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All Journal Jurnal Mitra Kesehatan Indonesian Journal on Medical Science (IJMS) Sinteza Journal of Clinical Pharmacy and Pharmaceutical Science Jurnal Pengabdian Ikifa
Sisca Devi
Politeknik Katolik Mangunwijaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health

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Pengaruh Konsentrasi Asam Stearat Sebagai Emulsifying Agent Terhadap Karakteristik Fisik Sediaan Krim Ekstrak Daun Pepaya (Carica Papaya L.) Ika Windi Sepriliani; Sisca Devi
Indonesian Journal on Medical Science Vol 9 No 2 (2022): IJMS 2022
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (728.612 KB) | DOI: 10.55181/ijms.v9i2.369

Abstract

Acne is one of the most common skin problems. Plants that can be used to treat acne are papaya plants, especially the leaves. Cream is a topical dosage form with a semi-solid form suitable for the treatment of acne. The purpose of this study was to determine the effect of stearic acid concentration as an emulsifying agent on the physical characteristics of papaya leaf extract cream preparations. The type of research carried out is an experimental study using a completely randomized design with one factor, namely the concentration of stearic acid, by testing the physical characteristics of organoleptic, homogeneity, pH, adhesion, spreadability, cream type, viscosity, protection power, and washability. The test results were analyzed using the ANOVA test. The effect of stearic acid concentration on all tests shown no effect on organoleptic, homogeneity, and type of papaya leaf extract cream. The results of all statistical tests yielded p value <0.05 which indicates the difference in the meaning of each formula.
PENGARUH VARIASI BASIS GELLING AGENT TERHADAP KARAKTERISTIK FISIK MASKER GEL PEEL-OFF EKSTRAK DAUN PEPAYA (Carica papaya L.) Sisca Devi
Jurnal Mitra Kesehatan Vol. 5 No. 2 (2023): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v5i2.170

Abstract

Introduction: Acne is a chronic inflammation of the sebaceous glands due to inflammation and bacterial infection. One of the plants used to treat acne is papaya leaves (Carica papaya L.) because it has alkaloid compounds as antibacterial causes of acne. This study aims to determine the effect of gelling agent base variations on the physical characteristics of peel-off gel mask preparations and to determine the gelling agent base that produces the best physical characteristics of the preparation. Method: The method used was an experimental study using a completely randomized design (CRD) with three treatments and nine repetitions. Variations of the base gelling agent used were gelatin, CMC-Na, and carbopol 940. Each formula was tested for physical characteristics in the form of organoleptic tests, homogeneity, viscosity, spreadability, adhesion, drying time, and pH. Data analysis was carried out by testing for normality and homogeneity with the SPSS program. If the distribution of the resulting data shows normal and homogeneous, then the ANOVA test is used, while if it does not meet the normality and homogeneity requirements, the Kruskal-Wallis test is used with a 95% confidence level. Results: The resulting research shows that variations in the gelling agent gelatin, CMC-Na, and carbopol affect the physical characteristic test of papaya leaf extract peel-off gel masks in the form of pH, viscosity, adhesion, spreadability and drying time. Statistical results show that variations in gelling agents produce significant differences. Conclusion: Variations in gelling agent bases affect the physical characteristics of papaya leaf extract peel-off gel masks (Carica papaya L.) in the form of pH, viscosity, adhesion, spreadability and drying time of preparations. The gelling agent base that produces the best characteristics of papaya leaf extract (Carica papaya L.) peel-off gel mask preparation, namely gelling agent Karbopol 940 in formula 3 because it produces preparations that meet the requirements of all physical characteristic tests.
PENYULUHAN EDUKASI TENTANG DAGUSIBU OBAT DI GEREJA KATOLIK SANTO FRANCISCUS XAVERIUS, SEMARANG Paulina Maya Octasari; Sisca Devi; Angela Desiani Ampur
Jurnal Pengabdian IKIFA Vol. 3 No. 3 (2024): Jurnal Pengabdian IKIFA
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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Abstract

Independent treatment is carried out to help improve people's health status at a more affordable cost. A good level of knowledge is required to ensure the success of self-medication therapy. A national movement regarding the drug DAGUSIBU needs to be carried out to increase public knowledge regarding good drug management to support self-medication behavior. One effort to increase knowledge is carried out through outreach activities to the community. This service activity aims to provide public knowledge about how to properly obtain, use, store and dispose of medicines. The activity stages consist of the preparation/survey, implementation, and evaluation stages. The activity will be held on Sunday, August 13, 2023 in Room A1 of St. Mary's Church Fransiscus Xaverius Kebon Dalem, Semarang and attended by 41 participants. The media used are presentation materials, pocketbooks, and drug samples. The results showed that 97,56% (40 participants) understand how to get the right medicine, but 87,80% (36 participants) are still not precise in using eye drops/ointment. There are 95,12% (39 participants) still do not know how to store and dispose of medicines properly. During the activity, participants were enthusiastic when listening to lectures and discussing. In general, educational outreach about the drug DAGUSIBU has provided additional knowledge to the public.
Pengaruh Konsentrasi Karbopol sebagai Emulgator terhadap Karakteristik Fisik Sediaan Lotion Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) Retno Dela Palma; Sisca Devi
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.27305

Abstract

Starfruit leaf extract produces antioxidant activity from the flavonoid compound content. The lotion dosage form is one of the dosage forms used as an antioxidant application to the skin. The lotion formula consists of a water phase, an oil phase, and an emulsifier. The emulsifier is the most important part of the formation of lotion because it determines the physical characteristics produced and the stability of the preparation. Carbopol is a synthetic emulsifier that can absorb liquid and form a stable mass to produce stable physical characteristics of the lotion. The purpose of this study was to influence the concentration of carbopol on the physical attributes of starfruit leaf extract lotion and to determine the concentration of carbopol with the best physical characteristics of starfruit leaf extract lotion. This study is an experimental study with different concentrations of Carbopol, namely 0.3%; 0.4%; and 0.5%. The physical characteristics measured were organoleptic, pH, homogeneity, viscosity, spreadability, adhesion, protection power, and emulsion type. Viscosity and adhesion test data were tested using Kruskal Wallis and continued with Mann Whitney, while spreadability and protection test data were tested using ANOVA followed by Pos Hoc. The results showed that increasing the concentration of Carbopol affected protection power (p<0.05). The concentration of Carbopol that produced the best characteristics was 0.3% (formula 1).
Pengaruh Perbedaan Kombinasi Basis Hidrokarbon Terhadap Karakteristik Fisik Sediaan Salep Ekstrak Etanolik Daun Binahong (Anredera cordifolia(Ten.) Steenis): Pengaruh Perbedaan Kombinasi Basis Hidrokarbon Terhadap Karakteristik Fisik Sediaan Salep Ekstrak Etanolik Daun Binahong (Anredera cordifolia(Ten.) Steenis) Sisca Devi; Ifka Perdana Putri
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 4 No. 2 (2025): Oktober : Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v2i2.42

Abstract

The skin is the most important organ in protection against injury and pathogens. One of the skin disorders in the form of burns. The binahong plant has flavonoid compounds, saponins and oleanolic acid which are efficacious as anti-inflammatory and reduce pain in burns. The selection of the right ointment base greatly affects the therapeutic effect of the ointment. This study aims to determine the effect of different combinations of hydrocarbon bases on the physical characteristics of the ethanolic extract of binahong (Anredera cordifolia (Ten.) Steenis) ointment preparations. This type of research is experimental with a completely randomized design (CRD). Extraction using maceration method with 70% ethanol. The hydrocarbon bases are 5% cera flava, 10% liquid paraffin, and 24% Vaseline album. The physical characteristics of organoleptic test, homogeneity, pH, protective power were analyzed descriptively. Adhesion, dispersion, viscosity were tested for normality and homogeneity using the Shapiro Wilk test and Levene's test. Normal and homogeneous distributed data were tested with one-way ANOVA with 95% confidence level followed by the Tuckey test. The combination of hydrocarbon bases affects the physical characteristics of the ethanolic extract of binahong leaf ointment, including viscosity, spreadability, and adhesion. The test results of organoleptic, homogeneity, pH met the requirements. The test of adhesion, dispersibility and viscosity, with a significance of p<0.05, had a significant difference between each formula.
Co-Authors Angela Desiani Ampur Ifka Perdana Putri Ika Windi Sepriliani Paulina Maya Octasari Retno Dela Palma