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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya El-Hayah : Jurnal Biologi STOMATOGNATIC- Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Journal Of Vocational Health Studies
Nuzulul Hikmah
Biomedik Fakultas Kedokteran Gigi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology

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SEPUTAR REAKSI HIPERSENSITIVITAS (ALERGI) Nuzulul Hikmah; I Dewa Ayu Ratna Dewanti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 7 No 2 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Introduction. Till now allergy was a piquancy to be submitted, because most all people have everexperienced it. Symptom and also allergen all kinds and varies can come from neither outside body nor in bodyx'self. Purpose of Writing. Co-signature deeper in around allergic reaction. Discussion. Allergic reaction is immunesystem trouble marked by abundant reaction from immune response. Allergic reaction entangles allergen, is causingcells discharges matters or mediator chemistry which can destroy or hurts network in vinicity. Allergen can in the formof mote, crop powder, drug or food, is acting as antigen stimulating the happening of immune responds. Allergicreaction divided to become allergic reaction type I entangling Ig E, type II Antibody-Mediated Cytotoxi ity ( Ig G),type III ( Immune Complex Disorders) and type IV (delayed hypersensitivities). Conclusion. Allergic reaction is caused[by] allergen having manifestation to vary and divided to become reaction quickly ( type I), type II, type III and typeIV.
KEJADIAN HIV/AIDS DENGAN MANIFESTASI ORAL PADA ANAK-ANAK Nuzulul Hikmah; I Dewa Ayu Ratna Dewanti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 7 No 1 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Nowadays HIV/AIDS infection was increase to children in the world. In development countries include Indonesia, it was caused fourth killer to children. Oral manifestation to the children who has infected HIV have a different been compared with adult. Discussion.Candidiasis and necrotizing ulcerative gingivitis is oral lesion who was found in the children. Linear gingival erythema leukoplakia, caries and kaposis sarcoma can be an indicator of moderate and hard immunosupression. Parotis swollen, herpes simplex virus infection and recurrent aphtous stomatitis not special connected with immunosupression grade. The best of management patients was consider immunology status andexamined oral continuity. Conclusion. Oral manifestation in the childen very important to known because it was often first indication clinical so that someone had been infected of HIV.
The Effect of Different Orthodontic Force on MMP 9 Expression in a Rat Diabetic Model Hafiedz Maulana; Nuzulul Hikmah; Amandia Dewi permana Shita; Nur Permatasari; Sri Widyarti
Journal of Tropical Life Science Vol. 4 No. 2 (2014)
Publisher : Journal of Tropical Life Science

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Abstract

Orthodontic forces produce alveolar bone and periodontal ligament remodeling that cause tooth movement. Diabetes can increase tissue damage and, therefore, contributes to the process of orthodontic tooth movement. The aim of this study was to determine the effect of differently orthodontic forces on the expression of MMP nine in rat diabetic model. Twenty four male Wistar rats were divided into three groups of control and three groups of treatment streptozotocin-induced diabetes with stratified doses. Application of orthodontic appliance was performed with different forces (10, 20 and 30 grF). Orthodontic appliance was performed on both upper incisors. Immunohistochemical (IHC) analysis was used to observe the expression of MMP 9 and HE (Hematoxylen Eosin) staining to observe the number of fibroblasts. Statistical analysis was carried out using t-test and Spearman correlation analysis to determine the difference of MMP nine expression and number of fibroblasts between groups, and determine the correlation of both. The results showed an increased expression of MMP 9 and decreased of fibroblasts number in diabetic rats, along with increasing magnitude of orthodontic forces. The different orthodontic forces given to diabetic rats affect the expression of MMP 9 and the number of fibroblasts, in which the expression of MMP 9 increased along with the increase of orthodontic forces, both at pressure and tension sides.
Diabetic Blood Glucose Level Profile with Stratified Dose Streptozotocin (SD-STZ) and Multi Low Dose Streptozotocin (MLD-STZ) Induction Methods Nuzulul Hikmah; Amandia Dewi Permana Shita; Hafiedz Maulana
Journal of Tropical Life Science Vol. 5 No. 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

Abstract

The prevalence of diabetes increased from year to year. Diabetic animal model was developed to study the pathogenesis and treatment in diabetes. The aim of this study was to determine the profile of diabetic blood glucose levels using a stratified dose streptozotocin (STZ-SD) and multi-low dose streptozotocin (MLD-STZ) induction methods. 27 Wistar rats were divided into three groups, control group, SD-STZ group, and MLD-STZ group. The induction of experimental animal was using the method of SD-STZ and MLD-STZ for 5 consecutive days intraperitoneally. SD-STZ method using stratified dose of 40, 35, 30, 25, and 20 mg/Kg of body weight, while MLD-STZ method using a dose of 20 mg/Kg of body weight for 5 times. The measurement of blood glucose level (BGL) and body weight (BW) in animal was made on 2, 4, 7, and 14 days after STZ induction. The results of this study indicate that the diabetic conditions (BGL ≥ 300 mg/dl) on the SD-STZ induction method was more stable, and no deaths occurred in experimental animals.Keywords: Streptozotocin (STZ), diabetes, blood glucose level (BGL).
MANDIBULAR RADIOGRAPHIC ANALYSIS FOR GENDER DETERMINATION OF DOWN SYNDROME SUFFERERS Rendra Chriestedy Prasetya; Amandia Dewi Permana Shita; Nadie Fatimatuzzahro; Nuzulul Hikmah; Hafiedz Maulana; Indonesia Koes Wijayaningrat; Adinda Febriyanti; Dwi Kartika Apriyono
Journal of Vocational Health Studies Vol. 9 No. 2 (2025): November 2025 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V9.I2.2025.130-138

Abstract

Background: Natural disasters frequently occur in Indonesia, creating a need for effective victim identification. Gender identification is a crucial initial step, as it can narrow the search space by 50% during individual identification. The corpus and ramus mandible are an organ that plays an important role in gender prediction with a high predictive accuracy. However, the Down syndrome mandibular size is different from that of normal people. Purpose: To analyze the difference in corpus length and total height of the mandibular ramus between individuals with down syndrome and those without, as a step to gender determination. Method: This observational cross-sectional study involved 12 individuals with down syndrome and 12 individuals without, aged 10 – 17 years. The mandibular corpus length was measured through panoramic radiography from the gonion to the menton point. The mandibular ramus was measured from the apex of the condyle to the gonion point using the Clinicview application. Data were analyzed using the T-test with SPSS Ver. 26 software. Result: The length of the mandibular corpus differs significantly (p-value = 0.000) between Down syndrome with normal people. The length of the mandibular corpus in down syndrome does not differ significantly (p-value > 0.000) between males and females. The total height of the mandibular ramus does not differ significantly between down syndrome and non-down syndrome groups, both in males and females. Conclusion: The corpus length and the mandibular ramus's total height cannot be used as indicators of gender determination in down syndrome.
Co-Authors Adinda Febriyanti Amandia Dewi Permana Shita Dwi Kartika Apriyono Hafiedz Maulana I Dewa Ayu Ratna Dewanti Indonesia Koes Wijayaningrat Nadie Fatimatuzzahro Nur Permatasari Nur Permatasari Rendra Chriestedy Prasetya Sri Widyarti