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All Journal Inspiratif Pendidikan Jurnal Administrasi Pendidikan : Program Pascasarjana Unsyiah Journal of Maternity Care and Reproductive Health JURNAL KIMIA SAINTEK DAN PENDIDIKAN Journal of Global Pharma Technology
Sukmawati .
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Religion Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Journal : Journal of Global Pharma Technology

 1 
The Activity Test of Ethanol Extract in Hibiscus Leaves (Hibiscus Tiliaceus L.) as the α-Glucosidase Enzyme Inhibitor by Using ELISA (Enzyme Linked Immunosorbent Assay) Reader Sukmawati .
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Hibiscus leaves (Hibiscus tiliaceus L.) was a plant from the family of Malvaceae, which contained triterpenoid, saponins, flavonoids, and polyphenols compounds that functioned as antidiabetic mellitus. The purpose of this study was to determine the activity of α-glucosidase enzyme inhibitor from the ethanol extract of hibiscus leaves (Hibiscus tiliaceus L.). The test was carried out through in vitro by using α-glucosidase enzyme and p-nitrofenil-α-D-glukopiranosida (PNPG) substrate, and measured by ELISA reader. The simplicia was macerated with alcohol 96%. The reaction of α-glucosidase enzyme and p-nitrofenil-α-D-glukopiranosida substrate produced yellow p-nitrofenol. The reaction product was measured at a wavelength of 405 nm. The results showed that ethanol extract of hibiscus leaves (Hibiscus tiliaceus L.) had activity as an inhibitor of α-glucosidase enzyme with Inhibitor Consentration IC50 37.98 µg / mL and could be categorized as active.Keywords: Hibiscus tiliaceus L., Hibiscus leaves, Α-glucosidase enzyme inhibitor.
Potential of Astaxanthin from Asian Tiger Shrimp (Penaeus Monodon) Shell Extract as an Antibacterial and Ant Inflamatory Sukmawati .
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Asian tiger shrimp (Penaeus monodon) shell is an industrial waste which becomes one of the sources of carotenoids in the form of astaxanthin (3.3’-dihydroxy-β, β′-carotene-4.4′-dione) which has a very potential biological activity because it can work on target molecules. Astaxanthin in Asian tiger shrimp shell is well known to be lipophilic, being insoluble in water but soluble in organic solvents, one of which acetonitrile. The characteristics of astaxanthin were obtained through qualitative and quantitative analyses using FTIR (Fourier Transform Infra-Red) and HPLC (High Performance Liquid Chromatography). Furthermore, antibacterial and anti-inflammatory activities had been tested. Based on the research results done on the inhibition of Asian tiger shrimp (Penaeus monodon ) shell extract on the 5th growth of the test bacteria, the tiger shrimp shell extract had antibacterial activity on Eschericia coli., Streptococcus mutans, Pseudomans auriginosa, Salmonella typhi, Staphylococcus aureus which was characterized by the presence of clear zone / inhibition zone / Oligodynamic zone which showed the effect of tiger shrimp shell extract in killing and inhibiting the growth of test bacteria. Besides, An anti-inflammatory testing through extracting chemical components with acetonitrile solvent with several concentrations showed that the anti-inflammatory activity with a concentration of 1000 ppm with % stability on erythrocyte membrane obtained 60.516%, indicating that the higher the concentration used, the better was the anti-inflammatory effect.Keywords: Astaxanthin, Asian tiger shrimp, Antibacterial, Anti-inflammatory.
Co-Authors Furkon Nurhakim Imas Rafiyah Lilis Mamuroh Niswanto2 . Pratiwi Putri Lestari Rohiman . Yusrizal .