Veronika Maria Sidharta
Department Of Histology, School Of Medicine And Health Sciences, Atma Jaya Catholic University Of Indonesia, Jakarta, Indonesia

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Body Mass Index, a Body Shape Index, and Waist-to-Height Ratio in Predicting Elevated Blood Pressure Bryan Junius Winata; Veronika Maria Sidharta; Linawati Hananta; Vetinly Vetinly; Nawanto Agung Prastowo
Althea Medical Journal Vol 9, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n1.2291

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Background: One of the complications of obesity is an elevation in blood pressure  which can increase the risk of hypertension. This study aimed to explore body mass index (BMI), a body shape index (ABSI), and waist-to-height ratio (WHtR) in predicting elevated blood pressure (BP).Methods: This study was conducted in a cross-sectional design on 215 medical students from October 2019 to September 2020. Respondents measured their own weight, height, waist circumference and BP. Receiver operating characteristics (ROC) curve were analyzed using IBM SPSS v.23. Results: Of the 215 medical students who participated in this study, only 102 met the inclusion criteria. The majority of the students were female (n=71, 69.6%) with a mean age of 19.37 years, and normal blood pressure (n=90, 88.2%). Area under the ROC curve (AUC) of WHtR and ABSI were 0.774 (p-value= 0.002) and 0.766 (p-value= 0.003) respectively, which were still acceptable. However, the AUC of BMI (p-value=0.589) was 0.11, which was considered poor.Conclusion: The indicators of obesity can be used as a screening value for increased blood pressure in adults, with BMI being the weakest indicator compared to ABSI and WHtR. Further research is needed to examine ABSI and WHtR indicators as predictor of increased blood pressure in adults.
Sedentary Screen Time as a Coping Strategy of Distance Learning-induced Distress during COVID-19 Pandemic Ghea Mangkuliguna; Mahaputra Mahaputra; Veronika Maria Sidharta; Linawati Hananta
Journal of Educational, Health and Community Psychology Vol 10 No 2 June 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jehcp.v10i2.19969

Abstract

During the COVID-19 pandemic, medical students might be vulnerable to excessive screen time exposure to cope with distance learning-induced distress. This study aimed to evaluate the distress and screen time before and after distance learning was initiated. Data were collected from 215 subjects. Statistical significance was accepted at P<0.05. The prevalence of distress among medical students was 25.61% and 27.06% before and after distance learning was executed, respectively. Academic-related stressor (ARS) was reported by 49.28% and 63.29% of students during the first and second surveys. The proportion of students with daily screen time ≥7 hours was 51.21% and 63.77% for the first and second surveys, respectively. ARS, interpersonal and intrapersonal-related stressor (IRS), social-related stressor (SRS), and average daily screen time significantly rose in 3-month-time (P<0.0001, P=0.0014, P=0.0261, P=0.0022). There was a significant association between distress and screen time (P=0.0313). ARS was the leading cause of distress. The majority of respondents had a daily screen time ≥7 hours. Both distress and screen time levels significantly increased as distance learning kept progressing.Keywords: COVID-19; distance learning; mental distress; medical students;                        screen time.
High VEGF Level is Produced by Human Umbilical Cord- Mesenchymal Stem Cells (hUC-MSCs) in Amino Acid-Rich Medium and under Hypoxia Condition Veronika Maria Sidharta; Elizabeth Henny Herningtyas; Christine Ayu Lagonda; Dilafitria Fauza; Yuyus Kusnadi; Rina Susilowati; Ginus Partadiredja
The Indonesian Biomedical Journal Vol 10, No 3 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i3.457

Abstract

BACKGROUND: Secretome production by stem cells depends on their culture conditions such as oxygen concentration and the composition of the culture media. In this study, we investigated the secretion of neurotrophic growth factors of human umbilical cord mesenchymal stem cells (hUC-MSCs) in amino acid-rich culture medium and under hypoxic condition.METHODS: hUC-MSCs were cultured in normoxic and various hypoxic (1%, 5%, 10%) conditions in an amino acid-rich culture medium. The end-point parameters (cell proliferation and survival, cell morphology and growth factor secretion) were measured at 3 time-points (48 hours, 72 hours and 96 hours). ELISA-based methods were used for neurotrophic factors detection, including neurotrophic growth factor (NGF), vascular endothelial factor (VEGF), and brain-derived neurotrophic factor (BDNF).RESULTS: NGF secretion was not detectable at any time points both in normoxia and hypoxia. BDNF secretion under normoxia was induced at 48 h time point and reached the highest level at an average of 181.9±13.01 pg/mL at 96 hours, whereas hypoxia exposure to hUC-MSCs only induced the BDNF secretion at low level. VEGF secretion was barely detectable in normoxic condition. However, VEGF secretion reached the highest level at an average of 7707.55±2110.85 pg/mL in 5% hypoxia at 96 hours.CONCLUSION: Combination of amino acid-rich culture medium and hypoxia condition dramatically induced high VEGF secretion by hUC-MSCs, especially at 5% hypoxia, induced mild BDNF secretion and had no effect toward NGF secretion.KEYWORDS: human umbilical cord mesenchymal stem cells, neurotrophic growth factor, amino acid-rich, hypoxia
The Correlation between Vitamin D Intake and Quality of Life in the 17-35 Age Group Suci Prasetyo; Veronika Maria Sidharta; Komang Ardi Wahyuningsih; Yunisa Astiarani; In Sil Huh
Media Kesehatan Masyarakat Indonesia Vol. 18 No. 3: SEPTEMBER 2022
Publisher : Faculty of Public Health, Hasanuddin University, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30597/mkmi.v18i3.20932

Abstract

Vitamin D testing increased significantly during the Coronavirus Disease-19 (COVID-19) pandemics due to its role in regulating the immune system. Therefore, vitamin D deficiency is associated with susceptibility to various diseases that may affect the quality of life regarding physical health, psychological well-being, social and environmental aspects. The study aimed to determine whether there is an association between vitamin D intake and quality of life in the 17 to 35-year-old age group. A cross-sectional study was conducted from April to November 2021. The sample consisted of students from the School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia, and their relatives in the same age group, who were selected using a consecutive sampling. Vitamin D intake was measured using Vitamin D Estimation Only - Food Frequency Questionnaire (VIDEO-FFQ). At the same time, the quality of life was assessed using the World Health Organization Quality of Life (WHOQOL)-BREF questionnaire. Data analysis was performed using the Chi-square test. Of the 127 respondents, the results showed that most of respondents had inadequate vitamin D intake and good quality of life (68.50%;59.10%). The highest mean of the four quality of life domains belongs to the environmental domain (3.94) with a standard deviation (SD) of ± 0.83. Data analysis showed no significant correlation between vitamin D intake and quality of life (p>0.05). The conclusion shows that there was no correlation between vitamin D intake and quality of life in the 17–35-year age group.
Hubungan Asupan Vitamin D dan Keluhan Muskuloskeletal pada Kelompok Usia 17-35 Tahun Florent Hasthiono; Komang Ardi Wahyuningsih; Veronika Maria Sidharta; Nawanto Agung Prastowo
Jurnal Ilmu Kesehatan Masyarakat Vol 12 No 02 (2023): Jurnal Ilmu Kesehatan Masyarakat
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikm.v12i02.1676

Abstract

Defisiensi vitamin D masih menjadi masalah kesehatan global sampai saat ini, tidak terkecuali negara tropis yang memiliki lebih banyak paparan sinar matahari. Studi di negara-negara Eropa, Amerika dan Asia menunjukkan tingkat defisiensi vitamin D berkisar antara 45-90%. Indonesia termasuk negara dengan tingkat defisiensi vitamin D yang tinggi, tetapi laporan mengenai status vitamin D dan upaya pencegahannya belum banyak dilakukan. Keluhan pada muskuloskeletal akan menimbulkan gangguan atau sensasi ketidaknyamanan, memengaruhi performa dalam bekerja dan mengurangi produktivitas terutama pada kelompok usia dewasa. Penelitian ini bertujuan untuk mengetahui hubungan antara asupan vitamin D dan keluhan muskuloskeletal pada kelompok usia 17-35 tahun pada mahasuswa Fakultas Kedokteran dan Ilmu Kesehatan (FKIK) Unika Atma Jaya dan kerabatnya pada rentang usia tersebut. Desain penelitian observasional analitik dengan pendekatan potong lintang. Pengambilan data dilakukan dengan metode consecutive sampling pada tahun 2021 di Indonesia. Asupan vitamin D diukur dengan Vitamin D Estimation Only - Food Frequency Questionnaire dan keluhan muskuloskeletal diukur dengan kuesioner Nordic Body Map. Data dianalisis dengan menggunakan uji Chi-square. Subjek penelitian sebanyak 108 responden. Hasil penelitian menunjukkan terdapat 67,6% responden dengan asupan vitamin D yang tidak adekuat dan 80,6% yang memiliki keluhan muskuloskeletal. Tidak terdapat hubungan yang signifikan antara asupan vitamin D dengan keluhan muskuloskeletal pada kelompok usia 17-35 tahun (P-value= 0,379).
Skin manifestations in patients with covid-19: A literature review Gunawan, Danny; Stella, Maureen Miracle; Sidharta, Veronika Maria
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022): June 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1237.235 KB) | DOI: 10.30659/sainsmed.v13i1.15563

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Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. In December 2019, cases of pneumonia with unknown cause were first reported in Wuhan, Hubei Province, China. Confirmed cases and death rates due to COVID-19 in the world are still increasing. One part of the body that is affected and causes clinical symptoms in COVID-19 is the skin. This review aims to describe and analyze cutaneous manifestation in COVID-19. This study method is a review of the literature sourced from Google Scholar and PubMed. The literature was selected using English language criteria, using the clinical study method in the form of case reports. Meanwhile, literature review, systematic literature, and meta-analysis were excluded. Journal searches were carried out using the keywords "skin" OR "cutaneous" AND "manifestation" AND "COVID-19" OR "coronavirus". The skin manifestations of COVID-19 have been observed. The most common clinical symptoms of COVID-19 were fever (47%), dry or productive cough (25%), sore throat (16%), generalized sore throat (6%), and pain (5%). However, currently there has been a shift in the approach to diagnosing COVID-19 because it can cause symptoms in other organ systems, one of which is skin manifestations. There are early reports of skin involvement (erythematous rash, extensive urticaria, and chickenpox-like vesicles) occurring in 20% of patients in the course of the COVID-19 disease. In addition, several case reports provide descriptions of petechiae and chilblains. Based on the cases that have been reported, patients with COVID-19 who have manifestations on the skin can give a picture of maculopapular eruptions, vesicular eruptions, petechiae, and also childblains.
Association between melanin and vitamin D: A systematic review Andre Colin Hartono; Veronika Maria Sidharta; Yunisa Astiarani; Regina Regina
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art13

Abstract

Globally, there is an increasing prevalence of vitamin D deficiency, including in Southeast Asia, which ranges from 6% to 70%. Vitamin D plays an important role in calcium metabolism and bone health. Melanin is one factor that contributes to vitamin D deficiency. It has photoprotective properties that inhibit vitamin D synthesis, but the mechanism has not been fully understood. To determine the mechanism of the association between melanin and vitamin D, this systematic review was conducted on 11 articles, including cross-sectional studies, cohort studies, and randomised controlled trials published from 2010 to 2020. The search included Pubmed, EBSCO, and Proquest databases, and data were synthesised from 11 studies. This critical review found nine of the 11 studies reported a significant association between melanin and vitamin D, while two reported non-significant results. Of the nine significant studies, eight reported that people with higher melanin have lower vitamin D levels, while one study suggested that melanin levels do not necessarily associate with lower vitamin D levels. In conclusion, the review establishes a significant association between melanin and vitamin D.
The association between vitamin D intake and sleep quality index within the 17-35 year age group Veronika Maria Sidharta; Patricia Anggraeni; Komang Ardi Wahyuningsih; Mariani Mariani
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.738

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Background : Vitamin D deficiency is a common health problem in the world, even in tropical countries such as Indonesia. The Lack of vitamin D intake from food or supplements can increase the risk of having vitamin D deficiency. The association between vitamin D and sleep quality has been proven by the discovery of vitamin D receptors in the brain and brainstem, which are the sleep centers of the body. Vitamin D also takes part in the process of light transduction and melatonin production, that affects circadian rhythm and sleep quality. Poor sleep quality often causes health problems which will affect the quality of life, work productivity, and increases the risk of death. The purpose of this study is to determine the association between vitamin D intake and sleep quality index within the 17-35 year age group.Method : This study is an observational analytic study using a cross-sectional approach. Data was collected using consecutive sampling methods. Vitamin D intake was measured by the Vitamin D Estimation Only - Food Frequency Questionnaire (VIDEO-FFQ) and sleep quality index was measured by the Pittsburgh Sleep Quality Index (PSQI). Data analysis is proceeded using the chi-square method.Results : The total of respondents were 119. 68,1% of the respondents had inadequate vitamin D intake and 80.4% of the respondents had poor sleep quality index. The analysis shows that there was no significant association between vitamin D intake and sleep quality index (p value = 0.325). Conclusion : Most of the respondents had inadequate vitamin intake and poor sleep quality index. There was no significant association between vitamin D intake and sleep quality index within the 17-35 year age group. Key words: Vitamin D intake, food and supplement, sleep quality index, 17-35 year age group
Association between Lamp Light During Sleep and Sleep Quality in Medical Students Yurike, Vony; Harjanto, Bernardus Realino; Widjaja, Nelly Tina; Sidharta, Veronika Maria
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3170

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Background: Sleep quality is influenced by numerous factors, including external factors, such as the sleep environment. One aspect of the sleep environment that can influence sleep is lighting. Light exposure emitted by lamps during sleep can impair sleep quality. The aim of this study was to investigate the association between lamp light during sleep and sleep quality in preclinical medical students.Methods: This cross-sectional observational analytic study was carried out on 386 preclinical medical students who were determined using the cluster sampling method. Data was collected in November 2022. Lamp light during sleep and sleep quality among students were measured using the Indonesian version of the Pittsburgh Sleep Quality Index. The association between lamp light and quality of sleep was analyzed by the Chi-Square test.Results: There were 26.68% of students who used lights when sleeping. Poor sleep quality was detected in 46.37% of students. The association between lamp light during sleep and quality of sleep yielded a p-value of 0.002.Conclusion: There is a significant association between lamp light during sleep and sleep quality in preclinical medical students. Thus, improving sleep quality in preclinical medical students may be achieved by modifying the lamp light during sleep.
EFFECT OF INTRAVENOUS ADMINISTRATION OF SECRETOME ON MALONDIALDEHYDE LEVELS IN ROTENONE-INDUCED PARKINSON'S DISEASE RATS Aliza, Sharla; Sidharta, Veronika Maria; Sasmita, Poppy Kristina; Ardianto, Christian; Barus, Jimmy
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.03

Abstract

Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder with an increasing prevalence. Oxidative stress is known to contribute to the development of PD through lipid peroxidation, which causes damage to the substantia nigra pars compacta. Lipid peroxidation produces malondialdehyde (MDA), which is known to be elevated in PD patients. Up till now, there is no cure for PD, and the available therapies are only symptomatic. The secretome from Mesenchymal Stem Cell (MSC) has antioxidant and neuroprotective components, making it a potential therapeutic agent that may slow the progression of PD. Objective: This study seeks to determine the effect of MSC secretome on oxidative stress in rotenone-induced PD rats. Methods: This research was an in-vivo experiment conducted with 30 male Sprague Dawley rats, divided into sham control, rotenone (+) secretome (-), and rotenone (+) secretome (+) groups. Rotenone (2.75 mg/kgBW) was administered for seven days to induce a PD model. Secretome administration (1 mg/ml) was carried out on days 3, 5, and 7. MDA levels were determined using the sandwich ELISA method. Results: This study found no significant difference in MDA levels among the three groups (p = 0.203). The sham control group had the lowest MDA 1.32(0.53) nmol/mL, followed by the rotenone (+) secretome (+) group 1.56(0.33) nmol/ml, and the highest MDA was observed in the rotenone (+) secretome (-) group 1.88(0.14) nmol/mL. Conclusion: Administration of MSC secretome did not significantly cause changes in plasma MDA levels of rotenone-induced Parkinson Disease rats.