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All Journal Makara Journal of Health Research
Md Isa, Muhammad Lokman
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Obesity is associated with depression in Malaysian schoolchildren: A cross-sectional study Nurumal, Mohd Said; Zainal Abidin, Rohulizzat; Ibrahim, Wisam Nabeel; Md Isa, Muhammad Lokman; Che Hasan, Muhammad Kamil
Makara Journal of Health Research Vol. 24, No. 1
Publisher : UI Scholars Hub

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Background: Overweight and obesity, which may lead to depression, have become prevalent among children worldwide. Hence, this study aimed to measure obesity and depression among schoolchildren in Kuantan. Methods: This cross-sectional study was conducted in three different primary schools in Kuantan by purposive sampling. With consent from their parents/guardians, participants were given a self-administered questionnaire. Demographics and anthropometric measurement data were self-reported on the basis of the school records. Furthermore, body mass index was calculated. Data were analyzed using SPSS version 20.0, and chi-square and correlation tests were conducted for the variables. Results: Among the 300 schoolchildren who responded, 14.3% were underweight, 37.7% were normal, 11% were overweight, and 37% were obese. Statistically, obesity and ethnicity, as well as obesity and sex, were not associated. Conversely, obesity and age, as well as obesity and depression, were significantly associated. Conclusion: Depression is associated with obesity among schoolchildren. Hence, a special approach for designing and implementing prevention programs is necessary to reduce the risk of obesity-led depression and other forms of comorbidity later in life.
A high glucose concentration is well tolerated by colorectal adenocarcinoma and melanoma cells but toxic to normal human gingival fibroblast: Results of an in vitro investigation Mazlan, Muhammad Alif; Yusof, Afzan Mat; Md Isa, Muhammad Lokman
Makara Journal of Health Research Vol. 24, No. 1
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Background: Glucose is associated with weight gain, which increases the risk of cancer. There is insufficient information on the effects of high glucose concentrations on cell lines. This study evaluated the viability patterns of human cancer and normal cell lines treated with glucose. Methods: Human gingival fibroblast (hGF), colorectal adenocarcinoma (HT29), and skin malignant melanoma (A375) cell lines were cultured and treated with additional glucose in three respective concentrations: 1 mg/ml, 5 mg/ml, and 10 mg/ml. Then, cell viability was measured using an MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide)-assay. The data were analyzed using the Statistical Package for the Social Sciences software. Results: The hGF cells’ percentage pattern of viability showed a rapid decline of nearly 95% on the third day of treatment. Both HT29 and A375 were able to survive in the high glucose condition when the cell viability percentage was above 100% on Day 5. The data exhibited significance; the p-value was less than 0.001. Conclusion: The high glucose concentration can be toxic to hGF. In addition, HT29 and A375 might be adaptive to the hyperglycaemic condition.
Effects of L-fucose supplementation on the viability of cancer cell lines Mazlan, Muhammad Alif; Yusof, Afzan Mat; Md Isa, Muhammad Lokman
Makara Journal of Health Research Vol. 24, No. 2
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Background: Fucose is a deoxyhexose sugar. While the biological roles of L-fucose remain unclear, the sugar is known to accelerate the malignant potential of cancer cells. Therefore, this study aimed to evaluate the viability pattern of human cancer and normal cell lines treated with fucose. Methods: The human gingival fibroblast (HGF-1), colorectal adenocarcinoma (HT-29) and skin malignant melanoma (A375) cell lines were cultured and treated with fucose at three concentrations of 1, 5, and 10 mg/ml. Cell viability was then measured using (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay. The data were analyzed using Statistical Package for the Social Sciences software. Results: The percentage of HGF-1 cell viability showed a rapid decline after day 1 of treatment. HT-29 and A375 were capable of surviving treatment with high fucose concentrations. The data were highly significant at p < 0.001. Conclusion: Whereas a high concentration of fucose is toxic to the HGF-1 cell line, the HT-29 and A375 cell lines could potentially adapt to this condition. Down- or upregulation of certain molecules that could induce or inhibit cell death may explain such adaptation. Further testing of up- and downregulated molecules should be conducted in future work.
An assessment of knowledge, attitude, and practice of the Kuantan community on the effects of monosaccharides on cancer Mazlan, Muhammad Alif; Che Hasan, Muhammad Kamil; Mat Yusof, Afzan; Md Isa, Muhammad Lokman
Makara Journal of Health Research Vol. 24, No. 3
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Background: Cancer knowledge, attitude, and practice (KAP) levels of communities are essential to be assessed to enhance cancer educational programs. This study aimed to determine the KAP level of the Kuantan community on the effects of monosaccharides on cancer. The association between the sociodemographic data and KAP level of the community has also been evaluated. Methods: A cross-sectional survey was performed among residents living in the Kuantan community. Only 303 of 380 responses were included in the data analysis using the chi-square test. Results: The knowledge and practice levels were moderate, whereas the attitude was at a positive level. Moreover, the association of sociodemographic factors (sex and education level) showed significant difference with the knowledge level (p ≤ 0.05). Additionally, only the age factor showed significant difference toward the practice level of the Kuantan community, with p < 0.05. Conclusion: In conclusion, although the attitude score is positive, educational programs still need to be conducted as the knowledge and practice levels of the community have moderate scores.
A Cross-Sectional Study on Bullying and Psychological Disturbances among Malaysian School Children Md Isa, Muhammad Lokman; Mocktar, Nurfatin Aina; Ibrahim, Wisam Nabeel; Nurumal, Mohd Said; Che Hasan, Muhammad Kamil
Makara Journal of Health Research Vol. 25, No. 1
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Background: Bullying is a common violence in school and has become a major public health and global concern. Bullying influences mental health and is identified as a leading factor of depression. Therefore, this study aimed to identify bullying prevalence and its association toward psychological disturbances (stress, anxiety, and depression). Methods: This cross-sectional study was conducted in three secondary schools in Kuantan. After obtaining consent from parents/guardians, participants were asked to answer a self-administered questionnaire, including School Climate Bullying Survey, Depression Anxiety Stress Questionnaire-21, Patient Depression Questionnaire, and Generalized Anxiety Disorder. Demographic data were self-reported. Data were analyzed using SPSS version 20.0, and chi-square and correlation tests were conducted for variables. Results: A total of 207 students were included in this study. Of respondents, 50.7% were boys and 49.3% girls, and the majority (92.8%) were Malays. Of students, 63.2% were involved in bullying problems through the school years, with verbal bullying as the highest (55.1%). Bullying is significantly associated with stress (p = 0.045), anxiety (p = 0.018), and depression (p = 0.012). Conclusions: School children in Kuantan continue to be involved in bullying. The current study supported that involvement with any bullying activity was associated with psychological disturbances including anxiety, stress, and depression.
Co-Authors Ibrahim, Wisam Nabeel Mat Yusof, Afzan Mazlan, Muhammad Alif Mocktar, Nurfatin Aina Muhammad Kamil Nurumal, Mohd Said Yusof, Afzan Mat Zainal Abidin, Rohulizzat