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All Journal BALI MEDICAL JOURNAL (BMJ) MNJ (Malang Neurology Journal) YARSI Medical Journal Cermin Dunia Kedokteran
Jimmy Barus, Jimmy
Departemen Ilmu Penyakit Saraf, Fakultas Kedokteran Unika Atma Jaya
Health Professions Medicine & Pharmacology Neuroscience Public Health

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In connection with the publication in Bali Med J 2016, Volume 5, Number 2: 25-29, entitled "Intra-Arterial Heparin Flushing Increases Manual Muscle Test – Medical Research Councils (MMT-MRC) Score in Chronic Ischemic Stroke Patient " Machfoed, Moh Hasan; Usman, Fritz Sumantri; Barus, Jimmy; Wreksoatmodjo, Budi Riyanto; Gunawan, Dede; Bintang, Andi Kurnia; Tugasworo, Dodik; Subroto, Gatot; Lamsudin, Rusdi; Harsono, H.; Sulthan, Riza
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
Publisher : BALI MEDICAL JOURNAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.667 KB)

Abstract

In connection with the publication in Bali Med J 2016, Volume 5, Number 2: 25-29,entitled "Intra-Arterial Heparin Flushing Increases Manual Muscle Test – Medical Research Councils (MMT-MRC) Score in Chronic Ischemic Stroke Patient ", herewith, please allow us to do reviews of the study discussion. By assessing the discussion, it can be proved whether there are references that support the results of study.
PSYCHIATRIC DISORDER COMORBIDITY IN CHRONIC NEUROMUSCULOSKELETAL PAIN IN ATMA JAYA HOSPITAL Barus, Jimmy; Yaputra, Faldi
Jurnal Kedokteran YARSI Vol 25, No 2 (2017): MEI - AGUSTUS 2017
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.737 KB) | DOI: 10.33476/jky.v25i2.336

Abstract

Background : This study describe comorbid psychiatric disorder especially in depressive disorder, anxiety disorder and sleep disturbance in chronic neuromusculoskeletal pain patients.Objective : The aim of this research is to measure the prevalence of psychiatric comorbidity in choric neuromusculoskeletal pain.Methods : Cross sectional study with consecutive sampling method is used in this study. The data are collected in the neurology clinic in Atma Jaya Hospital, Jakarta between July ? December 2015. Diagnostic and Statistical Manual of Mental Disorder (DSM) V criteria was used to diagnose the psychiatric condition. Results : The data were obtain from 55 study samples, consist of 12 males (21,8%), 43 females (78,2%). Thirty of them are ? 60 years old (55%) and 25 are ? 60 years old (45%). The most common is low back pain 30 patients (55%). Non-neuropathic pain 12 patients (22%), and neurophatic pain 43 patients (78%). The most common pain intensity is severe, Visual Analog Scale (VAS) ?8 (43%). The most common psychiatric disorder is insomnia (20%), followed by anxiety and insomnia (16,3%), and anxiety (12,7%).Discussion : Majority of chronic pain has psychiatric disoder comorbidity, coexisting condition should be considered in evaluation, diagnosis, and therapy.Conclusions : Chronic pain usually accompanied by psychiatric disorder, so thorough evaluation, diagnosis and therapy have to be fully addressed to achieve optimum functionality and good quality of life.Suggestions : Next study should collect samples from some hospitals and design the analitic study that can explain association between factors that can influence the comorbidity.
Penatalaksanaan Farmakologis Nyeri pada Lanjut Usia Barus, Jimmy
Cermin Dunia Kedokteran Vol 42, No 3 (2015): Nyeri
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.468 KB) | DOI: 10.55175/cdk.v42i3.1027

Abstract

Sejalan dengan meningkatnya populasi lansia maka meningkat pula jumlah kasus nyeri terkait disabilitas dan perubahan degeneratif pada kelompok ini. Penggunaan analgetik pada lansia perlu pertimbangan khusus. Secara umum, asetaminofen/parasetamol merupakan pilihan pertama untuk kasus nyeri muskuloskeletal dengan pemantauan dosis dan efek samping. Jika perlu, COX 2 inhibitor lebih diutamakan untuk menghindari efek gastrointestinal, dan pemberian aspirin bersama PPI untuk mengurangi risiko kardiovaskuler. Penggunaan OAINS sedapat mungkin dibatasi, karena berkaitan dengan efek samping gastrointestinal dan peningkatan risiko gangguan kardiovaskuler. OAINS harus dihindari pada gangguan ginjal. Opioid secara umum dianggap lebih aman, tetapi efek samping harus tetap diperhatikan. Analgetik adjuvan yang dianjurkan adalah antikonvulsan golongan gabapentin dan pregabalin, dan antidepresan golongan SNRI.The increase of elderly population resulted in increasing problem of pain connected to degenerative diseases and disabilities. The use of analgetics among elderly needs special consideration. Acetaminophen/paracetamol is still the first choice for musculoskeletal pain with dose and side effect monitoring. COX2 inhibitor is preferred to avoid gastrointestinal effect, and aspirin in combination with PPI is used to minimize cardiovascular risk. NSAID use is limited as much as possible, because it is associated with gastrointestinal side effects and increased risk of cardiovascular disorders. NSAID should be avoided in renal insufficiency. Opioid is relatively safe but needs monitoring of side effect. Adjuvant analgesics that can be considered are anticonvulsants: gabapentin and pregabalin, and SNRI antidepressant.
EFFECT OF INTRAVENOUS ADMINISTRATION OF SECRETOME ON MALONDIALDEHYDE LEVELS IN ROTENONE-INDUCED PARKINSON'S DISEASE RATS Aliza, Sharla; Sidharta, Veronika Maria; Sasmita, Poppy Kristina; Ardianto, Christian; Barus, Jimmy
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.03

Abstract

Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder with an increasing prevalence. Oxidative stress is known to contribute to the development of PD through lipid peroxidation, which causes damage to the substantia nigra pars compacta. Lipid peroxidation produces malondialdehyde (MDA), which is known to be elevated in PD patients. Up till now, there is no cure for PD, and the available therapies are only symptomatic. The secretome from Mesenchymal Stem Cell (MSC) has antioxidant and neuroprotective components, making it a potential therapeutic agent that may slow the progression of PD. Objective: This study seeks to determine the effect of MSC secretome on oxidative stress in rotenone-induced PD rats. Methods: This research was an in-vivo experiment conducted with 30 male Sprague Dawley rats, divided into sham control, rotenone (+) secretome (-), and rotenone (+) secretome (+) groups. Rotenone (2.75 mg/kgBW) was administered for seven days to induce a PD model. Secretome administration (1 mg/ml) was carried out on days 3, 5, and 7. MDA levels were determined using the sandwich ELISA method. Results: This study found no significant difference in MDA levels among the three groups (p = 0.203). The sham control group had the lowest MDA 1.32(0.53) nmol/mL, followed by the rotenone (+) secretome (+) group 1.56(0.33) nmol/ml, and the highest MDA was observed in the rotenone (+) secretome (-) group 1.88(0.14) nmol/mL. Conclusion: Administration of MSC secretome did not significantly cause changes in plasma MDA levels of rotenone-induced Parkinson Disease rats.
EFFECTS OF MSC-DERIVED SECRETOME TOWARDS PLASMA-TOTAL CHOLESTEROL LEVELS ON ROTENONE-INDUCED PARKINSON’S DISEASE RAT MODELS Putria, Fani Mustika; Sasmita, Poppy Kristina; Sidharta, Veronika Maria; Ardianto, Christian; Barus, Jimmy
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.01

Abstract

Background: Parkinson's disease (PD), a chronic progressive neurodegenerative disease, threatens much of the world's increasingly aging population and has no promise for disease-modifying drugs, only symptomatic treatment. One potential biomarker correlates PD to the disruption of cholesterol metabolizing processes that results in formation of cytotoxic bile acids (BA) which induces mitochondrial dysfunction that leads to the decrease of dopaminergic neurons in various PD models. Objective: This study aims to determine the effect of rotenone-induction as well as MSC-Secretome administration on plasma-total cholesterol levels in rat models.. Methods: This was an experimental research using 30 male Sprague Dawley rats divided into sham control, rotenone (+) secretome (-) and rotenone (+) secretome (+). Blood was withdrawn on day 0 and day 8 and analyzed under colorimetry and spectrophotometry for its plasma-total cholesterol concentration. Results: The Tukey Post-Hoc Test showed that there was no significant difference between the sham control and rotenone (+) secretome (-)  (p = 0.073), plasma-total cholesterol level is lower in rotenone (+) secretome (-) than in the sham control. Furthermore, we were unable to prove for a significant difference between the rotenone (+) secretome (-) and rotenone (+) secretome (+) group (p= 0.234), even though in average the plasma-total cholesterol level is lower in the rotenone (+) secretome (+)  group. Conclusion: Induction of rotenone followed by an intervention of MSC-Secretome has no effect on the change in plasma-total cholesterol levels on rat models.
Co-Authors A.A. Ketut Agung Cahyawan W Aliza, Sharla Andi Kurnia Bintang, Andi Kurnia Ardianto, Christian Budi Riyanto Wreksoatmodjo, Budi Riyanto Dede Gunawan, Dede Dodik Tugasworo Fritz Sumantri Usman, Fritz Sumantri H. Harsono, H. Moh Hasan Machfoed, Moh Hasan Poppy Kristina Sasmita Putria, Fani Mustika Riza Sulthan, Riza Rusdi Lamsudin, Rusdi Veronika Maria Sidharta Yaputra, Faldi