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All Journal Jurnal Kebidanan Jurnal Kesehatan Reproduksi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan
Yuli Trisetiyono, Yuli
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Education Health Professions Medicine & Pharmacology Nursing Public Health

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Endothelin-1 Level In Early Onset Preeclampsia Riantyoko, Yoshi; Hadijono, Raden Soerjo; Iskandar, Teuku Mirza; Trisetiyono, Yuli; Pramono, Besari Adi; Suhartono, Suhartono; Kristanto, Herman
DINAMIKA KESEHATAN: JURNAL KEBIDANAN DAN KEPERAWATAN Vol 14, No 1 (2023): Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan
Publisher : Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/dksm.v14i1.917

Abstract

Introductions: Preeclampsia is a specific syndrome in pregnancy as a result of abnormal placental invasion leading to placental hypoperfusion. Persistent hypoxia of the placenta causes the release of various inflammatory mediators into the circulation and results in local endothelial dysfunction. Increased endothelin-1 (ET-1) secretion and increased inflammatory mediators occur in preeclampsia.Aims: To analyze the relationship between endothelin-1 and early onset preeclampsia.Methods: This crosssectional study included 50 pregnant women with early onset preeclampsia (n=25) and normal pregnancies (n=25). Pregnant women aged 20-35 years with single intrauterine fetus, primigravida and multigravida who experienced early onset preeclampsia 34 weeks of gestation were included in this study. Endothelin-1 levels was measured using the Enzyme Linked Immunosorbant Assay (ELISA) method. The analysis was performed using the Mann-Whitney test. Receiving Operator Characteristic (ROC) curve analysis was used to find the cut-off value and diagnostic accuracy of endothelin-1 levels.Results: The mean of ET-1 level was significantly higher in early onset preeclampsia (0.732 ± 0.56 pg/mL) compared to normal pregnancy (0.318 ± 0.09 pg/mL) with value of p = 0.000. The ROC analysis showed the AUC value of 87.8% (p = 0.000, 95% CI 78.6%-97.1%). The cut-off value for ET-1 was 0.385 pg/mL, with 80% sensitivity and 68% specificity (PR=3.14; 95% CI 1.40-7.03).Conclusion: Increased levels of endothelin-1 (ET-1) significantly associated with early onset preeclampsia. ET-1 level ≥ 0.385 pg/mL in pregnant women with 34 weeks of gestation is potential biomarkers to predict the occurrence of early onset preeclampsia with a risk up to 3.14 times.
Perbandingan Luaran Maternal dan Perinatal Kehamilan Terkonfirmasi Covid-19 antara Gelombang Pertama dan Kedua Pandemi Irsan, Raissa Alifia; Farhanah, Nur; Trisetiyono, Yuli; Cahyanti, Ratnasari Dwi
JURNAL KESEHATAN REPRODUKSI Vol 10, No 3 (2023)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.81781

Abstract

Background : New cases of COVID-19 continued to emerge due to the new variants. Pregnant women are more susceptible to severe infections.Objective : To compare the effect of COVID-19 infection on maternal and perinatal outcomes in the first and second waves.Method : An analytical observational study with a cross-sectional design was used. Samples were selected by consecutive sampling from the medical record data of RSUP Dr. Kariadi Semarang, Indonesia, with 47 cases during the first wave (1 August 2020 to 14 May 2021) and 47 cases during the second wave (16 May to 30 September 2021). Data were analysed using univariate, chi-square, fisher’s exact, and logistic regression tests with a significant value of p <0,05.Results and Discussion : Pneumonia, ICU admission, and oxygen consumptions were higher in the second than the first wave as 87.23% VS 70.21%; p = 0.044, 36.17% VS 14.89%; p = 0.018, 65.96% VS 12.77%; p < 0.0001 respectively. The severe COVID-19 infection and maternal mortality increased in the second wave (51,06% VS 14,89%; p = 0.009; 29,79% VS 8,51%; p = <0.001). There were no differences in perinatal outcomes between the first and second waves such as fetal distress, fetal growth retardation, low birth weight, nICU admission, and mortality (0.00% VS 8.51%; p = 0.117, 0.00% VS 4.26%; p = 0.495, 12.77% VS 25.53%; p = 0.116, 12.77% VS 21.28%; p = 0.272, 4.26% VS 8.51%; p = 0.677). The incidence of COVID-19 infection in neonates remained low in both waves at 17.02% VS 12.77%; p = 0.562.Conclusion : Even though a high number of severe diseases to maternal deaths were found during the second wave, neonatal COVID-19 infections remained low. 
The Effect of Green Tea Extract Supplementation on Superoxide Dismutase Levels and Endometriosis Lesions: A Clinical Trial in Mice Trisetiyono, Yuli; Artanto, Yosef Adi
JURNAL KEBIDANAN Vol 14, No 2 (2024): Oktober 2024
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v14i2.11387

Abstract

Endometriosis is a gynaecological disorder characterised by the presence of endometrial tissue outside the uterine cavity. It affects approximately 10-15% of females of reproductive age. Oxidative stress has been identified as a significant contributing factor to the development and progression of endometriosis. In this study, we investigated the effect of green tea extract on the endometriotic implant area and serum superoxide dismutase (SOD) levels in a rat model of endometriosis. Twenty-six female Balb/c rats were randomly divided into the experimental group (EG) and the control group (CG). All subjects in the EG received green tea extract (3 mg daily) for 14 days. On the fourteenth day, endometriosis was induced in all subjects (both EG and CG). The endometriotic implant area and serum SOD levels were assessed 14 days after induction. The endometriotic implant area in the green tea extract-treated group was significantly lower than that in the control group (p=0.022, RR=0.455, 95% CI=0.065-0.96). Serum SOD levels in the EG and CG were 5.33±0.52 ng/ml and 5.20±0.91 ng/ml, respectively (p=0.507). Green tea extract effectively inhibited the progression of endometriotic implants and increased serum SOD levels in the endometriosis-induced rat model. These findings suggest that the anti-angiogenic and antioxidant properties of green tea may have therapeutic potential in managing endometriosis.
The Effect of Green Tea Extract Supplementation on Superoxide Dismutase Levels and Endometriosis Lesions: A Clinical Trial in Mice Trisetiyono, Yuli; Artanto, Yosef Adi
JURNAL KEBIDANAN Vol. 14 No. 2 (2024): Oktober 2024
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v14i2.11387

Abstract

Endometriosis is a gynaecological disorder characterised by the presence of endometrial tissue outside the uterine cavity. It affects approximately 10-15% of females of reproductive age. Oxidative stress has been identified as a significant contributing factor to the development and progression of endometriosis. In this study, we investigated the effect of green tea extract on the endometriotic implant area and serum superoxide dismutase (SOD) levels in a rat model of endometriosis. Twenty-six female Balb/c rats were randomly divided into the experimental group (EG) and the control group (CG). All subjects in the EG received green tea extract (3 mg daily) for 14 days. On the fourteenth day, endometriosis was induced in all subjects (both EG and CG). The endometriotic implant area and serum SOD levels were assessed 14 days after induction. The endometriotic implant area in the green tea extract-treated group was significantly lower than that in the control group (p=0.022, RR=0.455, 95% CI=0.065-0.96). Serum SOD levels in the EG and CG were 5.33±0.52 ng/ml and 5.20±0.91 ng/ml, respectively (p=0.507). Green tea extract effectively inhibited the progression of endometriotic implants and increased serum SOD levels in the endometriosis-induced rat model. These findings suggest that the anti-angiogenic and antioxidant properties of green tea may have therapeutic potential in managing endometriosis.
Efficacy and Tolerability of Short-Term Hormonal Therapy Following Conservative Surgery for Endometriosis: Efficay and Clinical Tolerability of Short-Term Hormonal Treatment for Endometriosis Pain Trisetiyono, Yuli; Sarastry, Razmaeda; Dewantiningrum, Julian; Anityo Mochtar, Arufiadi; Kristanto, Herman; Thaufik Hidayat, Syarief
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 4 October2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i4.2588

Abstract

AbstractObjective: To compare the efficacy and tolerability of four short-term hormonal therapies; Dienogest (DNG), Depot Medroxyprogesterone Acetate (DMPA), continuous Combined Oral Contraceptive (COC), and Leuprolide Acetate (LA); administered for 12 weeks after conservative endometriosis surgery. Methods: This randomized, prospective, open-label study enrolled reproductive-aged women with surgically confirmed endometriosis. Participants were randomly assigned to receive DNG 2 mg daily, DMPA 150 mg intramuscularly every 12 weeks, continuous COC (ethinyl estradiol 0.03 mg and levonogestrel 0.15 mg) daily, or LA 3.75 mg intramuscularly every 4 weeks. Primary outcomes were changes in pain intensity (visual analog scale, VAS), hormonal markers (estradiol, E2), inflammatory markers (TNF-?), and the Menopause Rating Scale (MRS) as an indicator of tolerability. Data were analyzed using ANOVA with a significance level of p < 0.05. Results: All four regimens resulted in significant reductions in dysmenorrhea, dyspareunia, and chronic pelvic pain after 12 weeks (p < 0.001). E2 and TNF-? levels decreased significantly in all groups, with the greatest decline observed in the LA arm. No significant differences were found among regimens in pain reduction or biomarker changes (p > 0.05). MRS scores increased transiently at week 8, particularly in the LA group, reflecting hypoestrogenic effects, but decreased by week 12 in all groups. Conclusion: Short-term postoperative hormonal therapy with DNG, DMPA, COC, or LA effectively reduces pain and inflammatory markers following endometriosis surgery. Progestin-based therapies achieve comparable clinical efficacy to GnRH agonists with superior tolerability. Individualized selection based on symptom profile, side effects, and accessibility is recommended in accordance with ESHRE guidelines. Keywords: endometriosis-associated pain, Menopause Rating Scale, short-term hormonal therapy.
Co-Authors AA Sudharmawan, AA Anityo Mochtar, Arufiadi Artanto, Yosef Adi Besari Adi Pramono Hadijono, Raden Soerjo Herman Kristanto Irsan, Raissa Alifia Julian Dewantiningrum Nur Farhanah, Nur Ratnasari Dwi Cahyanti, Ratnasari Dwi Riantyoko, Yoshi Sarastry, Razmaeda Teuku Mirza Iskandar, Teuku Mirza Thaufik Hidayat, Syarief