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All Journal Program Kreativitas Mahasiswa - Penelitian Jurnal Mitra Kesehatan ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Journal of Pharmaceutical Care and Sciences Pharmaceutical Sciences and Research (PSR) Borobudur Pharmacy Review Journal of Pharmaceutical and Sciences. Kenduri: Jurnal Pengabdian Dan Pemberdayaan Masyarakat SEGARA : Jurnal Pengabdian Kepada Masyarakat Journal of Research in Pharmacy and Pharmaceutical Sciences Jurnal Abdimas Mahakam
Ariska Deffy Anggarany, Ariska Deffy
Universitas Pembangunan Nasional Veteran Jakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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POTENSI BIJI LABU KUNING SEBAGAI AGEN FITOESTROGEN PADA WANITA POST MENSTRUAL Lestari, Beni; Hanif, Naisbitt Iman; Anggarany, Ariska Deffy; Ziyad, Thoriq; Walidah, Ziana; Murwanti, Retno
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (756.169 KB)

Abstract

Osteoporosis and hypercholesterolemia are prevalent condition in menopausal women. The common therapy to prevent the estrogen degrading condition is Hormone Replacement Therapy (HRT). However, HRT possessed various risks. Curcubita pepo L. seed (pumpkin seed) contains lignan secoisolariciresinol and lariciresinol which exhibit estrogenic effect. The aim of this study is to determine the estrogenic effect of Ethanolic Extract of Pumpkin Seeds (EEPS) through in silico and in vivo study. In silico study were conducted by molecular docking of lignan which is secoisolariciresinol and lariciresinol with Estrogen Receptor (ERα and Erβ). In vivo study conducted by using ovariectomized Sprague dawley female rats as a model of postmenopausal women. Blood lipid profile, bone density, and uterine weight were assayed after thirty days. Molecular docking score of secoisolariciresinol and lariciresinol were similar to estradiol. In vivo study found that EEPS increase bone density and uterine weight percentage while also improve the blood profile. In conclusion, these result showed that EEPS is potential to be developed as an osteoporosis and hypercholesterolemia prevention agent. Keywords:  Lime peel, Limonene, Aromatic candles, Repellent
The Effect of Heparinoid as Systemic Prophylactic Anticoagulants on COVID-19 Patient Mortality and Its Safety Profiles: A Systematic Review and Meta-Analysis Anggarany, Ariska Deffy; Sauriasari, Rani; Alkaff, Muhammad; Takhwifa, Famila; Nufus, Hayatun; Paramita, Diana
Pharmaceutical Sciences and Research Vol. 8, No. 3
Publisher : UI Scholars Hub

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Abstract

Coagulopathy is one of the complications of COVID-19 and is associated with a higher risk of mortality. However, evidence regarding the effectiveness and safety of anticoagulant therapy in various doses among COVID-19 patients is limited. This systematic review and meta-analysis aims to review and explore the effect of using heparinoids as a systemic anticoagulant at prophylactic doses on mortality in COVID-19 patients. Systematic searches were conducted of various databases (Pubmed, ScienceDirect, SpringerLink, Scopus, and ProQuest) covering the period 2019-2021. We assessed the quality of the articles using the STROBE checklist. Studies with a high risk of bias were excluded before pooled effect size was synthesized with 95% confidence intervals (CI) using random-effects models. From the 12 identified studies (N=8,968), six observational studies (N=7,176) were involved in the meta-analysis. The studies reviewed in the paper used a retrospective cohort design in various settings. The pooled effect size of mortality comparing prophylactic anticoagulant and no anticoagulant in three studies showed that there was an association between using prophylactic anticoagulant and a lower risk of in-hospital mortality (pooled OR= 0.47; 95% CI 0.19-0.76). A prophylactic dose of heparinoid anticoagulant was also associated with lower mortality (pooled OR= 0.51; 95% CI 0.21-0.82) and with lower bleeding events compared to intermediate-to-therapeutic dose anticoagulants. Administration of heparinoid anticoagulants at prophylactic doses was associated with reduced mortality risk in hospitalized COVID-19 patients. Due to the increased risk of bleeding with therapeutic doses, the use of prophylaxis anticoagulant is suggested in COVID-19 patients who are not critically ill.
POTENSI ANTIOKSIDAN INFUSA BUNGA TELANG (Clitoria ternatea), ROSELLA (Hibiscus sabdariffa) DAN DAUN STEVIA (Stevia rebaudiana) SEBAGAI ANTIDIABETES Melania Perwitasari; Sinta Nuriyah Awaliyah; Intan Kurnia Putri; Nofria Rizki Amalia Harahap; Ariska Deffy Anggarany; Reza Anindita; Maya Uzia Beandrade; Dede Dwi Nathalia
Jurnal Mitra Kesehatan Vol. 5 No. 2 (2023): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v5i2.194

Abstract

Reactive Oxygen Species (ROS) can induce oxidation that caused aging and degenerative diseases such as Diabetic Mellitus. To prevent the incident of degenerative disease, antioxidant needed that found in many herbs, especially colored herbs. Butterfly pea, Rosella flower, and Stevia leaf known as herbs contains phenolic and flavonoid. This constituent are responsible as antioxidant activity. Many people consume the herbs by brewing with hot water as infused water. The purpose of this research is to determine antioxidant activity of infused Butterfly pea, Rosella flower, and Stevia leaf by FRAP method. This is non experiment method descriptive with dry herbs of Butterfly pea, Rosella flower, and Stevia leaf infused extract as sample. The research was conducted in September 2022-February 2023 at STIKes Mitra Keluarga Laboratory. The antioxidant activity is expressed as % FRAP activity. Based on the experiment, it knows that % FRAP activity of Butterfly pea, Rosella flower, and Stevia leaf consecutive 55,29% ± 0,0, 69,17% ± 0,12 , 61,55% ± 0,04.
Aktivitas farmakologi dan fitokimia ekstrak Moringa oleifera lam. terhadap sistem reproduksi pria dan wanita: scoping review Anggarany, Ariska Deffy
Borobudur Pharmacy Review Vol 5 No 1 (2025): January- June
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bphr.v5i1.13889

Abstract

Reproductive health is an important part of life continuity. Moringa oleifera plant is reported to have benefits on growth and reproduction that have been tested on animals, such as steroid alkaloids, alkaloid-pyricine, pyrrolidine, phenolics, steroid glycosides, saponins and triterpenoids. This study aims to demonstrate the pharmacological activity of Moringa oleifera Lam. extract as an antifertility agent in the male and female reproductive systems. This study assessed the phytochemical compounds and antifertility effects of moringa on reproductive parameters in both men and women. This study was conducted through a literature study based on an online database search by combining Boolean search terms (“AND”, “OR”) in the electronic databases PubMed, ScienceDirect and Google Scholar. There were 15 articles that met the inclusion and exclusion criteria of the study. Several phytochemical compounds such as tannins, alkaloids, phenols, flavonoids, saponins and anthraquinones were reported in extracts of both flowers, stems, seeds and leaves of the moringa plant. The effects of these compounds have the potential to improve sperm quality, increase testosterone production in men, and affect hormone levels and estrus cycles in female reproduction. These findings support the role of Moringa oleifera as an antifertility agent in various reproductive parameters in both men and women.
Analisis Rasionalitas Penggunaan Obat Anticemas Pada Pasien Gangguan Cemas Menyeluruh Di Poli Jiwa Rawat Jalan Rumah Sakit Swasta X Kota Bekasi Anggarany, Ariska Deffy; Kartika, Elsa
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.881

Abstract

Background: Anxiety is a normal basic emotion that appears in the survival of every individual human being. Pathologically elevated anxiety can be considered a generalized anxiety disorder characterized by prolonged and excessive anxiety and worry that can occur indefinitely in certain circumstances. Objective: This study aims to evaluate the suitability of the use of anti-anxiety drugs in patients with generalized anxiety disorders in one of the Bekasi Private Hospitals for the 2022 period. Methods: This study used a cross- sectional, non-probability study design with retrospective data. The sample used was 85 medical records of patients with generalized anxiety disorders with the majority of patients being women (53%). Data is presented in the form of percentages, tables and charts. The study’s results revealed Evaluation of drug use of patients with comprehensive anxiety disorders showed the use of a single drug of 2 patients and a combination drug of 83 patients, treatment dominated by SSRIs, Antipsychotics, and Benzodiazepines. Accuracy assessment based on 4 parameters, namely appropriate indication (100%), appropriate drug (79%), appropriate dose (67%) and drug inaccuracy (21%) and dosage inaccuracy (33%). Conclusion: These findings highlight the need to improve dosing accuracy and treatment management. Future research should adopt a prospective design to assess dosing, duration, side effects, and drug interactions for more comprehensive patient care.
Edukasi Dan Pemberdayaan Masyarakat Dalam Upaya Pencegahan Stunting Di Kelurahan Panggang, Kecamatan Kepulauan Seribu Anggarany, Ariska Deffy; Rabani, Alya Layyina; Elzuhria A, Nadia; Kaffah, Nur Silmi; Ningrum, Anggita Cahya; Pratama, Deri Putra; Manurungi, Anggita Virginia Naulina; Syafad, Aisyah Malika; Farkhani, Aulia; Muti, Annisa Farida; Esadini, Ayu Rana; Pradana, Dhigna Luthfiyani Citra; Andini, Putri
ADMA : Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 6 No. 2 (2025): ADMA: Jurnal Pengabdian dan Pemberdayaan Mayarakat: In-Progress
Publisher : LPPM Universitas Bumigora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/adma.v6i2.5396

Abstract

Stunting masih menjadi masalah kesehatan yang signifikan di Kepulauan Seribu, terutama di wilayah Pulau Panggang. Inisiatif pengabdian masyarakat ini dirancang untuk meningkatkan pemahaman dan perspektif masyarakat tentang pencegahan stunting dengan menggunakan sesi edukasi dan demonstrasi menggunakan bahan pangan lokal. Teknik yang digunakan meliputi sesi edukasi dan lokakarya yang menarik dengan fokus pada pembuatan makanan bergizi, seperti nugget kelor dan tuna, yang kaya nutrisi. Program ini melibatkan 23 ibu dengan anak kecil, yang menjadi fokus inisiatif, dan menilai pengetahuan serta pandangan mereka melalui tes yang dilakukan sebelum dan sesudah program. Temuan menunjukkan bahwa pengetahuan meningkat dari 95,7% menjadi 100%, masuk dalam kategori baik, sementara sikap meningkat dari 91,4% menjadi 95,7%, juga masuk dalam kategori baik. Meskipun perubahannya tidak signifikan secara statistik, upaya ini memberikan nilai tambah bagi kesadaran dan partisipasi masyarakat. Memanfaatkan bahan-bahan lokal seperti daun kelor berpotensi berkontribusi pada ketahanan pangan keluarga dan membantu mencegah stunting secara berkelanjutan.
Peningkatan Tingkat Pengetahuan terkait Penyakit Diare pada Generasi Z di Pondok Pesantren Zamzami, Limo, Depok Wafa; Primayanti Nurul Ilmi; Ariska Deffy Anggarany; Ayu Rana Esadini; Via Rifkia Rifkia
Jurnal Abdimas Mahakam Vol. 10 No. 02 (2026): Juli
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24903/jam.v10i02.3945

Abstract

Diare masih menjadi salah satu masalah kesehatan yang sering terjadi di masyarakat, sementara praktik swamedikasi yang tidak didukung pengetahuan yang memadai berpotensi menyebabkan penggunaan obat yang tidak rasional. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan Generasi Z di Pondok Pesantren Zamzami mengenai penyakit diare, penggunaan oralit, penanganan awal diare, serta penggunaan obat secara rasional dalam swamedikasi diare. Kegiatan dilaksanakan pada 25 September 2025 dengan melibatkan 54 santri tingkat Madrasah Tsanawiyah dan Madrasah Aliyah. Intervensi dilakukan melalui penyuluhan kesehatan menggunakan metode ceramah interaktif, diskusi, dan tanya jawab dengan media slide presentasi dan leaflet. Evaluasi menggunakan desain one-group pretest-posttest dengan pengukuran tingkat pengetahuan sebelum dan sesudah penyuluhan menggunakan kuesioner terstruktur. Data dianalisis secara deskriptif dan inferensial menggunakan paired t-test dengan tingkat kepercayaan 95%. Hasil menunjukkan peningkatan rerata skor pengetahuan dari 58,15 sebelum intervensi menjadi 82,37 setelah intervensi. Peningkatan tersebut bermakna secara statistik (p < 0,001). Proporsi peserta dengan kategori pengetahuan baik meningkat dari 18,5% menjadi 74,1%, sedangkan kategori pengetahuan kurang menurun dari 29,6% menjadi 3,7%. Temuan ini menunjukkan bahwa penyuluhan kesehatan berpotensi meningkatkan pengetahuan santri mengenai penyakit diare, penggunaan oralit, penanganan awal diare, dan penggunaan obat yang rasional dalam swamedikasi. Kegiatan edukasi serupa perlu dilakukan secara berkelanjutan untuk mendukung perilaku swamedikasi yang tepat di masyarakat.
The Hubungan Parameter Farmakokinetik Klinis dengan Variabilitas Respons Antibiotik pada Pasien Gangguan Fungsi Ginjal: Suatu Tinjauan Sistematis Ariska Deffy Anggarany; Wafa Wafa; Rifaldi Saputra
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1714

Abstract

Introduction: Renal impairment affects the pharmacokinetics of various antibiotics eliminated through the renal route, potentially leading to drug accumulation, toxicity, or therapeutic failure if doses are not appropriately adjusted. The variability in antibiotic response in this population remains a clinical challenge due to the complexity of pharmacokinetic/pharmacodynamic (PK/PD) parameters, degree of renal dysfunction, comorbidities, and dosing strategies. Objective: This systematic review aims to explore the relationship between clinical pharmacokinetic parameters and antibiotic response variability in adult patients with renal impairment, as well as to identify implementable PK/PD-based individualized therapy strategies. Methods: A literature search was conducted through PubMed/MEDLINE, Scopus, Embase, and Cochrane Library (2016–2026) following PRISMA 2020 guidelines. Studies involving adult patients (≥18 years) with renal impairment that reported PK/PD parameters and clinical outcomes were included. A narrative synthesis was performed on 18 articles meeting the inclusion criteria. Results: Renal function is a major determinant of antibiotic exposure, particularly for renally eliminated drugs. PK/PD parameters such as AUC/MIC, trough concentration, and %fT>MIC play important roles in assessing therapeutic adequacy, although their association with clinical outcomes is not always consistent due to population heterogeneity, infection severity, and differences in dosing strategies. Higher vancomycin exposure is consistently associated with an increased risk of nephrotoxicity. PK/PD-based individualized approaches through therapeutic drug monitoring, Bayesian forecasting, and model-informed precision dosing have been shown to improve target concentration attainment and reduce toxicity risk. Conclusion: Clinical pharmacokinetic parameters are associated with antibiotic response variability in patients with renal impairment, with more consistent relationships observed for toxicity than for efficacy. Integration of PK/PD-based individualized dosing strategies into routine clinical practice is necessary to optimize antibiotic therapy effectiveness and safety, supported by the development of comprehensive predictive models in this population.
Edukasi Teh Herbal Daun Cempedak dan Secang sebagai Peningkat Imunitas di Pondok Pesantren Zamzami Depok Ayu Rana Esadini; Wafa; Ariska Deffy Anggarany; Via Rifkia; Primayanti Nurul Ilmi
Segara : Jurnal Pengabdian Kepada Masyarakat Vol 4 No 1 (2026): Vol. 4 No. 1 (2026) SEGARA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Fakultas Kedokteran UPN "Veteran" Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/segara.v3i1.14240

Abstract

Sistem imunitas merupakan mekanisme pertahanan vital tubuh dalam melawan berbagai agen patogen dan menjaga integritas kesehatan dari kerusakan oksidatif. Ketahanan sistem imun menjadi sangat krusial di lingkungan komunal dengan interaksi sosial tinggi seperti pondok pesantren, di mana kepadatan populasi asrama meningkatkan risiko penularan penyakit secara signifikan. Namun, pengetahuan santri mengenai pemanfaatan tanaman herbal lokal sebagai imunomodulator masih terbatas. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukasi serta keterampilan praktis kepada santri di Pondok Pesantren Al-Qur'an Zamzami, Depok, dalam mengolah teh herbal daun cempedak dan secang sebagai upaya penguatan imunitas mandiri. Metode pelaksanaan menggunakan pendekatan edukatif partisipatif yang meliputi pre-test, pemaparan materi sistem imun, pemutaran video demonstrasi pembuatan teh, serta post-test. Hasil kegiatan menunjukkan adanya peningkatan pemahaman yang signifikan dari para peserta mengenai khasiat tanaman herbal dan teknik pengolahannya. Kesimpulannya, kegiatan ini efektif dalam meningkatkan pengetahuan teoritis dan keterampilan praktis santri. Inisiatif ini diharapkan dapat membentuk kebiasaan hidup sehat yang berkelanjutan di lingkungan pesantren melalui pemanfaatan bahan alam sebagai upaya preventif untuk menjaga kesehatan di lingkungan pondok pesantren.
MICROBIAL CONTAMINATION TEST USING THE MOST PROBABLE NUMBER (MPN) METHOD ON SWEET SOY SAUCE AROUND UPN “VETERAN” JAKARTA PONDOK LABU CAMPUS MICROBIAL CONTAMINATION TEST USING THE MOST PROBABLE NUMBER (MPN) METHOD ON SWEET SOY SAUCE AROUND UPN “VETERAN” JAKARTA PONDOK LABU CAMPUS Ariska Deffy Anggarany; Alisha Dian Prasasti; Amara Ayu Karlina; Anisa Puja Ningrum; Aurelie Reginia Iteh; Bimo Asrul Seno; Nabilah Siti Zahara
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 2 (2024): Vol.3 No.2 DECEMBER (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i2.10997

Abstract

Sweet soy sauce is a fermented soybean product widely used as a traditional Indonesian seasoning. Its production process involves specific microorganisms to develop unique taste, aroma, and texture characteristics. However, poor hygiene and sanitation can lead to microbial contamination, such as Coliform, which may degrade quality and pose health risks. This study aimed to evaluate the microbiological quality of sweet soy sauce using the Most Probable Number (MPN) method. Samples were collected from food vendors around the UPN "Veteran" Jakarta campus and tested using liquid media to detect the presence of Coliform. The results showed that sample 1 (street vendor) had an MPN value of 14 MPN/gram, exceeding the BPOM safety limit (3 MPN/gram), while sample 2 (packaged soy sauce from a minimarket) was within the safety limit at 3 MPN/gram. A confirmatory test detected the presence of Escherichia coli in sample 1 but not in sample 2. Proper product handling, implementation of Good Manufacturing Practices (GMP), and regular microbiological monitoring are necessary to ensure the safety of sweet soy sauce products.
Co-Authors Alisha Dian Prasasti Amara Ayu Karlina Andiri Niza Syarifah Anisa Puja Ningrum Annisa Farida Muti Aulia Farkhani Aurelie Reginia Iteh Ayu Rana Esadini Ayu Rana Esadini Beni Lestari Bimo Asrul Seno Dhigna Luthfiyani Citra Pradana Dwi Nathalia, Dede Elva Dwi Pamungkas Elzuhria A, Nadia Esadini, Ayu Rana Farkhani, Aulia Hayatun Nufus Intan Kurnia Putri Intan Kurnia Putri Kaffah, Nur Silmi Kartika, Elsa Manurungi, Anggita Virginia Naulina Maulin Inggraini Maya Uzia Beandrade Maya Uzia Beandrade Melania Perwitasari Melania Perwitasari Muhammad Alkaff Nabilah Siti Zahara Naisbitt Iman Hanif, Naisbitt Iman Ningrum, Anggita Cahya Nofria Rizki Amalia Harahap Paramita, Diana Pratama, Deri Putra Primayanti Nurul Ilmi Putri Andini, Putri Rabani, Alya Layyina Rani Sauriasari, Rani Renaldi, Fransiskus Samuel Retno Murwanti Reza Anindita Anindita Rifaldi Saputra Sinta Nuriyah Awaliyah Syafad, Aisyah Malika Takhwifa, Famila Thoriq Ziyad, Thoriq Via Rifkia Via Rifkia Rifkia Wafa Wafa Wafa Wafa Ziana Walidah, Ziana