Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Urology Jurnal Serambi Abdimas Medical and Health Journal
Hajid Rahmadianto Mardihusodo, Hajid Rahmadianto
Unknown Affiliation
Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
The effect of active compound isolated from the leaves of kembang bulan [Tithonia diversifolia (Hemsley) A. Gray] on cell cycle and angiogenesis of WiDr cell line Mardihusodo, Hajid Rahmadianto; Hartati Wahyuningsih, Mae Sri; Astuti, Indwiani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 03 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (908.662 KB) | DOI: 10.19106/JMedScie004503201301

Abstract

Colorectal cancer is the tenth most common form of malignant tumor of hospital inpatients inIndonesia. Advance approaches in anticancer development is discovery molecular-targeted drugs.Molecular targets for anticancer drug have been identified including genes associated with cellcycle control and angiogenesis. Previously, an active and selective compound against WiDr fromTithonia diversifolia (Hemsley) A. has been isolated. The aim of this study was to evaluate theeffect of the isolated active compound fromT. diversifolia on the WiDr cell cycle and angiogenesis.Isolation of the active compound was performed by preparative thin layer chromatography (TLC)method. WiDr cell cycle was analyzed by flowcytometry using propidium iodide (PI).Antiangiogenesis effect was evaluated by immunocytochemistry method using anti-human VEGFmonoclonal antibody. The results showed that the effect of the isolated active compound onthe WiDr cell cycle depended on the concentration and the incubation time periods. Atconcentration of 4 μg/mL, it inhibited the WiDr cell cycle SubG1 phase after 36 and 48 hoursincubation and G1 phase after 72 hours incubation. While at concentration of 8 μg/mL, it clearlyinhibited the WiDr cell cycle G1 phase after 36, 48 and 72 hours incubation. Furthermore, theisolated active compound at concentration of 4 μg/mL significantly inhibited the VEGF expressionuntil 47.38% compared to control. In conclusion, the isolated active compound fromT. diversifoliainhibited cell cycle and angiogenesis of WiDr cell.
EFFECT OF NIFEDIPINE ON APOPTOSIS, NECROSIS AND VIABILITY OF GERMINAL EPITHELIAL CELLS IN THE CONTRALATERAL TESTICLE AND PLASMA TESTOSTERONE LEVELS IN MALE WHITE RATS (RATTUS NORVEGICUS, WISTAR STRAIN) AFTER UNILATERAL TESTICULAR TORSION Mardihusodo, Hajid Rahmadianto; Rizaldi, Fikri; Hakim, Lukman
Indonesian Journal of Urology Vol 26 No 2 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i2.513

Abstract

Objective: To compare the number of apoptosis, necrosis and viability of germinal epithelial cells in the contralateral testicle (CT) and plasma testosterone (PT) levels in white male rats which administered Nifedipine after unilateral testicular torsion (TT) compared with control group. Material & Methods: This research was an experimental study using male white rats (Rattus Norvegicus, Wistar strain) aged 10-12 weeks and body weight 150-200 gram. A total of 30 rats were then randomly divided into 5 groups (n=6) which were negative control group (KN), positive control group (KP1 and KP2) and Nifedipine-administered group (N1 and N2). Each group performed unilateral left side torsion of testicular of 1080o anticlockwise except the KN group. There was 4-hour ischemic duration in the KP1 and N1 groups while 10 hours in the KP2 and N2 groups. Administration of Nifedipine 30 minutes before detorsion by intraperitoneal injection dosed 100 μg/kgBW. All groups performed right orchidectomy and plasma blood sampling. Measurement of apoptosis, necrosis and viability of germinal epithelial cells in the CT using flowcytometry. Measurement of PT levels using Enzyme-Linked Immunosorbent Assay (ELISA). Results: The number of apoptosis, necrosis and viability of contralateral testicular germinal epithelial cells and PT levels in the KN group compared with KP1 and KP2 groups were significantly different (p<0.05). There was no significant discrepancy in apoptosis (p>0.05) in KP1 group compared with N1 group, as well as in KP2 group compared with N2 groups. The number of necrosis, viability of germinal epithelial cells in the CT and PT level in KP1 group in compared with N1 group, as well as in KP2 group in compared with N2 group were significantly different (p<0.05). Conclusion: Nifedipine administration prior to testicular detorsion can maintain cell viability and decrease the amount of necrotic germinal epithelial cells in the CT and prevent the decrease in PT levels after unilateral TT.
Program Edukasi Pencegahan dan Deteksi Dini Faktor Risiko Penyakit Ginjal Kronik pada Lansia di Kelurahan Grendeng, Kabupaten Banyumas Afifah, Afifah; Hestiyani, Rani Afifah Nur; Ati, Viva Ratih Bening; Mardihusodo, Hajid Rahmadianto; Wisesa, Sindhu; Nafiisah, Nafiisah; Fadhilah, Synta Haqqul; Munfiah, Siti; Wahyudin, Wahyudin
Jurnal Serambi Abdimas Vol 5 No 1 (2024): Jurnal Serambi Abdimas
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/sa.v5i1.11079

Abstract

Penyakit ginjal kronik masih menjadi salah satu masalah kesehatan pada lansia di dunia termasuk Indonesia. Hipertensi dan diabetes melitus merupakan penyebab terbanyak penyakit ginjal kronis di Indonesia. Pengabdian ini bertujuan untuk memberikan edukasi pencegahan dan melakukan deteksi dini faktor risiko penyakit ginjal kronis pada lansia. Kegiatan edukasi dilakukan dengan metode ceramah dan pemeriksaan tekanan darah serta kadar glukosa darah. Terdapat peningkatan pengetahuan setelah kegiatan dan diketahui sebanyak 34% peserta mengalami hipertensi serta 11% mengalami hiperglikemia dari sebanyak 102 peserta. Secara keseluruhan, pengabdian ini telah berhasil meningkatkan pengetahuan dan terdeteksi faktor risiko utama penyakit ginjal kronis.
The Role of Rumination in University Students’ Mental Health: A Mediation Analysis of Depression and Anxiety Maghfiroh, Nisaul; Oktavilia, Ernasiwi Astri; Hidayah, Arfi Nurul; Kamal, Isran; Mardihusodo, Hajid Rahmadianto; Syamsu Hidayat, Muhammad Zaenuri
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19800

Abstract

This study examined the relationship between rumination and mental health among university students by testing the mediating roles of depression and anxiety. Rumination refers to a repetitive and passive focus on negative experiences and emotions that may influence psychological functioning. A quantitative correlational design was employed. A total of 113 students completed the Ruminative Response Scale (RRS), Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and General Health Questionnaire (GHQ-12). Parallel mediation analysis indicated that rumination significantly predicted depression (β = .6197, p < .001) and anxiety (β = .5830, p < .001). Depression significantly predicted mental health (β = .2893, p = .025), whereas anxiety was not a significant predictor (β = .1186, p = .343). The direct effect of rumination on mental health was not significant (β = −.0940, p = .427), nor was the total effect (β = .1544, p = .098). However, the indirect effect through depression was significant (β = .1793, p = .031; 95% CI [.00464, .0957]), whereas the indirect path through anxiety was not significant (β = .0692, p = .347). These findings indicate that depression fully mediates the relationship between rumination and mental health. Thus, the influence of rumination on students’ mental health primarily operates through increased depressive symptoms.
Co-Authors Fadhilah, Synta Haqqul Hidayah, Arfi Nurul Indwiani Astuti Kamal, Isran Lukman Hakim Mae Sri Hartati Wahyuningsih Maghfiroh, Nisaul Muhammad Afif Nafiisah, Nafiisah Oktavilia, Ernasiwi Astri Rizaldi, Fikri Siti Munfiah Syamsu Hidayat, Muhammad Zaenuri Viva Ratih Bening Ati Wahyudin Wahyudin Wisesa, Sindhu