Garuda - Garba Rujukan Digital

Profil Keganasan Primer Kulit Tersering di Departemen Patologi Anatomik Rumah Sakit Cipto Mangunkusumo Tahun 2005-2009 . Riesye Arisanty, Budiana Tanurahardja
Majalah Patologi Indonesia Vol 20 No 1 (2011): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.124 KB)

ABSTRAK Latar Belakang Keganasan kulit secara umum dikelompokkan menjadi golongan keratinositik dan melanositik. Jenis keganasan tersering adalah karsinoma sel basal dan karsinoma sel skuamosa (dari golongan keratinositik) serta melanoma malignum (dari golongan melanositik). Penelitian ini menilai jumlah dan pola distribusi dari 3 keganasan primer kulit tersering pada tahun 2005-2009 dan dibandingkan dengan data tahun 1990-1998. Bahan dan Cara Penelitian merupakan penelitian deskriptif-retrospekstif. Data berasal dari sediaan arsip di Departemen Patologi Anatomik FKUI yang didiagnosis secara histopatologik sebagai karsinoma sel basal, karsinoma sel skuamosa, dan melanoma malignum, pada organ kulit berdasarkan kode ICD-O sejak tahun 2005-2009. Data kemudian dibandingkan dengan data penelitian tahun 1990-1998. Hasil Terdapat 395 kasus tumor ganas primer kulit melanositik dan non melanositik yang dapat dikumpulkan selama kurun waktu 5 tahun sejak tahun 2005-2009. Sebanyak 171 kasus (43.3%) adalah karsinoma sel basal, 196 kasus (49.6%) karsinoma sel skuamosa serta 28 kasus (7.1%) adalah melanoma malignum. Berdasar-kan jenis kelamin, sebanyak 204 kasus (51.6%) adalah laki-laki dan 191 kasus (48.9%) adalah perempuan (tabel 1). Mayoritas usia penderita berkisar antara 60-69 tahun (27%). Kesimpulan Keganasan pada kulit yang ada di Departemen Patologi Anatomik antara tahun 2005-2009 meningkat 5 kali lipat dibandingkan dengan penelitian sebelumnya kira-kira 10 tahun yang lalu, yang dilakukan pada tahun 1996-1998. Penderita karsinoma sel skuamosa meningkat 29 kali lipat, karsinoma sel basal meningkat 6 kali lipat, dan penderita melanoma malignum 4.3 kali lipat dibandingkan 10 tahun sebelumnya. Kata kunci: keganasan primer kulit, karsinoma sel skuamosa, karsinoma sel basal, melanoma malignum. ABSTRACT Background Classification in cutaneous neoplasm diviided into keratinazing and melanocytic neoplasm. The most common neoplasm in cutaneous lesion are basal cell carcinoma, and squamous cell carcinoma (from keratinazing neoplasm) also malignant melanoma (from melanocytic neoplasm). This study examines number of cases and type of distribution form of 3 most common primary cutaneous neoplasm in 2005-2009 and compared to data in 1990-1998. Material and methods Data within 2005-2009 was obtained from archeiving of Anatomical Pathology Department Faculty of Medicine University of Indonesia-Cipto Mangunkusumo Hospital, histopathological based. All cases with histopathological diagnosis as Basal cell carcinoma, Squamous cell carcinoma and Malignant melanoma based on ICD-O was assesed and compared to same criteria of data in 1990-1998. Result 395 cases were obtained consisted of 43% (171) was Basal cell carcinoma, 49.6% (196) was squamous cell carcinoma and 7.1% (28) was diagnose as malignant melanoma, with male predominance and the range of age was 60-69 years old. Conclution The number of cutaneous neoplasm was increased about 5 times comparing to previous data in 1996-1998. Number of SCC was increased 29 times, BCC was 6 times, and MM was 4.3 times comparing to the previous data. Key words : Squamous cell carcinoma (SCC), Basal cell carcinoma (BCC),malignant melanoma (MM)

Hubungan antara Ekspresi Protein P16 dan Ki67 dengan Faktor Prognostik Histopatologik Melanoma Malignum Kulit Jenis Nodular Riesye Arisanty; Budiana Tanurahardja; Mpu Kanoko
Majalah Patologi Indonesia Vol 22 No 2 (2013): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (427.092 KB)

ABSTRAK Latar belakang Pemahaman mengenai karakteristik biologik dan faktor prognostik melanoma malignum yang merupakan tumor ganas melanositik merupakan hal yang penting karena berhubungan dengan pemilihan terapi serta kesintasan penderita. Agresivitas tumor dapat dinilai dari beberapa faktor histopatologik, antara lain: adanya ulserasi, aktivitas mitosis, dan keterlibatan kelenjar getah bening. Protein p16 dan ki67 merupakan yang memiliki peran dalam prediktif prognostik melanoma malignum.Penelitian ini bertujuan mengetahui hubungan antara ekspresi protein p16 dan Ki67 pada beberapa faktor prognostik histopatologik yang dapat digunakan sebagai penanda agresivitas tumor yaitu ulserasi, aktivitas mitosis dan metastasis pada tumor primer melanoma malignum jenis nodular. Metode Penelitian ini merupakan studi potong lintang dengan metode imunohistokimia menggunakan p16 dan Ki67 pada 25 kasus melanoma malignum jenis nodular. Hasil Ekspresi protein p16 negatif ditemukan pada 40% kasus melanoma ulseratif, 52% kasus dengan aktivitas mitosis tinggi, dan 16% kasus pada metastasis kelenjar getah bening (KGB). Ekspresi Ki67 positif pada 44% kasus melanoma dengan aktivitas mitosis tinggi, dan 20% kasus melanoma metastasis serta 32% kasus dengan ulserasi. Kesimpulan Pada melanoma malignum kulit jenis noduler tidak ditemukan hubungan antara ekspresi p16 dan Ki67 dengan gambaran ulserasi, aktivitas mitosis, dan metastasis KGB. Kata kunci: aktivitas mitosis, faktor prognostik histopatologik, Ki67, melanoma malignum, melanoma nodular kutaneus, p16. ABSTRACT Background To understanding about biological behaviour and prognostic factor of melanoma malignum as a malignant tumor from melanocyte was important, because its relationship with choise of therapy and survival of the patiens. The aggresivity of the tumour, can be predicted from several prognostic factors such as: ulceration of the tumour, mitotic activity, and lymph nodes metastasis. P16 and Ki67 protein expressions can be used as a prognostic markers in cutaneous nodular melanoma malignum. Aim Assesing p16 and Ki67 protein expression and its relatinoship with several histopatological prognostic factors as a marker of aggressiveness of the tumors: ulceration, mitotic activity, and lymph nodes metastasis in cutaneous nodular melanoma malignum. Methods This was a cross-sectional study on 25 cases of nodular melanoma, stained with p16 and Ki67 antibody with immunohistochemical methods. Results P16 negative expression can be found in 40% of ulcerated melanoma cases, and 52% cases with high mitotic activity and 16% of cutaneous nodular melanoma with lymph nodes metastasis. Ki67 positive expression was found in 44% of cases with high mitotic activity, 20% cases of metastasis melanoma and 32% cases in ulcerated melanoma. Conclusion There was no statistically significant association between p16 and Ki67 expression with ulcerated melanoma, mitotic activity, and metastatic melanoma in lymph nodes. Key words: cutaneous nodular melanoma, histopathologic prognostic factors, Ki67, malignant melanoma, mitotic activity, p16.

Karakteristik Klinikohistopatologik dan Profil Imunofluoresensi Kasus Pemfigoid bulosa di Departemen Patologi Anatomik Rumah Sakit Cipto Mangunkusumo Tahun 2011-2018 Fetisari Kurniawan; Riesye Arisanty
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundBullous pemphigoid is the most common autoimmune bullous disease. It is characterized by the presence of autoantibodies againsthemidesmosomal proteins in dermo-epidermal junction. Immune complexes subsequently induce skin blisters formation clinically, which willappear as subepidermal cleft histopathologically, and revealed as immune depositions immunologically. These three findings are required inorder to estabilsh the diagnosis of Bullous pemphigoid. This study was aimed to asses the clinico histopathological characteristics andimmunofluorescence studies of bullous pemphigoid in Anatomical Pathology Department, Cipto Mangunkusumo General Hospital.MethodsA cross sectional study was conducted in Anatomical Pathology Department ,Cipto Mangunkusumo General Hospital from January 2011 toDecember 2018. Clinical, histopathological, and direct immunofluorescence results were evaluated.ResultsDuring the last 8 years, bullous pemphigoid was the second most common form of autoimmune bullous diseases. The mean age of thesample was 60 years old. Women were affected more common than men (61.6%). Majority of patients present with blisters eruption (67.4%)and most commonly found in the lower extremities (48.8%). Histopathological examinations showed mostly a subepidermal cleft (89.5%)containing infiltrates of eosinophil, neutrophil, and lymphocyte. DIF staining demonstrated 31 cases (36.0%) with immune depositscharacteristic for bullous pemphigoid.ConclusionThe diagnosis of bullous pemphigoid is relied on a combination of clinical, histopathological, and direct immunofluorescence findings.

Clinicopathologic and Histomorphological Aspect of Basal Cell Carcinoma in Dr. Cipto Mangunkusumo Hospital: A Retrospective Analysis of Twenty Years Experience Riesye Arisanty; Muhammad Habiburrahman; Maria Angela Putri
eJournal Kedokteran Indonesia Vol 9, No. 2 - Agustus 2021
Publisher : Faculty of Medicine Universitas Indonesia

Basal cell carcinoma (BCC) is the most common skin malignancy, and the incidence increases over time. However, epidemiological data and analysis of the histopathological characteristic of BCC in Asia and Indonesia are limited. This study evaluates the clinicopathological and histomorphological features of BCC cases at Dr. Cipto Mangunkusumo Hospital (CMH) for the last 20 years (2000-2019). This is a cross-sectional retrospective study, using medical records and slides data screened based on inclusion and exclusion criteria. The re-diagnostic assessment was performed independently by two investigators. Data were analyzed statistically by the chi-square test, Kruskal Wallis, and Mann Whitney tests. There were 896 cases of total 20 years, with an increase of 51.4% between the first and second decades, female: male ratio was 1.34: 1, the median age was 63 y.o (0-99), and 54% patient was 60-79 y.o. The majority of cases are located on the head, face, and neck (95.8%), nodular as the most common histological subtypes (49.2%), with adenoid as the highest number of variants (63.1%). Single vs mixed subtype BCC (58.4% vs 41.6%), low-risk vs high-risk BCC (53.9% vs 46.1%). There were different levels of risk and a number of subtypes based on anatomical location. The differences were also found in the number of subtypes, the aggressiveness of subtypes, and risk levels based on gender and histological subtypes based on anatomical location. Residual tumours were present in 2.8% of cases. Thus the cases of BCC in CMH have increased in the last 20 years, and differences are observed in anatomical distribution, gender, age, risk, number of subtypes, histological subtypes, and aggressiveness. Keywords: basal cell carcinoma, retrospective, epidemiology, histomorphological characteristics. Aspek Klinikopatologis dan Histomorfologikal Karsinoma Sel Basal di Rumah Sakit Dr. Cipto Mangunkusumo: Analisis Retrospektif 20 Tahun Abstrak Karsinoma sel basal (KSB) merupakan keganasan kulit yang paling sering. Namun data epidemiologi dan telaah karakteristik histopatologi KSB di Asia dan Indonesia sangat terbatas. Penelitian ini bertujuan mengevaluasi kasus KSB di Rumah Sakit Dr. Cipto Mangunkusumo (RSCM) dan meninjau gambaran klinikopatologis serta histomorfologinya selama 20 tahun terakhir (2000-2019). Penelitian ini menggunakan desain potong lintang retrospektif dengan mengambil data dari rekam medis dan slide tersimpan. Skrining formulir permintaan patologi berdasarkan kriteria inklusi dan eksklusi. Penilaian diagnosis ulang dilakukan secara independen oleh dua peneliti. Data dianalisis dengan uji chi square, Kruskal Wallis, dan Mann Whitney. Terdapat 896 kasus KSB dalam waktu 20 thn dengan peningkatan 51,4% KSB antara dekade ke-1 dan ke-2, rasio perempuan: laki-laki adalah 1,34:1, median usia 63 tahun (0-99) dan 54% berusia 60-79 tahun. Lokasi anatomis terbanyak di kepala, wajah, dan leher (95,8%), subtipe nodular (49,2%) dengan varian adenoid tertinggi (63,1%). KSB subtipe tunggal vs. campuran (58,4% vs. 41,6%), KSB risiko rendah vs. tinggi (53,9% vs. 46,1%), terdapat beda tingkat risiko dan jumlah subtipe berdasarkan lokasi anatomis, jumlah subtipe, sifat agresivitas subtipe, dan tingkat risiko berdasarkan jenis kelamin, serta beda jenis subtipe dengan lokasi anatomis. Tumor residif terdapat pada 2,8% kasus. Kasus KSB di RSCM meningkat dalam 20 tahun terakhir dan perbedaan diamati pada distribusi anatomi, jenis kelamin, usia, risiko histopatologik, jumlah subtipe, berbagai subtipe histopatologi, dan agresivitasnya. Kata kunci: karsinoma sel basal, retropsektif, epidemiologi, karakter histomorfologi.

The epidemiology of skin cancer at Dr. Cipto Mangunkusumo National Central General Hospital from 2014 to 2017 Wibawa, Larisa Paramitha; Andardewi, Melody Febriana; Kristanti, Inge Adi; Arisanty, Riesye
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 4, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: The incidence of skin cancer has been increasing over the past decades globally. At present, there is no valid national cancer data in Indonesia. The purpose of this study is to evaluate the increment of skin cancer cases at Dr. Cipto Mangunkusumo National General Hospital, Jakarta. Methods: In this retrospective descriptive study, we evaluated all pigmented skin tumor cases from June 2014 to June 2017. Data were obtained from the Department of Anatomical Pathology and medical records at Dr. Cipto Mangunkusumo National General Hospital. Data were compared with previous reports. Results: From 263 skin cancer cases, the most frequent skin cancer was basal cell carcinoma (BCC; 66.9%), followed by squamous cell carcinoma (SCC; 27.4%), and malignant melanoma (MM; 5.7%). Most of the skin cancer were predominantly in the female population. In BCC and SCC, most of the patients were within the age group above 60 years (n = 106 and 18, respectively). In MM, the incidence is greater in age group of 41–50 years (n = 5). For BCC and SCC, the distribution sites of lesions were mostly in sun-exposed areas, whereas the distribution sites of MM were mostly in non-sun-exposed areas. Median diameters of BCC, SCC, and MM were 2, 4, and 6.5 cm, respectively. There was an increase of BCC incidence from 1996 to 2017. Conclusion: In comparison with other types, the incidence of BCC in Dr. Cipto Mangunkusumo National General Hospital is increasing. A well-documented skin cancer registry is required to establish national data of skin cancer in Indonesia.

Nail involvement in Langerhans cell histiocytosis: Diagnostic and prognostic Clues Sirait, Sondang P.; Rihatmadja, Rahadi; Prayogo, Rizky Lendl; Arisanty, Riesye; Melviana, Gisca; Ohara, Kuniaki
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 4, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Introduction: Despite its rarity, nail involvement in Langerhans cell histiocytosis (LCH) may show various clinical presentations. This study aims to show the roles of nail involvement in LCH patients as the diagnostic and prognostic clues.Case illustrations: We presented four cases of multisystem LCH in children which were already confirmed by skin biopsy with various nail abnormalities. We were able to perform nail biopsy in two patients and confirmed the nail involvement. Histopathological examination showed the infiltration of Langerhans cells characterized by indented/reniform nuclei and CD1a expressions. All patients had high-risk organ involvements. Discussion: Langerhans cells may infiltrate the nail bed, proximal nail fold, and nail matrix. Further infiltration may destruct the nail plate. Hypothetically, we suggest that the nail bed as the initial infiltration site of Langerhans cells. The different sites of involvement lead to different clinical presentation. Nail abnormalities may predict a poorer prognosis, as they mostly occur in patients with multisystem disease. Conclusions: Nails should be routinely inspected in the suspicion of LCH. The presence of nail abnormalities in LCH patients may predict a poorer prognosis.

Clinicopathological Characteristics of Cutaneous Melanocytic Lesions for Predicting Biological Behavior: 5 Years Retrospective Study in National Referral Hospital Rosari, Bayu Perkasa; Arisanty, Riesye
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.648

Background Cutaneous melanocytic lesions have variety of subtypes ranging from benign (nevus) to malignant lesions (malignant melanoma). Differentiating benign and malignant melanocytic lesions is challening, particularly due to overlapping characteristics. This study was conducted to determine clinicopathological characteristics of cutaneous melanocytic lesions and the prevalence ratio of each characteristic for predicting malignant behavior. Method Cross-sectional study was conducted with data retrieved from Anatomic Pathology Department of Faculty of Medicine Universitas Indonesia and Dr. Cipto Mangunkusumo Hospital. Data of 145 histopathology-confirmed cutaneous melanocytic lesions cases between 2018 – 2022 were sampled and collected. Bivariate analysis was used to determine the prevalence ratio of each characteristic to predict malignant behavior. Result Out of 145 cases, 14.5% were malignant lesions (melanoma) and the rest were benign (nevus). Clinicopathology features and characteristics were correlated with malignant behavior, such as cytological atypia (p <0.01), dermal mitosis (PR=91.5; p<0.01), asymmetry (PR=31.8; p <0.01), suprabasal melanocyte (PR=21.4; p <0.01), lower extremity location (PR=6.5; p <0.01), sized >6 mm (PR=5.2; p <0.01), and male gender (PR=3.3; p <0.01). Conclusion Clinicopathological characteristics of cutaneous melanocytic lesions such as cytological atypia, dermal mitosis, asymmetry, suprabasal melanocyte, lower extremity location, sized >6 mm, dermal lymphocytic infiltrate, and male gender were predictive to predict malignant lesions.

Penyuluhan Kebersihan Lingkungan, Sanitasi, dan Bakti Sosial Pembagian Paket Kesehatan Pasca Banjir di Kelurahan Terjun Medan Marelan: Environmental Hygiene and Sanitation Education, and Social Service Through the Distribution of Health Packages After the Flood in Terjun Village, Medan Marelan Fauzan Abdillah; Yasmine Mashabi; Mario; Riesye Arisanty; Ilfi Fia Alfaroh; Luki Darmawan; Yuni Lestari
Bestari: Jurnal Pengabdian Kepada Masyarakat Vol 6 No 2 (2026): Mei 2026
Publisher : Sekolah Tinggi Keguruan dan Ilmu Pendidikan (STKIP) Melawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46368/dpkm.v6i2.4888

Abstrak Keterbatasan fasilitas sanitasi yang layak, kebiasaan membuang sampah sembarangan, dan rendahnya penerapan perilaku hidup bersih dan sehat (PHBS) menjadikan kegiatan penyuluhan kebersihan lingkungan dan sanitasi sebagai kebutuhan mendesak pasca banjir, dan mendorong perubahan perilaku higienis di tingkat keluarga. Intervensi dilakukan melalui penyuluhan interaktif, serta bakti sosial pembagian paket kesehatan, serta menilai keberhasilannya dengan memberikan pre tes sebelum edukasi serta post tes setelah edukasi. Hasil edukasi menunjukkan adanya peningkatan pengetahuan pada masyarakat, di mana sebanyak 49 responden (81,7%) mengalami peningkatan pemahaman setelah mengikuti kegiatan. Berdasarkan hasil pengukuran, kategori pengetahuan baik pada saat pre-test tercatat sebesar 40% responden, sedangkan pada post-test meningkat menjadi 87.7%. Hal ini menunjukkan adanya peningkatan signifikan dalam tingkat pengetahuan setelah diberikan edukasi. Dengan demikian, program ini diharapkan berkontribusi pada pembentukan komunitas yang lebih bersih, sehat, dan tangguh terhadap dampak banjir. Kata Kunci: Banjir, Perilaku Hidup Bersih dan Sehat (PHBS), Penyuluhan, Sampah, Sanitasi. Abstract Limited availability of sanitation facilities, the habit of littering, and the low level of implementation of clean and healthy living behaviors (PHBS) made environmental hygiene and sanitation education an urgent need after the floods, encouraging changes in hygienic behavior at the family level. The intervention was carried out through interactive education and community service programs, distributing health packages, and assessing its success by administering a pre-test before and a post-test after the education. The results of the education showed an increase in community knowledge, with 49 respondents (81.7%) experiencing an increase in understanding after participating in the activity. Based on the measurement results, the category of good knowledge during the pre-test was recorded at 40% of respondents, while in the post-test it increased to 81.7%. This indicates a significant increase in the level of knowledge after the education. Thus, this program is expected to contribute to the formation of a cleaner, healthier, and more resilient community to the impacts of flooding. Keywords: Floods, Clean and Healthy Living Behavior (PHBS), Awareness Campaigns, Waste, Sanitation

Profil Keganasan Primer Kulit Tersering di Departemen Patologi Anatomik Rumah Sakit Cipto Mangunkusumo Tahun 2005-2009 . Riesye Arisanty, Budiana Tanurahardja
Majalah Patologi Indonesia Vol. 20 No. 1, Januari 2011
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRAK Latar Belakang Keganasan kulit secara umum dikelompokkan menjadi golongan keratinositik dan melanositik. Jenis keganasan tersering adalah karsinoma sel basal dan karsinoma sel skuamosa (dari golongan keratinositik) serta melanoma malignum (dari golongan melanositik). Penelitian ini menilai jumlah dan pola distribusi dari 3 keganasan primer kulit tersering pada tahun 2005-2009 dan dibandingkan dengan data tahun 1990-1998. Bahan dan Cara Penelitian merupakan penelitian deskriptif-retrospekstif. Data berasal dari sediaan arsip di Departemen Patologi Anatomik FKUI yang didiagnosis secara histopatologik sebagai karsinoma sel basal, karsinoma sel skuamosa, dan melanoma malignum, pada organ kulit berdasarkan kode ICD-O sejak tahun 2005-2009. Data kemudian dibandingkan dengan data penelitian tahun 1990-1998. Hasil Terdapat 395 kasus tumor ganas primer kulit melanositik dan non melanositik yang dapat dikumpulkan selama kurun waktu 5 tahun sejak tahun 2005-2009. Sebanyak 171 kasus (43.3%) adalah karsinoma sel basal, 196 kasus (49.6%) karsinoma sel skuamosa serta 28 kasus (7.1%) adalah melanoma malignum. Berdasar-kan jenis kelamin, sebanyak 204 kasus (51.6%) adalah laki-laki dan 191 kasus (48.9%) adalah perempuan (tabel 1). Mayoritas usia penderita berkisar antara 60-69 tahun (27%). Kesimpulan Keganasan pada kulit yang ada di Departemen Patologi Anatomik antara tahun 2005-2009 meningkat 5 kali lipat dibandingkan dengan penelitian sebelumnya kira-kira 10 tahun yang lalu, yang dilakukan pada tahun 1996-1998. Penderita karsinoma sel skuamosa meningkat 29 kali lipat, karsinoma sel basal meningkat 6 kali lipat, dan penderita melanoma malignum 4.3 kali lipat dibandingkan 10 tahun sebelumnya. Kata kunci: keganasan primer kulit, karsinoma sel skuamosa, karsinoma sel basal, melanoma malignum. ABSTRACT Background Classification in cutaneous neoplasm diviided into keratinazing and melanocytic neoplasm. The most common neoplasm in cutaneous lesion are basal cell carcinoma, and squamous cell carcinoma (from keratinazing neoplasm) also malignant melanoma (from melanocytic neoplasm). This study examines number of cases and type of distribution form of 3 most common primary cutaneous neoplasm in 2005-2009 and compared to data in 1990-1998. Material and methods Data within 2005-2009 was obtained from archeiving of Anatomical Pathology Department Faculty of Medicine University of Indonesia-Cipto Mangunkusumo Hospital, histopathological based. All cases with histopathological diagnosis as Basal cell carcinoma, Squamous cell carcinoma and Malignant melanoma based on ICD-O was assesed and compared to same criteria of data in 1990-1998. Result 395 cases were obtained consisted of 43% (171) was Basal cell carcinoma, 49.6% (196) was squamous cell carcinoma and 7.1% (28) was diagnose as malignant melanoma, with male predominance and the range of age was 60-69 years old. Conclution The number of cutaneous neoplasm was increased about 5 times comparing to previous data in 1996-1998. Number of SCC was increased 29 times, BCC was 6 times, and MM was 4.3 times comparing to the previous data. Key words : Squamous cell carcinoma (SCC), Basal cell carcinoma (BCC),malignant melanoma (MM)

Hubungan antara Ekspresi Protein P16 dan Ki67 dengan Faktor Prognostik Histopatologik Melanoma Malignum Kulit Jenis Nodular Arisanty, Riesye; Tanurahardja, Budiana; Kanoko, Mpu
Majalah Patologi Indonesia Vol. 22 No. 2, Mei 2013
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRAK Latar belakang Pemahaman mengenai karakteristik biologik dan faktor prognostik melanoma malignum yang merupakan tumor ganas melanositik merupakan hal yang penting karena berhubungan dengan pemilihan terapi serta kesintasan penderita. Agresivitas tumor dapat dinilai dari beberapa faktor histopatologik, antara lain: adanya ulserasi, aktivitas mitosis, dan keterlibatan kelenjar getah bening. Protein p16 dan ki67 merupakan yang memiliki peran dalam prediktif prognostik melanoma malignum.Penelitian ini bertujuan mengetahui hubungan antara ekspresi protein p16 dan Ki67 pada beberapa faktor prognostik histopatologik yang dapat digunakan sebagai penanda agresivitas tumor yaitu ulserasi, aktivitas mitosis dan metastasis pada tumor primer melanoma malignum jenis nodular. Metode Penelitian ini merupakan studi potong lintang dengan metode imunohistokimia menggunakan p16 dan Ki67 pada 25 kasus melanoma malignum jenis nodular. Hasil Ekspresi protein p16 negatif ditemukan pada 40% kasus melanoma ulseratif, 52% kasus dengan aktivitas mitosis tinggi, dan 16% kasus pada metastasis kelenjar getah bening (KGB). Ekspresi Ki67 positif pada 44% kasus melanoma dengan aktivitas mitosis tinggi, dan 20% kasus melanoma metastasis serta 32% kasus dengan ulserasi. Kesimpulan Pada melanoma malignum kulit jenis noduler tidak ditemukan hubungan antara ekspresi p16 dan Ki67 dengan gambaran ulserasi, aktivitas mitosis, dan metastasis KGB. Kata kunci: aktivitas mitosis, faktor prognostik histopatologik, Ki67, melanoma malignum, melanoma nodular kutaneus, p16. ABSTRACT Background To understanding about biological behaviour and prognostic factor of melanoma malignum as a malignant tumor from melanocyte was important, because its relationship with choise of therapy and survival of the patiens. The aggresivity of the tumour, can be predicted from several prognostic factors such as: ulceration of the tumour, mitotic activity, and lymph nodes metastasis. P16 and Ki67 protein expressions can be used as a prognostic markers in cutaneous nodular melanoma malignum. Aim Assesing p16 and Ki67 protein expression and its relatinoship with several histopatological prognostic factors as a marker of aggressiveness of the tumors: ulceration, mitotic activity, and lymph nodes metastasis in cutaneous nodular melanoma malignum. Methods This was a cross-sectional study on 25 cases of nodular melanoma, stained with p16 and Ki67 antibody with immunohistochemical methods. Results P16 negative expression can be found in 40% of ulcerated melanoma cases, and 52% cases with high mitotic activity and 16% of cutaneous nodular melanoma with lymph nodes metastasis. Ki67 positive expression was found in 44% of cases with high mitotic activity, 20% cases of metastasis melanoma and 32% cases in ulcerated melanoma. Conclusion There was no statistically significant association between p16 and Ki67 expression with ulcerated melanoma, mitotic activity, and metastatic melanoma in lymph nodes. Key words: cutaneous nodular melanoma, histopathologic prognostic factors, Ki67, malignant melanoma, mitotic activity, p16.

Title

Found 11 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 11 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 11 Documents
Search