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All Journal Althea Medical Journal Global Medical and Health Communication Jurnal Sistem Kesehatan Oto Rhino Laryngologica Indonesiana Majalah Anestesia dan Critical Care Tunas Medika Jurnal Kedokteran & Kesehatan
Agung Dinasti Permana
Departemen Ilmu Kesehatan Telinga Hidung Tenggorok – Bedah Kepala Leher Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin - Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hubungan kadar CA 125 dengan karakteristik klinis Diffuse Large B cell Lymphoma Agung Dinasti Permana; Igor Hutabarat; Thaufiq Boesoirie; Bethy S. Hernowo; Rovina Ruslami
Oto Rhino Laryngologica Indonesiana Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v49i1.287

Abstract

Latar belakang: Kadar serum CA 125 telah diketahui mengalami peningkatan pada kasus limfoma non Hodgkin. Kegunaannya dalam menentukan prognosis, tingkat keparahan penyakit, dan follow up pasca terapi limfoma non Hodgkin telah banyak diteliti dan masih didapatkan hasil yang bervariasi. Saat ini belum diketahui mengenai kadar serum CA 125 pada kasus diffuse large B cell lymphoma (DLBCL) yang bermanifestasi di regio kepala dan leher. Tujuan: Mengetahui hubungan kadar serum CA 125 dengan karakteristik klinis pada kasus DLBCL regio kepala dan leher. Metode: Penelitian ini merupakan penelitian potong lintang yang melibatkan 31 subjek penelitian dengan diagnosis DLBCL regio kepala dan leher. Dilakukan pencatatan karakteristik klinis dan penentuan kadar serum CA 125 dengan pemeriksaan Immunoasai dan kemudian dilakukan analisis statistik untuk menentukan hubungan antar variabel. Hasil: Didapatkan peningkatan kadar serum CA 125 pada stadium lanjut dengan p<0,001. Analisis statistik terhadap kadar serum CA 125 dan Kadar Lactic Dehydrogenase (LDH) menunjukkan hubungan yang signifikan (p=0,018) demikian juga hubungannya dengan skorEastern Cooperative Oncology Group (ECOG) dengan nilai p=0,001. Pada penelitian ini tidak terdapat hubungan yang bermakna antara kadar serum CA 125 dengan skor Prognostic International Index (IPI). Kesimpulan: Kadar serum CA 125 berhubungan bermakna dengan stadium klinis, kadar LDH dan Skor ECOG pada DLBCL yang bermanifestasi di regio kepala dan leher. Dengan demikian CA 125 dapat digunakan sebagai marker untuk memprediksi prognosis dan mendekati stadium lanjut kasus limfoma non Hodgkin. Background: Serum CA 125 level has been known to increase in Non-Hodgkin Lymphoma cases.Many studies had elaborately researched the prognosis, disease severity and the follow up of Non Hodgkin Lymphoma cases using CA 125, yet the results had been varied. Up to now, serum CA 125 levels in cases of diffuse large B cell lymphoma (DLBCL) which manifest in the head and neck region, is still unclear. Purpose: To find out the correlation of serum CA 125 levels with clinical manifestations of DLBCL cases in the head and neck region. Method: A cross-sectional study involving 31 subjects diagnosed with DLBCL in the head and neck region. The clinical manifestations were recorded and serum CA 125 levels were obtained by Immunoassay examination. Statistical analysis was performed to determine the correlation between variables. Results: An increase in serum CA 125 levels at an advanced stage with p <0.001. The statistical result of CA 125 serum levels and LDH levels showed a significant correlation (p=0.018), as well as its significant correlation with the Eastern Cooperative Oncology Group (ECOG) score, with p=0.001. In this study there was no significant correlation between CA 125 serum levels and Prognostic International Index (IPI) scores. Conclusion: Serum CA 125 levels were significantly correlated with clinical stage, LDH level and ECOG score of DLBCL which manifested in the head and neck region. Therefore, CA 125 might be used as a marker to predict prognosis and to detect advanced disease in Non-Hodgkin Lymphoma cases.
Profile of Head and Neck Cancer Patients at Hasan Sadikin Hospital in 2013-2018 Nur Nathania; Yussy Afriani Dewi; Agung Dinasti Permana
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 2 (2020): Volume 50, No. 2 July - December 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i2.361

Abstract

ABSTRACTBackground: Head and neck cancer (HNC) is the 6th highest cancer worldwide. Risk factors include history of smoking, exposure of carcinogen, diet, oral hygiene, HPV and EBV infections, genetic, and alcohol consumption. Purpose: To identify the profile of HNC patients in the Department of Otorhinolaryngology-Head and Neck Surgery (ORL-HNS) Hasan Sadikin General Hospital Bandung from 2013 to 2018. Method: A retrospective descriptive study was conducted in 2013-2018 in the Department of ORL-HNS Hasan Sadikin General Hospital, using total sampling method. Medical record of the patients were used as secondary data. Result: There were 2952 HNC patients consisted of 1689 males and 1263 females. Most of the subjects were graduated from elementary school (45.56%), with mean age 47.45 years old. The majority types of HNC were nasopharyngeal (31.20%), sinonasal (19.65%) and laryngeal (14.16%) carcinoma. The main histopathological types were undifferentiated carcinoma (47.15%) and squamous cell carcinoma (34.08%). The major risk factors were smoking and salted fish consumptions. Discussion: Unlike previous studies, our study found out that most HNC cases occurred in patients under the age of 30 years old. In this research, smoking was the highest risk factor of research subjects, followed by salted fish intake, mosquito burnt coils, and alcohol consumption. Nasopharyngeal carcinoma and stadium IV were the highest incidence of HNC, mostly found in male patients. Histopathologically, the dominant type was the undifferentiated carcinoma. Conclusion: Nasopharyngeal carcinoma was the main cancer type. The main histopathological type was undifferentiated carcinoma. The main risk factors were smoking and salted fish consumptions. ABSTRAKLatar belakang: Karsinoma kepala leher (KKL) merupakan keganasan terbanyak ke enam di dunia. Faktor risiko KKL antara lain riwayat merokok, paparan karsinogen, diet, kebersihan mulut, infeksi Human Papilloma Virus, Virus Epstein Barr, genetika, konsumsi alkohol. Tujuan: Untuk mengetahui profil penderita KKL di Departemen T.H.T-K.L Rumah Sakit Hasan Sadikin Bandung, tahun 2013- 2018. Metode: Penelitian deskriptif retrospektif dengan total sampling, pada periode 2013-2018 di Dept/KSM THT-KL RSUP Dr Hasan Sadikin. Rekam medis subjek penelitian digunakan sebagai data sekunder. Hasil: Terdapat 2.952 penderita KKL terdiri dari 1.689 laki-laki dan 1.263 perempuan. Mayoritas berpendidikan SD (45,56%), dengan rerata usia 47,45 tahun. Jenis KKL terbanyak karsinoma nasofaring (31,20%), sinonasal (19,65%), dan laring (14,16%). Karakteristik histopatologi terbanyak karsinoma tak berdiferensiasi (47,15%) dan karsinoma sel skuamosa (34,08%). Faktor risiko terbanyak merokok serta konsumsi ikan asin. Diskusi: Berbeda dengan penelitian sebelumnya, penelitian kami mendapatkan kasus KKL terbanyak didapati pada pasien di bawah usia 30 tahun. Didapatkan juga faktor risiko tertinggi adalah merokok, diikuti oleh mengonsumsi ikan asin, obat nyamuk bakar, dan minum alkohol. Angka kejadian KKL terbanyak adalah karsinoma nasofaring stadium IV, yang kebanyakan didapati pada pasien laki-laki. Secara histopatologi, tipe yang dominan adalah jenis karsinoma tak berdiferensiasi. Kesimpulan: Karsinoma nasofaring merupakan jenis KKL terbanyak. Jenis histopatologi terbanyak karsinoma tak berdiferensiasi. Faktor risiko KKL yang paling banyak ditemui yaitu merokok dan konsumsi ikan asin.
Non-Powder gunshot injury of the parapharynx space Raden Ayu Hardianti Saputri; Annika Famiasti; Nur Akbar Aroeman; Agung Dinasti Permana; Sinta Sari Ratunanda
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 2 (2021): VOLUME 51, NO. 2 JULY - DECEMBER 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i2.402

Abstract

ABSTRACTBackground: Non-powder firearm is a weapon which used compressed air or CO2 gas to propel lead or steel ball pellets. Trauma caused by non-powder firearm has the potential for significant morbidity and mortality. Head and neck wounds account for 13.8%-30% of all non-powder firearm injuries. Bullets from gunshots often nest in the parapharyngeal space. Purpose: To present a case of non-powder firearm trauma in parapharyngeal space and its management. Case Report: A 13 years-old boy came with non-powder firearm trauma on the left cheek and bleeding from the left nostril. Upon physical examination there was a vulnus sclopetorum sized 0.5x0.5 cm without active bleeding in the left zygoma area. Three dimensional CTscan showed a hyperdense metal lesion in the left parapharyngeal space with 42.6 cm distance from penetrating site to the bullet location. The bullet was then extracted with transparotid approach surgery guided by C-arm imaging. Clinical Question: How is the management of trauma from a non-powder gunshot in the parapharyngeal space? Review method: Literature search through Pubmed, Cochrane Library, and Wiley using non-powder firearm injury in parapharyngeal space and its management as keywords. Result: The search obtained 11 articles. Based on inclusion and exclusion criteria, one article was found relevant with the topic i.e. one case report of non-powder firearm injury in parapharyngeal space and its surgical management. Conclusion: The safe procedure for retrieving bullets from the parapharyngeal space is in the form of surgery with the help of C-arm imaging to pinpoint the bullet’s location and to prevent further complication.Keywords: non-powder firearm, gunshot injury, parapharynx space, C-armABSTRAKLatar belakang: Senapan angin merupakan senjata yang menggunakan tenaga penggerak berjenis gas CO2 untuk melontarkan peluru. Trauma akibat senapan angin dapat berpotensi fatal. Sebanyak 13,8-30% luka tembak senapan angin terjadi pada daerah kepala dan leher. Salah satu ruang leher yang kerap menjadi tempat bersarangnya peluru adalah ruang parafaring. Tujuan: Melaporkan kasus dan penanganan trauma tembak senapan angin pada parafaring. Laporan kasus: Anak laki-laki berusia 13 tahun dengan riwayat tertembak senapan angin di pipi kiri dan perdarahan dari hidung kiri. Pada pemeriksaan fisis didapatkan vulnus sklopetorum berukuran 0,5 x 0,5 cm tanpa perdarahan aktif di area zigoma kiri. Hasil CT scan 3D didapatkan lesi hiperdens dengan densitas metal pada parafaring kiri, berjarak 42,6 mm dari luka. Benda asing peluru kemudian diekstraksi melalui tindakan operatif menggunakan pendekatan transparotid dengan bantuan C-Arm. Pertanyaan klinis: Bagaimana penatalaksanaan trauma tembak senapan angin pada ruang parafaring? Telaah literatur: Penelusuran literatur melalui Pubmed, Cochrane Library, dan Wiley menggunakan kata kunci luka tembak senapan angin pada ruang parafaring dan penatalaksanaannya. Ditemukan 11 artikel, dan pemilihan artikel berdasarkan kriteria inklusi dan eksklusi, terdapat satu penelitian yang relevan. Hasil: Didapat satu laporan kasus tentang luka tembak senapan angin di ruang parafaring dengan tindakan bedah sebagai penanganannya. Kesimpulan: Tatalaksana pengambilan peluru yang aman adalah dengan pendekatan pembedahan dengan bantuan C-Arm untuk mencegah komplikasi lebih lanjut.Kata kunci: senapan angin, luka tembak, trauma, ruang parapfaring, C-arm
Profile and characteristic of laryngeal cancer in Radiotherapy Department of Hasan Sadikin General Hospital Pinakaratna, Afifah; Utama, Marhendra Satria; Permana, Agung Dinasti
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 1 (2023): VOLUME 53, NO. 1 JANUARY - JUNE 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i1.489

Abstract

Background: A laryngeal cancer diagnosis is often in the advanced stage, while the screening has not much done at this time. Studies on laryngeal cancer that uses radiotherapy are also still difficult to find, especially in Indonesia. Purposes: This study aimed to describe patients' profiles with laryngeal cancer who received radiotherapy treatment in the 2018 to 2019 period. Methods: This research was a descriptive quantitative with a cross-sectional study conducted at Radiotherapy Department, Hasan Sadikin General Hospital. Results: The patient's medical record was collected, and 38 patients with laryngeal cancer were found. Most of the patients are male (86,8%), ranging from age 51-60 (55,3%), work as staff office/traders (21,1%), and have a smoking history (52%). The chief complaint is often in the form of hoarseness (76,3%), the location of the cancer is No Other Specified (31,6%), most of the cells were squamous cell carcinoma (86,8%), and the stage was mainly in stage IV (60,5%). Surgery with radiotherapy is the most common management (50%), and surgery that is commonly used is total laryngectomy (36,8%). Some patients also have a tracheostomy before management (36,8%). Radiotherapy is more often for adjuvant purposes (52,6%). Conclusions: Laryngeal cancer is still uncommon, but we need to increase awareness and screening because of the advanced stage that more commonly occurs.
Co-Authors Achmad Prihadianto Annika Famiasti Attaufany, Fahmi Bambang Purwanto Bambang Purwanto Bambang Purwanto Bethy S. Hernowo Bethy S. Hernowo Bethy S. Hernowo Bogi Soeseno Debbi Yuniserani Desno Marbun Dini Atiyah Dini Atiyah, Dini Evy Shavilla Fanny Yudhiono Ifiq Budiyan Nazar Igor Hutabarat Igor Togar Hutabarat Indri Hutagalung Ismi Cahyadi Melati Sudiro Muhammad Syah Mirza Sabirin Nur Akbar Aroeman Nur Nathania Pandu Putra Harsarapama Pandu Putra Harsarapama, Pandu Putra Pinakaratna, Afifah Raden Ayu Hardianti Saputri Raden Isma Nurul Aini Rovina Ruslami, Rovina Rudy Hartanto Sally Mahdiani Samiadi, Dindi Sinta Sari Ratunanda Thaufiq Boesoirie Utama, Marhendra Satria Yuniserani, Debbi Yussy Afriani Dewi Yussy Afriani Dewi Yussy Afriani Dewi Yussy Afriani Dewi Yussy Afriani Dewi Yussy Afriani Dewi Yussy Afriani Dewi Yussy Afriani Dewi Yussy Afriani Dewi