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Peran Pengawasan Pemerintah Dan Badan Pengawas Obat Dan Makanan (BPOM) Dalam Peredaran Obat Palsu di Negara Indonesia (Ditinjau dari Undang-Undang Nomor 36 Tahun 2009 dan Peraturan Kepala Badan Pengurus Obat dan Makanan) Marisca Evalina Gondokesumo; Nabbilah Amir
Perspektif Hukum VOLUME 21 ISSUE 2
Publisher : Faculty of Law Hang Tuah University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/ph.v21i2.16

Abstract

Abstract Drugs play a very important role in health services because the handling and prevention of various diseases cannot be separated from the treatment with drugs. Therefore, a supervisory role is needed for the Government and the National Agency of Drug and Food Control (NADFC) to always supervise the circulation of counterfeit drugs in the community as a form of prevention. The research method used is normative juridical. The results showed that monitoring the presence of counterfeit drugs had a wide-dimensional and complex problem aspect. In order to reduce the risk as small as possible, it requires a supervisory role by the government and NADFC through regulation and standardization; safety, efficacy and quality assessments through Good Manufacturing Practices (GMP) and medicinal products before being allowed to circulate in Indonesia must obtain a distribution permit, inspection, sampling and laboratory testing of products in circulation as well as warnings to the public supported by law enforcement.
Laporan Kasus: Keamanan Kombinasi Terapi Nimodipine dan Nicardipine pada Pasien Cerebrovascular Accident Subarachnoid Hemorrhage (CVA SAH) Syafira Nur Hayati; Rani Nur Badriah; Reta Anggraeni Widya; Jainuri Erik Pratama; Antonius Adji Prayitno Setiadi; Fauna Herawati; Marisca Evalina Gondokesumo
MAHESA : Malahayati Health Student Journal Vol 4, No 10 (2024): Volume 4 Nomor 10 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i10.15815

Abstract

ABSTRACT Hemorrhage stroke is caused by injury due to acute extravasation of blood into the brain parenchyma from rupture of small cerebral blood vessels. One of the etiologies of hemorrhage stroke is hypertension. Hypertension is a disease in which the blood pressure value exceeds normal, namely if the systolic blood pressure value is ≥ 140mmHg and/or the diastolic blood pressure value is ≥ 90mmHg. Giving calcium channel blocker drugs has good benefits. This research is a descriptive case study, namely describing the problem of the safety of using a combination of Nimodipine and Nicardipine therapy in Cerebrovascular Accident Subarachnoid Hemorrhage (CVA SAH) patients. Below we present a case of hypertension in a 59 year old female patient who was admitted to hospital with complaints of decreased consciousness, a history of diabetes mellitus, and a history of hypertension. The patient received combination therapy of Nicardipine (drip) 5-15mg and Nimodipine PO 4x60mg. For five days the patient was treated in hospital with the administration of two anti-hypertension drugs from the same class, namely the calcium channel blocker class. It can be seen from the patient's blood pressure profile that the patient's blood pressure tends to be stable so it is safe not to cause hypotension side effects that are harmful to the patient. Keywords: Case Report, Hypertension, Nimodipine, Nicardipine  ABSTRAK Stroke hemorrhage atau stroke perdarahan disebabkan oleh cedera karena ekstravasasi darah akut ke dalam parenkim otak dari pecahnya pembuluh darah otak kecil. Salah satu etiologi dari munculnya stroke hemorrhage adalah kondisi hipertensi. Hipertensi merupakan penyakit yang mana nilai tekanan darah melebihi normal, yaitu apabila nilai tekanan darah sistolik ≥ 140mmHg dan/atau nilai tekanan darah diastolik ≥ 90mmHg. Pemberian obat golongan calcium channel blocker memiliki manfaat yang baik. Penelitian ini merupakan studi kasus deskriptif mendeskripsikan kasus dari keamanan penggunaan kombinasi terapi Nimodipine dan Nicardipine pada pasien Cerebrovascular Accident Subarachnoid Hemorrhage (CVA SAH). Berikut ini kami presentasikan sebuah kasus hipertensi pada pasien perempuan berusia 59 tahun yang masuk rumah sakit dengan keluhan penurunan kesadaran, riwayat penyakit diabetes mellitus, dan riwayat penyakit hipertensi. Pasien mendapat terapi kombinasi Nicardipine (drip) 5-15mg dan Nimodipine PO 4x60mg. Selama lima hari pasien dirawat di rumah sakit dengan pemberian dua obat anti hipertensi dari golongan yang sama yaitu golongan calcium channel blocker, maka dapat dilihat dari profil tekanan darah pasien bahwa tekanan darah pasien cenderung stabil sehingga aman tidak menyebabkan munculnya efek samping hipotensi yang membahayakan pasien. Kata Kunci: Motivasi, Gaya Kepemimpinan, Perilaku Perawat, Sampah Medis