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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Ilmu Kesehatan Kulit dan Kelamin Cermin Dunia Kedokteran Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Jurnal MedScientiae Cermin Dunia Kedokteran
Larisa Paramitha
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Ultraviolet phototherapy for treatment of various dermatoses Irwan Saputra Batubara; Larisa Paramitha Wibawa; Erdina Pusponegoro; Windy Keumala Budianti; Githa Rahmayunita; Shannaz Nadia Yusharyahya
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 4 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005304202107

Abstract

Ultraviolet (UV) radiation has been applied to treat many chronic skin diseases. Based on the wavelength, UV radiation consists of three types, namely ultraviolet C (UVC), ultraviolet B (UVB), and ultraviolet A (UVA). The types of UV that are widely used in dermatology are narrowband ultraviolet B (NB-UVB), broadband ultraviolet B (BB-UVB), UVA1, and psoralen combined with UVA (PUVA). The interaction between UV and the skin determines the effectiveness of phototherapy. The biological effects of UV are used in the management of inflammatory skin diseases, malignancies, and various rare dermatoses. Apart from these benefits, UV increases the risk of photoaging and skin cancer. Therefore, further researches are necessary to enhance the effectiveness and safety of phototherapy. This literature review discusses the role of phototherapy in various dermatoses other than psoriasis and vitiligo.
Kriteria ABCDE untuk Deteksi Dini Keganasan Kulit Parikesit Muhammad; Adhika Ayu Lestari; Kara Adistri; Ridha Sarly Amalia; Larisa Paramitha Wibawa
Cermin Dunia Kedokteran Vol. 49 No. 11 (2022): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i11.322

Abstract

Tingginya insiden keganasan kulit yang ditemukan pada stadium lanjut membutuhkan kemampuan lebih baik untuk mengenali tanda dan gejala awal. Pengenalan dini gejala klinis kanker kulit berpigmen, terutama melanoma maligna, dapat dengan pemeriksaan lesi menggunakan kriteria ABCDE. Kriteria ini sederhana dan mudah digunakan, baik oleh tenaga medis maupun masyarakat awam. Makin banyak kriteria ABCDE yang terpenuhi, makin tinggi kemungkinan suatu lesi adalah kanker kulit. High incidence of skin malignancy found in advanced stages calls for a better clinical judgment to detect early signs and symptoms. Screening for early clinical findings of pigmented skin cancer, especially malignant melanoma, can use ABCDE criteria. The criteria are simple and easy to apply, either by medical professionals or general public. The more ABCDE criteria were met, the higher chance that a lesion is a skin cancer.
Challenge in diagnosis and management of lentigo maligna and lentigo maligna melanoma Anggraini, Ika; Miranda, Elisa; Wibawa, Larisa Paramitha; Krisanti, Roro Inge Ade; Sampurna, Adhimukti T
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 1
Publisher : UI Scholars Hub

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Abstract

Lentigo maligna (LM) is a subtype of melanoma in situ, which can evolve into lentigo maligna melanoma (LMM) if treated inadequately. LM and LMM are usually found on chronically sun damaged skin such as the face (cheek and nose) of the elderly on seventh or eight decades. Clinical manifestation of LM may be quite subtle, so early diagnosis is difficult to perform.The treatment of LM and LMM are challenging due to ill-defined clinical margin, predilection on the face with great size, and preponderance of the elderly, which are potential for recurrency and progressiveness from LM into LMM.
Vaginal microbiota in menopause Martinus, Martinus; Wibawa, Larisa Paramitha; Effendi, Evita Halim; Yusharyahya, Shannaz Nadia; Nilasari, Hanny; Indriatmi, Wresti
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 1, No. 3
Publisher : UI Scholars Hub

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Abstract

The human vagina together with its resident, microbiota, comprise a dynamic ecosystem. Normal microbiota is dominated by Lactobacillus species, and pathogen microbiota such as Gardnerella species and Bacteroides species can occur due to decrease in Lactobacillus domination. Lactobacillus plays an essential role in keeping normal vaginal microbiota in balance. Vaginal microbiota adapts to pH change and hormonal value. Changes in the vaginal microbiota over a woman’s lifespan will influence the colonization of pathogenic microbes. They include changes in child, puberty, reproductive state, menopause, and postmenopause. Estrogen levels change will affect the colonization of pathogenic microbium, leading to genitourinary syndrome of menopause. Vulvovaginal atrophy is often found in postmenopausal women, and dominated by L. iners, Anaerococcus sp, Peptoniphilus sp, Prevotella sp, and Streptococcus sp. The normal vaginal microbiota’s imbalance in menopause will cause diseases such as bacterial vaginosis, and recurrent vulvovaginal candidiasis due to hormonal therapies. Changes in the vaginal microbiota due to bacterial vaginosis are characterized by decrease in H2O2-producing Lactobacillus. They are also caused by the increase in numbers and concentration of Gardnerella vaginalis, Mycoplasma hominis, and other anaerob species such as Peptostreptococci, Prevotella spp, and Mobiluncus spp.
Eccrine poroma: The prominent mimicker Shihab, Nahla; Kristanti, Inge Ade; Sampurna, Adhimukti T.; Wibawa, Larisa Paramitha
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Eccrine poroma (EP) is an adnexal benign tumor arising from the eccrine duct epithelium. The appearance of EP can mimic benign and malignant skin tumors, thus often making the diagnosis delayed or inaccurate. Case Illustration: We report two cases of EP, with clinical and dermoscopic features mimicking Bowen’s disease, verruca vulgaris, pyogenic granuloma, skin metastases of breast cancer, and amelanotic melanoma. Both patients were surgically excised and biopsied. Histopathology examination of both cases revealed eccrine poroma. Discussion: Both cases showed similarity with the theories, that EP is most found in middle age population and its predilection on extremities. The dermoscopy appearance of the first patient showed two major components, multiple red dots and lacunae mimicking glomerular vessels, and multiple whitish halos-likekeratosis. Red dots with whitish halos can be seen in dermoscopy of verruca vulgaris, while glomerular vessels and keratosis is usually found in Bowen’s disease. The dermoscopy examination of our second patient only showed some loop hemorrhagic and thrombosed vessels, which are quite inconclusive. Diagnoses were made with histopathology examination which revealed similar pattern of eccrine poroma in both cases. Conclusion: EP is a prominent mimicker, often misdiagnosed because it is uncommon in clinical practice, has variable clinical presentations and dermoscopic appearances. Hence, recognizing and diagnosing this disease becomes a challenge for dermatologist.
Dermoscopy-guided carbon dioxide laser destruction for nevus sebaceous: two case reports Wibawa, Larisa Paramitha; Ohara, Kuniaki
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Nevus sebaceous (NS) is a common hamartoma of the cutaneous adnexal structure, clinically appear as a well demarcated yellow-orange plaque, sometimes with verrucous surface. Dermoscopy may aid the diagnosis of NS and also guide carbon dioxide (CO2) laser therapy. Case Illustration: Two cases of brown and yellowish plaque on the face, with clinical appearance, dermoscopic, and histopathological findings consistent with NS. The patients consented to undergo serial CO­2laser destruction, aimed to reduce recurrences and shorten the duration of the downtime. Dermoscopy aided in locating the area and the depth of each treatment. Discussion: The dermoscopy finding of NS were already reported as milia-like structure and multiple whitish structures (dots) varying in size, with orange background. The dermoscopy findings of these two cases were in accordance with previous reports. CO2laser destruction was reported to produce satisfying results, but with known recurrences. With the knowledge of dermoscopy appearance, we could determine the area and depth of the lesion to prevent reoccurrence. After two years of follow-up, the area where the deep ablation was performed had not reoccurred. Conclusion: Dermoscopy may aid the diagnosis and therapeutic confirmation of NS.
MALFORMASI VENA VERUKOSA: PERKEMBANGAN DIAGNOSIS DAN TATA LAKSANA Dina Evyana; Larisa Paramitha Wibawa; Yudo Irawan
Media Dermato-Venereologica Indonesiana Vol 49 No 2 (2022): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i2.336

Abstract

Verrucous venous malformation (VVM), formerly known as verrucous hemangioma, is a rare, congenital, non-hereditary vascular malformation. The initial clinical manifestations of VVM include bluish patches that become erythematous to purplish, then enlarge slowly to become verrucous and hyperkeratotic papules, plaques, or nodules. Its etiopathogenesis remain unknown. It used to be one of unclassified vascular anomalies due to its clinical feature consistent with malformations, but shows positive results on immunohistochemical for tumors. The identification of somatic mutations in the mitogen-activated protein kinase 3 (MAP3K3) gene has classified it into venous malformation group. Clinically this lesion often resembles other diseases that may lead to misdiagnosis. Investigations such as dermoscopy, radiology, histopathology, and immunohistochemical are continually updated as new cases are found. Superficial ablative procedures often result in recurrence of the lesions. There is potential for targeted therapy using sirolimus but surgical excision remain preferred choice. Early diagnosis and prompt treatment are important due to the risk of recurrence.
Epidemiologic Profile of Seborrheic Keratosis and Acrochordon at the National Referral Hospital in Indonesia Purbasari, Lusiana; Larasati, Anindya; Paramitha Wibawa, Larisa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 3 (2023): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.3.2023.182-186

Abstract

Background: Seborrheic keratosis (SK) and acrochordon are common benign neoplasms of the skin thatan be diagnosed clinically.  Management of SK and acrochordon has a wide range of purposes, including aesthetic appearance and health concerns. Epidemiologic data for these entities is rare in Indonesia. Purpose: To determine the epidemiology of SK and acrochordon patients at the Dermatology & Venereology (DV) Clinic, dr. Cipto Mangunkusumo National Central General Hospital (RSCM). Method: Patient registry data at the DV Clinic, RSCM from 2014 to 2017 was collected retrospectively. Data was obtained by using the total sampling method and retrieving characteristics such as age, sex, and outpatient-based procedures. Result: In the four-year period, there were 1.202 SK patient visits with 447 new cases and 374 acrochordon patient visits with 169 new cases. The proportion of SK patients in this study was 2.2%; acrochordon was 1.8% of all patients at the DV Clinic of RSCM. The highest prevalence of SK was found in patients older than the 6th decade, while for acrochordon, it was within the 4th decade. Both SK and acrochordon were seen higher in women, with a male-to-female ratio of 1:2. Electrosurgery was the most common office procedure performed. Conclusion: Seborrheic keratosis and acrochordon proportion, respectively, are 2.2% and 1.8% at the DV Clinic, RSCM. Seborrheic keratosis and acrochordon are more frequent in women, with the peak occurring in 6th decade and 4th decade, respectively
Inhibitor Transient Receptor Potential Vanilloid Type 1: Penggunaan Topikal pada Berbagai Dermatosis Muhammad, Parikesit; Paramitha Wibawa, Larisa; Keumala Budianti, Windy; Legiawati, Lili; Menaldi, Sri Linuwih; Rosdiana, Dewi Selvina
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3179

Abstract

Transient receptor potential vanilloid type 1 (TRPV1) plays an important role in the pathophysiology of pruritus and pain. TRPV1 inhibitors can reduce the sensation of itching and pain by blocking nociceptive signals from peripheral nerve fibers to the central nervous system. Topical TRPV1 inhibitors is also thought to improve skin barrier function. Therefore, TRPV1 inhibitors are considered as potential therapy in various dermatoses. Topical TRPV1 inhibitors that are currently being studied are asivatrep for atopic dermatitis and trans-4-tert-butylcyclohexanol for various dermatoses associated with sensitive skin. Further studies with better quality and longer duration are needed to assess the efficacy and safety profile of TRPV1 inhibitors.
Skrining pada Kanker Kulit Chairista, Inadia Putri; Paramitha, Larisa; Sampurna, Adhimukti T; Krisanti, RR Inge Ade; Wahyudi, Danang T; Hoemardani, Aida SD; Sujudi, Yufanti; Legiawati, Lili
Media Dermato-Venereologica Indonesiana Vol 51 No 3 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i3.423

Abstract

Tingginya insiden, prevalensi, morbiditas, dan mortalitas kanker kulit telah menjadi permasalahan kesehatan masyarakat di seluruh dunia. Skrining kanker kulit dilakukan sebagai salah satu upaya dalam mengurangi beban kanker kulit yang ditimbulkan. Skrining kanker kulit meliputi total body skin examination yang bersifat non-invasif, mudah, cepat, dan hemat biaya bila dibandingkan dengan skrining untuk kanker lainnya. Akan tetapi, efektivitas skrining kanker kulit pada tingkat populasi masih diperdebatkan. Tenaga kesehatan, khususnya dokter spesialis kulit berperan penting dalam pelayanan skrining kanker kulit. Pengetahuan lebih lanjut mengenai skrining kanker kulit, rekomendasi, dan berbagai teknik pendekatan diagnostik sangat diperlukan untuk memajukan program skrining kanker kulit. 
Co-Authors Adhika Ayu Lestari Adhimukti T Sampurna Adhimukti T Sampurna Anggraini, Ika Astri Adelia Chairista, Inadia Putri Dina Evyana Erdina Pusponegoro Evita Halim Effendi Farida Zubier Githa Rahmayunita Hafiza Fathan Hanny Nilasari Herman Cipto Hoemardani, Aida SD Indah Widyasari Inge Ade Krisanti Irwan Saputra Batubara Isni Maulina Sukmara, Isni Maulina Kara Adistri Keumala Budianti, Windy Krisanti, Roro Inge Ade Krisanti, RR Inge Ade Kristanti, Inge Ade Kusumaningrat, I Gst. Ayu Mirah Larasati, Anindya Lili Legiawati Martinus, Martinus Melody Febriana Andardewi Miranda, Elisa Muhammad, Parikesit Nahla Shihab, Nahla Ohara, Kuniaki Parikesit Muhammad Parrol, Firman Purbasari, Lusiana Rakasiwi Ningrum, Rizki Irianti Ridha Sarly Amalia Riesye Arisanty Riva Ambardina Pradita Rosdiana, Dewi Selvina Saldi, Siti Rizny Fitriana Sampurna, Adhimukti T Sampurna, Adhimukti T. Shannaz Nadia Yusharyahya Shannaz Nadia Yusharyahya Sitohang, Irma Bernadette Simbolon Sondang P Sirait Sri L. Menaldi Sujudi, Yufanti Wahyudi, Danang T Windy Keumala Budianti Windy Keumala Budianti Wresti Indriatmi B. Makes Yudo Irawan