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All Journal Ophthalmologica Indonesiana JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Yurike Mandrasari
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Health Professions Medicine & Pharmacology Public Health

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INTRAOCULAR PRESSURE (IOP) IN CHILDREN WITH DEVELOPMENTAL DISABILITIES IN MALANG; WHICH TYPE OF DISABILITY IS MOST AT RISK? Oral Presentation - Observational Study - Resident YURIKE MANDRASARI; Lely Retno Wulandari; Nanda Wahyu Anandita; Anny Sulistiyowati
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/67b5nb71

Abstract

Abstract Introduction & Objectives : Visual disabilities are the highest percentage of disabilities affecting children under five years old at about 0.17%. Childhood glaucoma affects over 300,000 children worldwide. 6.8% of Cerebral palsy children have high IOP. Developmental disabilities children require services to manage eye development. There is not much data on their eye examinations, especially IOP. This study aimed to know IOP values in children with developmental disabilities based on the type of disabilities in Malang. Methods : We measured IOP on 233 children with developmental disabilities, 6-19 years old, in 8 special education elementary schools, divided into 6 groups based on the types, namely autism, cerebral palsy, physical impairment, intellectual impairment, deafness and speech impairment, and others (with informed consent). IOP measurement using Icare Tonometer TA03, then categorized into 2 groups, normal and high IOP. Observation period 2019-2020. Results : Tonometer measurement can be done in 320 eyes of 163 children, with mean age of 11.14 years old. The mean value of IOP was 18.62 mmHg, the lowest was 9.5 mmHg, and the highest was 31.1 mmHg (SD± 3.39). Eyes with normal lOP are 245 eyes (76.6.%) mostly from intellectual impairment and high IOP are 75 eyes (23.4.%) mostly from deafness and speech impairment. Conclusion : There is a significant difference between IOP and type of developmental disability in children. Children with deafness and speech impairment have higher IOP than others, since they have high risk of ocular problems. IOP are influenced by outflow facility, aqueous humor production rate, episcleral venous pressure and uveoscleral flow rate.
Pengaruh Induksi Cathepsin K terhadap Pembetukan Imunoglobulin (IgG) Anti-Cathepsin K, Osteosit, dan Kadar Alkaline Phosphatase (ALP) pada Tikus Putih (Rattus norvegicus L. Betina Galur Wistar Pascaovariektomi Fransisco Wahyu Santoso; Arif Ismail; Oktavia Rahayu Adianingsih; Yurike Mandrasari
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 1 No 2 (2012): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Abstract

ABSTRACT Osteoporosis is a "silent disease" that can weaken bones and cause fractures. Two from five of Indonesia's population at risk of osteoporosis and it is estimated in 2025 that number will become tripled. It has been found a kind of drug, that serves as cathepsin K inhibitors, that shows great potential in reducing osteoporosis. Cathepsin K has an important role in tissue destruction, bone remodeling, and cartilage destruction, This study is aimed to verify the effect of the cathepsin K vaccine candidate to the decrease of bone resorption in Rattusnorvegicus strain wistar post-ovariectomy. Female Rattusnorvegicas Strain Wistar (age: 10-12 weeks) are divided into 5 groups: control (-), control (+) with ovariectomy, the treatment groups are ovariectomized and given cathepsin K 50 ng/200 µL, 100 ng/200 µL, and 200 ng/200 µL.. Surgery perform on the 30th day and then IgG titers of anti-cathepsin K and ALP serum level are measured and the number of osteocytes is counted. ANOVA test shows that the administration of the vaccine candidate, cathepsin K that are added with CFA-IFA, is significantly increase the titers of IgG anti-cathepsin K in the serum (p = 0.00). The administration of cathepsin K 50 ng/200 µL, 100 ng /200 µL, and 200 ng/200 µL do not significantly reduce the number of osteocytes. The administration of cathepsin K 50 ng/200 µL, 100 rig / 200 µL, and 200 ng/200 µL do not increase the ALP serum levels (p> 0.05) significantly. The conclusion of the study is that the administration of the cathepsin K vaccine candidate can increase the IgG anti-cathepsin K titers in Female Rattusnorvegicus Strain Wistar Rats Post-ovariectomy, but do not significantly affect the number of osteocytes and ALP serum levels. Therefore, the osteoporosis vaccine candidate with cathepsin K as a basic material still need to be researched and develop
Co-Authors Anny Sulistiyowati Arif Ismail Fransisco Wahyu Santoso Lely Retno W Oktavia Rahayu Adianingsih Wahyu Anandita, Nanda