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All Journal Jurnal e-Biomedik Narra J
Sri S. Ningsih, Sri S.
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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HUBUNGAN PENGGUNAAN LAPTOP DAN FUNGSI PENGLIHATAN MAHASISWA ANGKATAN 2011 FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO Ningsih, Sri S.; Lintong, Fransiska; Rumampuk, Jimmy F.
e-Biomedik Vol 3, No 3 (2015): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v3i3.9627

Abstract

Abstract: Nowadays, laptop is very trendy because it can be used anywhere. It is very useful in teaching and learning. This study aimed to determine the relation of the use of laptop and visual function. This was a descriptive study using questionnairre and survey. Respondents were students Faculty of Medicine, University of Sam Ratulangi batch 2011. Based on duration, time interval, occurence of complaints, and laptop lighting, the bivariate analysis showed a P value >0.05. Conclusion: There was no correlation between the use of laptop and vision function among students of Faculty of Medicine, University of Sam Ratulangi Manado batch 2011.Keywords: laptop, visionAbstrak: Dewasa ini, laptop sangat diminati karena dapat digunakan dimana saja. Laptop juga berdampak positif bagi proses belajar dan mengajar. Penelitian ini bertujuan untuk mendapatkan hubungan penggunaan laptop dan fungsi penglihatan. Penelitian ini bersifat deskriptif dengan menggunakan survei berupa kuesioner pada mahasiswa angkatan 2011 Fakultas Kedokteran Universitas Sam Ratulangi Manado. Analisis bivariat berdasarkan hubungan antara lama penggunaan laptop, waktu rata-rata pengnaan laptop, jeda, timbulnya keluhan, dan pencahayaan laptop memperlihatkan nilai P >0,05. Simpulan: Tidak terdapat hubungan antara penggunaan laptop dan fungsi penglihatan mahasiswa angkatan 2011 Fakultas Kedokteran Universitas Sam Ratulangi Manado.Kata kunci: laptop, penglihatan
Beetroot (Beta vulgaris) potential in preventing colorectal cancer using in-silico analysis Dwijayanti, Adisti; Azizah, Norma N.; Erlina, Linda; Kusmardi, Kusmardi; Ningsih, Sri S.; Fadilah, Fadilah; Hashim, Najihah M.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1578

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide, necessitating the need for an effective therapeutic strategy. Beta vulgaris (beetroot) possesses active compounds that exert anti-cancer properties. The aim of this study was to evaluate the potential of beetroot as a preventative agent against the progression of CRC using differentially expressed gene (DEG) analysis and network pharmacology approaches. The protein-protein interaction network and molecular docking analyses were employed to assess the key interactions of beetroot active compounds with CRC-related target protein. Cytotoxicity of beetroot extract was experimentally evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay on the HT29 cell line. The result of this study showed that protein in the cell cycle was significantly enriched in CRC, with cyclin-dependent kinase 4 (CDK4) gene as one of the specific genes. Quercetin, galangin, hesperidin, farrerol, and betanin were the most typical compounds of beetroot based on the Comparative Toxicogenomics Database (CTD). Molecular docking studies revealed the strong binding affinity between quercetin (-7.04 kcal/mol) and bentanin (-8.11 kcal/mol) with CDK4. Beetroot demonstrated anticancer properties against the HT29 cell line with IC50 value of 39.03±1.4 µg/mL. In conclusion, the beetroot extract has inhibitory activity against HT29 cell line proliferation, highlighting its potential in preventing the development of CRC through the substantial suppression of gene expression within the cell cycle pathway.
Co-Authors Adisti Dwijayanti Azizah, Norma N. Erlina, Linda Fadilah Fadilah, Fadilah Fransiska Lintong Hashim, Najihah M. Jimmy Rumampuk Kusmardi Kusmardi Mohamad Sadikin Novi S. Hardiany Radiana D. Antarianto Sari, Dewi H. Septelia I. Wanandi Sri W.A. Jusman