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All Journal Jurnal Kebidanan Jurnal Kesehatan Reproduksi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Diponegoro International Medical Journal (DIMJ) Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan
Yuli Trisetiyono, Yuli
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Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Endothelin-1 Level In Early Onset Preeclampsia Riantyoko, Yoshi; Hadijono, Raden Soerjo; Iskandar, Teuku Mirza; Trisetiyono, Yuli; Pramono, Besari Adi; Suhartono, Suhartono; Kristanto, Herman
DINAMIKA KESEHATAN: JURNAL KEBIDANAN DAN KEPERAWATAN Vol 14, No 1 (2023): Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan
Publisher : Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/dksm.v14i1.917

Abstract

Introductions: Preeclampsia is a specific syndrome in pregnancy as a result of abnormal placental invasion leading to placental hypoperfusion. Persistent hypoxia of the placenta causes the release of various inflammatory mediators into the circulation and results in local endothelial dysfunction. Increased endothelin-1 (ET-1) secretion and increased inflammatory mediators occur in preeclampsia.Aims: To analyze the relationship between endothelin-1 and early onset preeclampsia.Methods: This crosssectional study included 50 pregnant women with early onset preeclampsia (n=25) and normal pregnancies (n=25). Pregnant women aged 20-35 years with single intrauterine fetus, primigravida and multigravida who experienced early onset preeclampsia 34 weeks of gestation were included in this study. Endothelin-1 levels was measured using the Enzyme Linked Immunosorbant Assay (ELISA) method. The analysis was performed using the Mann-Whitney test. Receiving Operator Characteristic (ROC) curve analysis was used to find the cut-off value and diagnostic accuracy of endothelin-1 levels.Results: The mean of ET-1 level was significantly higher in early onset preeclampsia (0.732 ± 0.56 pg/mL) compared to normal pregnancy (0.318 ± 0.09 pg/mL) with value of p = 0.000. The ROC analysis showed the AUC value of 87.8% (p = 0.000, 95% CI 78.6%-97.1%). The cut-off value for ET-1 was 0.385 pg/mL, with 80% sensitivity and 68% specificity (PR=3.14; 95% CI 1.40-7.03).Conclusion: Increased levels of endothelin-1 (ET-1) significantly associated with early onset preeclampsia. ET-1 level ≥ 0.385 pg/mL in pregnant women with 34 weeks of gestation is potential biomarkers to predict the occurrence of early onset preeclampsia with a risk up to 3.14 times.
Effect of DLBS3233, Metformin, and Their Combination on the Expressions of VEGF and Endometriosis Implants in Endometriosis Mice (A Mouse Model in Endometriosis Study) Wardana, Setya Girindra; Trisetiyono, Yuli; Hadijono, Raden Soerjo; Mulyantoro, Inu; Cahyanti, Ratnasari Dwi; Dewantiningrum, Julian
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.18393

Abstract

Abstract Background: Endometriosis is a gynaecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. The process of angiogenesis is regulated by VEGF which plays an important role in the development of endometriosis implants. Metformin is an insulin sensitizer that is known to have a beneficial effect in the treatment of endometriosis and DLBS3233 is a PPARγ agonist, it is hoped that it can reduce VEGF and reduce endometrial implants..Objective: To explore the effect of DLBS3233, metformin, and combination on VEGF expression and endometrial implant area of endometriosis-induced mice.Methods: This experimental study used 3-months old 28 BALB/c mice of endometriosis that were randomly and equally divided into four groups (K, P1, P2, and P3). On the 15th day, the K group was given a placebo, the P1 group was given DLBS3233 0.25 mg/day for 14 days, the P2 group was given metformin 4 mg/day for 14 days and the P3 group was given a combination. The immunohistochemistry of VEGF expression was performed from the abdominal cavity and pelvic peritoneal tissues of the mice and measured by the Remmele Scale Index, while the extracted mice's endometrial implants were analyzed with a computer tracing method. All data normality tests were calculated with the Shapiro-Wilk test. The mean difference test of all groups was analyzed using the one-way ANOVA test and the Kruskal-Wallis test.Results: There were significant differences in the expressions of VEGF (p=0.005) and endometrial implants (p=0.001). Expression of VEGF in the P3 group was significantly lower compared to others and endometrial implant area in the P2 group was significantly lower compared to others.Conclusion: DLBS3233 and Metformin may be a potentially effective drug treatments for endometriosis by decreasing VEGF expression and endometrial implants. Keywords: DLBS3233, Endometriosis, Metformin, VEGF
Factors Associated With Recurrence Of Epithelial Ovarian Cancer In RSUP Dr. Kariadi Semarang Kurube, Isabela Marsialina; Ambari, Ediwibowo; Iskandar, Teuku Mirza; Tjahjanto, Hary; Dewantiningrum, Julian; Mochtar, Arufiadi Anityo; Trisetiyono, Yuli
Diponegoro International Medical Journal Vol 3, No 2 (2022): December 2022
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v3i2.15448

Abstract

Introductions: Epithelial ovarian cancer accounts for 90% of all ovarian malignancies. More than 70% of patients will experience a relapse even after receiving operative therapy and chemotherapy. There are several prognostic factors that influence the recurrence of ovarian cancer. In Indonesia, especially at Dr. Kariadi Hospital, Semarang, the data as mentioned above is still very limited.objective: Knowing the disease-free survival rate, optimizing surgery and factors related to the incidence of recurrence in epithelial ovarian cancer patients at Dr. Kariadi Hospital SemarangMethods: This study is a retrospective cohort study with survival analysis. Data were collected through medical records, with the study population are patients with a diagnosis of epithelial ovarian cancer who were treated at Dr. Kariadi Hospital Semarang in period January 2018-December 2019. Furthermore, patients who had been remission were observed for signs of disease recurrence for 2 years period.Results: There were 361 patients with epithelial ovarian cancer who underwent primary treatment at Dr. Kariadi Hospital, Semarang in  2018-2019. Furthermore, there were observations of recurrence in 148 patients who achieved remission. Of these 76 patients (51.4%) experienced recurrence, while 72 patients not relapse. From 148 epithelial ovarian cancer patients who underwent cytoreduction surgery at Dr. Kariadi Hospital, Semarang, 113 patients (76.4%) achieved optimal operation with a residu less than 2 cm, while 35 patients (23.6%) were not optimal with a residu more than 2 cm. FIGO stage (HR 2.44) and tumor residu (HR 2.15) were shown to be significant factors associated with the recurrence of epithelial ovarian cancer.Conclusion: Overall disease-free survival in epithelial ovarian cancer at Dr. Kariadi Semarang were 74.8% (6 months), 57.1% (1 year), 42.5% (18 months), and 37.4% (2 years). Tumor residual factors and FIGO stage were shown to be significant prognostic factors influencing the recurrence of epithelial ovarian cancer. 
Perbandingan Luaran Maternal dan Perinatal Kehamilan Terkonfirmasi Covid-19 antara Gelombang Pertama dan Kedua Pandemi Irsan, Raissa Alifia; Farhanah, Nur; Trisetiyono, Yuli; Cahyanti, Ratnasari Dwi
JURNAL KESEHATAN REPRODUKSI Vol 10, No 3 (2023)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.81781

Abstract

Background : New cases of COVID-19 continued to emerge due to the new variants. Pregnant women are more susceptible to severe infections.Objective : To compare the effect of COVID-19 infection on maternal and perinatal outcomes in the first and second waves.Method : An analytical observational study with a cross-sectional design was used. Samples were selected by consecutive sampling from the medical record data of RSUP Dr. Kariadi Semarang, Indonesia, with 47 cases during the first wave (1 August 2020 to 14 May 2021) and 47 cases during the second wave (16 May to 30 September 2021). Data were analysed using univariate, chi-square, fisher’s exact, and logistic regression tests with a significant value of p <0,05.Results and Discussion : Pneumonia, ICU admission, and oxygen consumptions were higher in the second than the first wave as 87.23% VS 70.21%; p = 0.044, 36.17% VS 14.89%; p = 0.018, 65.96% VS 12.77%; p < 0.0001 respectively. The severe COVID-19 infection and maternal mortality increased in the second wave (51,06% VS 14,89%; p = 0.009; 29,79% VS 8,51%; p = <0.001). There were no differences in perinatal outcomes between the first and second waves such as fetal distress, fetal growth retardation, low birth weight, nICU admission, and mortality (0.00% VS 8.51%; p = 0.117, 0.00% VS 4.26%; p = 0.495, 12.77% VS 25.53%; p = 0.116, 12.77% VS 21.28%; p = 0.272, 4.26% VS 8.51%; p = 0.677). The incidence of COVID-19 infection in neonates remained low in both waves at 17.02% VS 12.77%; p = 0.562.Conclusion : Even though a high number of severe diseases to maternal deaths were found during the second wave, neonatal COVID-19 infections remained low. 
The Effect of Green Tea Extract Supplementation on Superoxide Dismutase Levels and Endometriosis Lesions: A Clinical Trial in Mice Trisetiyono, Yuli; Artanto, Yosef Adi
JURNAL KEBIDANAN Vol 14, No 2 (2024): Oktober 2024
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v14i2.11387

Abstract

Endometriosis is a gynaecological disorder characterised by the presence of endometrial tissue outside the uterine cavity. It affects approximately 10-15% of females of reproductive age. Oxidative stress has been identified as a significant contributing factor to the development and progression of endometriosis. In this study, we investigated the effect of green tea extract on the endometriotic implant area and serum superoxide dismutase (SOD) levels in a rat model of endometriosis. Twenty-six female Balb/c rats were randomly divided into the experimental group (EG) and the control group (CG). All subjects in the EG received green tea extract (3 mg daily) for 14 days. On the fourteenth day, endometriosis was induced in all subjects (both EG and CG). The endometriotic implant area and serum SOD levels were assessed 14 days after induction. The endometriotic implant area in the green tea extract-treated group was significantly lower than that in the control group (p=0.022, RR=0.455, 95% CI=0.065-0.96). Serum SOD levels in the EG and CG were 5.33±0.52 ng/ml and 5.20±0.91 ng/ml, respectively (p=0.507). Green tea extract effectively inhibited the progression of endometriotic implants and increased serum SOD levels in the endometriosis-induced rat model. These findings suggest that the anti-angiogenic and antioxidant properties of green tea may have therapeutic potential in managing endometriosis.
The Effect of Green Tea Extract Supplementation on Superoxide Dismutase Levels and Endometriosis Lesions: A Clinical Trial in Mice Trisetiyono, Yuli; Artanto, Yosef Adi
JURNAL KEBIDANAN Vol. 14 No. 2 (2024): Oktober 2024
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v14i2.11387

Abstract

Endometriosis is a gynaecological disorder characterised by the presence of endometrial tissue outside the uterine cavity. It affects approximately 10-15% of females of reproductive age. Oxidative stress has been identified as a significant contributing factor to the development and progression of endometriosis. In this study, we investigated the effect of green tea extract on the endometriotic implant area and serum superoxide dismutase (SOD) levels in a rat model of endometriosis. Twenty-six female Balb/c rats were randomly divided into the experimental group (EG) and the control group (CG). All subjects in the EG received green tea extract (3 mg daily) for 14 days. On the fourteenth day, endometriosis was induced in all subjects (both EG and CG). The endometriotic implant area and serum SOD levels were assessed 14 days after induction. The endometriotic implant area in the green tea extract-treated group was significantly lower than that in the control group (p=0.022, RR=0.455, 95% CI=0.065-0.96). Serum SOD levels in the EG and CG were 5.33±0.52 ng/ml and 5.20±0.91 ng/ml, respectively (p=0.507). Green tea extract effectively inhibited the progression of endometriotic implants and increased serum SOD levels in the endometriosis-induced rat model. These findings suggest that the anti-angiogenic and antioxidant properties of green tea may have therapeutic potential in managing endometriosis.
Risk Factors of Ectopic Pregnancy at Dr. Kariadi Hospital Zahwa, Kamila Zettira; Trisetiyono, Yuli; Pramono, M Besari Adi; Dewantiningrum, Julian
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.25368

Abstract

Background: Ectopic pregnancy lead to maternal death. There were several risk factors for ectopic pregnancy, including age, IUD, parity, history of ectopic pregnancy, history of pelvic and abdominal surgery, infertility, history of PID, history of abortion, and infertility treatment. This study aimed to prove the correlation between these factors with ectopic pregnancy at RSUP Dr. Kariadi.Objective: This study examines to prove the correlation between these factors with ectopic pregnancy at RSUP Dr. KariadiMethods: This study was an analytical observational study with case control design consisted of 134 samples, divided into ectopic pregnancy (n=67) and threatened abortion as controls (n=67), collected from patient medical records from 2019 – 2024 using purposive sampling. Data analysis was carried out using bivariate analysis with Chi Square & Fisher Exact Test and multivariate analysis with Logistic Regression Test.Results: There were correlation between history of ectopic pregnancy (p = 0,034), history of abortion (p = 0,002), and infertility (p = 0,009) with ectopic pregnancy. Other variables didn’t have significant relationship with ectopic pregnancy (p>0,05). Two risk factors were identified for ectopic pregnancy: history of abortion (p = 0,001; aOR = 3,516; 95% CI 1,632 – 7,577) and infertility (p = 0,005; aOR = 2,913; 95% CI 1,387 – 6,119).Conclusion: There were correlation between history of ectopic pregnancy, history of abortion, and infertility with ectopic pregnancy, while other variables were not related to ectopic pregnancy. History of threatened abortion and infertility were risk factors for ectopic pregnancy.
Efficacy and Tolerability of Short-Term Hormonal Therapy Following Conservative Surgery for Endometriosis: Efficay and Clinical Tolerability of Short-Term Hormonal Treatment for Endometriosis Pain Trisetiyono, Yuli; Sarastry, Razmaeda; Dewantiningrum, Julian; Anityo Mochtar, Arufiadi; Kristanto, Herman; Thaufik Hidayat, Syarief
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 4 October2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i4.2588

Abstract

AbstractObjective: To compare the efficacy and tolerability of four short-term hormonal therapies; Dienogest (DNG), Depot Medroxyprogesterone Acetate (DMPA), continuous Combined Oral Contraceptive (COC), and Leuprolide Acetate (LA); administered for 12 weeks after conservative endometriosis surgery. Methods: This randomized, prospective, open-label study enrolled reproductive-aged women with surgically confirmed endometriosis. Participants were randomly assigned to receive DNG 2 mg daily, DMPA 150 mg intramuscularly every 12 weeks, continuous COC (ethinyl estradiol 0.03 mg and levonogestrel 0.15 mg) daily, or LA 3.75 mg intramuscularly every 4 weeks. Primary outcomes were changes in pain intensity (visual analog scale, VAS), hormonal markers (estradiol, E2), inflammatory markers (TNF-?), and the Menopause Rating Scale (MRS) as an indicator of tolerability. Data were analyzed using ANOVA with a significance level of p < 0.05. Results: All four regimens resulted in significant reductions in dysmenorrhea, dyspareunia, and chronic pelvic pain after 12 weeks (p < 0.001). E2 and TNF-? levels decreased significantly in all groups, with the greatest decline observed in the LA arm. No significant differences were found among regimens in pain reduction or biomarker changes (p > 0.05). MRS scores increased transiently at week 8, particularly in the LA group, reflecting hypoestrogenic effects, but decreased by week 12 in all groups. Conclusion: Short-term postoperative hormonal therapy with DNG, DMPA, COC, or LA effectively reduces pain and inflammatory markers following endometriosis surgery. Progestin-based therapies achieve comparable clinical efficacy to GnRH agonists with superior tolerability. Individualized selection based on symptom profile, side effects, and accessibility is recommended in accordance with ESHRE guidelines. Keywords: endometriosis-associated pain, Menopause Rating Scale, short-term hormonal therapy.
Co-Authors AA Sudharmawan, AA Anityo Mochtar, Arufiadi Artanto, Yosef Adi Besari Adi Pramono Ediwibowo Ambari Hadijono, Raden Soerjo Hary Tjahjanto Herman Kristanto Irsan, Raissa Alifia Julian Dewantiningrum Kurube, Isabela Marsialina Mochtar, Arufiadi Anityo Mulyantoro, Inu Nur Farhanah, Nur Pramono, M Besari Adi Ratnasari Dwi Cahyanti, Ratnasari Dwi Riantyoko, Yoshi Sarastry, Razmaeda Teuku Mirza Iskandar, Teuku Mirza Thaufik Hidayat, Syarief Wardana, Setya Girindra Zahwa, Kamila Zettira