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All Journal Journal of Food and Pharmaceutical Science Gema Pendidikan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Pharmaceutical Education Jurnal Pengabdian Nusantara (JPN) DEVOTE: Jurnal Pengabdian Masyarakat Global MOSIRAHA : Jurnal Pengabdian Farmasi Lansau: Jurnal Ilmu Kefarmasian Journal of Food and Pharmaceutical Sciences Kartika : Jurnal Ilmiah Farmasi Jurnal Sains dan Kesehatan

,, Suryani

Fakultas Farmasi Universitas Halu Oleo

Author-ID : 1261520

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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PENDIDIKAN KESEHATAN BAGI PARA PELAJAR DI KOTA KENDARI Nur Illiyyin Akib; Muh. Arba; Suryani ,; Henny Kasmawati; Yamin ,; Ruslin ,; Sunandar Ihsan
Gema Pendidikan Vol 26, No 1 (2019): Januari, Gema Pendidikan
Publisher : Universitas Halu Oleo

Telah dilaksanakan kegiatan Pengabdian pada Masyarakat terintegrasi KKN-Tematik berupa pendidikan kesehatan bagi para pelajar di Kota Kendari. Kegiatan ini bertujuan untuk meningkatkan pemahaman tentang kesehatan bagi para pelajar. Kegiatan ini dilaksanakan di beberapa sekolah di Kota Kendari. Kegiatan dilaksanakan mulai Agustus hingga Oktober 2018. Pelaksanaan kegiatan terdiri atas penyuluhan keamanan pangan, obat, dan kosmetika oleh dosen terhadap pelajar SMAN 11 Kendari, SMA Muhammadiyah Kendari, SMKN 6 Kendari, dan SMK Satria Kendari; penyuluhan penggunaan obat bagi pelajar SMPN 05 Kendari; pengenalan profesi apoteker dan penyuluhan Pola Hidup Bersih dan Sehat (PHBS) bagi pelajar SDN 02 Baruga dan SDN 03 Poasia; serta penyebaran informasi melalui media cetak. Penyuluhan dilakukan dengan metode ceramah, praktek, tanya jawab. Media cetak yang digunakan adalah leaflet. Kegiatan ini berhasil meningkatkan pemahaman tentang kesehatan bagi para pelajar di Kota Kendari. Kata Kunci: Pendidikan Kesehatan, Pelajar, Penyuluhan, Obat, Kota Kendari.

Optimasi Formula Gel Antioksidan Ekstrak Etanol Buah Bligo (Benincasa hispida) dengan Metode Simplex Lattice Design (SLD): Antioxidants Gel Formula Optimation of Bligo Fruit Ethanolic Extract (Benincasa hispida) by Simplex Lattice Design (SLD) method Suryani Suryani; Andi Nafisah; Syahrir Mana'an
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Benincasa hispida has many benefits including as antioxidant. This study aims to evaluate the effect of Carbomer 940, HPMC and NaOH concentrations in antioxidant gel formula and to determine Carbomer 940, HPMC and NaOH concentrations that could produce the optimal antioxidant gel formula. Benincasa hispida was extracted by maceration method and antioxidant activity was tested by DPPH method. The antioxidant gels were formulated with variety combinations of Carbomer 940, HPMC and NaOH. The optimal gel formula was obtained by Design Expert 7.1.5 with Simplex Lattice Design method. The physical characteristic of optimal gel formula was retested and compared with the results of Simplex Lattice Design .The results showed that antioxidant activity of Benincasa hispida ethanolic extract has potent activity with the IC50 40,28 μg/mL. The increasing concentration of Carbomer 940, HPMC and NaOH possessed the high coefficients viscosity (cPs) with the value of 4366, 4133 and 3750 respectively. The increasing concentration of NaOH possessed pH and dispersive power of the gel with coefficients of 11,0 and 5,21 respectively. The desirability values suggested by Simplex Lattice Design were 1,000 with component variation of the optimal formula were Carbomer 940 1,5%, HPMC 0,5% and NaOH 0,4%. The significance test of the optimal formula compared to the results of laboratory experiments showed the significance of viscosity of 0,130, the dispersive power of 0,348 and pH of 0,184 that means there was no significant difference between the prediction values by using Simplex Lattice Design and results of laboratory experiments. It was indicated that significance values of each responses were over 0,05 (p>0.05).

Formulasi Self-Nanoemulsifiying Drug Delivery System (SNEDDS) Asam Mefenamat menggunakan VCO dengan Kombinasi Surfaktan Tween dan Span Muhamad Handoyo Sahumena; Suryani Suryani; Neni Rahmadani
Journal Syifa Sciences and Clinical Research Vol 1, No 2 (2019): Volume 1 Edisi 2 2019
Publisher : State University of Gorontalo

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) which has analgesic, anti-inflammatory and antipyretic effects. Mefenamic acid works by inhibiting prostaglandin synthesis as an inflammatory mediator. Mefenamic acid has low drug solubility and a long process of dissolution in the body which greatly affects the speed of absorption and bioavailability of the drug. In this study, mefenamic acid nanoemulsion formulation was carried out through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) delivery system. SNEDDS is a drug delivery method through isotropic oil extraction, surfactants, cosurfactans and drug that form oil in water (m/a) emulsions which when in contact with the water phase in the digestive tract wiil from a nanoemulsion that occurs spontaneously so that the drug dissolves with a particle size small so as to increase the effective surface area for absorption. The purpose of the study was to determine the ratio of surfactant and cosurfactant composition to the optimum formula of SNEDDS of mefenamic acid with VCO as an oil phase. The SNEDDS formula was obtained by mixing the surfactants tween 80 and span 80, cosurfactant PEG 400 and VCO as the oil phase using the characterization of determining the optimum formula, namely emulsion formation, transmittance and emulsification time. The composition of the optimum formula of SNEDDS of mefenamic acid is 1 mL VCO; 1 mL PEG 400; 6 mL tween 80; 1 mL span 80. Optimum formula showed clear emulsion results, with transmittance values of 89,04% and emulsification time under 1 minute. In this study produced the optimum formula SNEDDS the met the criteria based on droplet size parameters of 153,5 nm, potential zeta value of 8,2 mV and showed good stability.

MIKROENKAPSULASI ASAM MEFENAMAT MENGGUNAKAN POLIMER HIDROKSI PROPIL METIL SELULOSA DAN NATRIUM ALGINAT DENGAN METODE GELAS IONIK Sandra Aulia Mardikasari; Suryani Suryani; Nur Illiyyin Akib; Muhammad Handoyo Sahumena; Sri Hastuti; Suci Ananda Putri
Majalah Farmasi dan Farmakologi Vol. 23 No. 3 (2019): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Asam mefenamat bersifat rentan terhadap cahaya maupun terhadap udara dan kelembaban. Selain itu asam mefenamat memiliki waktu paruh yang sempit, dapat menyebabkan peningkatan resiko gangguan gastrointestinal termasuk iritasi lambung pada penggunaan jangka panjang. Teknologi Mikroenkapsulasi merupakan proses penyalutan bahan aktif berupa cairan ataupun padatan dengan lapisan yang relatif tipis dengan ukuran partikel yang sangat kecil antara 0,2-5000 μm. Tujuan penelitian ini untuk melakukan preparasi mikroenkapsulasi terhadap asam mefenamat menggunakan polimer Hidroksi Propil Metil Selulosa (HPMC) dan Natrium alginat dengan metode gelasi ionik lalu mengkarakterisasi hasil mikrokapsul yang diperoleh. Preparasi mikroenkapsulasi dilakukan dengan membandingkan konsentrasi polimer yang digunakan, dibuat dalam 3 formula. Parameter karakterisasi meliputi penetapan efisiensi penjerapan, distribusi ukuran partikel, bentuk partikel dan pengujian disolusi. Hasil karakterisasi menujukan mikroenkapsulasi Asam Mefenamat yang dihasilkan memiliki bentuk partikel yang spheris, dengan nilai efisiensi penjerapan terbesar yaitu 67,53% untuk perbandingan HPMC dan natrium alginat masing-masing 4 : 1, sedangkan distribusi ukuran partikel bervariasi dengan ukuran terkecil yakni 1.105 , untuk hasil pengujian disolusi pada medium asam diperoleh konsentrasi pelepasan obat terbesar adalah 10,39 mg/L dan medium basa sebesar 74,456mg/mL. Penelitian Hasil penelitian ini menunjukkan bahwa asam mefenamat dapat dipreparasi dengan teknik mikroenkapsulasi sehingga dapat mengatasi beberapa kekurangan asam mefenamat.

EDUKASI DAN PEMBUATAN TAMAN OBAT KELUARGA UNTUK PENCEGAHAN DAN PEMELIHARAAN KESEHATAN MASYARAKAT Suryani Suryani; Henny Kasmawati; La Ode Muh. Fitrawan; Nurull Hikmah; Nurramadhani A Sida; Ruslin Ruslin; Aswani Aswani
Jurnal Pengabdian NUSANTARA Vol 2, No 2 (2022): Juli - Desember
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/jpnus.v2i2.28430

Indonesian people have used herbal ingredients for health. However, there are differences in natural resources and knowledge of plant processing techniques in medicine which differ from region to region. This community service aims to increase public knowledge about the types of plants that can be cultivated in Family Medicine Garden and their health benefits. Educational activities and the establishment of a Family Medicine Garden (TOGA) were held at the UHO Faculty of Pharmacy drug park. The method of educational activities is in the form of lectures and question-and-answer interactions, followed by manufacturing and planting medicinal plants at Family Medicine Garden. Education is carried out by introducing the efficacy of 21 plants, the parts used and the benefits of Family Medicine Garden. The activity went well, and the community was enthusiastic about getting new knowledge about types of plants and how to make Family Medicine Garden.

EDUKASI PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) DAN PENGELOMPOKKAN SAMPAH DI SD ISLAM INSAN UNGGUL KOTA KENDARI, PROVINSI SULAWESI TENGGARA Henny Kasmawati; Suryani Suryani; La Ode Muhammad Fitrawan; Nurull Hikmah; Nurramadhani A. Sida; Ruslin Ruslin; Aswani Aswani
Jurnal Pengabdian NUSANTARA Vol 2, No 2 (2022): Juli - Desember
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/jpnus.v2i2.28310

In order to accelerate recovery after the Covid-19 pandemic, especially in Kendari, South East Sulawesi, it is necessary to understand and be aware of the importance of maintaining health which starts with a healthy clean-living behaviour (PHBS) which starts from an early understanding of doing PHBS in elementary schools (SD). Important indicators that become critical in this activity are how to wash hands well and group organic and inorganic waste. This activity is also a manifestation of the President's vision for 2020-2024 through the Ministry of Health to improve public health. This community service aims to increase public understanding and awareness, especially students of SD Islam Insan Unggul Kendari about the importance of carrying out healthy clean-living behaviour (PHBS). The method used is education by showing PHBS videos and socialization followed by interactive quizzes. This activity was easily well received by the participants because it used a learning-by-play approach so that the participants were easier to remember and apply in everyday life.

Optimasi Fosfatidilkolin dan Span 80 sebagai Penyusun Vesikel Transfersom Natrium Diklofenak menggunakan Design-Expert Wa Ode Sitti Zubaydah; Suryani Suryani; Nur Janna Kurniawati
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5581

Natrium diklofenak merupakan golongan NSAID (Non Steroid Anti-Inflammatory Drugs) yang banyak diresepkan untuk inflamasi dan nyeri. Namun dalam penggunaannya secara oral, natrium diklofenak mengalami first pass metabolism di hati sehingga hanya sekitar 50% saja obat yang sampai pada sirkulasi sistemik dan jika seringkali diberikan dengan dosis yang lebih tinggi dapat memperparah efek samping di saluran pencernaan. Karena beberapa kerugian diklofenak pada penggunaan oral, maka diklofenak dikembangkan ke sistem penghantaran transdermal dalam hal ini nanovesikel transfersom yang dipilih sebagai alternatif untuk mengatasi permasalahan tersebut. Penelitian ini bertujuan untuk memformulasi vesikel transfersom natrium diklofenak dengan perbandingan (4,5%:0,5%), (4,5%:1%), (4%:0,5%) dan (4%:1%) agar diperoleh perbandingan formula optimum vesikel transfersom natrium diklofenak dengan basis fosfatidilkolin kedelai dan span 80 menggunakan design expert dan untuk mengetahui karakteristik transfersom natrium diklofenak berupa efisiensi penjerapan, distribusi ukuran partikel dan zeta potensial. Optimasi formula transfersom menggunakan metode desain faktorial 22 dengan faktor fosfatidilkolin kedelai dan span 80 menggunakan respon efisiensi penjerapan dan ukuran vesikel. Hasil dari penelitian ini yaitu formula optimum dengan konsentrasi fosfatidilkolin kedelai 4,5% dan span 80 0,5% serta pengujian karakteristik vesikel transfersom allopurinol dengan efisiensi penjerapan 99,56%, distribusi ukuran partikel 160,1 nm dan zeta potensial -57,1 mV.

Optimization of Soya Phosphatidylcholine and Tween 80 As A Preparation of Diclofenac Sodium Transfersome Vesicles Using Design-Expert: Optimasi Fosfatidilkolin Kedelai dan Tween 80 Sebagai Penyusun Vesikel Transfersom Natrium Diklofenak Menggunakan Design- Expert Wa Ode Sitti Zubaydah; Rina Andriani; Suryani Suryani; Astrid Indalifiani; Sitti Raodah Nurul Jannah; Devi Hidayati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 1 (2023): (March 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i1.16085

Background: Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) widely prescribed for inflammation and pain. However, when used orally, diclofenac sodium has poor bioavailability because it undergoes first-pass metabolism in the liver, so only about 50% of the drug reaches systemic circulation. Therefore, the transdermal delivery system, in this case, transfersome nanovesicles, was chosen as an alternative to overcome these problems. Transfersome is a lipid vesicle with the best deformability in penetrating the skin layer among other nanovesicles. Transfersomes consist of active substances, phospholipids, surfactants, and other ingredients. The composition of phosphatidylcholine as a phospholipid and tween 80 as a surfactant is a variable that can affect the optimization of the transfersome formula. Therefore, the ratio of phospholipids and surfactants should be varied to obtain the most stable transfersome formula with high drug entrapment efficiency. Optimization as an approach to get the best combination of a formula can be done in a more efficient way using software called Design-Expert. This software is used to help carry out experimental designs, such as determining the optimum formula for a preparation. Objectives: This study aims to determine the ratio of soya phosphatidylcholine as a phospholipid and tween 80 as a surfactant in the optimum formula of diclofenac sodium transfersome vesicles using Design-Expert and to determine the characteristics of the resulting transfersome vesicles. Material and Methods: Optimizing the transfersome Diclofenac Sodium formula using the factorial design 22 with soya phosphatidylcholine and tween 80 factors, particle size response, and entrapment efficiency. The thin layer hydration method carried out the process of making diclofenac sodium transfersome. Results: The results obtained from this study, namely the optimum formula based on Design-Expert, obtained a ratio of soya phosphatidylcholine and tween 80 of 4.5%: 0.5%. The results of the characterization of the optimum formula obtained a particle size of 224.3 nm, a zeta potential of -57.1 mV, and entrapment efficiency of 99.85%. Conclusions: The results of the characterization of the diclofenac sodium transfersome have met the specifications required for each test.

Formulasi Self Nano-Emulsifying Drug Delivery System (SNEDDS) Ibuprofen dengan VCO dan Kombinasi Surfaktan Muhamad Handoyo Sahumena; Suryani Suryani
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.20405

Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) class of propionic acid derivatives which has potent anti-inflammatory and antipyretic activity. The solubility of ibuprofen is disadvantageous because it is practically insoluble and has poor dissolution. The aim of this study was to overcome the solubility of ibuprofen through a stable SNEDDS formula. One way to overcome the solubility of ibuprofen is to prepare nanoemulsions using the Self-Emulsifying Drug Delivery System (SNEDDS) technique. SNEDDS is a form of preemulsion drug which spontaneously forms nanoemulsion when it encounters the aqueous phase in the digestive tract. Parameters for the success of the SNEDDS formula include emulsification time, stability, and droplet size using a particle size analyzer (PSA). The SNEDDS formulation was carried out by mixing span 80 and tween 20, PEG 400 and VCO as the oil phase. The characteristics of SNEDDS ibuprofen include homogeneity of SNEDDS, clarity, transmittance, emulsification time, and droplet size. The composition of the optimum formula for SNEDDS ibuprofen is 1 mL of VCO; 1 mL PEG; 7 mL tween 20; 1 mL span 80. The formula shows good homogeneity, is clear with emulsification time of 15 seconds, transmittance is 92.69%, and droplet size is 221.9 nm.

Preparasi dan Karakterisasi Sistem Pembawa Liposom dari Ekstrak Etanol Daun Miana (Coleus atropurpureus L. Benth) Muhamad Handoyo Sahumena; Suryani Suryani; Widya Pratiwi
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.20414

Miana (Coleus atropurpureus L. Benth) is a plant in the ornamental plant group that has benefits for the body. The part of the plant that is efficacious as medicine is on the leaves with a brownish red color. However, extracts from miana leaves are hydrophilic, making it difficult to penetrate biological membranes which are rich in lipids and difficult to use topically. One way to overcome this problem is by making liposome carrier systems. Liposomes are carrier systems consisting of phospholipids and cholesterol with the ability to encapsulate hydrophilic and hydrophobic compounds. Parameters for the success of the liposome formula include vesicle shape, high adsorption efficiency and liposome vesicle size using a particle size analyzer (PSA). The liposome formula was obtained through the thin layer hydration method using phosphatidylcholine and cholesterol. The composition of the optimum liposome formula of miana leaf ethanol extract is 0.2% phosphatidylcholine and 0.4% cholesterol. The optimum formula obtained is a complex spherical structure, efficiency entrapment 92.91%, vesicle size 573.6 nm and polydispersity index is 0,505.

Co-Authors Andi Nafisah Anton Anton Asriullah Jabbar Astrid Indalifiani Astrid Indalifiany Aswani Aswani Aswani Aswani Aswani Devi Hidayati Dian Munasari Dian Munasari Solo Fadhliyah Malik Fifi Nirmala Fitrawan, La Ode Muhammad Halik Halik Kasmawati, Henny La Ode Ahmad Nur Ramadhan La Ode Muh. Fitrawan Mubarak Mubarak Muh. Arba Muhamad Handoyo Sahumena Muhamad Handoyo Sahumena Muhammad Aswan Muhammad Handoyo Sahumena Muhammad Handoyo Sahumena Muhammad Ilyas Y Munarsi Munarsi Nasrudin Nasrudin Neni Rahmadani Nur Aisyah Abdullah Nur Illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Janna Kurniawati Nurramadhani A. Sida Nurramadhani A. Sida Nurull Hikmah Nurull Hikmah Rezki Annisa Rifa’atul Mahmudah Rina Andriani Ruslin , Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Sabarudin Sabarudin Sahidin Sandra Aulia Mardikasari Sitti Raodah Nurul Jannah Sitti Raodah Nurul Jannah Sri Hastuti Suci Ananda Putri Sunandar Ihsan Sundar Ihsan Syahrir Mana'an Vica Aspadiah W. Wahyuni Wa Ode Erna Fitriani Wa Ode Sitti Zubaydah Wahyuni Wahyuni Widya Pratiwi Yamin Yamin ,

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