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All Journal JOURNAL LA MEDIHEALTICO Jurnal Farmasi Sains dan Praktis
Nur Illiyyin Akib
Universitas Halu Oleo, Indonesia
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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PREPARATION OF PHYTOSOME OF KERSEN LEAVES (Muntingia calabura L.) ETHANOL EXRTACT AS ANTIOXIDANT Nur Illiyyin Akib; Nabila Saraswati Hendra; Andi Eka Purnama Putri; Indradewi Armadhani; Andi Nafisah Tendri Adjeng; Rifa’atul Mahmudah
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6206

Abstract

Kersen (Muntingia calabura L.) contains flavonoids that have the potential as antioxidants. However, its hydrophilic characteristics cause poor penetration so that its bioavailability is low. Research had been carried out on the preparation of ethanol extract of cherry leaves in ethosomal vesicle carriers. This study aimed to obtain the optimal phytosome suspension formula. Methods: Sample extraction was carried out by maceration method using ethanol as a solvent and was delipidated was by liquid-liquid method with n-hexane. The characterization of the extract included organoleptic, water-soluble extract content, ethanol soluble extract content, water content, ash content, acid insoluble ash content, and residual solvent. flavonoid contents were carried out by the TLC method and antioxidant activity was determined using DPPH method. Phytosome preparation was prepared by solvent evaporation and thin film hidration with ratio of extract and phosphatidylcholine 1:1 with concentration of 0.5% (A); 1% (B); and 1.5% (C). The characterization included observing morphology of vesicles using optical microscope, determining the size distribution of vesicles using PSA, and calculating the sorption efficiency using a spectrophotometer at max 281 nm. Results: The characteristics of extract were dark green; thick; distinctive aroma; ethanol soluble content were 70.91%; water soluble content were 32.5%; water content were 1.19%; ash content were 1.25%; acid insoluble ash content were 0.49%; and the remaining solvent was 0. The identification of flavonoids showed positive results. The extract has flavonoids and strong antioxidant activity with 62.71 g/mL for IC50. The shape is single layer large vesicle (LUV), diameter was 445.7 nm (A); 420.7 nm (B); and 419.6 nm (C). Vesicle entrapment efficiency was 5.83% (A); 47.575% (B); and 68.81% (C). It can be concluded that the optimal phytosome suspension formula is C with 1.5% phosphatidylcholine and 1.5% of extract.
Evaluation of the Rationality of Antibiotic Use in Pneumonia Patients Using the Gyssens Method Agustiana Agustiana; Adryan Fristiohady; Muhammad Arba; Asriullah Jabbar; Nur Illiyyin Akib; Suryani Suryani
Journal La Medihealtico Vol. 6 No. 6 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i6.2757

Abstract

Pneumonia is one of the leading causes of morbidity and mortality worldwide. The irrational use of antibiotics in pneumonia management can reduce therapeutic effectiveness and increase the risk of antimicrobial resistance. This study aimed to evaluate the rationality of antibiotic use in pneumonia patients at Hospital X using the Gyssens method. This research employed a descriptive observational design with a retrospective approach, utilizing medical record data of adult inpatients diagnosed with pneumonia during the period of January–December 2024. A total of 86 patient records meeting the inclusion criteria were analyzed. Evaluation was conducted using the Gyssens method by comparing the appropriateness of therapy with the Guidelines for the Management of Adult Pneumonia issued by the Indonesian Ministry of Health (Regulation No. 28 of 2021) and the Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS, 2023) guidelines. The results showed that the most frequently used antibiotics were Ceftriaxone (34.88%), Azithromycin (32.56%), and Levofloxacin (32.56%). The most common duration of therapy was five days (53.9%). Based on the Gyssens categories, rational antibiotic use (category 0) was found in 57 cases (66.28%), while the remaining cases were categorized as I (6.98%), IIa (11.63%), IIIa (9.30%), and IIIb (5.81%). These findings indicate that most antibiotic use at Hospital X was rational; however, continuous monitoring and periodic evaluation through the Antimicrobial Resistance Control Program (PPRA) are still necessary to optimize therapeutic effectiveness and prevent antibiotic resistance.
Co-Authors Adryan Fristiohady Agustiana Agustiana Andi Eka Purnama Putri Asriullah Jabbar Indradewi Armadhani Mallarangeng, Andi Nafisah Tendri Adjeng Muhammad Arba Nabila Saraswati Hendra Rifa’atul Mahmudah Suryani Suryani