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All Journal Jurnal Gizi JURNAL GIZI INDONESIA JURNAL PROMOSI KESEHATAN INDONESIA Amerta Nutrition International Journal of Health and Information System (IJHIS)
Puspito Arum
Dosen Program Studi D-IV Gizi Klinik, Politeknik Kesehatan Negeri Jember
Computer Science & IT Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health Other

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Pengaruh pemberian klorofilin berbagai dosis terhadap indeks fagositosis makrofag dan kadar nitric oxide mencit BALB/c yang diinfeksi dengan Salmonella typhimurium Arum, Puspito; Suromo, Lisyani B; Puruhita, Niken
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 2, No 2 (2014)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.322 KB) | DOI: 10.14710/jgi.2.2.78-82

Abstract

Background: Immune responses to eliminate Salmonella infection are by activating macrophage and by producing NO. Chlorophyllin is a chlorophyll derivate that has immunomodulator properties. Objective: The aim of this study was to prove effect of chlorophyllin in macrophage phagocytosis index and NO level. Methods: A post test only controlled group design was conducted in 5 groups Balb/c mice (negative control, positive control, dosage 100 µg/200 g BW, dosage 200 µg/200 g BW and dosage 380 µg/200 g BW). Macrophage phagocytosis index was measured by counting cells that phagocyte latexs particles. NO level was measured by Griess method. Macrophage phagocytosis index difference was analyzed by one way anova and NO level deference was analyzed by Kruskall-Wallis test (α 0,05).Results: Means of macrophage phagocytosis index were 0,7(±0,80), 1,8(±0,80), 2(±0,22), 2,5(±0,43) and 3,2(±0,68) respectively in negative control, positive control, chlorophyllin dosage 100 µg/g BW/day, 200 µg/g BW/day and 380 µg/g BW/day. There was a significant difference of macrophage phagocytosis index between group (p 0,000). Mean of NO level were 0,4 µM(±0,10), 0,6 µM(±0,60), 0,8 µM(±0,64), 0,6 µM(±0,67) and 0,4 µM(±0,26) respectively in negative control, positive control, chlorophyllin dosage 100 µg/g BW/day, 200 µg/g BW/day and 380 µg/g BW/day. There was no difference of  NO level between group (p 0,813).Conclusion: There was a significant difference of macrophage phagocytosis index between chlorophyllin administered group and control. The higher chlorophyllin dosage, the higher macrophage phagocytosis index. Therewas no difference of  NO level between chlorophyllin administered group and control.
Pengaruh Pemberian Sari Buah Kersen terhadap Kadar Asam Urat pada Penderita Hiperurisemia Mahendra, Himeldah Isa; Arum, Puspito
Jurnal Gizi Vol 10, No 1 (2021): Jurnal Gizi UNIMUS
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jg.10.1.2021.1-13

Abstract

Hyperuricemia is a health condition characterized by increasing uric acid levels in the body. Jamaican cherry (Muntingia calabura) is vitamin C containing fruit that have lowering-purine effect.The aim of this study was to determine the effect of Kersen (Muntingia calabura) extract on uric acidlevels. This was experimental study with pretest-posttest control group design. Male and female aged above 50 years and not taking vitamins were reqruites as subjects . In this study, the subjects were divided into control and treatment group with the total of 17 subjects for each group. The subjects consume 40.5 grams Kersen. The uric acid level was measured by helath professionals using Easy Touch. The diference of uric acid level were analized using Wilcoxon test  and Man-Whitney test, and the correlation and effect of Kersen were analyzed using Partial Correlation test and LinearRegression Test. The results show that uric acid levels in the treatment group were above normal as well as the control group because at the beginning of the study there were differences in the subject selection of each group. The results show that there is an effect of granting cherry juice to uric acid level ( p 0.004).Keywords: Gout, Hyperuricemia, Cherry Fruit, Vitamin C.
The Implementation of Smart Application System for Early Detection of Stunting as a Solution to Nutritional Problems Based on Anthropometry Standards Muflihatin, Indah; Wicaksono, Andri Permana; Mudiono, Demiawan Rachmatta Putro; Arum, Puspito; Nurmawati, Ida; Muna, Niyalatul
International Journal of Health and Information System Vol. 1 No. 3 (2024): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/ijhis.v1i3.3

Abstract

Stunting is a nutritional status determined by the PB/U or TB/U index. These measurements fall within the threshold (Z-Score) <-2 SD to -3 SD (short/stunted) and <-3 SD (highly short). Per the 2024 target established by the president, the frequency of stunting can be reduced to 14%. It has been demonstrated that there are still dietary disorders, particularly in the vulnerable age group, namely toddlers in Kemuning Lor Village. In 2018, there were still 33 toddlers with nutritional status disorders, including 24 toddlers (19.7%) with overnutrition, 5 toddlers (4.1%) with undernutrition, and 4 toddlers (3.2%) with malnutrition. Smart Systems is a subfield of Computer Science that focuses on developing competent methods inspired by natural events to address various complicated problems in the real world, including the health realm; early detection of stunting. This study aimed to develop an early detection method for nutritional status and stunting based on anthropometric standards in toddlers in Kemuning Lor Village, which is anticipated to aid cadres or the community in overcoming nutritional status and stunting in toddlers.
Comparison of Mother’s and Toddler’s Characteristics Based On The Nutritional Status of The Toddler Arum, Puspito; Nurmawati, Ida; Muna, Niyalatul; Muflihatin, Indah; Mudiono, Demiawan Rahmatta Putro; Wicaksono, Andri Permana
International Journal of Health and Information System Vol. 1 No. 2 (2023): September
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/ijhis.v1i2.4

Abstract

Nutritional status in toddlers is one of the indicators used to describe the quality of toddler health. Toddlers’ nutritional status is interpreted based on some indices, namely weight for age, length/height for age, and weight for length/height Z-score. The nutritional status of toddlers is affected by various factors, both maternal and child factors. Anaemia and chronic energy deficiency during pregnancy affect a toddler’s nutrition status. Birth weight, exclusive breastfeeding, and complementary food may result in a toddler’s nutrition status as well. This study aims to compare the mother’s and toddler’s characteristics based on the nutritional status of the toddler. This was an observational analytical cross-sectional study. All data for the analysis of this paper were obtained from observations of the toddlers, interviews with mothers, and recorded data from KIA book. Toddlers’ weight and length/height were measured when the subject came to Posyandu. Questions about exclusive breastfeeding and complementary food were asked of mothers. Information about anaemia and chronic energy deficiency status was obtained from KIA book. This study used chi-square test to finds evidence that, on 88 subjects, there is no difference in anaemia and chronic energy deficiency during pregnancy, birth weight, exclusive breastfeeding, and complementary food among all nutritional status indices.
Maternal Factors Influencing Low Birth Weight in Newborns: A Retrospective Study Nurmawati, Ida; Arum, Puspito; Muna, Niyalatul; Sutantio, R Alamsyah; Nurjihan, Ikha; Anelia, Zaifatul; Hanin, Tasya Nadia
Jurnal Promosi Kesehatan Indonesia Vol 20 No 3: July 2025
Publisher : Master Program of Health Promotion Faculty of Public Health Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpki.20.3.209-215

Abstract

Background: Birth weight is a critical indicator of an infant's health. Research conducted in Indonesia has identified low birth weight (LBW) as a leading cause of neonatal mortality, accounting for approximately 35% of all cases. This study aims to determine the factors influencing the incidence of LBW.Method: The study used a retrospective design and included 83 respondents selected through quota sampling. Data were collected from the Maternal and Child Health (MCH) handbooks at Manggis Integrated Service Post (posyandu). Univariate analysis was performed to calculate frequency and percentage values. Bivariate analysis was carried out using the chi-squared test to examine relationships between variables. Multivariate analysis was conducted using the logistic regression test to assess the influence of multiple variables.Result: Maternal age at pregnancy (p=0.037) and maternal mid-upper arm circumference (MUAC) (p=0.034) were significantly associated with the occurrence of LBW in newborns. The odds ratio (OR) analysis revealed MUAC as the primary factor influencing LBW (OR=4.278), followed by maternal age during pregnancy (OR = 3.750). In comparison, haemoglobin levels (p = 0.500), maternal height (p = 0.408), and gestational age (p=0.118) were not significantly associated with the occurrence of LBW. MUAC was found to influence the occurrence of LBW in Kemuning Lor Village (p = 0.027). The MUAC variable accounted for 16.9% of the variance in LBW cases (R2 = 0.169). Improving the nutritional status of adolescent girls is imperative to ensure optimal health outcomes in future pregnancies. 
Pengaruh Suplementasi β-Carotene terhadap Kadar Trigliserida Studi pada Tikus Wistar Diabetes Mellitus Tipe 2 yang Diberikan Pakan Tinggi Lemak dan Diinduksi Streptozotocin-Nicotinamide: The Effect of β-Carotene Supplementation on Triglyceride Levels Study on Type 2 Diabetes Mellitus Wistar Rats Fed High-Fat Diet and Induced Streptozotocin-Nicotinamide Soviana, Elida; Aviarani, Tea; Arum, Puspito
Amerta Nutrition Vol. 9 No. 3 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i3.2025.496-505

Abstract

Background: Hypertriglyceridemia is associated with decreasing insulin sensitivity and increasing insulin resistance in type 2 diabetes mellitus. β-carotene has a cytoprotective effect that can improve and protect β-cells of the pancreas, resulting in increased insulin synthesis and secretion. β-carotene prevents the deleterious effects of uncontrolled glucose and lipid metabolism. Objectives: This research aimed to investigate the effect of β-carotene supplementation on triglyceride levels in high-fat diet and streptozotocin-nicotinamide induced Type 2 Diabetes Mellitus Wistar Rats. Methods: 18 Wistar rats were randomly divided into three groups: X1 (negative controls), X2 (positive controls), and X3 (STZ-NA+β-carotene 10 mg/KgBW). High-fat diet intervention was given 14 days before diabetic induction in X2 and X3 groups; the negative control group X1 was given standard feed. To condition Wistar rats to be type 2 Diabetes Mellitus, rats in groups X2 and X3 received intraperitoneal injections of Streptozotocin at a dose of 45 mg/KgBW and nicotinamide at a dose of 110 mg/kgBW. Supplementation of β-carotene was given by the nasogastric feeding tube method every 2 days within 30 days. Plasma Triglyceride levels were measured using GPO-PAP. The effect of triglyceride levels after β-carotene supplementation was tested with a statistical test using a paired t-test and one-way ANOVA. Results: Blood glucose levels in groups X2 and X3 increased by 188.34 g/dl and 186.34 g/dl after being injected with STZ and NA. There was a significant effect of triglyceride levels (p-value<0.001) after supplementation with β-carotene at a dose of 10 mg/kgBW. Serum triglyceride levels decreased by a mean of 21.90% or 28.42 mg/dl. Conclusions: This research revealed that the supplementation of β-carotene at a dose of 10 mg/kgBW every 2 days within 30 days by the nasogastric feeding tube method can lower triglyceride levels in diabetic Wistar rats.
Soy and Dragon Fruit Functional Drink : The Potential to Reduce Cholesterol Total Levels in Hypercholesterolemic Sprague Dawley Rats Suryana, Arinda Lironika; Putri, Chindy Yulita Krismuntiani; Rosiana, Nita Maria; Arum, Puspito
International Journal of Health and Information System Vol. 2 No. 1 (2024): May
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/ijhis.v2i1.41

Abstract

Hypercholesterolemia is a lipid metabolism disorder characterized by increased blood cholesterol levels. The alternative functional drinks that can reduce cholesterol levels are beverage ingredients that contain flavonoids, such as red dragon fruit and soybeans. Flavonoids can inhibit cholesterol synthesis by inhibiting the HMG-CoA reductase enzyme. Soybeans are also have a hypocholesterolemic effect because they contain isoflavones. This study aimed to determined the potential of soybean and dragon fruit peel powder on the cholesterol levels of hypercholesterolemic Sprague Dawley rats. This study was a true-experimental design with a pretest - posttest with control group. The samples were 27 male Sprague Dawley rats, weighing 150-250 grams and aged 2 -3 months. The samples were divided into a control group and a treatment group that was given soybeans dragon fruit peel powder drink at a dose of 12.8 ml/kgBB/day for 14 days. Total cholesterol levels were measured using the CHOD–PAP method. Data were analyzed using the One Way Anova test, Post Hoc or Man Whitney test and Paired T-test. The results showed that there was a significant difference in total cholesterol levels in mice before and after the intervention (p= 0.003). Giving soybeans dragon fruit peels powder drink can significantly reduce total cholesterol levels in the treatment group (P) by 18.45% (p= 0.044).
Co-Authors Anelia, Zaifatul Aviarani, Tea Elida Soviana Hanin, Tasya Nadia Ida Nurmawati, Ida Ikha Nurjihan Lisyani B Suromo Mahendra, Himeldah Isa Mudiono, Demiawan Rachmatta Putro Mudiono, Demiawan Rahmatta Putro Muflihatin, Indah Muna, Niyalatul Niken Puruhita Putri, Chindy Yulita Krismuntiani Rosiana, Nita Maria Suryana, Arinda Lironika Sutantio, R Alamsyah Wicaksono, Andri Permana