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All Journal Aquasains : Jurnal Ilmu Perikanan dan Sumberdaya Perairan Hydrogen: Jurnal Kependidikan Kimia Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi
Dian Oktavianti, Dian
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Chemistry Economics, Econometrics & Finance Education Other

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Partial Substitution of Fish Meal with Petek (Leiougnathus equulus) Flour in Commercial Feed of Patin Siam (Pangasius hypopthalamus) Fry Oktavianti, Dian; Santoso, Limin; Suparmono, Suparmono
AQUASAINS Vol 4, No 1 (2015)
Publisher : Jurusan Perikanan dan Kelautan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (591.186 KB)

Abstract

Patin Siam (Pangasius hypopthalamus) is a freshwater fish which is received considerable attention by public and has high economic value. In process of cultivation, farmers often got problems because of high price of feed. It’s because raw materials feed such fish meal still import from another country. One of the efforts to reduce the use of imported fish meal is using Petek fish meal. The aim of this research was to determine the effect of the use of Petek fishmeal as partial substitution of fish meal. This research used Completely Randomized Design (CRD) with 5 treatments and 3 replications namely treatment A (commercial pellets / control), B (fish meal 75% + Petek fish meal 25%), C: (fish meal 50% + Petek fish meal 50%), D (25% fish meal + 75% Petek fish meal) and E: (0% fish meal + Petek fish meal 100%). Observed variables were absolute growth, daily growth rate, survival rate, and feed conversion ratio (FCR). Data were analyzed by ANOVA and Duncan test. The tested fish were cultivated in aquarium with dimension of 60 x 40 x 40 cm3 for 50 days. Fishes were feed three times a days with feeding rate of 5%. The results showed that the use of Petek fishmeal in feed could increase absolute growth and daily growth rate. The treatment of C resulted in highest absolute growth of Patin Siam and lowest feed conversion ratio. The treatments did not effect the survival rate of Patin Siam.
ANALISIS DUKUNGAN ORGANISASI DAN MOTIVASI KERJA TERHADAP KEPUASAN KERJA KARYAWAN PADA PT. THONG LANGKAT ENERGY DI KECAMATAN BAHOROK Oktavianti, Dian; Parinduri , Siti Ira Wati; Ghazali , Muhammad Rio; Malau , Agnes Monika; Malikhah, Ikhah
Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi Vol. 2 No. 3 (2024): Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi
Publisher : Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.572349/neraca.v2i3.1122

Abstract

Penelitian ini bertujuan untuk menganalisis pengaruh dukungan organisasi dan motivasi kerja terhadap kepuasan kerja karyawan di PT. Thong Langkat Energy di Kecamatan Bahorok. Penelitian ini menggunakan metode kualitatif yaitu dengan wawancara dan observasi langsung untuk pengumpulan data. Hasil analisis data menujukkan bahwa terdapat hubungan positif antara dukungan organisasi dan motivasi kerja terhadap kepuasan kerja karyawan. Dukungan organisasi, termasuk dalam bentuk fasilitas, kebijakan perusahaan, dan komunikasi yang efektif, memiliki pengaruh yang signifikan terhadap kepuasan kerja karyawan. Begitu pula dengan motivasi kerja, yang dapat menjadi pendorong utama bagi karyawan untuk mencapai kinerja optimal dan merasa terpenuhi dalam pekerjaan mereka. Penelitian ini memberikan implikasi manajerial yang penting bagi perusahaan dalam memperbaiki kepuasan kerja karyawan. Manajemen perusahaan perlu memastikan adanya dukungan yang memadai dari tingkat atas dan menciptakan lingkungan kerja yang mendorong motivasi karyawan. Dengan demikian, hasil penelitian ini dapat membantu perusahaan dalam meningkatkan kesejahteraan dan produktivitas karyawan. Dukungan organisasi dan motivasi kerja memainkan peran penting dalam meningkatkan kepuasan kerja karyawan. Penelitian ini memberikan wawasan yang berharga bagi manajemen perusahaan dalam upaya meningkatkan kondisi kerja dan kesejahteraan karyawan di PT Thong Langkat Energy.
In Silico Study of Antidiabetic Activity Mikania Cordata as PPAR- γ Agents Oktavianti, Dian; Masriani; Arief, Ihsanul
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.18110

Abstract

Diabetes mellitus remains a significant global health problem, requiring safer and more effective therapeutic agents. Peroxisome Proliferator-Activated Receptor gamma (PPAR-γ) plays a crucial role in regulating glucose metabolism by enhancing insulin sensitivity, making it a key target in the development of antidiabetic drugs. Pioglitazone, a PPAR-γ agonist from the thiazolidinedione class, has long been used as a conventional therapy; however, its long-term use is associated with side effects such as fluid retention, weight gain, and an increased risk of heart failure. The World Health Organization recommends the development of natural-based drugs with minimal adverse effects. One promising plant candidate is Mikania cordata, which has been reported to possess antidiabetic activity and contains various bioactive compounds, including terpenoids, flavonoids, sterols, and sesquiterpenoids. This study aimed to evaluate the bioactive compounds of Mikania cordata as potential natural PPAR-γ agonists using a molecular docking approach. A total of 36 ligands from M. cordata were docked to the PPAR-γ protein (PDB ID: 2PRG), with Pioglitazone serving as the positive control. Docking was performed using PyRx with the AutoDock Vina system after ligand and protein preparation with UCSF Chimera 1.16. The docking results were analyzed using BIOVIA Discovery Studio Visualizer to identify the interactions between the ligand–protein complexes. The results showed that Cordatolide exhibited the lowest binding affinity (–9.1 kcal/mol), followed by Stigmasterol (–8.9 kcal/mol), both of which were better than Pioglitazone (–8.8 kcal/mol). Interaction analysis revealed that Cordatolide formed two hydrogen bonds with key residues ARG288 and GLY284, accompanied by stable hydrophobic interactions without any unfavorable contacts. Meanwhile, Stigmasterol also showed competitive affinity, although its stability relied solely on hydrophobic interactions without hydrogen bonding. Therefore, Cordatolide demonstrates strong potential as a natural PPAR-γ agonist with fewer side effects compared to conventional therapies. This study provides a novel finding on the potential of M. cordata as a natural PPAR-γ agonist; however, further in vitro and in vivo evaluations are required to confirm its pharmacological activity.
Co-Authors Ghazali , Muhammad Rio Ihsanul Arief Limin Santoso Malau , Agnes Monika Malikhah, Ikhah Masriani . Parinduri , Siti Ira Wati Suparmono Suparmono