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All Journal Majalah Patologi Indonesia eJournal Kedokteran Indonesia Dedikasi: Jurnal Pengabdian Kepada Masyarakat Journal of General Procedural Dermatology and Venereology Indonesia
Riesye Arisanty
Departement Of Anatomical Pathology Faculty Of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Jakarta
Religion Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Karakteristik Klinikohistopatologik dan Profil Imunofluoresensi Kasus Pemfigoid bulosa di Departemen Patologi Anatomik Rumah Sakit Cipto Mangunkusumo Tahun 2011-2018 Fetisari Kurniawan; Riesye Arisanty
Majalah Patologi Indonesia Vol. 29 No. 3, September 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i3.445

Abstract

BackgroundBullous pemphigoid is the most common autoimmune bullous disease. It is characterized by the presence of autoantibodies againsthemidesmosomal proteins in dermo-epidermal junction. Immune complexes subsequently induce skin blisters formation clinically, which willappear as subepidermal cleft histopathologically, and revealed as immune depositions immunologically. These three findings are required inorder to estabilsh the diagnosis of Bullous pemphigoid. This study was aimed to asses the clinico histopathological characteristics andimmunofluorescence studies of bullous pemphigoid in Anatomical Pathology Department, Cipto Mangunkusumo General Hospital.MethodsA cross sectional study was conducted in Anatomical Pathology Department ,Cipto Mangunkusumo General Hospital from January 2011 toDecember 2018. Clinical, histopathological, and direct immunofluorescence results were evaluated.ResultsDuring the last 8 years, bullous pemphigoid was the second most common form of autoimmune bullous diseases. The mean age of thesample was 60 years old. Women were affected more common than men (61.6%). Majority of patients present with blisters eruption (67.4%)and most commonly found in the lower extremities (48.8%). Histopathological examinations showed mostly a subepidermal cleft (89.5%)containing infiltrates of eosinophil, neutrophil, and lymphocyte. DIF staining demonstrated 31 cases (36.0%) with immune depositscharacteristic for bullous pemphigoid.ConclusionThe diagnosis of bullous pemphigoid is relied on a combination of clinical, histopathological, and direct immunofluorescence findings.
Co-Authors Andardewi, Melody Febriana Bayu Perkasa Rosari Budiana Tanurahardja Budiana Tanurahardja Fauzan Abdillah Fetisari Kurniawan Gisca Meiviana Ilfi Fia Alfaroh Inge Ade Krisanti Kristanti, Inge Adi Kuniaki Ohara Larisa Paramitha Luki Darmawan Maria Angela Putri Mario Melody Febriana Andardewi Melviana, Gisca Mpu Kanoko Mpu Kanoko Muhammad Habiburrahman Ohara, Kuniaki Prayogo, Rizky Lendl Rahadi Rihatmadja Rahadi Rihatmadja Rizky Lendl Prayogo Sirait, Sondang Panjaitan Sondang P. Sirait Tiara Aninditha Yasmine Mashabi Yuni Lestari