Ziana Walidah, Ziana
Farmasi, Fakultas Farmasi, Universitas Gadjah Mada

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POTENSI BIJI LABU KUNING SEBAGAI AGEN FITOESTROGEN PADA WANITA POST MENSTRUAL Lestari, Beni; Hanif, Naisbitt Iman; Anggarany, Ariska Deffy; Ziyad, Thoriq; Walidah, Ziana; Murwanti, Retno
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (756.169 KB)

Abstract

Osteoporosis and hypercholesterolemia are prevalent condition in menopausal women. The common therapy to prevent the estrogen degrading condition is Hormone Replacement Therapy (HRT). However, HRT possessed various risks. Curcubita pepo L. seed (pumpkin seed) contains lignan secoisolariciresinol and lariciresinol which exhibit estrogenic effect. The aim of this study is to determine the estrogenic effect of Ethanolic Extract of Pumpkin Seeds (EEPS) through in silico and in vivo study. In silico study were conducted by molecular docking of lignan which is secoisolariciresinol and lariciresinol with Estrogen Receptor (ERα and Erβ). In vivo study conducted by using ovariectomized Sprague dawley female rats as a model of postmenopausal women. Blood lipid profile, bone density, and uterine weight were assayed after thirty days. Molecular docking score of secoisolariciresinol and lariciresinol were similar to estradiol. In vivo study found that EEPS increase bone density and uterine weight percentage while also improve the blood profile. In conclusion, these result showed that EEPS is potential to be developed as an osteoporosis and hypercholesterolemia prevention agent. Keywords:  Lime peel, Limonene, Aromatic candles, Repellent
IMPLEMENTASI KEBIJAKAN KONSERVASI DALAM MENGATASI DEFORESTASI DI KALIMANTAN walidah, ziana
Law Research Review Quarterly Vol. 10 No. 4 (2024): Contemporary Issues in Crime and Justice
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/llrq.v10i4.14557

Abstract

Penulisan ini bertujuan untuk mengetahui perkembangan dampak deforestasi terhadap ekosistem hutan dan kehidupan masyarakat lokal di Kalimantan dan implementasi kebijakan konservasi dalam mengatasi deforestasi di Kalimantan. Kehidupan di Kalimantan menjadi terancam dikarenakan oleh menurunnya luasan dan mutu hutan. deforestasi tidak hanya merusak ekosistem tetapi juga mengancam kelangsungan hidup dan kesejahteraan masyarakat lokal yang telah lama bergantung pada hutan. Penelitian ini menggunakan metode penelitian kualitatif yang bersumber dari berbagai literatur atau studi kepustakaan dalam menjawab hasil penulisan.