoria and C. fenestratum showed an immunosuppressant effect
Potensi Stabilisasi Membran Sel dari Ekstrak Berbeda Kepolaran Sirih Bumi (Peperomia pellucida [L.] Kunth) sebagai Agen Antiinflamasi Ayu Kartika, I Gusti Agung; Suryani, Suryani; Setya Palupi, Dwi Hadi; Adnyana, I Ketut
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1440

Abstract

Sirih bumi (Peperomia pellucida [L.] Kunth.) is a medicinal herb. Anti-inflammatory activities are reported. These plant extracts have been shown to reduce inflammation in many studies, but it is unknown which extract works best. The objectives if this study were determine the extract that has the best anti-inflammatory activity from sirih bumi. The activity was assessed from the impact of stabilising red blood cell membranes in vitro. The research was then continued with a literature study on the chemical compounds containing the best extracts. To determine the prediction of the compound responsible for its activity and potency, several in silico tests were carried out, such as PASS online, Pre-ADMET online, and Protox II. The test results showed that the ethyl acetate extract at 200 g/mL concentration showed similar activity to aspirin at the same concentration. The activity of this extract increased with increasing concentration of the extract. Six compounds were reported to be isolated from this type of extract. Dillapiol and its derivative 6-allyl-5-methoxy-1,3-benzodioxol-4-ol are predicted to be compounds that have anti-inflammatory effects by inhibiting the membrane permeability mechanism of ethyl acetate extract. Ethyl acetate extract showed the best anti-inflammatory activity among the other type of extract from sirih bumi. Ethyl acetate extract is a type of extract with the best anti-inflammatory activity from sirih bumi.
Co-Authors Eka Pratiwi, Arik Dian Hananun Zharfa Hanifah I Gusti Agung Ayu Kartika I Ketut Adnyana Ika Puspitaningrum Sulistiarini, Riski Suryani Suryani Vita Olivia Siregar Wulansari, Rina