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Sisca Devi
Politeknik Katolik Mangunwijaya
Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pengaruh Konsentrasi Asam Stearat Sebagai Emulsifying Agent Terhadap Karakteristik Fisik Sediaan Krim Ekstrak Daun Pepaya (Carica Papaya L.) Ika Windi Sepriliani; Sisca Devi
Indonesian Journal on Medical Science Vol 9 No 2 (2022): IJMS 2022
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (728.612 KB) | DOI: 10.55181/ijms.v9i2.369

Abstract

Acne is one of the most common skin problems. Plants that can be used to treat acne are papaya plants, especially the leaves. Cream is a topical dosage form with a semi-solid form suitable for the treatment of acne. The purpose of this study was to determine the effect of stearic acid concentration as an emulsifying agent on the physical characteristics of papaya leaf extract cream preparations. The type of research carried out is an experimental study using a completely randomized design with one factor, namely the concentration of stearic acid, by testing the physical characteristics of organoleptic, homogeneity, pH, adhesion, spreadability, cream type, viscosity, protection power, and washability. The test results were analyzed using the ANOVA test. The effect of stearic acid concentration on all tests shown no effect on organoleptic, homogeneity, and type of papaya leaf extract cream. The results of all statistical tests yielded p value <0.05 which indicates the difference in the meaning of each formula.
PENGARUH VARIASI BASIS GELLING AGENT TERHADAP KARAKTERISTIK FISIK MASKER GEL PEEL-OFF EKSTRAK DAUN PEPAYA (Carica papaya L.) Sisca Devi
Jurnal Mitra Kesehatan Vol. 5 No. 2 (2023): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v5i2.170

Abstract

Introduction: Acne is a chronic inflammation of the sebaceous glands due to inflammation and bacterial infection. One of the plants used to treat acne is papaya leaves (Carica papaya L.) because it has alkaloid compounds as antibacterial causes of acne. This study aims to determine the effect of gelling agent base variations on the physical characteristics of peel-off gel mask preparations and to determine the gelling agent base that produces the best physical characteristics of the preparation. Method: The method used was an experimental study using a completely randomized design (CRD) with three treatments and nine repetitions. Variations of the base gelling agent used were gelatin, CMC-Na, and carbopol 940. Each formula was tested for physical characteristics in the form of organoleptic tests, homogeneity, viscosity, spreadability, adhesion, drying time, and pH. Data analysis was carried out by testing for normality and homogeneity with the SPSS program. If the distribution of the resulting data shows normal and homogeneous, then the ANOVA test is used, while if it does not meet the normality and homogeneity requirements, the Kruskal-Wallis test is used with a 95% confidence level. Results: The resulting research shows that variations in the gelling agent gelatin, CMC-Na, and carbopol affect the physical characteristic test of papaya leaf extract peel-off gel masks in the form of pH, viscosity, adhesion, spreadability and drying time. Statistical results show that variations in gelling agents produce significant differences. Conclusion: Variations in gelling agent bases affect the physical characteristics of papaya leaf extract peel-off gel masks (Carica papaya L.) in the form of pH, viscosity, adhesion, spreadability and drying time of preparations. The gelling agent base that produces the best characteristics of papaya leaf extract (Carica papaya L.) peel-off gel mask preparation, namely gelling agent Karbopol 940 in formula 3 because it produces preparations that meet the requirements of all physical characteristic tests.
Co-Authors Ika Windi Sepriliani